Scholars@Duke
Adam Richard Williams

Adam Richard Williams

Assistant Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
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Selected Publications

18F-FDG PET/CT and Radiolabeled Leukocyte SPECT/CT Imaging for the Evaluation of Cardiovascular Infection in the Multimodality Context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations From ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article JACC Cardiovasc Imaging · June 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article Heart Rhythm · May 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

Quality improvement initiative to increase radial artery usage as a second arterial conduit in coronary artery bypass grafting

Journal Article Interdisciplinary Cardiovascular and Thoracic Surgery · May 1, 2024 OBJECTIVES: Use of radial artery as a second arterial graft, compared to a saphenous vein, in coronary artery bypass grafting (CABG) can improve late outcomes. However, the radial artery remains underutilized. We initiated a quality improvement (QI) initia ... Full text Cite

Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial.

Journal Article Circ Cardiovasc Interv · May 2024 BACKGROUND: XC001 is a novel adenoviral-5 vector designed to express multiple isoforms of VEGF (vascular endothelial growth factor) and more safely and potently induce angiogenesis. The EXACT trial (Epicardial Delivery of XC001 Gene Therapy for Refractory ... Full text Link to item Cite

18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article J Nucl Cardiol · April 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

Infarct exclusion repair of postmyocardial infarction ventricular septal rupture with a hybrid patch and septal occluder device compared with patch only.

Conference JTCVS Tech · December 2023 OBJECTIVE: We developed a hybrid technique for repairing post-myocardial infarction (MI) ventricular septal defect (VSD) that combines infarct exclusion with patch and a nitinol-mesh septal occluder device (SOD) to provide a scaffold to support the damaged ... Full text Link to item Cite

Scoping review of percutaneous mechanical aspiration for valvular and cardiac implantable electronic device infective endocarditis.

Journal Article Clin Microbiol Infect · December 2023 BACKGROUND: Percutaneous mechanical aspiration (PMA) of intravascular vegetations is a novel strategy for management of patients with infective endocarditis (IE) who are at high risk of poor outcomes with conventional cardiac surgery. However, clear indica ... Full text Link to item Cite

Tailored approach and outcomes of aortic arch reconstruction after acute type A dissection repair.

Journal Article J Thorac Cardiovasc Surg · October 2023 OBJECTIVE: After limited root/ascending with or without hemiarch repair for acute type A aortic dissection (ATAAD), 20% to 30% of patients require distal reintervention, frequently for arch pathology. In this report, we describe an institutional algorithm ... Full text Link to item Cite

Initial Management Strategy and Long-Term Outcomes in 186 Cases of Spontaneous Coronary Artery Dissection.

Journal Article Semin Thorac Cardiovasc Surg · August 25, 2023 Spontaneous coronary artery dissection (SCAD) is a rare but important nonatherosclerotic cause of acute coronary syndrome. Indications for revascularization and long-term outcomes of SCAD remain areas of active investigation. We report our experience with ... Full text Link to item Cite

EXACT Trial: Results of the Phase 1 Dose-Escalation Study.

Journal Article Circ Cardiovasc Interv · August 2023 BACKGROUND: New therapies are needed for patients with refractory angina. Encoberminogene rezmadenovec (XC001), a novel adenoviral-5 vector coding for all 3 major isoforms of VEGF (vascular endothelial growth factor), demonstrated enhanced local angiogenes ... Full text Link to item Cite

Selective Sinus Replacement for Aortic Root Aneurysm: Durable Approach in Selected Patients.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Selective sinus replacement (SSR) allows a tailored repair approach in patients with sinus of Valsalva or asymmetric aortic root aneurysm. SSR avoids the need for coronary reimplantation for nondiseased sinuses and shortens operative time, alth ... Full text Link to item Cite

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

Journal Article Cell Stem Cell · January 5, 2023 The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TREEs) i ... Full text Link to item Cite

Emerging role of positron emission tomography (PET) imaging in cardiac surgery.

