Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiothoracic Surgery, Surgery, Duke University School of Medicine 2014 - 2017
  • Chief Resident in General Surgery, Surgery, Jackson Memorial Hospital 2013 - 2014
  • Senior Resident in General Surgery, Surgery, Jackson Memorial Hospital 2011 - 2013
  • Postdoctoral Research Fellow, Surgery, Jackson Memorial Hospital 2009 - 2011
  • Junior Resident in General Surgery, Surgery, University of Miami, Leonard M. Miller School of Medicine 2007 - 2009
  • M.D., University of Miami, Leonard M. Miller School of Medicine 2007
  • B.S., Vanderbilt University 2001
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2017 - 2020
• Recognition
• 

  In the News

  • NOV 8, 2019

    Duke School of Medicine

    Healing Hearts in Honduras
• Research
• 

  Selected Grants

  • Human Fresh Tissue Lab - Corporate non-CME Educational Program Agreement awarded by AtriCure, Inc. 2020 - 2021
• 

  External Relationships

  • XyloCor
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Vekstein, Andrew M., Charles M. Wojnarski, E Hope Weissler, Adam R. Williams, Ryan P. Plichta, Jacob N. Schroder, and G Chad Hughes. “Selective Sinus Replacement for Aortic Root Aneurysm: Durable Approach in Selected Patients.” Ann Thorac Surg 115, no. 2 (February 2023): 378–85. https://doi.org/10.1016/j.athoracsur.2022.05.071.
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    • Yan, Ruorong, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, et al. “An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.” Cell Stem Cell 30, no. 1 (January 5, 2023): 96-111.e6. https://doi.org/10.1016/j.stem.2022.11.012.
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    • Williams, Aaron M., Nishant P. Shah, Todd Rosengart, Thomas J. Povsic, and Adam R. Williams. “Emerging role of positron emission tomography (PET) imaging in cardiac surgery.” J Card Surg 37, no. 12 (December 2022): 4158–64. https://doi.org/10.1111/jocs.16992.
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    • Williams, Adam R., and Edward P. Chen. “Commentary: Innominate artery cannulation for antegrade cerebral perfusion: Keeping the light bulb lit.” J Thorac Cardiovasc Surg 164, no. 5 (November 2022): 1439–40. https://doi.org/10.1016/j.jtcvs.2020.11.068.
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    • Doberne, Julie W., Ashraf A. Sabe, Andrew M. Vekstein, Charles M. Wojnarski, Jatin Anand, Soraya Voight, Vignesh Raman, et al. “Stent Graft-induced Aortic Wall Injury: Incidence, Risk Factors, and Outcomes.” Ann Thorac Surg 114, no. 3 (September 2022): 684–92. https://doi.org/10.1016/j.athoracsur.2022.01.028.
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    • Stoker, Alexander, Andre Gosling, Adam Williams, Douglas Overbey, Alina Nicoara, and Angela Pollak. “Transesophageal Echocardiography-Guided Percutaneous Aspiration of a Large Tricuspid Valve Vegetation in a Patient with Infective Endocarditis.” Case (Phila) 6, no. 7 (September 2022): 335–39. https://doi.org/10.1016/j.case.2022.04.006.
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    • Vekstein, Andrew M., Julie W. Doberne, E Hope Weissler, Charles M. Wojnarski, Chandler A. Long, Adam R. Williams, Ryan P. Plichta, Jeffrey G. Gaca, and G Chad Hughes. “Tailored approach and outcomes of aortic arch reconstruction after acute type A dissection repair.” J Thorac Cardiovasc Surg, February 16, 2022. https://doi.org/10.1016/j.jtcvs.2022.02.016.
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    • Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.
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    • Vekstein, Andrew M., David C. Wendell, Dawn E. Bowles, Sophia DeLuca, Ruorong Yan, Muath Bishawi, Garth Devlin, et al. “Abstract 12181: Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study.” Circulation 144, no. Suppl_1 (November 16, 2021). https://doi.org/10.1161/circ.144.suppl_1.12181.
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    • Narayanasamy, Shanti, Adam R. Williams, Wiley A. Schell, Rebekah W. Moehring, Barbara D. Alexander, Thuy Le, Ramesh A. Bharadwaj, Michelle McGauvran, Jacob N. Schroder, and John R. Perfect. “Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.” Open Forum Infect Dis 8, no. 11 (November 2021): ofab536. https://doi.org/10.1093/ofid/ofab536.
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    • Vekstein, Andrew, Krunal Amin, Sydney Record, Adam Williams, Ryan Plichta, Andrew Wang, Todd Kiefer, J Kevin Harrison, Jeffrey G. Gaca, and G Chad Hughes. “TCT-269 Five-Year Outcomes After Valve-in-Valve Transcatheter Aortic Valve Replacement: Excellent Valve-Specific Outcomes but Poor Overall Survival.” Journal of the American College of Cardiology 78, no. 19 (November 2021): B110–B110. https://doi.org/10.1016/j.jacc.2021.09.1122.
