Ara Y. Tourian | Scholars@Duke

Ara Y. Tourian
Associate Professor Emeritus of Medicine

Metabolic Basis of Inherited Central Nervous Disorders
Biochemical genetics and metabolism
Key Words:
Phenylalanine Hydroxylase, Phenylketonuria,
Huntington's Chorea: Membrane abnormalities, Glucosamine metabolism, Cell Death
Wilson's Disease, Alzheimer's Disease

Chronic central pain secondary to central and peripheral nervous system damage:
Strategies for multidisciplinary evaluation and treatment: Centrally acting non-narcotic medications.

Current Appointments & Affiliations

Associate Professor Emeritus of Medicine, Neurology, Clinical Science Departments 1998

Contact Information

122 Baker House, Durham, NC 27710
Box 3066 Med Ctr, Durham, NC 27710
ara.tourian@duke.edu (919) 684-4454

Background
Education, Training, & Certifications
- Chief Neurology Resident, Neurology, Bellevue Hospital Center 1966 - 1969
- Resident, Neurology, Bellevue Hospital Center 1962 - 1964
- M.D., University of Iowa 1958
Duke Appointment History
- Associate Professor of Medicine, Neurology, Clinical Science Departments 1973 - 1998
Expertise
Subject Headings
Research
Selected Grants
- Huntington'S Chorea: Studies Of Protein Glycosylation awarded by National Institutes of Health 1984 - 1985
Publications & Artistic Works
Selected Publications
- Academic Articles
  - DRESSER, L. P., A. Y. TOURIAN, and D. C. ANTHONY. “A CASE OF MYELINOCLASTIC DIFFUSE SCLEROSIS IN AN ADULT.” Neurology 41, no. 2 (February 1991): 316–18. https://doi.org/10.1212/WNL.41.2_Part_1.316.
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  - Dresser, L. P., A. Y. Tourian, and D. C. Anthony. “A case of myelinoclastic diffuse sclerosis in an adult..” Neurology 41, no. 2 ( Pt 1) (February 1991): 316–18. https://doi.org/10.1212/wnl.41.2_part_1.316.
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  - Dresser, L. P., A. Y. Tourian, and D. C. Anthony. “A case of myelinoclastic diffuse sclerosis in an adult.” Neurology 41, no. 2 (January 1, 1991): 316–18.
  - Tourian, A., R. Iacono, B. Nashold, B. Urban, and D. Sanders. “Involuntary movements of the lower extremity following dorsal root entry zone lesions in a man treated for phantom limb pain.” Applied Neurophysiology 51, no. 2–5 (January 1, 1988): 212–17.
  - Iacono, R. P., J. Linford, A. Tourian, and R. Sandyk. “Baclofen in the treatment of post-amputation autonomous stump movements..” European Neurology 26, no. 3 (January 1987): 141–44. https://doi.org/10.1159/000116326.
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  - Tourian, A. Y., and W. Y. Hung. “Fibroblasts in Huntington's disease..” Archives of Neurology 41, no. 3 (March 1984). https://doi.org/10.1001/archneur.1984.04050150029007.
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  - Tourian, A., M. Callahan, and W. Hung. “l-Glutamine d-Fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-Acetylglucosamine.” Neurochemical Research 8, no. 12 (December 1, 1983): 1589–95. https://doi.org/10.1007/BF00964160.
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  - Callahan, M., A. Tourian, and W. Y. Hung. “A sensitive, specific radioisotope assay for l-glutamine-d-fructose-6-phosphate aminotransferase.” Analytical Biochemistry 115, no. 2 (January 1, 1981): 347–52. https://doi.org/10.1016/0003-2697(81)90016-6.
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  - Hung, W. Y., and A. Tourian. “Differential labelling of UDP-N-acetylglucosamine in Huntington's-chorea fibroblasts.” Biochemical Journal 196, no. 2 (January 1, 1981): 495–98. https://doi.org/10.1042/bj1960495.
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  - Hung, W. Y., D. E. Mold, and A. Tourian. “Huntington's-chorea fibroblasts. Cellular protein glycosylation.” Biochemical Journal 190, no. 3 (January 1, 1980): 711–19. https://doi.org/10.1042/bj1900711.
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  - Tourian, A., and W. Y. Hung. “Huntington's disease: membrane abnormalities and protein glycosylation..” Progress in Clinical and Biological Research 39 (January 1980): 195–204.
  - Tourian, A. Y., and W. Hung. “Huntington's disease fibroblasts: nutritional and protein glyscosylation studies..” Advances in Neurology 23 (1979): 371–86.
