Scholars@Duke
Alexander Paraschos

Alexander Paraschos

Clinical Associate in the Department of Medicine
Medicine, Cardiology
alexander.paraschos@duke.edu
1234 Hufman Mill Rd, Burlington, NC 27215
1234 Hufman Mill Rd, Burlington, NC 27215
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Selected Publications

Outcomes following elective percutaneous coronary intervention without on-site surgical backup in a community hospital.

Journal Article Am J Cardiol · May 1, 2005 Despite guidelines to the contrary, limited numbers of elective percutaneous coronary intervention (PCI) procedures without on-site surgical backup are being performed, particularly in Europe and Canada. In the United States, many hospitals are considering ... Full text Link to item Cite

Arrhythmia monitoring through pacemakers - Response

Journal Article CIRCULATION · October 14, 2003 Link to item Cite

Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST).

Journal Article Circulation · April 1, 2003 BACKGROUND: Some current pacing systems can automatically detect and record atrial tachyarrhythmias that may be asymptomatic. We prospectively studied a 312-patient (pt) subgroup of MOST (MOde Selection Trial), a 2010-patient, 6-year randomized trial of DD ... Full text Link to item Cite

Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.

Journal Article Naunyn Schmiedebergs Arch Pharmacol · September 1994 Supersensitivity of adenylyl cyclase after exposure to inhibitory agonists is a general means of cellular adaptation. We hypothesized that such "crosstalk" between muscarinic cholinergic agonists, beta 1-adrenoceptors, and adenylyl cyclase may be an import ... Full text Link to item Cite

A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.

Journal Article Cardiovasc Res · December 1993 OBJECTIVES: In cultured neonatal rat myocardial cells the phorbol ester, phorbol-12 myristate 13-acetate (PMA), was used as a probe to examine the short term effects of augmented protein kinase C activity on the adenylyl cyclase system and on beta adrenoce ... Full text Link to item Cite

The clinical spectrum of patients with aneurysms of the ascending aorta.

Journal Article Am Heart J · May 1993 Aneurysms of the ascending aorta are often unsuspected, yet they can quickly lead to death from aortic rupture or dissection. To examine the clinical spectrum of patients with aneurysms of the ascending aorta, we searched the University of California, San ... Full text Link to item Cite

DETERGENT SOLUBILIZATION IN THE STUDY OF ACETYLCHOLINE-RECEPTOR LIPID ASSOCIATIONS

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · January 1, 1984 Link to item Cite

Absorption filtration. A tool for the measurement of ion tracer flux in native membranes and reconstituted lipid vesicles.

Journal Article Biochim Biophys Acta · September 7, 1983 A rapid, simple and reproducible method has been developed for the measurement of ion tracer flux with both native membrane vesicles and reconstituted lipid vesicle systems. Following the absorption of vesicles onto glass fiber filters, tracer flux is perf ... Full text Link to item Cite

Acetylcholine receptor from Torpedo. Preferential solubilization and efficient reintegration into lipid vesicles.

Journal Article Biochim Biophys Acta · October 7, 1982 The acetylcholine receptor has been effectively solubilized from Torpedo californica electroplax under defined conditions with the nonionic detergent, beta-D-octylglucopyranoside. Preferential solubilization of the receptor protein, with regard to yield an ... Full text Link to item Cite

Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, beta-D-octylglucopyranoside.

Journal Article Biochim Biophys Acta · May 6, 1981 Non-ionic detergents used for the solubilization and purification of acetylcholine receptor from Torpedo californica electroplax may remain tightly bound to this protein. The presence of detergent greatly hinders spectrophotometric and hydrodynamic studies ... Full text Link to item Cite

Outcomes following elective percutaneous coronary intervention without on-site surgical backup in a community hospital.

Journal Article Am J Cardiol · May 1, 2005 Despite guidelines to the contrary, limited numbers of elective percutaneous coronary intervention (PCI) procedures without on-site surgical backup are being performed, particularly in Europe and Canada. In the United States, many hospitals are considering ... Full text Link to item Cite

Arrhythmia monitoring through pacemakers - Response

Journal Article CIRCULATION · October 14, 2003 Link to item Cite

Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST).

Journal Article Circulation · April 1, 2003 BACKGROUND: Some current pacing systems can automatically detect and record atrial tachyarrhythmias that may be asymptomatic. We prospectively studied a 312-patient (pt) subgroup of MOST (MOde Selection Trial), a 2010-patient, 6-year randomized trial of DD ... Full text Link to item Cite

Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.

Journal Article Naunyn Schmiedebergs Arch Pharmacol · September 1994 Supersensitivity of adenylyl cyclase after exposure to inhibitory agonists is a general means of cellular adaptation. We hypothesized that such "crosstalk" between muscarinic cholinergic agonists, beta 1-adrenoceptors, and adenylyl cyclase may be an import ... Full text Link to item Cite

A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.

Journal Article Cardiovasc Res · December 1993 OBJECTIVES: In cultured neonatal rat myocardial cells the phorbol ester, phorbol-12 myristate 13-acetate (PMA), was used as a probe to examine the short term effects of augmented protein kinase C activity on the adenylyl cyclase system and on beta adrenoce ... Full text Link to item Cite

The clinical spectrum of patients with aneurysms of the ascending aorta.

Journal Article Am Heart J · May 1993 Aneurysms of the ascending aorta are often unsuspected, yet they can quickly lead to death from aortic rupture or dissection. To examine the clinical spectrum of patients with aneurysms of the ascending aorta, we searched the University of California, San ... Full text Link to item Cite

DETERGENT SOLUBILIZATION IN THE STUDY OF ACETYLCHOLINE-RECEPTOR LIPID ASSOCIATIONS

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · January 1, 1984 Link to item Cite

Absorption filtration. A tool for the measurement of ion tracer flux in native membranes and reconstituted lipid vesicles.

Journal Article Biochim Biophys Acta · September 7, 1983 A rapid, simple and reproducible method has been developed for the measurement of ion tracer flux with both native membrane vesicles and reconstituted lipid vesicle systems. Following the absorption of vesicles onto glass fiber filters, tracer flux is perf ... Full text Link to item Cite

Acetylcholine receptor from Torpedo. Preferential solubilization and efficient reintegration into lipid vesicles.

Journal Article Biochim Biophys Acta · October 7, 1982 The acetylcholine receptor has been effectively solubilized from Torpedo californica electroplax under defined conditions with the nonionic detergent, beta-D-octylglucopyranoside. Preferential solubilization of the receptor protein, with regard to yield an ... Full text Link to item Cite

Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, beta-D-octylglucopyranoside.

Journal Article Biochim Biophys Acta · May 6, 1981 Non-ionic detergents used for the solubilization and purification of acetylcholine receptor from Torpedo californica electroplax may remain tightly bound to this protein. The presence of detergent greatly hinders spectrophotometric and hydrodynamic studies ... Full text Link to item Cite

Reconstitution of functional membrane-bound acetylcholine receptor from isolated Torpedo californica receptor protein and electroplax lipids.

Journal Article Proc Natl Acad Sci U S A · April 1980 Purified acetylcholine receptor and total lipids, both extracted from Torpedo californica electroplax, were utilized to reconstitute chemically excitable membrane vesicles. Reconstitution was achieved by dialysis of the extraction detergent, octyl beta-D-g ... Full text Link to item Cite