Alexander Tan Limkakeng Jr.

Alexander Tan Limkakeng Jr.
Associate Professor of Surgery

My personal research interest is finding new ways to diagnose acute coronary syndrome . In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery and translational research. The common element is time-sensitive health conditions. I help to oversee a team of research professionals in multicenter emergency department studies funded by the National Institutes of Health, foundations, and industry partners.

Current Research Interests

Acute Coronary Syndrome, Biomarkers, Myocardial Ischemia, Precision Medicine, Septic Shock, Pain Management, Clinical Trials

Current Appointments & Affiliations

Associate Professor of Surgery, Surgery, Emergency Medicine, Surgery 2013

Contact Information

2301 Erwin Road, Box 3096, Durham, NC 27710
(919) 681-0196
Duke Emergency Medicine Research

Background
Education, Training, & Certifications
- M.H.S., Duke University 2012
- M.D., University of Pennsylvania 2001
Duke Appointment History
- Assistant Professor of Surgery, Surgery, Emergency Medicine, Surgery 2007 - 2013
- Instructor, Temporary in the Department of Surgery, Surgery, Emergency Medicine, Surgery 2006 - 2007
Leadership & Clinical Positions at Duke
- Vice Chief of Research
  Director, Acute Care Research Team
Academic Positions Outside Duke
- Assistant Director, American College of Emergency Physicians Emergency Medicine Basic Research Skills (EMBRS) Course. 2018
- Vice Chair , American College of Emergency Physicians Research Committee. 2018 - 2019
- Co-Director, American College of Emergency Physicians Research Forum. 2016 - 2018
Recognition
In the News
- FEB 4, 2019 Duke Health News
  
  Blood Test Could Detect Early Risk Factors for Heart Disease
- JUL 11, 2017 Bass Connections
  
  These Kits Will Save Lives, But There Is Much More Work Ahead to Stem the Opiate Epidemic
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Capsule Endoscopy for HEmorrhage in the ER (CHEER) awarded by The George Washington University 2018 - 2020
- Prehospital Termination of Resuscitation in Out-of-Hospital Cardiac Arrest awarded by Society for Academic Emergency Medicine 2019 - 2020
- Assessment of Clinical Performance of Troponin Assays awarded by Siemens AG 2014 - 2020
- SC2i awarded by Henry M. Jackson Foundation 2014 - 2019
- Comparison of Dyspnea Measurement Instruments in Acute Heart Failure awarded by Heart Failure Society of America 2017 - 2019
- CCC for NHLBI Prevention and early Treatment of Acute Lung Injury PETAL Network - CLOVERS awarded by Vanderbilt University Medical Center 2017 - 2019
- Biomarkers for Acute Stroke Etilogy (BASE) awarded by Ischemia Care LLC 2016 - 2018
- CCC for NHLBI Prevention and early Treatment of Acute Lung Injury PETAL Network - VIOLET awarded by Vanderbilt University Medical Center 2017 - 2018
- MultiCenter trial of Rivaroxban for Early Discharge of Pulmonary Embolism from the ER awarded by Janssen Scientific Affairs, LLC. 2016 - 2017
- ACS Collection Study for Serum Claim awarded by Roche Diagnostics 2014 - 2017
- ARCHITECT STAT High Sensitive Troponin-I Assay Clinical Evaluation for Specimen Storage in Varying Specimen Tube Types awarded by Abbott Laboratories 2013 - 2015
- D-Dimer DVT/PE Exclusionary Sample Collection Project awarded by Siemens AG 2013 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hertz, JT, Fu, T, Vissoci, JR, Rocha, TAH, Carvalho, E, Flanagan, B, de Andrade, L, Limkakeng, AT, & Staton, CA. (2019, January 10). The distribution of cardiac diagnostic testing for acute coronary syndrome in the Brazilian healthcare system: A national geospatial evaluation of health access. Plos One , 14 (1), e0210502-null. Full Text
