Scholars@Duke
Alfonso Torquati

Alfonso Torquati

Adjunct Associate Professor in the Department of Surgery
Surgery, Minimally Invasive Surgery
alfonso.torquati@duke.edu
Duke Box 3351, Durham, NC 27704
3116 N. Duke St, Suite 209, Durham, NC 27704
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Selected Publications

Ursodiol Prescriptions Following Bariatric Surgery: National Prescribing Trends and Outcomes.

Journal Article Obesity surgery · August 2023 BackgroundRapid weight loss after bariatric surgery is a risk factor for gallstone development. Numerous studies have shown that ursodiol after surgery decreases rates of gallstone formation and cholecystitis. Real-world prescribing practices are ... Full text Cite

Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.

Conference J Laparoendosc Adv Surg Tech A · August 2022 Background: Irisin has been recently reported to provide beneficial effects in obesity and diabetes. Elevation of high-sensitivity C-reactive protein (hs-CRP) reflects the inflammatory state that has been shown to play a key role in obesity and its comorbi ... Full text Link to item Cite

The Association Between Bariatric Surgery and Psychiatric Disorders: a National Cohort Study.

Journal Article Obes Surg · April 2022 PURPOSE: Previous studies have shown that bariatric surgery reduces the risk of cardiovascular outcomes. Less is known about the effects of bariatric surgery on psychiatric disorders. This cohort study compared the differential risk of psychiatric disorder ... Full text Link to item Cite

Social determinants of health and their impact on rates of postoperative complications among patients undergoing vertical sleeve gastrectomy.

Journal Article Surgery · February 2022 BACKGROUND: Vertical sleeve gastrectomy is one of the most common bariatric procedures worldwide, but the impact of social determinants of health on postoperative outcomes for this procedure has not been well characterized. The objective of this study was ... Full text Link to item Cite

Association of Bariatric Surgery and Risk of Cancer in Patients With Morbid Obesity.

Journal Article Ann Surg · January 1, 2022 OBJECTIVE: This study investigates the rates of obesity-related cancers in patients undergoing vertical sleeve gastrectomy (VSG), Roux-en-Y gastric bypass (RYGB), or no surgical intervention. SUMMARY BACKGROUND DATA: Obesity has been previously associated ... Full text Link to item Cite

Metabolic profiles, energy expenditures, and body compositions of the weight regain versus sustained weight loss patients who underwent Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · December 2021 BACKGROUND: Weight regain (WR) has been an emerging problem after Roux-en Y gastric bypass (RYGB) and little is known about the mechanisms of WR after RYGB. OBJECTIVE: To evaluate the mechanisms of WR after RYGB through the postprandial gut hormones respon ... Full text Link to item Cite

The effect of bariatric surgery on ischemic stroke risk.

Journal Article Surg Obes Relat Dis · December 2021 BACKGROUND: Metabolic and bariatric surgery (MBS) has demonstrated improvements in diabetes and cardiovascular health. The effect of MBS on the risk of ischemic stroke remains unclear. OBJECTIVES: The goal of this study was to determine the risk of stroke ... Full text Link to item Cite

Laparoscopic-Assisted Versus Mini-Open Laparotomy for Ventriculoperitoneal Shunt Placement in the Medicare Population.

Journal Article Neurosurgery · March 15, 2021 BACKGROUND: Placement of the distal shunt catheter into the peritoneum during ventriculoperitoneal shunt (VPS) surgery can be done with either laparoscopic assistance or laparotomy. OBJECTIVE: To compare outcomes in laparoscopic-assisted vs laparotomy for ... Full text Link to item Cite

Roux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.

Journal Article Surgery · March 2021 BACKGROUND: Obesity and type 2 diabetes mellitus are associated with elevated levels of inflammatory markers. This chronic inflammation is known to contribute to increased risk of cardiovascular disease in these populations. Laparoscopic Roux-en-Y gastric ... Full text Link to item Cite

The Impact of Perioperative Antibiotic Prophylaxis on Weight Loss Following Laparoscopic Sleeve Gastrectomy.

Journal Article J Laparoendosc Adv Surg Tech A · September 2020 Although >10% of surgical patients receive alternative antibiotic prophylaxis for reported penicillin allergies, it is estimated that <20% of such cases represent true allergies that preclude standard prophylaxis. Each antibiotic class has a distinct impac ... Full text Link to item Cite

Association of Bariatric Surgery With Risk of Fracture in Patients With Severe Obesity.

Journal Article JAMA Netw Open · June 1, 2020 IMPORTANCE: Given the complex relationship between body mass index, body composition, and bone density and the correlative nature of the studies that have established the prevailing notion that higher body mass indices may be protective against osteopenia ... Full text Link to item Cite

Determining changes in bone metabolism after bariatric surgery in postmenopausal women.

