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Polymeric hydrogels as artificial extracellular microenvironments for cancer research

Publication ,  Journal Article
Park, KM; Gerecht, S
Published in: European Polymer Journal
June 29, 2015

An emerging trend in cancer research is to design in vitro tissue culture models that can accurately guide clinical trials to improve their therapeutic outcomes. Particularly, recent studies in cancer research have focused on utilizing three-dimensional (3D) microenvironments to precisely mimic in vivo conditions as a new tool to gain mechanistic understanding that will lead to the discovery of novel target therapeutics. In order to create 3D tumor microenvironments in vitro, polymeric hydrogel materials have been widely used as an artificial microenvironment due to their tunable properties and structural similarity to native extracellular matrices. In this review, we discuss how polymeric hydrogels may serve as 3D artificial tumor microenvironments to study cancer. Furthermore, we review the most recent approaches to integrate hydrogel materials and micro/nano-fabrication techniques, such as microfluidic devices and 3D printing techniques, for cancer research.

Duke Scholars

Published In

European Polymer Journal

DOI

ISSN

0014-3057

Publication Date

June 29, 2015

Volume

72

Start / End Page

507 / 513

Related Subject Headings

  • Polymers
  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry
  • 0912 Materials Engineering
  • 0904 Chemical Engineering
  • 0303 Macromolecular and Materials Chemistry
 

Citation

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Park, K. M., & Gerecht, S. (2015). Polymeric hydrogels as artificial extracellular microenvironments for cancer research. European Polymer Journal, 72, 507–513. https://doi.org/10.1016/j.eurpolymj.2015.06.030
Park, K. M., and S. Gerecht. “Polymeric hydrogels as artificial extracellular microenvironments for cancer research.” European Polymer Journal 72 (June 29, 2015): 507–13. https://doi.org/10.1016/j.eurpolymj.2015.06.030.
Park KM, Gerecht S. Polymeric hydrogels as artificial extracellular microenvironments for cancer research. European Polymer Journal. 2015 Jun 29;72:507–13.
Park, K. M., and S. Gerecht. “Polymeric hydrogels as artificial extracellular microenvironments for cancer research.” European Polymer Journal, vol. 72, June 2015, pp. 507–13. Scopus, doi:10.1016/j.eurpolymj.2015.06.030.
Park KM, Gerecht S. Polymeric hydrogels as artificial extracellular microenvironments for cancer research. European Polymer Journal. 2015 Jun 29;72:507–513.
Journal cover image

Published In

European Polymer Journal

DOI

ISSN

0014-3057

Publication Date

June 29, 2015

Volume

72

Start / End Page

507 / 513

Related Subject Headings

  • Polymers
  • 4016 Materials engineering
  • 3403 Macromolecular and materials chemistry
  • 0912 Materials Engineering
  • 0904 Chemical Engineering
  • 0303 Macromolecular and Materials Chemistry