Xin Li

Postdoctoral Associate

Pharmacology & Cancer Biology

xin.li@duke.edu

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Selected Publications

G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor

Journal Article JCI Insight · June 9, 2025 Full text Cite

The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression

Journal Article Journal of Clinical Investigation · June 2, 2025 Full text Cite

Enzyme family-centred approach identifies helicases as recurrent hemizygous tumour suppressor genes

Preprint · August 14, 2024 Full text Cite

BRCAness, DNA gaps, and gain and loss of PARP inhibitor-induced synthetic lethality.

Journal Article The Journal of clinical investigation · July 2024 Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2 deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other cancers. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-d ... Full text Cite

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.

Journal Article Nature genetics · December 2022 Determining the functional role of thousands of genetic sequence variants (mutations) associated with genetic diseases is a major challenge. Here we present clustered regularly interspaced short palindromic repeat (CRISPR)-SelectTIME, CRISPR-Sel ... Full text Cite