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    • Williams, Adam R., and Shanti Narayanasamy. “Curvularia alcornii Infection.” N Engl J Med 384, no. 24 (June 17, 2021): e95. https://doi.org/10.1056/NEJMicm2025646.
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    • Zwischenberger, Brittany A., Adam R. Williams, and Lynne M. H. Koweek. “Rethinking Aortic Root Replacement With Anomalous Left Coronary After Computed Tomographic Angiogram.” Ann Thorac Surg 111, no. 3 (March 2021): e219. https://doi.org/10.1016/j.athoracsur.2020.08.056.
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    • Williams, A. R., and E. P. Chen. “Commentary: A nano-sized step for man, a giant step for mankind?” Jtcvs Open 5 (March 1, 2021): 37–38. https://doi.org/10.1016/j.xjon.2020.09.007.
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    • Merchant, Akeel M., Mark D. Friedland, Marcus A. Behrens, Adam R. Williams, Andrew Berchuck, and Nicole R. Guinn. “Surgical management of ovarian carcinosarcoma with inferior vena cava extension into the right atrium.” J Surg Case Rep 2020, no. 12 (December 2020): rjaa530. https://doi.org/10.1093/jscr/rjaa530.
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    • Jimenez Contreras, Fabian, Alejandro Murillo-Berlioz, Jatin Anand, Claire Aksamit, Hugo Orellana, Carmelo A. Milano, and Adam R. Williams. “Use of an inverted On-X mitral valve in the aortic position in a resource limited setting.” J Card Surg 35, no. 11 (November 2020): 3239–41. https://doi.org/10.1111/jocs.14974.
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    • Madou, Isidore Dinga, Adam R. Williams, and Jeffrey G. Gaca. “Patch exclusion technique with Amplatzer septal occluder device for the treatment of postinfarction ventricular septal defect.” Jtcvs Tech 3 (September 2020): 198–201. https://doi.org/10.1016/j.xjtc.2020.04.004.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Adam Z. Banks, Lynne H. Koweek, Ryan Plichta, Adam Williams, et al. “Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.” Am Heart J 224 (June 2020): 105–12. https://doi.org/10.1016/j.ahj.2020.02.003.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Lynne H. Koweek, Adam Williams, Todd Kiefer, Andrew Wang, Jeffrey Gaca, G Chad Hughes, and J Kevin Harrison. “Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.” J Invasive Cardiol 31, no. 7 (July 2019): E184–91.
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    • Hatzistergos, Konstantinos E., Adam R. Williams, Derek Dykxhoorn, Michael A. Bellio, Wendou Yu, and Joshua M. Hare. “Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.” Circ Res 124, no. 8 (April 12, 2019): 1184–97. https://doi.org/10.1161/CIRCRESAHA.118.314063.
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    • Ranney, David N., Babatunde A. Yerokun, Ehsan Benrashid, Muath Bishawi, Adam Williams, Richard L. McCann, and G Chad Hughes. “Outcomes of Planned Two-Stage Hybrid Aortic Repair With Dacron-Replaced Proximal Landing Zone.” Ann Thorac Surg 106, no. 4 (October 2018): 1136–42. https://doi.org/10.1016/j.athoracsur.2018.04.044.
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    • Heath, Michele, Julie Walker, Atilio Barbeito, Adam Williams, Ian Welsby, Cory Maxwell, Mani Daneshmand, John Haney, and Maureane Hoffman. “Differentiating between cold agglutinins and rouleaux: a case series of seven patients.” Perfusion 33, no. 2 (March 2018): 164–69. https://doi.org/10.1177/0267659117727593.
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    • Kulandavelu, Shathiyah, Vasileios Karantalis, Julia Fritsch, Konstantinos E. Hatzistergos, Viky Y. Loescher, Frederic McCall, Bo Wang, et al. “Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine.” J Am Coll Cardiol 68, no. 22 (December 6, 2016): 2454–64. https://doi.org/10.1016/j.jacc.2016.09.925.
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    • Heath, Michele, Suraj Yalamuri, Julie Walker, Cory Maxwell, Adam Williams, Sharon McCartney, and Mani Daneshmand. “Cold Agglutinin Autoantibodies in a Patient without a Visible Coronary Sinus Ostium: Strategies for Myocardial Protection without Using Retrograde Cardioplegia.” J Extra Corpor Technol 48, no. 2 (June 2016): 79–82.
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    • Williams, Adam R., Andrew Wang, Han Kim, and Carmelo A. Milano. “Resection of Carcinoid Tumor Metastatic to the Right Ventricle and Tricuspid Valve.” Ann Thorac Surg 100, no. 6 (December 2015): 2348–50. https://doi.org/10.1016/j.athoracsur.2015.02.108.
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    • Suncion, Viky Y., Vasileios Karantalis, Luiza L. Bagno, Frederic McCall, Bo Wang, Samuel Golpanian, Jose E. Rodriguez, et al. “Abstract 140: Effect of Transendocardial Autologous Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and Restore Cardiac Function in a Heart Failure Swine Model.” Circulation Research 115, no. suppl_1 (July 18, 2014). https://doi.org/10.1161/res.115.suppl_1.140.
