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Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.

Publication ,  Journal Article
Lowenthal, J; Gerecht, S
Published in: Biochemical and biophysical research communications
May 2016

Proper blood vessel networks are necessary for constructing and re-constructing tissues, promoting wound healing, and delivering metabolic necessities throughout the body. Conversely, an understanding of vascular dysfunction has provided insight into the pathogenesis and progression of diseases both common and rare. Recent advances in stem cell-based regenerative medicine - including advances in stem cell technologies and related progress in bioscaffold design and complex tissue engineering - have allowed rapid advances in the field of vascular biology, leading in turn to more advanced modeling of vascular pathophysiology and improved engineering of vascularized tissue constructs. In this review we examine recent advances in the field of stem cell-derived vasculature, providing an overview of stem cell technologies as a source for vascular cell types and then focusing on their use in three primary areas: studies of vascular development and angiogenesis, improved disease modeling, and the engineering of vascularized constructs for tissue-level modeling and cell-based therapies.

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Published In

Biochemical and biophysical research communications

DOI

EISSN

1090-2104

ISSN

0006-291X

Publication Date

May 2016

Volume

473

Issue

3

Start / End Page

733 / 742

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Tissue Engineering
  • Stem Cells
  • Muscle, Smooth, Vascular
  • Microcirculation
  • Induced Pluripotent Stem Cells
  • Imaging, Three-Dimensional
  • Humans
  • Endothelial Cells
 

Citation

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Lowenthal, J., & Gerecht, S. (2016). Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering. Biochemical and Biophysical Research Communications, 473(3), 733–742. https://doi.org/10.1016/j.bbrc.2015.09.127
Lowenthal, Justin, and Sharon Gerecht. “Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.Biochemical and Biophysical Research Communications 473, no. 3 (May 2016): 733–42. https://doi.org/10.1016/j.bbrc.2015.09.127.
Lowenthal J, Gerecht S. Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering. Biochemical and biophysical research communications. 2016 May;473(3):733–42.
Lowenthal, Justin, and Sharon Gerecht. “Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering.Biochemical and Biophysical Research Communications, vol. 473, no. 3, May 2016, pp. 733–42. Epmc, doi:10.1016/j.bbrc.2015.09.127.
Lowenthal J, Gerecht S. Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering. Biochemical and biophysical research communications. 2016 May;473(3):733–742.
Journal cover image

Published In

Biochemical and biophysical research communications

DOI

EISSN

1090-2104

ISSN

0006-291X

Publication Date

May 2016

Volume

473

Issue

3

Start / End Page

733 / 742

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Tissue Engineering
  • Stem Cells
  • Muscle, Smooth, Vascular
  • Microcirculation
  • Induced Pluripotent Stem Cells
  • Imaging, Three-Dimensional
  • Humans
  • Endothelial Cells