Ara Y. Tourian
Associate Professor Emeritus of Medicine
Metabolic Basis of Inherited Central Nervous Disorders
Biochemical genetics and metabolism
Key Words:
Phenylalanine Hydroxylase, Phenylketonuria,
Huntington's Chorea: Membrane abnormalities, Glucosamine metabolism, Cell Death
Wilson's Disease, Alzheimer's Disease
Chronic central pain secondary to central and peripheral nervous system damage:
Strategies for multidisciplinary evaluation and treatment: Centrally acting non-narcotic medications.
Biochemical genetics and metabolism
Key Words:
Phenylalanine Hydroxylase, Phenylketonuria,
Huntington's Chorea: Membrane abnormalities, Glucosamine metabolism, Cell Death
Wilson's Disease, Alzheimer's Disease
Chronic central pain secondary to central and peripheral nervous system damage:
Strategies for multidisciplinary evaluation and treatment: Centrally acting non-narcotic medications.
Current Appointments & Affiliations
- Associate Professor Emeritus of Medicine, Neurology, Clinical Science Departments 1998
Contact Information
- 122 Baker House, Durham, NC 27710
- Box 3066 Med Ctr, Durham, NC 27710
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ara.tourian@duke.edu
(919) 684-4454
- Background
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Education, Training, & Certifications
- Chief Neurology Resident, Neurology, Bellevue Hospital Center 1966 - 1969
- Resident, Neurology, Bellevue Hospital Center 1962 - 1964
- M.D., University of Iowa 1958
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Previous Appointments & Affiliations
- Associate Professor of Medicine with Tenure, Neurology, Clinical Science Departments 1973 - 1998
- Expertise
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Subject Headings
- Research
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Selected Grants
- Huntington'S Chorea: Studies Of Protein Glycosylation awarded by National Institutes of Health 1984 - 1985
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Dresser, L. P., A. Y. Tourian, and D. C. Anthony. “A case of myelinoclastic diffuse sclerosis in an adult.” Neurology 41, no. 2 ( Pt 1) (February 1991): 316–18. https://doi.org/10.1212/wnl.41.2_part_1.316.Full Text Link to Item
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Iacono, R. P., J. Linford, A. Tourian, and R. Sandyk. “Baclofen in the treatment of post-amputation autonomous stump movements.” Eur Neurol 26, no. 3 (1987): 141–44. https://doi.org/10.1159/000116326.Full Text Link to Item
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Tourian, A. Y., and W. Y. Hung. “Fibroblasts in Huntington's disease.” Arch Neurol 41, no. 3 (March 1984): 251. https://doi.org/10.1001/archneur.1984.04050150029007.Full Text Link to Item
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Tourian, A., M. Callahan, and W. Hung. “L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.” Neurochem Res 8, no. 12 (December 1983): 1589–95. https://doi.org/10.1007/BF00964160.Full Text Link to Item
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Callahan, M., A. Tourian, and W. Y. Hung. “A sensitive, specific radioisotope assay for L-glutamine-D-fructose-6-phosphate aminotransferase.” Anal Biochem 115, no. 2 (August 1981): 347–52. https://doi.org/10.1016/0003-2697(81)90016-6.Full Text Link to Item
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Hung, W. Y., and A. Tourian. “Differential labelling of UDP-N-acetylglucosamine in Huntington's-chorea fibroblasts.” Biochem J 196, no. 2 (May 15, 1981): 495–98. https://doi.org/10.1042/bj1960495.Full Text Open Access Copy Link to Item
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Hung, W. Y., D. E. Mold, and A. Tourian. “Huntington's-chorea fibroblasts. Cellular protein glycosylation.” Biochem J 190, no. 3 (September 15, 1980): 711–19. https://doi.org/10.1042/bj1900711.Full Text Link to Item
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Tourian, A., and W. Y. Hung. “Huntington's disease: membrane abnormalities and protein glycosylation.” Prog Clin Biol Res 39 (1980): 195–204.Link to Item
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Tourian, A. Y., and W. Hung. “Huntington's disease fibroblasts: nutritional and protein glyscosylation studies.” Advances in Neurology 23 (1979): 371–86.
