Ara Y. Tourian | Scholars@Duke

Ara Y. Tourian
Associate Professor Emeritus of Medicine

Metabolic Basis of Inherited Central Nervous Disorders
Biochemical genetics and metabolism
Key Words:
Phenylalanine Hydroxylase, Phenylketonuria,
Huntington's Chorea: Membrane abnormalities, Glucosamine metabolism, Cell Death
Wilson's Disease, Alzheimer's Disease

Chronic central pain secondary to central and peripheral nervous system damage:
Strategies for multidisciplinary evaluation and treatment: Centrally acting non-narcotic medications.

Current Appointments & Affiliations

Associate Professor Emeritus of Medicine, Neurology, Clinical Science Departments 1998

Contact Information

122 Baker House, Durham, NC 27710
Box 3066 Med Ctr, Durham, NC 27710
ara.tourian@duke.edu (919) 684-4454

Background
Education, Training, & Certifications
- Chief Neurology Resident, Neurology, Bellevue Hospital Center 1966 - 1969
- Resident, Neurology, Bellevue Hospital Center 1962 - 1964
- M.D., University of Iowa 1958
Previous Appointments & Affiliations
- Associate Professor of Medicine with Tenure, Neurology, Clinical Science Departments 1973 - 1998
Expertise
Subject Headings
Research
Selected Grants
- Huntington'S Chorea: Studies Of Protein Glycosylation awarded by National Institutes of Health 1984 - 1985
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Dresser, L. P., A. Y. Tourian, and D. C. Anthony. “A case of myelinoclastic diffuse sclerosis in an adult.” Neurology 41, no. 2 ( Pt 1) (February 1991): 316–18. https://doi.org/10.1212/wnl.41.2_part_1.316.
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  - Iacono, R. P., J. Linford, A. Tourian, and R. Sandyk. “Baclofen in the treatment of post-amputation autonomous stump movements.” Eur Neurol 26, no. 3 (1987): 141–44. https://doi.org/10.1159/000116326.
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  - Tourian, A. Y., and W. Y. Hung. “Fibroblasts in Huntington's disease.” Arch Neurol 41, no. 3 (March 1984): 251. https://doi.org/10.1001/archneur.1984.04050150029007.
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  - Tourian, A., M. Callahan, and W. Hung. “L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.” Neurochem Res 8, no. 12 (December 1983): 1589–95. https://doi.org/10.1007/BF00964160.
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  - Callahan, M., A. Tourian, and W. Y. Hung. “A sensitive, specific radioisotope assay for L-glutamine-D-fructose-6-phosphate aminotransferase.” Anal Biochem 115, no. 2 (August 1981): 347–52. https://doi.org/10.1016/0003-2697(81)90016-6.
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  - Hung, W. Y., and A. Tourian. “Differential labelling of UDP-N-acetylglucosamine in Huntington's-chorea fibroblasts.” Biochem J 196, no. 2 (May 15, 1981): 495–98. https://doi.org/10.1042/bj1960495.
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  - Hung, W. Y., D. E. Mold, and A. Tourian. “Huntington's-chorea fibroblasts. Cellular protein glycosylation.” Biochem J 190, no. 3 (September 15, 1980): 711–19. https://doi.org/10.1042/bj1900711.
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  - Tourian, A., and W. Y. Hung. “Huntington's disease: membrane abnormalities and protein glycosylation.” Prog Clin Biol Res 39 (1980): 195–204.
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  - Tourian, A. Y., and W. Hung. “Huntington's disease fibroblasts: nutritional and protein glyscosylation studies.” Advances in Neurology 23 (1979): 371–86.
  - Tourian, A., R. T. Johnson, K. Burg, S. W. Nicolson, and K. Sperling. “Transfer of human chromosomes via human minisegregant cells into mouse cells and the quantitation of the expression of hypoxanthine phosphoribosyltransferase in the hybrids.” J Cell Sci 30 (April 1978): 193–209. https://doi.org/10.1242/jcs.30.1.193.