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    • Suncion, Viky Y., Eduard Ghersin, Joel E. Fishman, Juan Pablo Zambrano, Vasileios Karantalis, Nicole Mandel, Katarina H. Nelson, et al. “Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.” Circ Res 114, no. 8 (April 11, 2014): 1292–1301. https://doi.org/10.1161/CIRCRESAHA.114.302854.
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    • Heldman, Alan W., Darcy L. DiFede, Joel E. Fishman, Juan P. Zambrano, Barry H. Trachtenberg, Vasileios Karantalis, Muzammil Mushtaq, et al. “Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.” Jama 311, no. 1 (January 1, 2014): 62–73. https://doi.org/10.1001/jama.2013.282909.
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    • Williams, A. R., V. Y. Suncion, F. McCall, D. Guerra, J. Mather, J. P. Zambrano, A. W. Heldman, and J. M. Hare. “Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.” Journal of the American Heart Association 2, no. 3 (June 1, 2013).
    • Williams, Adam R., Viky Y. Suncion, Frederic McCall, Danny Guerra, Jacques Mather, Juan P. Zambrano, Alan W. Heldman, and Joshua M. Hare. “Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.” J Am Heart Assoc 2, no. 3 (May 17, 2013): e000140. https://doi.org/10.1161/JAHA.113.000140.
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    • Williams, Adam R., Konstantinos E. Hatzistergos, Benjamin Addicott, Fred McCall, Decio Carvalho, Viky Suncion, Azorides R. Morales, et al. “Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction.” Circulation 127, no. 2 (January 15, 2013): 213–23. https://doi.org/10.1161/CIRCULATIONAHA.112.131110.
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    • McCall, Frederic C., Adam R. Williams, Viky Y. Suncion, Vasileios Karantalis, Juan P. Zambrano, Alan W. Heldman, and Joshua M. Hare. “Abstract 246: Transendocardial Injections of Allogeneic Mesenchymal Stem Cells Demonstrate Reversal of Left Ventricular Remodeling to Baseline.” Circulation Research 111, no. suppl_1 (August 3, 2012). https://doi.org/10.1161/res.111.suppl_1.a246.
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    • McCall, Frederic C., Kartik S. Telukuntla, Vasileios Karantalis, Viky Y. Suncion, Alan W. Heldman, Muzammil Mushtaq, Adam R. Williams, and Joshua M. Hare. “Myocardial infarction and intramyocardial injection models in swine.” Nat Protoc 7, no. 8 (July 12, 2012): 1479–96. https://doi.org/10.1038/nprot.2012.075.
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    • McCall, Frederic C., Sabrina N. Taldone, Viky Y. Suncion, Vasileios Karantalis, Darcy L. Velazquez, Joel Fishman, Barry Trachtenberg, et al. “INTRAMYOCARDIAL STEM CELL INJECTION CAN REVERSE THE LEFT VENTRICULAR SPHERICAL REMODELING OF ISCHEMIC CARDIOMYOPATHY: TURNING SOCCER BALLS INTO (AMERICAN) FOOTBALLS.” Journal of the American College of Cardiology 59, no. 13 (March 2012): E921–E921. https://doi.org/10.1016/s0735-1097(12)60922-x.
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    • Junttila, M Juhani, Joel E. Fishman, Gustavo A. Lopera, Pradip M. Pattany, Darcy L. Velazquez, Adam R. Williams, Barry H. Trachtenberg, Cristina Sanina, Jacques Mather, and Joshua M. Hare. “Safety of serial MRI in patients with implantable cardioverter defibrillators.” Heart 97, no. 22 (November 2011): 1852–56. https://doi.org/10.1136/heartjnl-2011-300153.
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    • Williams, Adam R., and Joshua M. Hare. “Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease.” Circ Res 109, no. 8 (September 30, 2011): 923–40. https://doi.org/10.1161/CIRCRESAHA.111.243147.
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    • Williams, Adam R., Barry Trachtenberg, Darcy L. Velazquez, Ian McNiece, Peter Altman, Didier Rouy, Adam M. Mendizabal, et al. “Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling.” Circ Res 108, no. 7 (April 1, 2011): 792–96. https://doi.org/10.1161/CIRCRESAHA.111.242610.
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    • Trachtenberg, Barry, Darcy L. Velazquez, Adam R. Williams, Ian McNiece, Joel Fishman, Kim Nguyen, Didier Rouy, et al. “Rationale and design of the Transendocardial Injection of Autologous Human Cells (bone marrow or mesenchymal) in Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction (TAC-HFT) trial: A randomized, double-blind, placebo-controlled study of safety and efficacy.” Am Heart J 161, no. 3 (March 2011): 487–93. https://doi.org/10.1016/j.ahj.2010.11.024.
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    • Williams, Adam, and Charles H. Hennekens. “The role of aspirin in cardiovascular diseases--forgotten benefits?” Expert Opin Pharmacother 5, no. 1 (January 2004): 109–15. https://doi.org/10.1517/14656566.5.1.109.
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  • Conference Papers