  - Limkakeng, AT, Henao, R, Voora, D, O'Connell, T, Griffin, M, Tsalik, EL, Shah, S, Woods, CW, & Ginsburg, GS. (2019, January). Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing. Plos One , 14 (2), e0211762-null. Full Text
  - Puskarich, MA, Callaway, C, Silbergleit, R, Pines, JM, Obermeyer, Z, Wright, DW, Hsia, RY, Shah, MN, Monte, AA, Limkakeng, AT, Meisel, ZF, & Levy, PD. (2019, January). Priorities to Overcome Barriers Impacting Data Science Application in Emergency Care Research. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 26 (1), 97-105. Full Text
  - Gesell, SB, Golden, SL, Limkakeng, AT, Carr, CM, Matuskowitz, A, Smith, LM, & Mahler, SA. (2018, December). Implementation of the HEART Pathway: Using the Consolidated Framework for Implementation Research. Critical Pathways in Cardiology , 17 (4), 191-200. Full Text
  - Limkakeng, AT, & Granger, CB. (2018, December). In patients with chest pain, HEART Pathway-guided and usual care did not differ for MACE or health care use. Annals of Internal Medicine , 169 (12), JC69-null. Full Text
  - Darrabie, MD, Cheeseman, J, Limkakeng, AT, Borawski, J, Sullenger, BA, Elster, EA, Kirk, AD, & Lee, J. (2018, November). Toll-like receptor activation as a biomarker in traumatically injured patients. The Journal of Surgical Research , 231 , 270-277. Full Text Open Access Copy
  - Hocker, MB, Gerardo, CJ, Theiling, BJ, Villani, J, Donohoe, R, Sandesara, H, & Limkakeng, AT. (2018, September). NHAMCS Validation of Emergency Severity Index as an Indicator of Emergency Department Resource Utilization. The Western Journal of Emergency Medicine , 19 (5), 855-862. Full Text
  - Kabrhel, C, Van Hylckama Vlieg, A, Muzikanski, A, Singer, A, Fermann, GJ, Francis, S, Limkakeng, A, Chang, AM, Giordano, N, & Parry, B. (2018, September). Multicenter Evaluation of the YEARS Criteria in Emergency Department Patients Evaluated for Pulmonary Embolism. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 25 (9), 987-994. Full Text
  - Ziegler, CE, Painter, DM, Borawski, JB, Kim, RJ, Kim, HW, & Limkakeng, AT. (2018, September). Unexpected Cardiac MRI Findings in Patients Presenting to the Emergency Department for Possible Acute Coronary Syndrome. Critical Pathways in Cardiology , 17 (3), 167-171. Full Text Open Access Copy
  - Parry, BA, Chang, AM, Schellong, SM, House, SL, Fermann, GJ, Deadmon, EK, Giordano, NJ, Chang, Y, Cohen, J, Robak, N, Singer, AJ, Mulrow, M, Reibling, ET, Francis, S, Griffin, SM, Prochaska, JH, Davis, B, McNelis, P, Delgado, J, Kümpers, P, Werner, N, Gentile, NT, Zeserson, E, Wild, PS, Limkakeng, AT, Walters, EL, LoVecchio, F, Theodoro, D, Hollander, JE, & Kabrhel, C. (2018, June). International, multicenter evaluation of a new D-dimer assay for the exclusion of venous thromboembolism using standard and age-adjusted cut-offs. Thrombosis Research , 166 , 63-70. Full Text Open Access Copy
  - Beri, N, Daniels, LB, Jaffe, A, Mueller, C, Anand, I, Peacock, WF, Hollander, JE, DeFilippi, C, Schreiber, D, McCord, J, Limkakeng, AT, Wu, AHB, Apple, FS, Diercks, DB, Nagurney, JT, Nowak, RM, Cannon, CM, Clopton, P, Neath, S-X, Christenson, RH, Hogan, C, Vilke, G, & Maisel, A. (2018, May). Copeptin to rule out myocardial infarction in Blacks versus Caucasians. European Heart Journal. Acute Cardiovascular Care ,, 2048872618772500-null. Full Text
