Current Duke Appointments & Affiliations
Postdoctoral Associate
Pharmacology & Cancer Biology,
Basic Science Departments
Recent Scholarly Works
A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer
Preprint · April 9, 2026 AbstractChemoresistance is the leading cause of poor prognosis in triple-negative breast cancer (TNBC), yet the underlying mechanisms remain unknown. To reveal metabolic drivers of de novo chemoresistance i ... Full text CiteHemizygous loss of helicases promotes genomic instability and cancer development.
Journal article Science advances · February 2026 Cancer mutations perturb key processes, driving uncontrolled cell proliferation. With critical roles of enzymes in cell function and growth, we hypothesized that cancer driver mutations alter specific and recurrent enzymatic functions. Leveraging large pan ... Full text CiteG6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor.
Journal article JCI insight · June 2025 Mutations in genome maintenance factors drive sporadic and hereditary breast cancers. Here, we searched for potential drivers based on germline DNA analysis from a cohort consisting of patients with early-onset breast cancer negative for BRCA1/BRCA2 mutati ... Full text CiteRecent Grants
Mechanisms of replication fork protection and recovery
ResearchPostdoctoral Associate · Awarded by Washington University in St. Louis · 2023 - 2030Dissecting early pathogenesis of BRCA1/2-associated cancer for risk prediction and prevention
ResearchPostdoctoral Associate · Awarded by Massachusetts General Hospital · 2023 - 2025View All Grants