Journal Article Surg Endosc · April 2020 BACKGROUND: Accelerated bone loss is a known complication after bariatric surgery. Bone mineral density has been shown to decrease significantly after Laparoscopic Roux-en-Y gastric bypass (RYGB). Laparoscopic sleeve gastrectomy (SG) effects on bone densit ... Full text Link to item Cite

Racial Disparity in 30-Day Outcomes of Metabolic and Bariatric Surgery.

Conference Obes Surg · March 2020 BACKGROUND: There is evidence of racial disparity in the long-term weight loss outcomes of bariatric surgery. However, there has been a more limited evaluation of the impact of race on immediate perioperative outcomes. The aim of this study was to compare ... Full text Link to item Cite

Effects of Roux-en-Y Gastric Bypass on Osteoclast Activity and Bone Density in Morbidly Obese Patients with Type 2 Diabetes.

Journal Article Obes Surg · January 2020 INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is a well-established treatment for morbid obesity and type 2 diabetes. The effects of RYGB on bone metabolism and bone health are largely unknown. OBJECTIVE: Determine the changes in osteoclast function and bo ... Full text Link to item Cite

Surgical weight loss

Chapter · January 1, 2020 Surgical weight loss is the most effective treatment of morbid obesity. Bariatric surgery has a multitude of effects, including improving or resolving obstructive sleep apnea, improving glucose metabolism, decreasing the risk of heart disease, and improvin ... Full text Cite

Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery.

Journal Article Surgery · October 2019 BACKGROUND: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. ... Full text Link to item Cite

Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging.

Journal Article Ann N Y Acad Sci · April 2019 Over the last two decades, it has become increasingly apparent that Wnt signaling plays a critical role in development and adult tissue homeostasis in multiple organs and in the pathogenesis of many diseases. In particular, a crucial role for Wnt signaling ... Full text Link to item Cite

Ursodiol Prescriptions Following Bariatric Surgery: National Prescribing Trends and Outcomes.

Journal Article Obesity surgery · August 2023 BackgroundRapid weight loss after bariatric surgery is a risk factor for gallstone development. Numerous studies have shown that ursodiol after surgery decreases rates of gallstone formation and cholecystitis. Real-world prescribing practices are ... Full text Cite

Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.

Conference J Laparoendosc Adv Surg Tech A · August 2022 Background: Irisin has been recently reported to provide beneficial effects in obesity and diabetes. Elevation of high-sensitivity C-reactive protein (hs-CRP) reflects the inflammatory state that has been shown to play a key role in obesity and its comorbi ... Full text Link to item Cite

The Association Between Bariatric Surgery and Psychiatric Disorders: a National Cohort Study.

Journal Article Obes Surg · April 2022 PURPOSE: Previous studies have shown that bariatric surgery reduces the risk of cardiovascular outcomes. Less is known about the effects of bariatric surgery on psychiatric disorders. This cohort study compared the differential risk of psychiatric disorder ... Full text Link to item Cite

Social determinants of health and their impact on rates of postoperative complications among patients undergoing vertical sleeve gastrectomy.

Journal Article Surgery · February 2022 BACKGROUND: Vertical sleeve gastrectomy is one of the most common bariatric procedures worldwide, but the impact of social determinants of health on postoperative outcomes for this procedure has not been well characterized. The objective of this study was ... Full text Link to item Cite

Association of Bariatric Surgery and Risk of Cancer in Patients With Morbid Obesity.

Journal Article Ann Surg · January 1, 2022 OBJECTIVE: This study investigates the rates of obesity-related cancers in patients undergoing vertical sleeve gastrectomy (VSG), Roux-en-Y gastric bypass (RYGB), or no surgical intervention. SUMMARY BACKGROUND DATA: Obesity has been previously associated ... Full text Link to item Cite

Metabolic profiles, energy expenditures, and body compositions of the weight regain versus sustained weight loss patients who underwent Roux-en-Y gastric bypass.

Journal Article Surg Obes Relat Dis · December 2021 BACKGROUND: Weight regain (WR) has been an emerging problem after Roux-en Y gastric bypass (RYGB) and little is known about the mechanisms of WR after RYGB. OBJECTIVE: To evaluate the mechanisms of WR after RYGB through the postprandial gut hormones respon ... Full text Link to item Cite

The effect of bariatric surgery on ischemic stroke risk.