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  - Tourian, A., and W. Y. Hung. “Membrane abnormalities of Huntington's chorea fibroblasts in culture.” Biochem Biophys Res Commun 78, no. 4 (October 24, 1977): 1296–1303. https://doi.org/10.1016/0006-291x(77)91433-4.
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  - Tourian, A., and W. Hung. “Glucosamine dependence of Huntington's chorea fibroblasts in culture.” Biochem Biophys Res Commun 76, no. 2 (May 23, 1976): 345–53. https://doi.org/10.1016/0006-291x(77)90731-8.
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  - Tourian, A. “The unique identity of rat hepatoma phenylalanine hydroxylase.” Biochem Biophys Res Commun 68, no. 1 (January 12, 1976): 51–55. https://doi.org/10.1016/0006-291x(76)90008-5.
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  - Tourian, A. “Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.” J Cell Physiol 87, no. 1 (January 1976): 15–24. https://doi.org/10.1002/jcp.1040870104.
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  - Tourian, A., L. Treiman, and K. Abé. “Three Immunologically Distinct Isozymes of Phenylalanine Hydroxylase.” Biochemistry 14, no. 18 (September 1, 1975): 4055–60. https://doi.org/10.1021/bi00689a020.
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  - Tourian, A. “The effect of serum factors and hormones on phenylalanine hydroxylase synthesis.” Trans.Amer.Soc.Neurochem. 5, no. 1 (January 1, 1974): 127.
  - Treiman, D. M., and A. Tourian. “Phenylalanine hydroxylase in dilute lethal mice.” Biochim Biophys Acta 313, no. 1 (June 20, 1973): 163–69. https://doi.org/10.1016/0304-4165(73)90197-9.
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  - Tourian, A. “Phenylalanine hydroxylase activity in foetal hepatic organ culture.” Biochim Biophys Acta 309, no. 1 (May 5, 1973): 44–49. https://doi.org/10.1016/0005-2744(73)90315-x.
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  - Tourian, A. “Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase.” Vopr Biokhim Mozga 8 (1973): 211–19.
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  - Tourian, A. Y. “Administration of 5-hydroxy-L-tryptophan to individuals with Huntington's chorea.” Neurology 22, no. 11 (November 1972): 1201–4. https://doi.org/10.1212/wnl.22.11.1201.
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  - Tourian, A., D. M. Treiman, and J. S. Carr. “Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception.” Biochim Biophys Acta 279, no. 3 (October 25, 1972): 484–90. https://doi.org/10.1016/0304-4165(72)90170-5.
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  - Tourian, A. “Activation of phenylalanine hydroxylase by phenylalanine.” Biochim Biophys Acta 242, no. 2 (August 20, 1971): 345–54. https://doi.org/10.1016/0005-2744(71)90226-9.
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  - Tourian, A., J. Goddard, and T. T. Puck. “Phenylalanine hydroxylase activity in mammalian cells.” J Cell Physiol 73, no. 2 (April 1969): 159–70. https://doi.org/10.1002/jcp.1040730210.
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- Book Sections
  - Tourian, A. Y. “The Biology of Huntington's Chorea.” In Handbook of Neurochemistry: Pathological Neurochemistry, 225–39. Plenum Press, 1985.
  - Tourian, A. Y. “Hepatolenticular Degeneration (Wilson's Disease).” In Cecil Textbook of Medicine, 1158–60. W. B. Saunders Company, 1985.
  - Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease, 3:270–86. McGraw-Hill Inc., 1983. https://doi.org/10.1002/hep.1840030332.
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  - Tourian, A. Y., and J. Sidbury. “Phenylketonuria and Hyperphenylalaninemia.” In The Metabolic Basis of Inherited Disease. McGraw-Hill Inc., 1978.
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Service to the Profession

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Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Presentations & Appearances

Service to the Profession