Scholars@Duke
Irene Song

Irene Song

House Staff
Ophthalmology

Selected Publications

Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study.

Journal Article Clin Neurol Neurosurg · November 2024 INTRODUCTION: Migraine is an established risk factor for cerebral ischemic stroke, with an especially robust association in patients with migraine with aura. However, it is not known if migraine is a risk factor for retinal stroke (central or branch retina ... Full text Link to item Cite

Adalimumab to treat noninfectious pediatric chronic anterior uveitis: a case series.

Journal Article Int Ophthalmol · September 10, 2024 PURPOSE: Evaluate the response to adalimumab (ADA) in pediatric chronic anterior uveitis (pCAU). METHODS: Retrospective chart review of pCAU patients treated with ADA. Outcomes evaluated included the proportion of patients achieving zero ocular inflammatio ... Full text Link to item Cite

RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population.

Journal Article Transl Vis Sci Technol · March 1, 2024 PURPOSE: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with a deep learning model in detecting referable posterior segment pathology in OCT images of emergency department patients. METHO ... Full text Link to item Cite

Advances in Teleophthalmology Screening for Diabetic Retinopathy.

Journal Article International ophthalmology clinics · January 2024 Full text Cite

Automated Eye Tracking Enables Saccade Performance Evaluation of Patients with Concussion History.

Journal Article Optom Vis Sci · December 1, 2023 SIGNIFICANCE: Automated eye tracking could be used to evaluate saccade performance of patients with concussion history, providing quantitative insights about the degree of oculomotor impairment and potential vision rehabilitation strategies for this patien ... Full text Link to item Cite

MYCOBACTERIUM ABSCESSUS SCLERAL BUCKLE INFECTION.

Journal Article Retinal cases & brief reports · November 2023 PurposeTo report the successful management of a rare case of Mycobacterium abscessus scleral buckle infection.MethodsCase report.ResultsA 63-year-old woman with a history of sarcoid anterior uveitis and macula-off retinal detachm ... Full text Cite

Robotic Optical Coherence Tomography Retinal Imaging for Emergency Department Patients: A Pilot Study for Emergency Physicians' Diagnostic Performance.

Journal Article Ann Emerg Med · April 2023 STUDY OBJECTIVE: To evaluate the diagnostic performance of emergency physicians' interpretation of robotically acquired retinal optical coherence tomography images for detecting posterior eye abnormalities in patients seen in the emergency department (ED). ... Full text Link to item Cite

Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion.

Journal Article Stroke · April 2023 BACKGROUND: Carotid stenosis is thought to be the primary risk factor for central retinal artery occlusion (CRAO); however, it is not known whether atrial fibrillation (AF)-a cardiac arrhythmia that underlies over 25% of cerebral ischemic strokes-predispos ... Full text Link to item Cite

Systematic analysis of levels of evidence supporting American Academy of Ophthalmology Preferred Practice Pattern guidelines, 2012-2021.

Journal Article BMC Ophthalmol · March 31, 2023 BACKGROUND: Despite the increased emphasis on evidence-based medicine, the current state of evidence behind ophthalmology clinical practice guidelines is unknown. The purpose of this systematic analysis was to understand the levels of evidence (LOE) suppor ... Full text Link to item Cite

C-DU(KE) Calculator: A Clinical Tool for Risk Stratification in Infectious Keratitis.

Journal Article Cornea · March 1, 2023 PURPOSE: The aim of this study was to identify characteristics of infectious keratitis predictive of poor outcome to develop a web-based predictive calculator. METHOD: A retrospective chart review was performed at the Duke Eye Center. Two hundred fifteen a ... Full text Link to item Cite

Atrial fibrillation as a novel risk factor for retinal stroke: A protocol for a population-based retrospective cohort study.

Journal Article PLoS One · 2023 Central retinal artery occlusion (CRAO; retinal stroke or eye stroke) is an under-recognized, disabling form of acute ischemic stroke which causes severe visual loss in one eye. The classical risk factor for CRAO is ipsilateral carotid stenosis; however, n ... Full text Link to item Cite

Practice Patterns of Fundoscopic Examination for Diabetic Retinopathy Screening in Primary Care.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Primary care professionals (PCPs) have a central role in screening for diabetic retinopathy (DR), especially in settings where access to specialty eye care is limited. Data on current DR screening practice patterns in primary care are needed to ... Full text Link to item Cite

The P-DUKE calculator: a novel tool for predicting outcomes after penetrating keratoplasty

Conference Investigative Ophthalmology and Visual Science · June 1, 2022 Link to item Cite

Autonomous Robotically Aligned OCT Enables Remote, Telehealth Retinal Imaging and Angiography

Conference Investigative Ophthalmology and Visual Science · June 1, 2022 Link to item Cite

Recognizing vitamin A deficiency: special considerations in low-prevalence areas.