Journal Article Surg Obes Relat Dis · December 2021 BACKGROUND: Metabolic and bariatric surgery (MBS) has demonstrated improvements in diabetes and cardiovascular health. The effect of MBS on the risk of ischemic stroke remains unclear. OBJECTIVES: The goal of this study was to determine the risk of stroke ... Full text Link to item Cite

Laparoscopic-Assisted Versus Mini-Open Laparotomy for Ventriculoperitoneal Shunt Placement in the Medicare Population.

Journal Article Neurosurgery · March 15, 2021 BACKGROUND: Placement of the distal shunt catheter into the peritoneum during ventriculoperitoneal shunt (VPS) surgery can be done with either laparoscopic assistance or laparotomy. OBJECTIVE: To compare outcomes in laparoscopic-assisted vs laparotomy for ... Full text Link to item Cite

Roux-en-Y gastric bypass decreases serum inflammatory markers and cardiovascular risk factors in obese diabetics.

Journal Article Surgery · March 2021 BACKGROUND: Obesity and type 2 diabetes mellitus are associated with elevated levels of inflammatory markers. This chronic inflammation is known to contribute to increased risk of cardiovascular disease in these populations. Laparoscopic Roux-en-Y gastric ... Full text Link to item Cite

The Impact of Perioperative Antibiotic Prophylaxis on Weight Loss Following Laparoscopic Sleeve Gastrectomy.

Journal Article J Laparoendosc Adv Surg Tech A · September 2020 Although >10% of surgical patients receive alternative antibiotic prophylaxis for reported penicillin allergies, it is estimated that <20% of such cases represent true allergies that preclude standard prophylaxis. Each antibiotic class has a distinct impac ... Full text Link to item Cite

Association of Bariatric Surgery With Risk of Fracture in Patients With Severe Obesity.

Journal Article JAMA Netw Open · June 1, 2020 IMPORTANCE: Given the complex relationship between body mass index, body composition, and bone density and the correlative nature of the studies that have established the prevailing notion that higher body mass indices may be protective against osteopenia ... Full text Link to item Cite

Determining changes in bone metabolism after bariatric surgery in postmenopausal women.

Journal Article Surg Endosc · April 2020 BACKGROUND: Accelerated bone loss is a known complication after bariatric surgery. Bone mineral density has been shown to decrease significantly after Laparoscopic Roux-en-Y gastric bypass (RYGB). Laparoscopic sleeve gastrectomy (SG) effects on bone densit ... Full text Link to item Cite

Racial Disparity in 30-Day Outcomes of Metabolic and Bariatric Surgery.

Conference Obes Surg · March 2020 BACKGROUND: There is evidence of racial disparity in the long-term weight loss outcomes of bariatric surgery. However, there has been a more limited evaluation of the impact of race on immediate perioperative outcomes. The aim of this study was to compare ... Full text Link to item Cite

Effects of Roux-en-Y Gastric Bypass on Osteoclast Activity and Bone Density in Morbidly Obese Patients with Type 2 Diabetes.

Journal Article Obes Surg · January 2020 INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is a well-established treatment for morbid obesity and type 2 diabetes. The effects of RYGB on bone metabolism and bone health are largely unknown. OBJECTIVE: Determine the changes in osteoclast function and bo ... Full text Link to item Cite

Surgical weight loss

Chapter · January 1, 2020 Surgical weight loss is the most effective treatment of morbid obesity. Bariatric surgery has a multitude of effects, including improving or resolving obstructive sleep apnea, improving glucose metabolism, decreasing the risk of heart disease, and improvin ... Full text Cite

Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery.

Journal Article Surgery · October 2019 BACKGROUND: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. ... Full text Link to item Cite

Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging.

Journal Article Ann N Y Acad Sci · April 2019 Over the last two decades, it has become increasingly apparent that Wnt signaling plays a critical role in development and adult tissue homeostasis in multiple organs and in the pathogenesis of many diseases. In particular, a crucial role for Wnt signaling ... Full text Link to item Cite

Short-Term Outcomes of Conversion of Failed Gastric Banding to Laparoscopic Sleeve Gastrectomy or Roux-En-Y Gastric Bypass: a Meta-Analysis.

Journal Article Obes Surg · February 2019 BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) is associated with high long-term failure rates, often requiring conversion to an alternative bariatric procedure. The most efficacious procedure after failed LAGB is subject to debate. Our objecti ... Full text Link to item Cite

Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.

Journal Article Surg Obes Relat Dis · August 2018 BACKGROUND: Gastric bypass surgery for weight reduction often corrects dysglycemia in diabetic patients, but a full understanding of the underlying biochemical pathways continues to be investigated. OBJECTIVES: To explore the effects of weight loss by surg ... Full text Link to item Cite

Understanding intestinal glucose transporter expression in obese compared to non-obese subjects.

