Alexander Reed

Journal Article Sci Adv · April 26, 2024 We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguis ... Full text Link to item Cite

Serum proteomic biomarkers diagnostic of knee osteoarthritis.

Conference Osteoarthritis Cartilage · March 2024 OBJECTIVE: To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. DESIGN: We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foun ... Full text Link to item Cite

Serum proteomic panel validated for prediction of knee osteoarthritis progression.

Journal Article Osteoarthr Cartil Open · March 2024 OBJECTIVE: To further validate a serum proteomics panel for predicting radiographic (structural) knee OA progression. DESIGN: Serum peptides were targeted by multiple-reaction-monitoring mass spectrometry in the New York University cohort (n = 104). Knee ... Full text Link to item Cite

A "best-in-class" systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression.

Journal Article Sci Adv · January 25, 2023 We aimed to identify markers in blood (serum) to predict clinically relevant knee osteoarthritis (OA) progression defined as the combination of both joint structure and pain worsening over 48 months. A set of 15 serum proteomic markers corresponding to 13 ... Full text Link to item Cite

Increase in Free and Total Plasma TGF-β1 Following Physical Activity.

Journal Article Cartilage · December 2021 OBJECTIVE: To evaluate effects of physical activity and food consumption on plasma concentrations of free and total transforming growth factor beta-1 (TGF-β1), beta-2 (TGF-β2), and beta-3 (TGF-β3) in individuals with knee osteoarthritis (OA). METHODS: Part ... Full text Open Access Link to item Cite