Journal ArticleSci Adv · August 15, 2025
Nanoparticle-mediated photothermal therapy (PTT) is a promising strategy for cancer treatment; however, nanoparticle instability and lack of precise imaging tools for real-time temperature monitoring during therapy and nanoparticle tracking have hindered i ...
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Journal ArticleJournal of materials science · February 2025
The tunable optical properties and exceptional electromagnetic field enhancement of nanostar-based plasmonic nanoparticles have garnered much attention for use in a wide array of biomedical applications. However, a great challenge for their widespread use ...
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Journal ArticleNat Commun · January 29, 2025
Acoustically probing biological tissues with light or sound, photoacoustic and ultrasound imaging can provide anatomical, functional, and/or molecular information at depths far beyond the optical diffusion limit. However, most photoacoustic and ultrasound ...
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Journal ArticleAnal Bioanal Chem · December 2024
We present a plasmonics-enhanced spikey nanorattle-based biosensor for direct surface-enhanced Raman scattering (SERS) detection of mRNA cancer biomarkers. Early detection of cancers such as head and neck squamous cell carcinoma (HNSCC) is critical for imp ...
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Journal ArticleTrends in analytical chemistry : TRAC · November 2024
This article presents an overview of various nanoplasmonics biosensors and their diverse applications, focusing on recent developments in our laboratory. We describe the versatility and effectiveness of different plasmonics-active platforms, ranging from s ...
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Journal ArticleNanoscale · May 2024
Here, we first introduce caged gold nanostars (C-GNS), a novel hybrid nanoplatform combining the exceptional plasmonic properties of nanostars with the loading capability of hollow-shell structures. We present two synthetic routes used to produce C-GNS par ...
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Journal ArticleSci Adv · March 8, 2024
Efficient isolation and analysis of exosomal biomarkers hold transformative potential in biomedical applications. However, current methods are prone to contamination and require costly consumables, expensive equipment, and skilled personnel. Here, we intro ...
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Journal ArticleThe Analyst · March 2024
Recently, transparent and flexible surface-enhanced Raman scattering (SERS) substrates have received great interest for direct point-of-care detection of analytes on irregular nonplanar surfaces. In this study, we proposed a simple cost-effective strategy ...
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Journal ArticleIEEE transactions on medical imaging · February 2024
In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets. Low-frequency photo ...
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Journal ArticleAppl Spectrosc · January 2024
Surface-enhanced Raman spectroscopy (SERS) has wide diagnostic applications due to narrow spectral features that allow multiplex analysis. We have previously developed a multiplexed, SERS-based nanosensor for micro-RNA (miRNA) detection called the inverse ...
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Journal ArticleMikrochimica acta · January 2024
A high-throughput surface-enhanced Raman scattering (SERS)-sensing platform is presented for FNT detection in human urine without any sample preparation. The sensing platform is based on plasmonics-active silver-coated sharply branched gold nanostars (SGNS ...
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Journal ArticleClin Cancer Res · August 15, 2023
PURPOSE: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within intracranial tumors and a ...
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Journal ArticleAm J Transplant · July 2023
Porcine vascular endothelial cells (PECs) form a mechanistic centerpiece of xenograft rejection. Here, we determined that resting PECs release swine leukocyte antigen class I (SLA-I) but not swine leukocyte antigen class-II DR (SLA-DR) expressing extracell ...
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Journal ArticleACS Applied Nano Materials · March 10, 2023
Over the past few decades, colorimetric paper-based lateral flow immunoassay (LFIA) has emerged as a versatile analytical tool for rapid point-of-care detection of infectious diseases with high simplicity and flexibility. The LFIA sensitivity is based on c ...
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Journal ArticleBiosens Bioelectron · January 15, 2023
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There is a critical need for sensitive and rapid detection technologies utilizing molecular biotargets such as microRNAs (miRNAs), which regulate gene expression and are a promising class of diagnostic biomarkers for disease detection. Here, we present the ...
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Journal ArticleNanotechnology · August 31, 2022
Bladder cancer has been ranked as one of the most commonly occurring cancers in men and women with approximately half of the diagnoses being the late stage and/or metastatic diseases. We have developed a novel cancer treatment by combining gold nanostar-me ...
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