Journal Article Surg Endosc · April 2018 INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transp ... Full text Link to item Cite

Predictors of Increased Length of Hospital Stay Following Laparoscopic Sleeve Gastrectomy from the National Surgical Quality Improvement Program.

Journal Article J Gastrointest Surg · February 2018 BACKGROUND: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric procedure in the USA. Identifying preoperative risk factors for prolonged postoperative hospital stay will help appropriately select patients for fast-track protocols and ... Full text Link to item Cite

Author's Response.

Journal Article Surg Obes Relat Dis · July 2017 Full text Link to item Cite

Predictors of weight regain in patients who underwent Roux-en-Y gastric bypass surgery.

Journal Article Surg Obes Relat Dis · November 2016 BACKGROUND: Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for obesity and results in long-term weight loss and resolution of co-morbidities. However, weight regain may occur as soon as 1-2 years after surgery. OBJECTIVES: This retrospecti ... Full text Link to item Cite

Post-gastric bypass hypoglycaemia: a review.

Journal Article Clin Endocrinol (Oxf) · July 2016 Bariatric surgery is a highly effective treatment for severe obesity, resulting in substantial weight loss and normalizing obesity-related comorbidities. However, long-term consequences can occur, such as postbariatric surgery hypoglycaemia. This is a chal ... Full text Link to item Cite

Gastric bypass significantly improves quality of life in morbidly obese patients with type 2 diabetes.

Journal Article Surg Endosc · July 2016 OBJECTIVE: To evaluate the impact of Roux-en-Y gastric bypass (RYGB) on quality of life in obese diabetic patients compared to standard medical therapy for type 2 diabetes mellitus. METHODS: We prospectively studied two matched obese populations with type ... Full text Link to item Cite

Gastric Bypass Surgery Leads to Long-term Remission or Improvement of Type 2 Diabetes and Significant Decrease of Microvascular and Macrovascular Complications.

Journal Article Ann Surg · June 2016 OBJECTIVES: The aim of the study was to compare long-term outcomes of 2 groups of morbidly obese patients with type 2 diabetes mellitus-1 managed by Roux-en-Y gastric bypass surgery and a comparable group managed medically. METHODS: The present study was a ... Full text Link to item Cite

Predictors of long-term success after laparoscopic Roux-en-Y gastric bypass in African-American women.

Journal Article Surg Obes Relat Dis · February 2016 BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) provides sustained weight loss. However, short-term studies have suggested that African Americans (AAs) are not as successful as Caucasians (CAs) after LRYGB. OBJECTIVE: The present study was design ... Full text Link to item Cite

Emerging Techniques in Minimally Invasive Surgery. Pros and Cons.

Journal Article J Gastrointest Surg · July 2015 New trends have emerged regarding the best minimally invasive access approaches to perform gastrointestinal surgery. However, these newer approaches are seen critically by those who demand a more strict assessment of outcomes and safety. An international p ... Full text Link to item Cite

Cardiovascular risk in obese diabetic patients is significantly reduced one year after gastric bypass compared to one year of diabetes support and education.

Journal Article Surg Endosc · October 2014 BACKGROUND: Roux-en-Y gastric bypass (RYGB) reduces most of the obesity-related comorbidities known to increase the cardiovascular risk in obese subjects. The Framingham risk score (FRS) is designed to be independent of body weight and estimates the 10-yea ... Full text Link to item Cite

Improved insulin sensitivity after gastric bypass correlates with decreased total body fat, but not with changes in free fatty acids.

Journal Article Surg Endosc · May 2014 BACKGROUND: Increased plasma free fatty acids (FFAs) are considered one of the key elements in the pathogenesis of insulin resistance (IR) and type 2 diabetes (T2DM). We hypothesize that, in diabetic patients undergoing laparoscopic Roux-en-Y gastric bypas ... Full text Link to item Cite

Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction.

Journal Article Ann Surg · April 2014 BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery results in exaggerated postprandial insulin and incretin responses and increased susceptibility to hypoglycemia. OBJECTIVE: We examined whether these features are due to caloric restriction (CR) or altere ... Full text Link to item Cite

Effects of Roux-en-Y gastric bypass or diabetes support and education on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes.

Journal Article Ann Surg · March 2014 OBJECTIVE: The long-term changes in insulin sensitivity and β-cell function in morbidly obese patients with type 2 diabetes mellitus who undergo Roux-en-Y gastric bypass (RYGB) surgery or standard medical care remain unclear. We prospectively studied longi ... Full text Link to item Cite

Esophageal acid-clearance physiology is altered after Nissen-Collis gastroplasty.