Journal Article J Card Surg · December 2022 Historically, structural and anatomical imaging has been the mainstay in the diagnosis and management of cardiovascular diseases. In recent years there has been a shift toward increased use of functional imaging studies, including positron emission tomogra ... Full text Link to item Cite

Stent Graft-induced Aortic Wall Injury: Incidence, Risk Factors, and Outcomes.

Journal Article Ann Thorac Surg · September 2022 BACKGROUND: Stent graft-induced new entry has been described in thoracic endovascular aortic repair for aortic dissection. The incidence of stent graft-induced aortic wall injury (SAWI) related to iatrogenic injury in nondissections is incompletely describ ... Full text Link to item Cite

Transesophageal Echocardiography-Guided Percutaneous Aspiration of a Large Tricuspid Valve Vegetation in a Patient with Infective Endocarditis.

Journal Article CASE (Phila) · September 2022 • Right-sided IE is associated with IVDU. • Percutaneous debulking of TV vegetations can be a therapeutic option. • TEE can help guide debulking. • TEE can be used to monitor for and prevent complications. ... Full text Link to item Cite

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.

Journal Article Front Cardiovasc Med · 2022 BACKGROUND: The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targeted ... Full text Link to item Cite

Abstract 12181: Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study

Journal Article Circulation · November 16, 2021 Introduction: The optimal cardiac delivery route for stem cell and gene therapeutics is poorly understood. Direct intramyocardial (IM) injection has been proposed as the gold standard, however, it is ... Full text Cite

Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.

Journal Article Open Forum Infect Dis · November 2021 We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and a ... Full text Open Access Link to item Cite

18F-FDG PET/CT and Radiolabeled Leukocyte SPECT/CT Imaging for the Evaluation of Cardiovascular Infection in the Multimodality Context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations From ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article JACC Cardiovasc Imaging · June 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article Heart Rhythm · May 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

Quality improvement initiative to increase radial artery usage as a second arterial conduit in coronary artery bypass grafting

Journal Article Interdisciplinary Cardiovascular and Thoracic Surgery · May 1, 2024 OBJECTIVES: Use of radial artery as a second arterial graft, compared to a saphenous vein, in coronary artery bypass grafting (CABG) can improve late outcomes. However, the radial artery remains underutilized. We initiated a quality improvement (QI) initia ... Full text Cite

Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial.

Journal Article Circ Cardiovasc Interv · May 2024 BACKGROUND: XC001 is a novel adenoviral-5 vector designed to express multiple isoforms of VEGF (vascular endothelial growth factor) and more safely and potently induce angiogenesis. The EXACT trial (Epicardial Delivery of XC001 Gene Therapy for Refractory ... Full text Link to item Cite

18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations from ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS.

Journal Article J Nucl Cardiol · April 2024 This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the eva ... Full text Link to item Cite

Infarct exclusion repair of postmyocardial infarction ventricular septal rupture with a hybrid patch and septal occluder device compared with patch only.

Conference JTCVS Tech · December 2023 OBJECTIVE: We developed a hybrid technique for repairing post-myocardial infarction (MI) ventricular septal defect (VSD) that combines infarct exclusion with patch and a nitinol-mesh septal occluder device (SOD) to provide a scaffold to support the damaged ... Full text Link to item Cite

Scoping review of percutaneous mechanical aspiration for valvular and cardiac implantable electronic device infective endocarditis.

Journal Article Clin Microbiol Infect · December 2023 BACKGROUND: Percutaneous mechanical aspiration (PMA) of intravascular vegetations is a novel strategy for management of patients with infective endocarditis (IE) who are at high risk of poor outcomes with conventional cardiac surgery. However, clear indica ... Full text Link to item Cite

Tailored approach and outcomes of aortic arch reconstruction after acute type A dissection repair.