  - Peacock, WF, Baumann, BM, Bruton, D, Davis, TE, Handy, B, Jones, CW, Hollander, JE, Limkakeng, AT, Mehrotra, A, Than, M, Ziegler, A, & Dinkel, C. (2018, February). Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome. Jama Cardiology , 3 (2), 104-111. Full Text
  - Limkakeng, AT, Leahy, JC, Griffin, SM, Lokhnygina, Y, Jaffa, E, Christenson, RH, & Newby, LK. (2018, January). Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide. Open Heart , 5 (2), e000847-null. Full Text Open Access Copy
  - de Oliveira, LLH, Vissoci, JRN, Machado, WDL, Rodrigues, CG, & Limkakeng, AT. (2017, December). Are Well-Informed Potential Trial Participants More Likely to Participate?. Journal of Empirical Research on Human Research Ethics : Jerhre , 12 (5), 363-371. Full Text Open Access Copy
  - Gaspari, R, Weekes, A, Adhikari, S, Noble, V, Nomura, JT, Theodoro, D, Woo, M, Atkinson, P, Blehar, D, Brown, S, Caffery, T, Douglass, E, Fraser, J, Haines, C, Lam, S, Lanspa, M, Lewis, M, Liebmann, O, Limkakeng, A, Lopez, F, Platz, E, Mendoza, M, Minnigan, H, Moore, C, Novik, J, Rang, L, Scruggs, W, & Raio, C. (2017, November). A retrospective study of pulseless electrical activity, bedside ultrasound identifies interventions during resuscitation associated with improved survival to hospital admission. A REASON Study. Resuscitation , 120 , 103-107. Full Text
  - Boyd, LR, Borawski, J, Lairet, J, & Limkakeng, AT. (2017, October). Critical Care Air Transport Team severe traumatic brain injury short-term outcomes during flight for Operation Iraqi Freedom/Operation Enduring Freedom. Journal of the Royal Army Medical Corps , 163 (5), 342-346. Full Text Open Access Copy
  - Borawski, JB, Graff, LG, & Limkakeng, AT. (2017, August). Care of the Patient with Chest Pain in the Observation Unit. Emergency Medicine Clinics of North America , 35 (3), 535-547. (Review) Full Text Open Access Copy
  - PRISM Investigators, , Rowan, KM, Angus, DC, Bailey, M, Barnato, AE, Bellomo, R, Canter, RR, Coats, TJ, Delaney, A, Gimbel, E, Grieve, RD, Harrison, DA, Higgins, AM, Howe, B, Huang, DT, Kellum, JA, Mouncey, PR, Music, E, Peake, SL, Pike, F, Reade, MC, Sadique, MZ, Singer, M, & Yealy, DM. (2017, June). Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. The New England Journal of Medicine , 376 (23), 2223-2234. Full Text
  - Gaspari, R, Weekes, A, Adhikari, S, Noble, VE, Nomura, JT, Theodoro, D, Woo, M, Atkinson, P, Blehar, D, Brown, SM, Caffery, T, Douglass, E, Fraser, J, Haines, C, Lam, S, Lanspa, M, Lewis, M, Liebmann, O, Limkakeng, A, Lopez, F, Platz, E, Mendoza, M, Minnigan, H, Moore, C, Novik, J, Rang, L, Scruggs, W, & Raio, C. (2017, May). Reply to Letter: Letter to the Editor regarding Gaspari and colleague's "Emergency department point-of-care ultrasound in out-of-hospital and in-ED cardiac arrest". Resuscitation , 114 , e7-e8. (Letter) Full Text
  - Limkakeng, AT, Drake, W, Lokhnygina, Y, Meyers, HP, Shogilev, D, Christenson, RH, & Newby, LK. (2017, March). Myocardial Ischemia on Exercise Stress Echocardiography Testing Is Not Associated with Changes in Troponin T Concentrations. The Journal of Applied Laboratory Medicine: an Aacc Publication , 1 (5), 532-543. Full Text Open Access Copy