Journal Article Surg Endosc · April 2013 BACKGROUND: Nissen-Collis gastroplasty (NCG) is an effective treatment for short esophagus, but it sometimes is associated with abnormal postoperative esophageal acid exposure. This study was designed to test the hypothesis that NCG prevents gastric reflux ... Full text Link to item Cite

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Journal Article FASEB J · April 2013 Choline metabolism is important for very low-density lipoprotein secretion, making this nutritional pathway an important contributor to hepatic lipid balance. The purpose of this study was to assess whether the cumulative effects of multiple single nucleot ... Full text Link to item Cite

Conversion of vertical banded gastroplasty to stand-alone sleeve gastrectomy or biliopancreatic diversion with duodenal switch.

Journal Article J Gastrointest Surg · April 2013 INTRODUCTION: Vertical banded gastroplasty (VBG) originated as a simplified bariatric operation to avoid malabsorption and provide lasting results due to a fixed stoma. Short-term results were excellent (50-70 % excess weight loss); however, patients often ... Full text Link to item Cite

Case-matched analysis comparing outcomes of revisional versus primary laparoscopic Roux-en-Y gastric bypass.

Journal Article Surg Endosc · February 2013 BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is one of the most common approaches used to revise post-bariatric patients with inadequate weight loss or significant weight regain. Previous studies have analyzed the outcomes of open revisional R ... Full text Link to item Cite

Necdin-E2F4 interaction provides insulin-sensitizing effect after weight loss induced by gastric bypass surgery.

Journal Article Surg Obes Relat Dis · 2013 BACKGROUND: The insulin-like growth factor-1 (IGF-1) signaling pathway promotes adipocyte differentiation and, therefore, insulin sensitivity by suppression of necdin expression, which represses peroxisome proliferator-activated receptor-gamma promoter act ... Full text Link to item Cite

Adipogenic differentiation of adipose tissue-derived human mesenchymal stem cells: effect of gastric bypass surgery.

Journal Article Surg Endosc · December 2012 BACKGROUND: Adipose tissue dysfunction is an important feature of obesity characterized by enlarged adipocytes and marked changes in secretion of cytokines. These changes result in insulin resistance, chronic vascular inflammation, oxidative stress, and ac ... Full text Link to item Cite

Serum leptin levels are inversely correlated with omental gene expression of adiponectin and markedly decreased after gastric bypass surgery.

Journal Article Surg Endosc · May 2012 BACKGROUND: Adipose tissue is the most abundant endocrine tissue in the body, producing leptin, a hormone important in regulating hunger, and adiponectin, a hormone involved in insulin sensitivity and inflammation. This study aimed to assess the impact of ... Full text Link to item Cite

Gastric bypass surgery restores meal stimulation of the anorexigenic gut hormones glucagon-like peptide-1 and peptide YY independently of caloric restriction.

Journal Article Surg Endosc · April 2012 BACKGROUND: The effects of gastric bypass surgery on the secretion of the anorexigenic gut-derived hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), independent of caloric restriction and due to different dietary macronutrients, is not well ch ... Full text Link to item Cite

Initial learning experience of laparoendoscopic single site (LESS) gastric banding: finding predictors of success.

Journal Article Obes Surg · March 2012 Single-incision laparoscopic adjustable gastric banding (SI-LAGB) is a promising technique with potential to decrease pain and improve cosmesis. It is challenging and potentially time-consuming. We aimed to identify preoperative patient characteristics pre ... Full text Link to item Cite

Omental gene expression of adiponectin correlates with degree of insulin sensitivity before and after gastric bypass surgery.

Journal Article Obes Surg · March 2012 BACKGROUND: Circulating adiponectin is known to correlate negatively with insulin resistance in patients with obesity and diabetes. The aim of this study was to assess the effect of gastric bypass (GB) surgery on adiponectin gene expression in subcutaneous ... Full text Link to item Cite

Weight loss at first postoperative visit predicts long-term outcome of Roux-en-Y gastric bypass using Duke weight loss surgery chart.

Journal Article Surg Obes Relat Dis · 2012 BACKGROUND: Roux-en-Y gastric bypass has been used for >3 decades. However, no normative data are available to aid the bariatric surgeon in assessing the adequacy of weight loss at each postoperative visit. The objective of the present study was to constru ... Full text Link to item Cite

Physiology of weight loss surgery.

Journal Article Surg Clin North Am · December 2011 The clinical outcomes achieved by bariatric surgery have been impressive. However, the physiologic mechanisms and complex metabolic effects of bariatric surgery are only now beginning to be understood. Ongoing research has contributed a large amount of dat ... Full text Link to item Cite

Zfp423 in Human Adipose Stem Cell

Conference OBESITY · November 1, 2011 Link to item Cite

Pre-Lap-Band group education in Medicaid population: does it really make a difference?