Journal Article Current opinion in pediatrics · April 2022 Purpose of reviewAlthough vitamin A deficiency (VAD) is rare in well resourced countries, there is a growing trend of VAD in at-risk pediatric populations. Early diagnosis is critically important to prevent its associated morbidity and mortality. ... Full text Cite

Factors Associated with Ophthalmology Referral and Adherence in a Teleretinal Screening Program: Insights from a Federally Qualified Health Center.

Conference Clin Ophthalmol · 2022 BACKGROUND: Early detection of ophthalmic conditions such as diabetic retinopathy (DR) and glaucoma is crucial to preventing vision loss. Previous studies have evaluated teleretinal screening programs for DR in well-insured populations. The purpose of this ... Full text Link to item Cite

Maternal Self-Report of Tetanus Diphtheria Pertussis Vaccination during Pregnancy Correlates with Patient-Specific Electronic Medical Records.

Journal Article The Journal of pediatrics · July 2021 ObjectivesTo evaluate the concordance between maternal report of antepartum tetanus, diphtheria, pertussis (Tdap) vaccination and vaccination status documented in the electronic medical record (EMR), as well as factors associated with discordance. ... Full text Link to item Cite

57084 Combining artificial intelligence and robotics: a novel fully automated optical coherence tomography-based approach for eye disease screening

Conference Journal of Clinical and Translational Science · March 2021 ABSTRACT IMPACT: Despite its importance in systemic diseases such as diabetes, the eye is notably difficult to examine for non-specialists; this study introduces a fully automated approach for eye disease screening, coupling a deep learning algorit ... Full text Cite

Optical Coherence Tomography in Patients with Alzheimer's Disease: What Can It Tell Us?

Journal Article Eye and brain · January 2021 PurposeAlthough Alzheimer's disease (AD) is a leading cause of dementia worldwide, its clinical diagnosis remains a challenge. Optical coherence tomography (OCT) and OCT with angiography (OCTA) are non-invasive ophthalmic imaging tools with the po ... Full text Cite

Remote retinal imaging of patients from the ER using robotically aligned OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Mouse corneal transplant evaluation with topography and pachymetry using OCT

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

Caring for survivors of childhood cancer: it takes a village.

Journal Article Current opinion in pediatrics · December 2018 Purpose of reviewOver 80% of children diagnosed with cancer are now cured. The burgeoning population of survivors of childhood cancer experiences high rates of morbidity and mortality due to 'late-effects' of treatment. These can be defined as any ... Full text Cite

Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer

Journal Article Proceedings of SPIE--the International Society for Optical Engineering · 2017 Although there is long association of medical hyperthermia and immune stimulation, the relative lack of a quantifiable and reproducible effect has limited the utility and advancement of this relationship in preclinical/clinical cancer and non-cancer settin ... Full text Link to item Cite

The effect of hypofractionated radiation and magnetic nanoparticle hyperthermia on tumor immunogenicity and overall treatment response

Journal Article Proceedings of SPIE--the International Society for Optical Engineering · 2017 It is now known that many tumors develop molecular signals (immune checkpoint modulators) that inhibit an effective tumor immune response. New information also suggest that even well-known cancer treatment modalities such as radiation and hyperthermia gene ... Full text Link to item Cite

Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma

Conference Cancer Research · July 15, 2016 AbstractVHL disease is a classic tumor suppressor gene syndrome characterized by development of specific types of tumors in selective organs with nervous system and kidney being most consistently affected. D ... Full text Cite

Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: a study of ADNI cohorts.

Journal Article BioData mining · January 2016 BackgroundAlzheimer's disease (AD) is a neurodegenerative disease that causes dementia. While molecular basis of AD is not fully understood, genetic factors are expected to participate in the development and progression of the disease. Our goal wa ... Full text Cite