  - Beri, N, Marston, NA, Daniels, LB, Nowak, RM, Schreiber, D, Mueller, C, Jaffe, A, Diercks, DB, Wettersten, N, DeFilippi, C, Peacock, WF, Limkakeng, AT, Anand, I, McCord, J, Hollander, JE, Wu, AHB, Apple, FS, Nagurney, JT, Berardi, C, Cannon, CM, Clopton, P, Neath, S-X, Christenson, RH, Hogan, C, Vilke, G, & Maisel, A. (2017, February). Necessity of hospitalization and stress testing in low risk chest pain patients. The American Journal of Emergency Medicine , 35 (2), 274-280. Full Text
  - Mehta, R, Nankivil, D, Zielinski, DJ, Waterman, G, Keller, B, Limkakeng, AT, Kopper, R, Izatt, JA, & Kuo, AN. (2017, January 20). Wireless, Web-Based Interactive Control of Optical Coherence Tomography with Mobile Devices. Translational Vision Science & Technology , 6 (1), 5-null. Full Text Open Access Copy
  - Gaspari, R, Weekes, A, Adhikari, S, Noble, VE, Nomura, JT, Theodoro, D, Woo, M, Atkinson, P, Blehar, D, Brown, SM, Caffery, T, Douglass, E, Fraser, J, Haines, C, Lam, S, Lanspa, M, Lewis, M, Liebmann, O, Limkakeng, A, Lopez, F, Platz, E, Mendoza, M, Minnigan, H, Moore, C, Novik, J, Rang, L, Scruggs, W, & Raio, C. (2016, December). Emergency department point-of-care ultrasound in out-of-hospital and in-ED cardiac arrest. Resuscitation , 109 , 33-39. Full Text Open Access Copy
  - Limkakeng, AT, Monte, AA, Kabrhel, C, Puskarich, M, Heitsch, L, Tsalik, EL, & Shapiro, NI. (2016, October 3). Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 23 (10), 1097-1106. (Review) Full Text Open Access Copy
  - Meyers, HP, Jaffa, E, Smith, SW, Drake, W, & Limkakeng, AT. (2016, September). Evaluation of T-Wave Morphology in Patients With Left Bundle Branch Block and Suspected Acute Coronary Syndrome. The Journal of Emergency Medicine , 51 (3), 229-237. Full Text Open Access Copy
  - Broder, JS, Bhat, R, Boyd, JP, Ogloblin, IA, Limkakeng, A, Hocker, MB, Drake, WG, Miller, T, Harringa, JB, & Repplinger, MD. (2016, June). Who explicitly requests the ordering of computed tomography for emergency department patients? A multicenter prospective study. Emergency Radiology , 23 (3), 221-227. Full Text
  - Tsalik, EL, Li, Y, Hudson, LL, Chu, VH, Himmel, T, Limkakeng, AT, Katz, JN, Glickman, SW, McClain, MT, Welty-Wolf, KE, Fowler, VG, Ginsburg, GS, Woods, CW, & Reed, SD. (2016, March). Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. Annals of the American Thoracic Society , 13 (3), 401-413. Full Text Open Access Copy
  - Kellum, JA, Chawla, LS, Keener, C, Singbartl, K, Palevsky, PM, Pike, FL, Yealy, DM, Huang, DT, Angus, DC, & ProCESS and ProGReSS-AKI Investigators, . (2016, February). The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock. American Journal of Respiratory and Critical Care Medicine , 193 (3), 281-287. Full Text
  - Marston, NA, Shah, KS, Mueller, C, Neath, S-X, Christenson, RH, McCord, J, Nowak, RM, Daniels, LB, Hollander, JE, Apple, F, Nagurney, J, Schreiber, D, deFilippi, C, Diercks, D, Limkakeng, A, Anand, IS, Wu, AHB, Jaffe, AS, Peacock, WF, & Maisel, AS. (2016, January). Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial. Emergency Medicine Journal : Emj , 33 (1), 23-29. Full Text
  - Hoffman, K, Butt, CM, Chen, A, Limkakeng, AT, & Stapleton, HM. (2015, December). High Exposure to Organophosphate Flame Retardants in Infants: Associations with Baby Products. Environmental Science & Technology , 49 (24), 14554-14559. Full Text
  - Meyers, HP, Limkakeng, AT, Jaffa, EJ, Patel, A, Theiling, BJ, Rezaie, SR, Stewart, T, Zhuang, C, Pera, VK, & Smith, SW. (2015, December). Validation of the modified Sgarbossa criteria for acute coronary occlusion in the setting of left bundle branch block: A retrospective case-control study. American Heart Journal , 170 (6), 1255-1264. Full Text Open Access Copy