Journal Article Surg Obes Relat Dis · 2010 BACKGROUND: The effect of group education classes before a Lap-Band procedure has not been well defined. We hypothesized that in a Medicaid population, the completion of a standardized 12-week multidisciplinary preoperative program (SMPP) would significant ... Full text Link to item Cite

Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) grant impact on recipient academic career

Journal Article Surgical Endoscopy · December 29, 2009 Introduction: Surgical societies, including SAGES, distribute grant funds to support research, as well as to promote recipient careers. Although we hypothesize that these awards have a positive impact, no objective evidence exists. We sought to benchmark t ... Full text Cite

A research agenda for gastrointestinal and endoscopic surgery.

Journal Article Surg Endosc · September 2007 BACKGROUND: Development of a research agenda may help to inform researchers and research-granting agencies about the key research gaps in an area of research and clinical care. The authors sought to develop a list of research questions for which further re ... Full text Link to item Cite

Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women.

Journal Article Surg Endosc · August 2007 BACKGROUND: Metabolic bone disease is a potential complication of bariatric surgery. The aims of our study were to evaluate the effects of laparoscopic gastric bypass on calcium and vitamin D metabolism, and to identify patients at high risk to develop sec ... Full text Link to item Cite

Endoluminal GERD treatments: critical appraisal of current literature with evidence-based medicine instruments.

Journal Article Surg Endosc · May 2007 BACKGROUND: The literature of endoluminal treatment of gastroesophageal reflux disease (GERD) widely varies in the level of evidence presented for analysis. Therefore there is a need for a comprehensive evidence-based medicine (EBM) analysis of the current ... Full text Link to item Cite

Effect of gastric bypass operation on Framingham and actual risk of cardiovascular events in class II to III obesity.

Journal Article J Am Coll Surg · May 2007 BACKGROUND: Obesity is known to be a major risk factor for cardiovascular diseases. There are few studies in the literature assessing the effect of bariatric procedures on longterm risk of cardiovascular events. The aim of this study was to determine the e ... Full text Link to item Cite

A comparison of 399 open and 568 laparoscopic gastric bypasses performed during a 4-year period.

Journal Article Surg Endosc · April 2007 BACKGROUND: Laparoscopic Roux-en-Y gastric bypass surgery (RYGB) was introduced at the authors' institution 5 years ago. The authors analyzed the short- and long-term results of this procedure compared with those for the same procedure using the laparotomy ... Full text Link to item Cite

Predictors of early quality-of-life improvement after laparoscopic gastric bypass surgery.

Journal Article Am J Surg · April 2007 BACKGROUND: Quality of life is getting more attention in the medical literature. Treatment outcomes are now gauged by their effect on quality of life (QOL), along with their direct effect on diseases they are targeting. Similarly, in obesity, consensus has ... Full text Link to item Cite

Relief of dysphagia after laparoscopic Heller myotomy improves long-term quality of life.

Journal Article J Gastrointest Surg · March 2007 BACKGROUND AND OBJECTIVE: Quality of life (QoL) is getting more attention in the medical literature. Treatment outcomes are now gauged by their effect on the QoL along with their direct effect on the diseases they are targeting. The aim of the study was to ... Full text Link to item Cite

Long-term evaluation of patient satisfaction and reflux symptoms after laparoscopic fundoplication with Collis gastroplasty.

Journal Article Surg Endosc · November 2006 BACKGROUND: Esophageal shortening is a complication of advanced gastroesophageal reflux disease (GERD). For patients with short esophagus, Collis gastroplasty combined with fundoplication provides excellent symptomatic relief from GERD disease. The literat ... Full text Link to item Cite

Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease: A randomized, sham-controlled trial.

Journal Article Gastroenterology · September 2006 BACKGROUND & AIMS: The aim of this study was to determine the effectiveness of endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease (GERD) in comparison with a sham procedure. METHODS: Patients with symptomatic GERD requ ... Full text Link to item Cite

Experience with the optical access trocar for safe and rapid entry in the performance of laparoscopic gastric bypass.

Journal Article Surg Endosc · August 2006 BACKGROUND: In laparoscopic surgery, serious complications caused by the blind insertion of trocars are well known. The open technique is compromised by the leakage of carbon dioxide and can also be time consuming, especially in morbidly obese patients. Ou ... Full text Link to item Cite

Weight, dietary and physical activity behaviors two years after gastric bypass.