Journal Article J Thorac Cardiovasc Surg · October 2023 OBJECTIVE: After limited root/ascending with or without hemiarch repair for acute type A aortic dissection (ATAAD), 20% to 30% of patients require distal reintervention, frequently for arch pathology. In this report, we describe an institutional algorithm ... Full text Link to item Cite

Initial Management Strategy and Long-Term Outcomes in 186 Cases of Spontaneous Coronary Artery Dissection.

Journal Article Semin Thorac Cardiovasc Surg · August 25, 2023 Spontaneous coronary artery dissection (SCAD) is a rare but important nonatherosclerotic cause of acute coronary syndrome. Indications for revascularization and long-term outcomes of SCAD remain areas of active investigation. We report our experience with ... Full text Link to item Cite

EXACT Trial: Results of the Phase 1 Dose-Escalation Study.

Journal Article Circ Cardiovasc Interv · August 2023 BACKGROUND: New therapies are needed for patients with refractory angina. Encoberminogene rezmadenovec (XC001), a novel adenoviral-5 vector coding for all 3 major isoforms of VEGF (vascular endothelial growth factor), demonstrated enhanced local angiogenes ... Full text Link to item Cite

Selective Sinus Replacement for Aortic Root Aneurysm: Durable Approach in Selected Patients.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Selective sinus replacement (SSR) allows a tailored repair approach in patients with sinus of Valsalva or asymmetric aortic root aneurysm. SSR avoids the need for coronary reimplantation for nondiseased sinuses and shortens operative time, alth ... Full text Link to item Cite

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

Journal Article Cell Stem Cell · January 5, 2023 The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TREEs) i ... Full text Link to item Cite

Emerging role of positron emission tomography (PET) imaging in cardiac surgery.

Journal Article J Card Surg · December 2022 Historically, structural and anatomical imaging has been the mainstay in the diagnosis and management of cardiovascular diseases. In recent years there has been a shift toward increased use of functional imaging studies, including positron emission tomogra ... Full text Link to item Cite

Stent Graft-induced Aortic Wall Injury: Incidence, Risk Factors, and Outcomes.

Journal Article Ann Thorac Surg · September 2022 BACKGROUND: Stent graft-induced new entry has been described in thoracic endovascular aortic repair for aortic dissection. The incidence of stent graft-induced aortic wall injury (SAWI) related to iatrogenic injury in nondissections is incompletely describ ... Full text Link to item Cite

Transesophageal Echocardiography-Guided Percutaneous Aspiration of a Large Tricuspid Valve Vegetation in a Patient with Infective Endocarditis.

Journal Article CASE (Phila) · September 2022 • Right-sided IE is associated with IVDU. • Percutaneous debulking of TV vegetations can be a therapeutic option. • TEE can help guide debulking. • TEE can be used to monitor for and prevent complications. ... Full text Link to item Cite

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.

Journal Article Front Cardiovasc Med · 2022 BACKGROUND: The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targeted ... Full text Link to item Cite

Abstract 12181: Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study

Journal Article Circulation · November 16, 2021 Introduction: The optimal cardiac delivery route for stem cell and gene therapeutics is poorly understood. Direct intramyocardial (IM) injection has been proposed as the gold standard, however, it is ... Full text Cite

Curvularia alcornii Aortic Pseudoaneurysm Following Aortic Valve Replacement: Case Report and Review of the Literature.

Journal Article Open Forum Infect Dis · November 2021 We report the first case of Curvularia alcornii aortic pseudoaneurysm following bioprosthetic aortic valve replacement in an immunocompetent host. Infection was complicated by septic emboli to multiple organs. Despite aggressive surgical intervention and a ... Full text Open Access Link to item Cite

Curvularia alcornii Infection.

Journal Article N Engl J Med · June 17, 2021 Full text Link to item Cite

Monitoring After Surgery for Acute Aortic Syndromes

Chapter · January 1, 2021 After surgical repair for acute aortic syndromes, whether with open, endovascular or hybrid approaches, immediate post-operative and long-term monitoring require a patient specific approach. In the acute phase, dissection, in particular, can create a casca ... Full text Cite

Surgical management of ovarian carcinosarcoma with inferior vena cava extension into the right atrium.