  - Ranney, ML, Limkakeng, AT, Carr, B, Zink, B, Kaji, AH, & ACEP SAEM Research Committees (approved by ACEP-SAEM Board of Directors), . (2015, July). Improving the Emergency Care Research Investigator Pipeline: SAEM/ACEP Recommendations. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 22 (7), 849-851. Full Text Open Access Copy
  - Shah, KS, Marston, NA, Mueller, C, Neath, S-X, Christenson, RH, McCord, J, Nowak, RM, Vilke, GM, Daniels, LB, Hollander, JE, Apple, FS, Cannon, CM, Nagurney, J, Schreiber, D, deFilippi, C, Hogan, CJ, Diercks, DB, Limkakeng, A, Anand, IS, Wu, AHB, Clopton, P, Jaffe, AS, Peacock, WF, & Maisel, AS. (2015, May). Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 22 (5), 554-563. Full Text
  - Freiermuth, CE, Chandra, A, Peacock, WF, & Site Investigators, . (2015, March 17). Characteristics of patients that do not initially respond to intravenous antihypertensives in the emergency department: subanalysis of the CLUE trial. The Western Journal of Emergency Medicine , 16 (2), 276-283. Full Text
  - Limkakeng, AT, de Oliveira, LLH, Moreira, T, Phadtare, A, Garcia Rodrigues, C, Hocker, MB, McKinney, R, Voils, CI, & Pietrobon, R. (2014, June). Systematic review and metasummary of attitudes toward research in emergency medical conditions. J Med Ethics , 40 (6), 401-408. (Review) Full Text Open Access Copy Link to Item
  - Hertz, JT, Reardon, JM, Rodrigues, CG, de Andrade, L, Limkakeng, AT, Bloomfield, GS, & Lynch, CA. (2014, January). Acute myocardial infarction in sub-Saharan Africa: the need for data. Plos One , 9 (5), e96688-null. (Review) Full Text
  - Pike, F, Yealy, DM, Kellum, JA, Huang, DT, Barnato, AE, Eaton, TL, Angus, DC, Weissfeld, LA, & ProCESS Investigators, . (2013, December). Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. Critical Care and Resuscitation : Journal of the Australasian Academy of Critical Care Medicine , 15 (4), 301-310.
  - Chavez, J, Srinivasan, A, Ely, S, Drake, W, Freeman, D, Borawski, J, Chandra, A, & Limkakeng, AT. (2013, September). Thrombolysis in myocardial infarction risk score in an observation unit setting. Crit Pathw Cardiol , 12 (3), 137-140. Full Text Open Access Copy Link to Item
  - Maisel, A, Mueller, C, Neath, S-X, Christenson, RH, Morgenthaler, NG, McCord, J, Nowak, RM, Vilke, G, Daniels, LB, Hollander, JE, Apple, FS, Cannon, C, Nagurney, JT, Schreiber, D, deFilippi, C, Hogan, C, Diercks, DB, Stein, JC, Headden, G, Limkakeng, AT, Anand, I, Wu, AHB, Papassotiriou, J, Hartmann, O, Ebmeyer, S, Clopton, P, Jaffe, AS, & Peacock, WF. (2013, July 9). Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol , 62 (2), 150-160. Full Text Link to Item
  - Ely, S, Chandra, A, Mani, G, Drake, W, Freeman, D, & Limkakeng, AT. (2013, February). Utility of observation units for young emergency department chest pain patients. J Emerg Med , 44 (2), 306-312. Full Text Open Access Copy Link to Item
  - Ely, S, Chandra, A, Mani, G, Drake, W, Freeman, D, & Limkakeng, AT. (2013). Utility of observation units for young Emergency Department chest pain patients. Journal of Emergency Medicine , 44 (2), 306-312. Full Text Open Access Copy
  - Limkakeng, A, Phadtare, A, Shah, J, Vaghasia, M, Wei, DY, Shah, A, & Pietrobon, R. (2013). Willingness to participate in clinical trials among patients of Chinese heritage: a meta-synthesis. Plos One , 8 (1), e51328-null. Full Text Open Access Copy Link to Item
