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Steven M. Russo

Clinical Associate in the Department of Medicine
Medicine, Gastroenterology

Selected Publications

Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.

Journal Article J Immunol · April 15, 2014 The p110δ subunit of class IA PI3K modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δ(KD)) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110 ... Full text Link to item Cite

NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.

Journal Article J Immunol · February 15, 2014 NFIL3 is a transcription factor that regulates multiple immunologic functions. In myeloid cells, NFIL3 is IL-10 inducible and has a key role as a repressor of IL-12p40 transcription. NFIL3 is a susceptibility gene for the human inflammatory bowel diseases. ... Full text Link to item Cite

Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance.

Journal Article Gastroenterology · April 2013 BACKGROUND & AIMS: Heme oxygenase-1 (HO-1) and its metabolic by-product, carbon monoxide (CO), protect against intestinal inflammation in experimental models of colitis, but little is known about their intestinal immune mechanisms. We investigated the inte ... Full text Link to item Cite

In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery.

Journal Article AAPS J · January 2013 Peptide and protein drugs have become the new generation of therapeutics, yet most of them are only available as injections, and reports on oral local intestinal delivery of peptides and proteins are quite limited. The aim of this work was to develop and e ... Full text Link to item Cite

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

Journal Article J Immunol · August 15, 2012 To prevent excessive inflammatory responses to commensal microbes, intestinal macrophages, unlike their systemic counterparts, do not produce inflammatory cytokines in response to enteric bacteria. Consequently, loss of macrophage tolerance to the enteric ... Full text Link to item Cite

An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis.

Journal Article J Immunol · May 1, 2011 Cigarette smoking is a significant environmental factor in the human inflammatory bowel diseases, remarkably, conferring protection in ulcerative colitis. We previously demonstrated that a prominent component of cigarette smoke, CO, suppresses Th17-mediate ... Full text Link to item Cite