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Selected Publications

Caged gold nanostars: a novel plasmonic nanoplatform with potential theranostic applications.

Journal Article Nanoscale · May 2024 Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS par ... Full text Cite

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx.

Journal Article Sci Adv · March 8, 2024 Efficient isolation and analysis of exosomal biomarkers hold transformative potential in biomedical applications. However, current methods are prone to contamination and require costly consumables, expensive equipment, and skilled personnel. Here, we intro ... Full text Link to item Cite

A simple low-cost flexible plasmonic patch based on spiky gold nanostars for ultra-sensitive SERS sensing.

Journal Article The Analyst · March 2024 Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces. In this study, we proposed a simple cost-effective strategy ... Full text Cite

On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.

Journal Article IEEE transactions on medical imaging · February 2024 In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets. Low-frequency photo ... Full text Cite

Surface-Enhanced Raman Spectroscopy-Based Detection of Micro-RNA Biomarkers for Biomedical Diagnosis Using a Comparative Study of Interpretable Machine Learning Algorithms.

Journal Article Appl Spectrosc · January 2024 Surface-enhanced Raman spectroscopy (SERS) has wide diagnostic applications due to narrow spectral features that allow multiplex analysis. We have previously developed a multiplexed, SERS-based nanosensor for micro-RNA (miRNA) detection called the inverse ... Full text Link to item Cite

Rapid SERS assay for determination of the opioid fentanyl using silver-coated sharply branched gold nanostars.

Journal Article Mikrochimica acta · January 2024 A¬†high-throughput surface-enhanced Raman scattering (SERS)-sensing platform is presented¬†for FNT detection in human urine without any sample preparation. The sensing platform is based on plasmonics-active silver-coated sharply branched gold nanostars (SGNS ... Full text Cite

Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors.

Journal Article Clin Cancer Res · August 15, 2023 PURPOSE: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within intracranial tumors and a ... Full text Open Access Link to item Cite

Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses.

Journal Article Am J Transplant · July 2023 Porcine vascular endothelial cells (PECs) form a mechanistic centerpiece of xenograft rejection. Here, we determined that resting PECs release swine leukocyte antigen class I (SLA-I) but not swine leukocyte antigen class-II DR (SLA-DR) expressing extracell ... Full text Link to item Cite

Sharp Branched Gold Nanostar-Based Lateral-Flow Immunoassay for Detection of Yersinia pestis

Journal Article ACS Applied Nano Materials · March 10, 2023 Over the past few decades, colorimetric paper-based lateral flow immunoassay (LFIA) has emerged as a versatile analytical tool for rapid point-of-care detection of infectious diseases with high simplicity and flexibility. The LFIA sensitivity is based on c ... Full text Cite

miRNA probe integrated biosensor platform using bimetallic nanostars for amplification-free multiplexed detection of circulating colorectal cancer biomarkers in clinical samples.

Journal Article Biosens Bioelectron · January 15, 2023 Featured Publication There is a critical need for sensitive and rapid detection technologies utilizing molecular biotargets such as microRNAs (miRNAs), which regulate gene expression and are a promising class of diagnostic biomarkers for disease detection. Here, we present the ... Full text Link to item Cite

Intravital optical imaging for immune cell tracking after photoimmunotherapy with plasmonic gold nanostars.

Journal Article Nanotechnology · August 31, 2022 Bladder cancer has been ranked as one of the most commonly occurring cancers in men and women with approximately half of the diagnoses being the late stage and/or metastatic diseases. We have developed a novel cancer treatment by combining gold nanostar-me ... Full text Link to item Cite