  - Hocker, MB, Villani, JJ, Borawski, JB, Evans, CS, Nelson, SM, Gerardo, CJ, & Limkakeng, AT. (2012, September). Dental visits to a North Carolina emergency department: a painful problem. N C Med J , 73 (5), 346-351. Link to Item
  - Limkakeng, AT, Glickman, SW, Shofer, F, Mani, G, Drake, W, Freeman, D, Ascher, S, Pietrobon, R, & Cairns, CB. (2012, April). Are patients with longer emergency department wait times less likely to consent to research?. Acad Emerg Med , 19 (4), 396-401. Full Text Open Access Copy Link to Item
  - Anderson, KL, Limkakeng, A, Damuth, E, & Chandra, A. (2012). Cardiac evaluation for structural abnormalities may not be required in patients presenting with syncope and a normal ECG result in an observation unit setting. Annals of Emergency Medicine , 60 (4), 478-484.e1. Full Text
  - Limkakeng, AT, Drake, W, Mani, G, Freeman, D, Best, R, Newby, LK, & Chandra, A. (2012, January). Left ventricular dysfunction screening in hypertensive patients with N-terminal pro-B-type natriuretic peptide and electrocardiogram. The American Journal of Emergency Medicine , 30 (1), 214-217. Full Text Open Access Copy
  - Chandra, A, Sieck, S, Hocker, M, Gerardo, CJ, Villani, J, Harrison, D, Boardwine, A, & Limkakeng, A. (2011, June). An observation unit may help improve an institution's Press Ganey satisfaction score. Crit Pathw Cardiol , 10 (2), 104-106. Full Text Link to Item
  - Chandra, A, Nicks, B, Maniago, E, Nouh, A, & Limkakeng, A. (2010, October). A multicenter analysis of the ED diagnosis of pneumonia. Am J Emerg Med , 28 (8), 862-865. Full Text Link to Item
  - Limkakeng, AT, & Chandra, A. (2010, July). Impact of renal dysfunction on acute coronary syndrome evaluation in observation unit patients. The American Journal of Emergency Medicine , 28 (6), 658-662. Full Text Open Access Copy
  - Chandra, A, Lindsell, CJ, Limkakeng, A, Diercks, DB, Hoekstra, JW, Hollander, JE, Kirk, JD, Peacock, WF, Gibler, WB, Pollack, CV, & EMCREG i*trACS Investigators, . (2009, August). Emergency physician high pretest probability for acute coronary syndrome correlates with adverse cardiovascular outcomes. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 16 (8), 740-748. Full Text Open Access Copy
  - Limkakeng, AT, Glickman, SW, Cairns, CB, & Chandra, A. (2009, August). Unsuspected pulmonary embolism in observation unit patients. The Western Journal of Emergency Medicine , 10 (3), 130-134.
  - Takakuwa, KM, Shofer, FS, Limkakeng, AT, & Hollander, JE. (2008, June). Preferences for cardiac tests and procedures may partially explain sex but not race disparities. The American Journal of Emergency Medicine , 26 (5), 545-550. Full Text
  - Limkakeng, AT, Halpern, E, & Takakuwa, KM. (2007, May). Sixty-four-slice multidetector computed tomography: the future of ED cardiac care. The American Journal of Emergency Medicine , 25 (4), 450-458. (Review) Full Text
  - Sherman, SC, & Limkakeng, A. (2005, October). Xanthogranulomatous pyelonephritis with a nephrocutaneous fistula. The Journal of Emergency Medicine , 29 (3), 337-338. Full Text
  - Limkakeng, A, Gibler, WB, Pollack, C, Hoekstra, JW, Sites, F, Shofer, FS, Tiffany, B, Wilke, E, & Hollander, JE. (2001, July). Combination of Goldman risk and initial cardiac troponin I for emergency department chest pain patient risk stratification. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine , 8 (7), 696-702. Full Text
- Book Sections
  - Limkakeng, AT, & Kemnitz, MG. (2014, July 7). Globe rupture. In Rosen and Barkin's 5-Minute Emergency Medicine Consult: Fifth Edition.
