Scholars@Duke
Adrienne Ruth Barnosky

Adrienne Ruth Barnosky

Assistant Professor of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition

Selected Publications

Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial.

Journal Article Clin Nutr · December 2018 BACKGROUND & AIMS: Indirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested d ... Full text Link to item Cite

Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: An exploratory analysis of a randomized controlled trial.

Journal Article Nutr Health · March 2018 BACKGROUND: Alternate-day fasting (ADF) has gained popularity in recent years. The diet consists of a "fast day" where an individual consumes 0-25% of their energy needs, alternated with a "feast day" where a person is permitted to eat ad libitum. AIM: Thi ... Full text Link to item Cite

Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.

Journal Article Nutr Healthy Aging · December 7, 2017 BACKGROUND: Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown. OBJECTIVE: This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone m ... Full text Link to item Cite

Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial.

Journal Article JAMA Intern Med · July 1, 2017 IMPORTANCE: Alternate-day fasting has become increasingly popular, yet, to date, no long-term randomized clinical trials have evaluated its efficacy. OBJECTIVE: To compare the effects of alternate-day fasting vs daily calorie restriction on weight loss, we ... Full text Link to item Cite

Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.

Journal Article Clin Nutr · December 2016 BACKGROUND & AIMS: Alternate day fasting (ADF; 25% energy intake "fast day", alternated with an ad libitum intake "feed day") is effective for weight loss. Whether or not ADF modulates hunger, fullness and gut peptides in a way that enhances dietary compli ... Full text Link to item Cite

A primer on concentrated insulins: what an internist should know.

Journal Article Postgrad Med · May 2016 The common insulin concentration in most preparations of insulin is 100 units per mL or U-100. Human regular U-500 insulin was the first concentrated insulin introduced and it has been available in the United States since the 1950s. Humulin R is the only h ... Full text Link to item Cite

Determinants of weight loss success with alternate day fasting.

Journal Article Obes Res Clin Pract · 2016 This study examined what characteristics predict weight loss success with alternate day fasting (ADF). Four 8-week trials of ADF (n=121) were included in the analysis. Subjects aged 50-59 y achieved greater (P=0.01) weight loss than other age groups. Males ... Full text Link to item Cite

Safety of alternate day fasting and effect on disordered eating behaviors.

Journal Article Nutr J · May 6, 2015 BACKGROUND: Alternate day fasting (ADF; ad libitum intake "feed day" alternated with 75% restriction "fast day"), is effective for weight loss, but the safety of the diet has been questioned. Accordingly, this study examined occurrences of adverse events a ... Full text Link to item Cite

Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults.

Journal Article Obesity (Silver Spring) · December 2014 OBJECTIVE: Alternate day fasting (ADF; 24-h feeding/24-h 25% energy intake at lunchtime), is effective for weight loss, but diet tolerability is questionable. Moving the fast day meal to dinnertime, or dividing it into smaller meals, may improve tolerabili ... Full text Link to item Cite

Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings.

Journal Article Transl Res · October 2014 Intermittent fasting (IF) regimens have gained considerable popularity in recent years, as some people find these diets easier to follow than traditional calorie restriction (CR) approaches. IF involves restricting energy intake on 1-3 d/wk, and eating fre ... Full text Link to item Cite