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Tourian, A., R. T. Johnson, K. Burg, S. W. Nicolson, and K. Sperling. “Transfer of human chromosomes via human minisegregant cells into mouse cells and the quantitation of the expression of hypoxanthine phosphoribosyltransferase in the hybrids.” J Cell Sci 30 (April 1978): 193–209. https://doi.org/10.1242/jcs.30.1.193.Full Text Open Access Copy Link to Item
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Tourian, A., and W. Y. Hung. “Membrane abnormalities of Huntington's chorea fibroblasts in culture.” Biochem Biophys Res Commun 78, no. 4 (October 24, 1977): 1296–1303. https://doi.org/10.1016/0006-291x(77)91433-4.Full Text Link to Item
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Tourian, A., and W. Hung. “Glucosamine dependence of Huntington's chorea fibroblasts in culture.” Biochem Biophys Res Commun 76, no. 2 (May 23, 1976): 345–53. https://doi.org/10.1016/0006-291x(77)90731-8.Full Text Link to Item
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Tourian, A. “The unique identity of rat hepatoma phenylalanine hydroxylase.” Biochem Biophys Res Commun 68, no. 1 (January 12, 1976): 51–55. https://doi.org/10.1016/0006-291x(76)90008-5.Full Text Link to Item
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Tourian, A. “Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.” J Cell Physiol 87, no. 1 (January 1976): 15–24. https://doi.org/10.1002/jcp.1040870104.Full Text Link to Item
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Tourian, A., L. Treiman, and K. Abé. “Three Immunologically Distinct Isozymes of Phenylalanine Hydroxylase.” Biochemistry 14, no. 18 (September 1, 1975): 4055–60. https://doi.org/10.1021/bi00689a020.Full Text
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Tourian, A. “The effect of serum factors and hormones on phenylalanine hydroxylase synthesis.” Trans.Amer.Soc.Neurochem. 5, no. 1 (January 1, 1974): 127.
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Treiman, D. M., and A. Tourian. “Phenylalanine hydroxylase in dilute lethal mice.” Biochim Biophys Acta 313, no. 1 (June 20, 1973): 163–69. https://doi.org/10.1016/0304-4165(73)90197-9.Full Text Link to Item
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Tourian, A. “Phenylalanine hydroxylase activity in foetal hepatic organ culture.” Biochim Biophys Acta 309, no. 1 (May 5, 1973): 44–49. https://doi.org/10.1016/0005-2744(73)90315-x.Full Text Link to Item
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Tourian, A. “Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase.” Vopr Biokhim Mozga 8 (1973): 211–19.Link to Item
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Tourian, A. Y. “Administration of 5-hydroxy-L-tryptophan to individuals with Huntington's chorea.” Neurology 22, no. 11 (November 1972): 1201–4. https://doi.org/10.1212/wnl.22.11.1201.Full Text Link to Item
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Tourian, A., D. M. Treiman, and J. S. Carr. “Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception.” Biochim Biophys Acta 279, no. 3 (October 25, 1972): 484–90. https://doi.org/10.1016/0304-4165(72)90170-5.Full Text Link to Item
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Tourian, A. “Activation of phenylalanine hydroxylase by phenylalanine.” Biochim Biophys Acta 242, no. 2 (August 20, 1971): 345–54. https://doi.org/10.1016/0005-2744(71)90226-9.Full Text Link to Item
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Tourian, A., J. Goddard, and T. T. Puck. “Phenylalanine hydroxylase activity in mammalian cells.” J Cell Physiol 73, no. 2 (April 1969): 159–70. https://doi.org/10.1002/jcp.1040730210.Full Text Link to Item
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Book Sections
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Tourian, A. Y. “The Biology of Huntington's Chorea.” In Handbook of Neurochemistry: Pathological Neurochemistry, 225–39. Plenum Press, 1985.
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Tourian, A. Y. “Hepatolenticular Degeneration (Wilson's Disease).” In Cecil Textbook of Medicine, 1158–60. W. B. Saunders Company, 1985.
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Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease, 3:270–86. McGraw-Hill Inc., 1983. https://doi.org/10.1002/hep.1840030332.Full Text
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Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease. McGraw-Hill Inc., 1978.
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Creativity: A Multidisciplinary Symposium. Institue of Learning in Retirement at Duke: OLLIE. 2014 - 2014 2014
- An Exploration of Art and the Brain. Institue of Learning in Retirement at Duke: OLLIE. January 2013 - March 2013 2013
- An Exploration of Art and the Brain. Institue of Learning in Retirement at Duke: OLLIE. September 2012 - September 2012 2012
- Advances in the Behavioral Neurosciences and the Arts: An Interdisciplinary Series with an Evolutionary Biology Perspective. Institue of Learning in Retirement at Duke: OLLIE. January 2012 - March 2012 2012
- The Communication of Emotion: Is Music the Language of Emotion?. Durham Music Teacher's Association Lecture. May 1993 1993
- Anthropological Development of Dancing and the Brain. June 1981 1981
- The Evolutionary Origin of Human Ethical Behavior. Philosophy of Science: Medical Student Monthly Seminars. 1981 - 1985 1981 - 1985
- The Central Control of Movement - An Evolutionary Approach. June 1980 1980
- Huntington's Disease: Membrane Abnormalities and Protein Glycosylation. Satellite Symposium. International Society of Neurochemistry. 1978 1978
- Control of Liver and Brain Aromatic Amino Acid Metabolism by Phenylalanine Hydroxylase. Symposium of Neurochemistry: Celebration of th e50th Anniversary of the Institute of Biochemistry. October 24, 1972 - October 30, 1972 1972
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Service to the Profession
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