Journal Article Obes Surg · July 2006 BACKGROUND: This cross-sectional survey was designed to determine the self-reported weight management, dietary and physical activity behaviors of Roux-en-Y gastric bypass (RYGBP) patients who were 1 to 4 years after the RYGBP operation, and to identify gap ... Full text Link to item Cite

Internal hernia: postoperative complication of roux-en-Y gastric bypass surgery.

Journal Article Am Surg · July 2006 Obesity surgery is becoming one of the most common general surgery procedures done in the United States. Internal hernias are a known and increasingly more common occurrence after laparoscopic roux-en-Y gastric bypass (LRYGB). Increased clinical awareness ... Link to item Cite

Predictors of success after laparoscopic gastric bypass: a multivariate analysis of socioeconomic factors.

Journal Article Surg Endosc · June 2006 BACKGROUND: Laparoscopic gastric bypass (LGB) has proven efficacy in causing significant and durable weight loss. However, the degree of postoperative weight loss and metabolic improvement varies greatly among individuals. Our study is aimed to identify in ... Full text Link to item Cite

Laparoscopic myotomy for achalasia: predictors of successful outcome after 200 cases.

Journal Article Ann Surg · May 2006 OBJECTIVE: Laparoscopic myotomy is the preferred treatment of achalasia. Our objectives were to assess the long-term outcome of esophageal myotomy and to identify preoperative factors influencing the outcome. METHODS: Preoperative and long-term outcome dat ... Full text Link to item Cite

Heller myotomy vs Heller myotomy plus Dor fundoplication: cost-utility analysis of a randomized trial.

Journal Article Surg Endosc · March 2006 BACKGROUND: The addition of a Dor antireflux procedure reduces the risk of pathologic gastroesophageal reflux (GER) by ninefold following laparoscopic Heller myotomy for achalasia. It is not clear, however, how these benefits compare with the increased cos ... Full text Link to item Cite

Endoscopic evaluation of the gastrojejunostomy in laparoscopic gastric bypass. A series of 340 patients without postoperative leak.

Journal Article Surg Endosc · February 2006 BACKGROUND: A significant and potentially deadly complication of the Roux-en-Y gastric bypass is leakage from the gastrojejunostomy (GJ). The aim of our study was to evaluate the efficacy of intraoperative endoscopy in preventing postoperative anastomotic ... Full text Link to item Cite

Results of bariatric surgery.

Journal Article Annu Rev Nutr · 2006 Overweight and obesity are rapidly growing to epidemic proportions in the United States and globally. Since sustainable weight loss is only achieved by bariatric surgery, medicine has seen an explosion in the diversity and number of bariatric procedures pe ... Full text Link to item Cite

Myotomy: follow-up study of 50 patients.

Journal Article J Gastrointest Surg · December 2005 Laparoscopic myotomy has become the standard treatment for definitive management of achalasia. This study was undertaken to assess the long-term results of the procedure. Perioperative data, including a symptom score questionnaire, were collected prospecti ... Full text Link to item Cite

Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients?

Journal Article J Gastrointest Surg · November 2005 Type 2 diabetes mellitus (T2DM) has a very strong association with obesity. The aim of our study was to analyze the effects of Roux-en-Y gastric bypass (RYGB) surgery on the glucose metabolism in morbidly obese patients with T2DM. Morbidly obese patients ( ... Full text Link to item Cite

Three year's experience with the Stretta procedure: did it really make a difference?

Journal Article Surg Endosc · February 2005 BACKGROUND: Endoscopic treatment is merging as a new option for GERD treatment. Many modalities have been used with modest short-term success, but no long-term follow-ups have been published. We present our 3-yr experience at Vanderbilt University using en ... Full text Link to item Cite

Preoperative risk factors for common bile duct stones: defining the patient at high risk in the laparoscopic cholecystectomy era.

Journal Article J Laparoendosc Adv Surg Tech A · October 2004 BACKGROUND: Common bile duct stones (CBDS) are present in 3-20% of patients with cholelithiasis. Intraoperative cholangiography has high sensitivity in detecting CBDS but its routine use is associated with increased costs and operating room time. The aim o ... Full text Link to item Cite

Long-term follow-up study of the Stretta procedure for the treatment of gastroesophageal reflux disease.

Journal Article Surg Endosc · October 2004 BACKGROUND: The endoscopic delivery of temperature-controlled radiofrequency energy to the gastroesophageal junction (Stretta procedure) recently has been shown effective for patients with gastroesophageal reflux disease (GERD). However, its effectiveness ... Full text Link to item Cite

Endoscopic treatment modalities for gastroesophageal reflux disease.