    • Doberne, Julie W., Peter S. Downey, Andrew M. Vekstein, Samantha Halpern, E Hope Weissler, Isidore Dinga Madou, Ryan P. Plichta, et al. “Bilateral Thoracosternotomy (Clamshell Approach) for Complex Aortic Arch Surgery.” In Journal of Vascular Surgery, 74:e122–e122. Elsevier BV, 2021. https://doi.org/10.1016/j.jvs.2021.06.187.
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    • Vekstein, Andrew M., E Hope Weissler, Julie W. Doberne, Adam Williams, Ryan P. Plichta, Jeffrey G. Gaca, Chandler A. Long, and G Chad Hughes. “10-Year Outcomes After Endovascular Repair of Acute Complicated and High-Risk Type B Aortic Dissection.” In Journal of Vascular Surgery, 74:e232–33. Elsevier BV, 2021. https://doi.org/10.1016/j.jvs.2021.06.346.
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    • Yerokun, Babatunde A., Muath Bishawi, Adam R. Williams, David N. Ranney, Ehsan Benrashid, Richard L. McCann, and G Chad Hughes. “Impact of Early versus Late Timing of TEVAR on Aortic Remodeling and Long-Term Survival Following Type B Aortic Dissection.” In Journal of Vascular Surgery, 65:e3–4. Elsevier BV, 2017. https://doi.org/10.1016/j.jvs.2016.10.017.
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    • Lamas, Gervasio A., and Adam Williams. “Have the results of randomized clinical trials of pacing altered the practice of cardiac pacing?” In J Cardiovasc Electrophysiol, 14:S15–19, 2003. https://doi.org/10.1046/j.1540-8167.14.s9.14.x.
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