Scholars@Duke
Adrian Camarena

Adrian Camarena

House Staff
Surgery

Selected Publications

Platelet-rich plasma enhances rib fracture strength and callus formation in vivo.

Journal Article J Trauma Acute Care Surg · September 6, 2024 BACKGROUND: Rib fractures are a common traumatic injury affecting more than 350,000 patients a year. Early stabilization has shown to be effective in reducing pulmonary complications. Platelet-rich plasma (PRP) is a growth factor-rich blood product known t ... Full text Link to item Cite

Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci.

Journal Article medRxiv · March 13, 2024 Obsessive-compulsive disorder (OCD) affects ~1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on the genetic etiology and underlying biological mechanisms of th ... Full text Link to item Cite

Damage Control Resuscitation in Penetrating Trauma: Rules of the Game

Chapter · January 1, 2024 “One of the most frustrating situations ever encountered by the operating surgeon is an open wound in a patient whose blood will not clot and cannot be made to clot.” In their seminal 1981 description of damage control surgery for exsanguinating trauma pat ... Full text Cite

Rising Mortality in Pediatric Self-Inflicted Firearm Trauma Associated With Distinct Anatomic Injury.

Journal Article The Journal of surgical research · March 2023 IntroductionSelf-inflicted injuries are the second leading cause of pediatric (10-18 y old) mortality. Self-inflicted firearm trauma (SIFT) was responsible for up to half of these deaths in certain age groups. We hypothesized that SIFT prevalence ... Full text Cite

Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia.

Journal Article Biological psychiatry · August 2020 BackgroundGenome-wide association studies of schizophrenia have demonstrated that variations in noncoding regions are responsible for most of the common variation heritability of the disease. It is hypothesized that these risk variants alter gene ... Full text Cite

Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.

Journal Article Neurobiology of disease · March 2020 Mutations in Cu/Zn superoxide dismutase (SOD1) cause ~20% of familial ALS (FALS), which comprises 10% of total ALS cases. In mutant SOD1- (mtSOD1-) induced ALS, misfolded aggregates of SOD1 lead to activation of the unfolded protein response/integrated str ... Full text Cite

Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp.

Journal Article Scientific reports · February 2020 Most single cell RNA sequencing protocols start with single cells dispersed from intact tissue. High-throughput processing of the separated cells is enabled using microfluidics platforms. However, dissociation of tissue results in loss of information about ... Full text Cite

Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation.

Journal Article Science advances · December 2018 As part of PsychENCODE, we developed a three-dimensional (3D) epigenomic map of primary cultured neuronal cells derived from olfactory neuroepithelium (CNON). We mapped topologically associating domains and high-resolution chromatin interactions using Hi-C ... Full text Cite

Evaluation of biological and technical variations in low-input RNA-Seq and single-cell RNA-Seq

Journal Article International Journal of Computational Biology and Drug Design · 2018 Full text Cite

Assessing characteristics of RNA amplification methods for single cell RNA sequencing.

Journal Article BMC genomics · November 2016 BackgroundRecently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell methods and the fac ... Full text Cite