Journal Article J Surg Case Rep · December 2020 Gynecological carcinosarcomas are aggressive tumors with rare occurrence and high rates of metastases. We present the case of a 49-year-old woman with vaginal bleeding and abdominal distension who was found to have a large ovarian carcinosarcoma invading t ... Full text Link to item Cite

Use of an inverted On-X mitral valve in the aortic position in a resource limited setting.

Journal Article J Card Surg · November 2020 Implanting an inverted aortic valve prosthesis in the mitral position has shown to be a viable solution for a small mitral annulus. We describe a case of implanting an inverted in the mitral prosthesis in the aortic position in a patient with an excessivel ... Full text Open Access Link to item Cite

Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.

Journal Article Am Heart J · June 2020 BACKGROUND: Patients with bicuspid aortic valve stenosis (BAV) were excluded from all the trileaflet aortic valve stenosis (TAV) pivotal trials, and therefore, their outcomes are not clearly defined. The aim of the study was to evaluate the outcomes of tra ... Full text Link to item Cite

Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.

Journal Article J Invasive Cardiol · July 2019 BACKGROUND: Alternative access (AA) is still required for a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to compare the clinical outcomes of patients undergoing AA vs transfemoral (TF) access. METHO ... Link to item Cite

Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.

Journal Article Circ Res · April 12, 2019 RATIONALE: Although rare cardiomyogenesis is reported in the adult mammalian heart, whether this results from differentiation or proliferation of cardiomyogenic cells remains controversial. The tumor suppressor genes RB1 (retinoblastoma) and CDKN2a (cyclin ... Full text Link to item Cite

Outcomes of Planned Two-Stage Hybrid Aortic Repair With Dacron-Replaced Proximal Landing Zone.

Journal Article Ann Thorac Surg · October 2018 BACKGROUND: Results of hybrid arch repair (HAR) using the native zone 0 proximal landing zone (PLZ) have been unsatisfactory in many series, especially in the setting of ascending aortic dilation (>4.0 cm). This study reports early and late outcomes of pla ... Full text Link to item Cite

Differentiating between cold agglutinins and rouleaux: a case series of seven patients.

Journal Article Perfusion · March 2018 We present a case series of seven patients with suspected cold agglutinin antibodies, discovered after initiation of bypass. Laboratory analysis of blood samples intraoperatively determined the cause of the aggregation to be rouleaux formation in three of ... Full text Link to item Cite

Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine.

Journal Article J Am Coll Cardiol · December 6, 2016 BACKGROUND: Pim1 kinase plays an important role in cell division, survival, and commitment of precursor cells towards a myocardial lineage, and overexpression of Pim1 in ckit+ cardiac stem cells (CSCs) enhances their cardioreparative properties. OBJECTIVES ... Full text Link to item Cite

Cold Agglutinin Autoantibodies in a Patient without a Visible Coronary Sinus Ostium: Strategies for Myocardial Protection without Using Retrograde Cardioplegia.

Journal Article J Extra Corpor Technol · June 2016 The presence of cold agglutinins (CA) during cardiac surgery with cardiopulmonary bypass usually creates the need for an altered surgical plan. In this case, the CA were discovered after the initiation of bypass, limiting the time, and cardioplegia solutio ... Link to item Cite

Resection of Carcinoid Tumor Metastatic to the Right Ventricle and Tricuspid Valve.

Journal Article Ann Thorac Surg · December 2015 Carcinoid tumors rarely metastasize to the heart, and previous reports involved the myocardium only. We present a case of carcinoid tumor metastatic to the right ventricle (RV) and tricuspid valve. Preoperative cardiac magnetic resonance imaging (CMR) show ... Full text Link to item Cite

Abstract 140: Effect of Transendocardial Autologous Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and Restore Cardiac Function in a Heart Failure Swine Model

Journal Article Circulation Research · July 18, 2014 Background: A cell combination of human mesenchymal stem cells (MSCs) and c-kit+ cardiac stem cells (CSCs) improves left ventricular (LV) performance to a greater degree than MSCs alone in post myocar ... Full text Cite

Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.