  - Tourian, A., R. T. Johnson, K. Burg, S. W. Nicolson, and K. Sperling. “Transfer of human chromosomes via human minisegregant cells into mouse cells and the quantitation of the expression of hypoxanthine phosphoribosyltransferase in the hybrids..” Journal of Cell Science 30 (April 1978): 193–209.
    Open Access Copy
  - Tourian, A., and W. Y. Hung. “Membrane abnormalities of Huntington's Chorea fibroblasts in culture.” Biochemical and Biophysical Research Communications 78, no. 4 (October 24, 1977): 1296–1303. https://doi.org/10.1016/0006-291X(77)91433-4.
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  - Tourian, A., and W. Y. Hung. “Glucosamine dependence of Huntington's chorea fibroblasts in culture.” Biochemical and Biophysical Research Communications 76, no. 2 (May 23, 1977): 345–53. https://doi.org/10.1016/0006-291X(77)90731-8.
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  - Tourian, A. “The unique identity of rat hepatoma phenylalanine hydroxylase.” Biochemical and Biophysical Research Communications 68, no. 1 (January 12, 1976): 51–55. https://doi.org/10.1016/0006-291X(76)90008-5.
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  - Tourian, A. “Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.” Journal of Cellular Physiology 87, no. 1 (January 1, 1976): 15–23. https://doi.org/10.1002/jcp.1040870104.
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  - Tourian, A., L. Treiman, and K. Abé. “Three Immunologically Distinct Isozymes of Phenylalanine Hydroxylase.” Biochemistry 14, no. 18 (September 1, 1975): 4055–60. https://doi.org/10.1021/bi00689a020.
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  - Tourian, A. “The effect of serum factors and hormones on phenylalanine hydroxylase synthesis.” Trans.Amer.Soc.Neurochem. 5, no. 1 (January 1, 1974).
  - Treiman, D. M., and A. Tourian. “Phenylalanine hydroxylase in dilute lethal mice.” Bba General Subjects 313, no. 1 (June 30, 1973): 163–69. https://doi.org/10.1016/0304-4165(73)90197-9.
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  - Tourian, A. “Phenylalanine hydroxylase activity in foetal hepatic organ culture.” Bba Enzymology 309, no. 1 (May 5, 1973): 44–49. https://doi.org/10.1016/0005-2744(73)90315-X.
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  - Tourian, A. “Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase..” Voprosy Biokhimii Mozga 8 (January 1973): 211–19.
  - Tourian, A., D. M. Treiman, and J. S. Carr. “Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception.” Bba General Subjects 279, no. 3 (October 25, 1972): 484–90. https://doi.org/10.1016/0304-4165(72)90170-5.
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  - Tourian, A. Y. “Administration of 5-hydroxy-L-tryptophan to individuals with huntington’s chorea.” Neurology 22, no. 11 (January 1, 1972): 1201–4.
  - Tourian, A. “Activation of phenylalanine hydroxylase by phenylalanine.” Bba Enzymology 242, no. 2 (August 20, 1971): 345–54. https://doi.org/10.1016/0005-2744(71)90226-9.
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  - Tourian, A., J. Goddard, and T. T. Puck. “Phenylalanine hydroxylase activity in mammalian cells.” Journal of Cellular Physiology 73, no. 2 (January 1, 1969): 159–70. https://doi.org/10.1002/jcp.1040730210.
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- Book Sections
  - Tourian, A. Y. “The Biology of Huntington's Chorea.” In Handbook of Neurochemistry: Pathological Neurochemistry, 225–39. Plenum Press, 1985.
  - Tourian, A. Y. “Hepatolenticular Degeneration (Wilson's Disease).” In Cecil Textbook of Medicine, 1158–60. W. B. Saunders Company, 1985.
  - Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease, 3:270–86. McGraw-Hill Inc., 1983. https://doi.org/10.1002/hep.1840030332.
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  - Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease. McGraw-Hill Inc., 1978.
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Service to the Profession

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Presentations & Appearances

Service to the Profession