Current Appointments & Affiliations
Clinical Faculty in the Department of Medicine
·
2025 - Present
Medicine, Gastroenterology,
Medicine
Recent Publications
Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
Journal Article J Immunol · April 15, 2014 The p110δ subunit of class IA PI3K modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δ(KD)) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110 ... Full text Link to item CiteNFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.
Journal Article J Immunol · February 15, 2014 NFIL3 is a transcription factor that regulates multiple immunologic functions. In myeloid cells, NFIL3 is IL-10 inducible and has a key role as a repressor of IL-12p40 transcription. NFIL3 is a susceptibility gene for the human inflammatory bowel diseases. ... Full text Link to item CiteCarbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance.
Journal Article Gastroenterology · April 2013 BACKGROUND & AIMS: Heme oxygenase-1 (HO-1) and its metabolic by-product, carbon monoxide (CO), protect against intestinal inflammation in experimental models of colitis, but little is known about their intestinal immune mechanisms. We investigated the inte ... Full text Link to item CiteEducation, Training & Certifications
Philadelphia College of Osteopathic Medicine ·
2016
D.O.