Journal Article Circ Res · April 11, 2014 RATIONALE: Transendocardial stem cell injection (TESI) with mesenchymal stem cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of the injection site remains unknown. OBJECTIVE: To address whether TESI exerts its effects at the si ... Full text Link to item Cite

Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.

Journal Article JAMA · January 1, 2014 IMPORTANCE: Whether culture-expanded mesenchymal stem cells or whole bone marrow mononuclear cells are safe and effective in chronic ischemic cardiomyopathy is controversial. OBJECTIVE: To demonstrate the safety of transendocardial stem cell injection with ... Full text Link to item Cite

Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.

Journal Article Journal of the American Heart Association · June 1, 2013 Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling ... Cite

Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.

Journal Article J Am Heart Assoc · May 17, 2013 BACKGROUND: Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular ... Full text Link to item Cite

Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction.

Journal Article Circulation · January 15, 2013 BACKGROUND: Because mesenchymal stem cells (MSCs) induce proliferation and differentiation of c-kit(+) cardiac stem cells (CSCs) in vivo and in vitro, we hypothesized that combining human (h) MSCs with c-kit(+) hCSCs produces greater infarct size reduction ... Full text Link to item Cite

Abstract 246: Transendocardial Injections of Allogeneic Mesenchymal Stem Cells Demonstrate Reversal of Left Ventricular Remodeling to Baseline

Journal Article Circulation Research · August 3, 2012 Background: Mesenchymal stem cells (MSCs) improve ventricular function post MI Hypothesis: Transendocardial stem c ... Full text Cite

Myocardial infarction and intramyocardial injection models in swine.

Journal Article Nat Protoc · July 12, 2012 Sustainable and reproducible large animal models that closely replicate the clinical sequelae of myocardial infarction (MI) are important for the translation of basic science research into bedside medicine. Swine are well accepted by the scientific communi ... Full text Link to item Cite

Safety of serial MRI in patients with implantable cardioverter defibrillators.

Journal Article Heart · November 2011 OBJECTIVE: While patients with cardiac implantable electronic devices could benefit from magnetic resonance (MR) imaging, the presence of such devices has been designated as an absolute contraindication to MR. Although scanning algorithms are proposed for ... Full text Link to item Cite

Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease.

Journal Article Circ Res · September 30, 2011 Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution. Initially described in bone marrow, MSCs have the capacity to differentiate into mesoderm- and nonmesoderm ... Full text Link to item Cite

Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling.

Journal Article Circ Res · April 1, 2011 RATIONALE: Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy. OBJECTIVE: We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction ... Full text Link to item Cite

Rationale and design of the Transendocardial Injection of Autologous Human Cells (bone marrow or mesenchymal) in Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction (TAC-HFT) trial: A randomized, double-blind, placebo-controlled study of safety and efficacy.

Journal Article Am Heart J · March 2011 Although there is tremendous interest in stem cell (SC)-based therapies for cardiomyopathy caused by chronic myocardial infarction, many unanswered questions regarding the best approach remain. The TAC-HFT study is a phase I/II randomized, double-blind, pl ... Full text Link to item Cite

The role of aspirin in cardiovascular diseases--forgotten benefits?

Journal Article Expert Opin Pharmacother · January 2004 The increasing burden of cardiovascular diseases in developed, as well as developing countries, underscores the need for the more widespread and appropriate use of aspirin in secondary prevention of occlusive vascular events during acute evolving myocardia ... Full text Link to item Cite

Have the results of randomized clinical trials of pacing altered the practice of cardiac pacing?

Conference J Cardiovasc Electrophysiol · September 2003 Randomized clinical trials are the gold standard for the evaluation of new therapies. However, in the early years of pacing, the observational benefits were so great and the lifesaving benefits to patients so readily obvious that randomized trials were not ... Full text Link to item Cite