- Other Articles
  - Yealy, DM, Kellum, JA, Huang, DT, Barnato, AE, Weissfeld, LA, Pike, F, Terndrup, T, Wang, HE, Hou, PC, LoVecchio, F, Filbin, MR, Shapiro, NI, & Angus, DC. (2014, May). A randomized trial of protocol-based care for early septic shock. The New England Journal of Medicine , 370 (18), 1683-1693. Full Text Open Access Copy
  - Limkakeng, A, Broder, JS, & Theiling, BJ. (2013, September). Chicken or egg? Risks of misattribution of cause-effect relationships in studies of association. Acad Emerg Med , 20 (9), 965-null. (Letter) Full Text Link to Item
  - Limkakeng, A, Broder, JS, & Theiling, BJ. (2013). Chicken or egg? Risks of misattribution of cause-effect relationships in studies of association. Academic Emergency Medicine , 20 (9), 965--null. Full Text
  - Limkakeng, AT. (2002, August). Emergency Medicine national conventions: a medical student's perspective. The Journal of Emergency Medicine , 23 (2), 211-212. Full Text
- Conference Papers
  - Broder, JS, Jaffa, E, Irons, T, Peethumnongsin, E, Theophanous, R, Limkakeng, AT, Vissoci, JR, Morgan, MR, Herickhoff, CD, & Dahl, JJ. (2018, October). 212 3D Volume Ultrasound of the Right Lower Quadrant for Diagnosis of Appendicitis. Elsevier BV. Full Text
  - Goldberg, DF, Borawski, JB, Limkakeng, AT, Kaji, AH, Ruderman, BT, Fantegrossi, AE, & Griffin, M. (2018, October). 136 Utilization of Bougie Adjunct Devices in the Emergency Department: A National Emergency Airway Registry Study. Elsevier BV. Full Text
  - Greene, SJ, Mentz, RJ, Limkakeng, AT, Irons, T, Truong, T, Green, CL, Nowak, C, Griffin, S, Leahy, J, & Pang, PS. (2018, October). 67EMF Comparison of Dyspnea Measurement Instruments in Acute Heart Failure: Results From the DYSPNEA-AHF Study. Elsevier BV. Full Text
  - Limkakeng, AT, Griffin, M, Leahy, C, Hatch, A, Rowlette, L, Voora, D, & Nixon, A. (2018, October). 32EMF Isolating Micro-Ribonucleic Acids from Peripheral Plasma to Identify Myocardial Ischemia During Stress Testing in Emergency Department Patients. Elsevier BV. Full Text
  - Ruderman, BT, Mali, M, Kaji, A, Borawski, JB, Limkakeng, AT, Kilgo, R, Goldberg, DF, & Fantegrossi, AE. (2018, October). 99 A Comparison of Direct Versus Video Laryngoscopy for Difficult Airway Patients in the Emergency Department: A National Emergency Airway Registry Study. Elsevier BV. Full Text
  - Fitzgerald, R, deFilippi, C, Hollander, J, Peacock, WF, Limkakeng, AT, Breitenbeck, N, Rivers, J, & Kareen, B. (2018, March). OVERALL AND SEX-SPECIFIC REFERENCE RANGES FOR HIGH-SENSITIVITY TROPONIN T GEN 5 STAT IN THE UNITED STATES. Elsevier BV. Full Text
  - Johnston, BE, Quigley, CA, Griffin, SM, Limkakeng, AT, Darrabie, MD, Cheeseman, JA, Kirk, AD, & Elster, EA. (2017, October). 313 Evaluation of Phenylalanine and Tyrosine Concentrations in Traumatically Injured Patients. Elsevier BV. Full Text
  - Limkakeng, AT, Carr, C, Mehrotra, A, Smith, L, Pajewski, N, Burke, GL, Wells, BJ, & Mahler, S. (2017, October). 1 Chest Pain Care Patterns Across the Carolinas: Determining the Readiness for Widespread HEART Pathway Dissemination. Elsevier BV. Full Text
