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Alexander Tan Limkakeng Jr.

Professor of Emergency Medicine
Emergency Medicine
2301 Erwin Road Box 3096, Durham, NC 27710
2301 Erwin Road, Box 3096, Durham, NC 27710

Research Interests


Acute Coronary Syndrome, Biomarkers, Myocardial Ischemia, Precision Medicine, Septic Shock, Pain Management, Clinical Trials

Selected Grants


Eastern North Carolina and southern Virginia regIonal Stroke trIal cONsortium (ENVISION)

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2023 - 2028

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Patterns of Survivors Recovery Trajectories in the ICECAP Trial POST-ICECAP

ResearchPrincipal Investigator · Awarded by University of Michigan · 2024 - 2028

Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028

Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome - PERFORM-TSIX Study -

Clinical TrialPrincipal Investigator · Awarded by Roche Diagnostics · 2022 - 2027

Eastern North Carolina and southern Virginia regIonal Stroke trIal cONsortium (ENVISION)

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2023 - 2028

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Patterns of Survivors Recovery Trajectories in the ICECAP Trial POST-ICECAP

ResearchPrincipal Investigator · Awarded by University of Michigan · 2024 - 2028

Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028

Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome - PERFORM-TSIX Study -

Clinical TrialPrincipal Investigator · Awarded by Roche Diagnostics · 2022 - 2027

Self-aligning, motion-stabilized ocular imaging for eye care in urgent and emergent care settings

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2027

POC Troponin Study - Pro00110283

Clinical TrialPrincipal Investigator · Awarded by Quidel · 2022 - 2027

Robotically Assisted Anterior Eye Examinations for Acute Eye Care

ResearchCo Investigator · Awarded by Research To Prevent Blindness, Inc. · 2023 - 2025

Sen-Jam Pharmaceuticals - COVID Ketoifen/Indomethacin study

ResearchPrincipal Investigator · Awarded by Sen-Jam Pharmaceutical · 2021 - 2024

CRISPR-based, rapid bedside bacteremia detection for ED sepsis management

ResearchPrincipal Investigator · Awarded by Society for Academic Emergency Medicine · 2023 - 2024

Understanding patient perspective in ED triage: Opportunities to reduce bias in intake psychiatric patients

ResearchAdvisor · Awarded by Society for Academic Emergency Medicine · 2023 - 2024

Duke Pain Early-phase Research Clinical Center (PERC)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2024

1/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest Patients

Clinical TrialPrincipal Investigator · Awarded by University of Michigan · 2020 - 2023

Multi-center registry of potential COVID-19 patients presenting in US Emergency Departments

ResearchPrincipal Investigator · Awarded by The Trustees of Indiana University · 2020 - 2023

EPPIC-NET Centrexion Knee OA (EN20-01)

Clinical TrialPrincipal Investigator · Awarded by Massachusetts General Hospital · 2021 - 2023

Clinical Evaluation of the BinaxNOW¿ COVID-19 Ag / Flu A & B Combo Card

Clinical TrialPrincipal Investigator · Awarded by Abbott Disgnostic Scarborough, Inc. · 2022 - 2022

Barriers to myocardial infarction care among persons living with HIV in Tanzania

ResearchMentor · Awarded by Society for Academic Emergency Medicine · 2021 - 2022

Portable motion-stabilized optical coherence tomography for eye care in acute care settings

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2022

CCC for NHLBI Prevention and early Treatment of Acute Lung Injury PETAL Network - CLOVERS

Clinical TrialPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2017 - 2022

Biology and Longitudinal Epidemiology of COVID-19 Observational Study, BLUE CORAL

Clinical TrialPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2020 - 2022

Capsule Endoscopy for HEmorrhage in the ER (CHEER)

Clinical TrialPrincipal Investigator · Awarded by The George Washington University · 2018 - 2022

Clinical Evaluation of the Lateral Flow COVID-19 Antigen Test

Clinical TrialPrincipal Investigator · Awarded by Abbott Disgnostic Scarborough, Inc. · 2020 - 2021

BD Respiratory Specimen Collection for COVID-19

Clinical TrialPrincipal Investigator · Awarded by Becton Dickinson and Company · 2020 - 2021

Abbott Stress-Delta Biomarkers for ACS Risk Stratification

Clinical TrialPrincipal Investigator · Awarded by Abbott Laboratories · 2014 - 2021

Sc2i

ResearchCo Investigator · Awarded by Henry M. Jackson Foundation · 2020 - 2021

Abbott Rapid Diagnostics - COVID 19 - CATSS Study

Clinical TrialPrincipal Investigator · Awarded by Abbott Rapid Diagnostics · 2020 - 2021

Social Determinants of Health and COVID-19 Infection in North Carolina: A Geospatial and Qualitative Analysis

ResearchInvestigator · Awarded by Emergency Medicine Foundation · 2020 - 2021

RED CORAL: PETAL COVID-19 Observational Study

Clinical TrialPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2020 - 2021

Prehospital Termination of Resuscitation in Out-of-Hospital Cardiac Arrest

ResearchPrincipal Investigator · Awarded by Society for Academic Emergency Medicine · 2019 - 2020

SC2i

ResearchCo Investigator · Awarded by Henry M. Jackson Foundation · 2014 - 2020

Specimen Collection in the Emergency Department for The Assessment of Clinical Performance of Troponin Assays

Clinical TrialPrincipal Investigator · Awarded by Siemens AG · 2014 - 2020

Comparison of Dyspnea Measurement Instruments in Acute Heart Failure

Clinical TrialSenior Investigator · Awarded by Heart Failure Society of America · 2017 - 2019

CCC for NHLBI Prevention and early Treatment of Acute Lung Injury PETAL Network - VIOLET

Clinical TrialPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2017 - 2018

MultiCenter trial of Rivaroxban for Early Discharge of Pulmonary Embolism from the ER

Clinical TrialPrincipal Investigator · Awarded by Janssen Scientific Affairs, LLC. · 2016 - 2017

ARCHITECT STAT High Sensitive Troponin-I Assay Clinical Evaluation for Specimen Storage in Varying Specimen Tube Types

ResearchPrincipal Investigator · Awarded by Abbott Laboratories · 2013 - 2015

D-Dimer DVT/PE Exclusionary Sample Collection Project

Clinical TrialPrincipal Investigator · Awarded by Siemens AG · 2013 - 2015

External Relationships


  • American College of Emergency Physicians
  • Farrell, White, and Legg, PLLC

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.