  - Singer, AJ, Zheng, H, Kabrhel, C, Parry, BA, Chang, AM, Fermann, GJ, LoVecchio, F, Francis, SJ, Limkakeng, AT, & Zeserson, EM. (2017, October). 73 Clinical Suspicion and D-Dimer Levels in Venous Thromboembolism Patients With Low and High Clot Burden. Elsevier BV. Full Text
  - Ziegler, CE, Painter, DM, Borawski, JB, Kim, RJ, Kim, HW, & Limkakeng, AT. (2017, October). 105 Unexpected Cardiac Magnetic Resonance Imaging Findings in Patients Presenting to the Emergency Department for Potential Acute Coronary Syndrome. Elsevier BV. Full Text
  - Darrabie, MD, Lee, J, Cheeseman, J, Limkakeng, AT, Vaslef, SN, Sullenger, BA, & Kirk, AD. (2016, October). Toll-Like Receptor Signaling as a Prognostic Tool in Trauma Patients. Elsevier BV. Full Text
  - Freeman, D, Diskina, M, Drake, W, Jones, A, & Limkakeng, AT. (2013, October 1). The Protocol Acuity Scoring Tool for Prediction of Emergency Medicine Research Study Workload. Research Forum of the American-College-of-Emergency-Physicians (ACEP). Seattle, WA. MOSBY-ELSEVIER. Link to Item
  - Chandra, A, Limkakeng, AT, Barowski, J, Freeman, D, Drake, W, & Mani, G. (2011, October). 38 Exercise Treadmill Is an Appropriate Risk Stratification Tool in Low Risk Chest Pain Patients. Elsevier BV. Full Text
  - Ely, S, Chandra, A, Reinstein, A, & Limkakeng, AT. (2010, September). 41: Utility of Cardiac Stress Testing In Young Patients In an Observation Unit. Elsevier BV. Full Text
  - Limkakeng, AT, Glickman, SW, Freeman, D, Drake, W, Mani, G, Chandra, A, & Cairns, CB. (2009, September). 161: Do Prolonged Emergency Department Waiting Times Reduce Emergency Research Consent Rates?. Elsevier BV. Full Text
  - Limkakeng, AT, Glickman, S, Greene, V, & Chandra, A. (2008, October). 303: Incidence and Impact of Renal Dysfunction on Acute Coronary Syndrome in Chest Pain Observation Unit Patients. Elsevier BV. Full Text
  - Limkakeng, AT, Saraswat, A, Glickman, S, Molinar, G, Drake, W, Freeman, D, & Chandra, A. (2008, October). 150: Blood Pressure Response in Hypertensive Emergency Department Patients With a History of End Organ Disease. Elsevier BV. Full Text
  - Takakuwa, KM, Limkakeng Jr, AT, Shofer, FS, & Hollander, JE. (2006, October 1). Patients' pain and estimate of their risk for cardiac disease do not predict preferences for cardiac tests and procedures. Research Forum of the American-College-of-Emergency-Physicians. New Orleans, LA. MOSBY-ELSEVIER. Link to Item
  - Limkakeng, AT, Tsai, J, Lindsay, T, Ciavarella, G, Andrade, AA, Kampe, LM, Schaider, JJ, Taylor, P, & Roberts, RR. (2004, October). Effects of implementing a modified electronic medical record and comprehensive patient tracking system on the patient care activities of emergency department staff. Elsevier BV. Full Text
  - Tsai, J, Limkakeng, AT, Roberts, RR, & Schaider, J. (2004, October). Impact of institution of an electronic hospital information system on nursing quick registration and triage times. Elsevier BV. Full Text
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member . Stemming the Opiate Epidemic through Education and Outreach. August 2017 - May 2018 2017 - 2018
Service to the Profession
- Co-Director. American College of Emergency Physicians Scientific Assembly Research Forum. American College of Emergency Physicians. 2015 - 2018 2015 - 2018

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