Journal Article Surg Endosc · September 2004 A debate has been going for decades between surgeons and gastroenterologists about the treatment of choice for gastroesophageal reflux disease (GERD). The lower esophageal sphincter (LES) has been historically far from the reach of gastroenterologists, who ... Full text Link to item Cite

Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial.

Journal Article Ann Surg · September 2004 OBJECTIVE: We sought to determine the impact of the addition of Dor fundoplication on the incidence of postoperative gastroesophageal reflux (GER) after Heller myotomy. SUMMARY BACKGROUND DATA: Based only on case series, many surgeons believe that an antir ... Full text Link to item Cite

Predictors for quality of life improvement after laparoscopic gastric bypass (LGB)

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · September 1, 2004 Link to item Cite

RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells.

Journal Article Surgery · August 2004 BACKGROUND: SEG-1, a Barrett's-derived esophageal adenocarcinoma cell line, is not responsive to transforming growth factor beta (TGF-beta) growth effects. We hypothesize that SEG-1 cells lack the tumor-suppressor gene Runt domain transcription factor 3 (R ... Full text Link to item Cite

Laparoscopic fundoplication: 5-year follow-up.

Journal Article Am Surg · August 2004 There are few published reports on outcomes of 5 or more years following laparoscopic fundoplication. Gastroesophageal reflux disease (GERD) specific quality of life questionnaires (QOLRAD), short form health surveys (SF12), and queries regarding current m ... Link to item Cite

The endoscopic radiofrequency approach to management of GERD.

Journal Article Curr Opin Otolaryngol Head Neck Surg · June 2004 PURPOSE OF REVIEW: Endoscopic treatment has been recently introduced as a new option for treating gastroesophageal reflux disease. In this article the authors review the radiofrequency approach known as the Stretta procedure, as more evidence has linked re ... Full text Link to item Cite

Paradigm shift in the management of gastroesophageal reflux disease.

Journal Article Annals of surgery · May 1, 2003 OBJECTIVE: To compare the short-term results of the radiofrequency treatment of the gastroesophageal junction known as the Stretta procedure versus laparoscopic fundoplication (LF) in patients with gastroesophageal reflux disease (GERD). SUMMARY BACKGROUND ... Cite

Paradigm shift in the management of gastroesophageal reflux disease.

Journal Article Ann Surg · May 2003 OBJECTIVE: To compare the short-term results of the radiofrequency treatment of the gastroesophageal junction known as the Stretta procedure versus laparoscopic fundoplication (LF) in patients with gastroesophageal reflux disease (GERD). SUMMARY BACKGROUND ... Full text Link to item Cite

The Stretta procedure for the treatment of gastro esophageal reflux disease (GERD).

Journal Article Minim Invasive Ther Allied Technol · January 2002 Gastroesophageal reflux disease (GERD) is one of the most common disorders of the gastrointestinal tract. Laparoscopic anti-reflux surgery has been shown to be safe and effective for the treatment of GERD with excellent symptom control. However, an approac ... Full text Link to item Cite

Acute pseudo-obstruction of the colon (Ogilvie's syndrome): advances in management.

Journal Article Ann Ital Chir · 1997 The management of the patients with acute pseudo-obstruction of the colon (APOC) still represents a matter of debate. To better evaluate and compare the effectiveness of various therapeutic approaches in the management of APOC 29 patients were considered. ... Link to item Cite

Role of interleukin 1β, interleukin 6, and tumor necrosis factor in postoperative fever development.

Journal Article Chirurgia · 1997 Background. The aim of this study was to analyse the postoperative changes in plasma levels of some cytokines (interleukin 1β, interleukin 6, tumor necrosis factor) in order to evaluate their role in acute phase response as well as the possible correlation ... Cite

Major acute inflammatory complications of diverticular disease of the colon: planning of surgical management.

Journal Article Hepatogastroenterology · 1996 BACKGROUND/AIMS: The aim of this study was to determine the most appropriate surgical strategy in the management of patients with major inflammatory complications of colonic diverticular disease. MATERIALS AND METHODS: Out of 259 patients affected by compl ... Link to item Cite

Biological and clinical significance of tissue-CEA content in colorectal adenomas

Journal Article Giornale Italiano di Endoscopia Digestiva · 1995 In order to evaluate the significance of tissue-CEA content determination in colorectal adenomas, a study on 82 endoscopically removed adenomas from 70 patients has been carried out. The grade of dysplasia, size, and tissue-CEA content of adenomas were eva ... Cite

Multivariate analysis for predicting the presence of bacteria in bile in patients with acute cholecystitis.

Journal Article Eur J Surg · October 1993 OBJECTIVE: to find out whether the presence of bacteria in bile could be predicted accurately from preoperative data in patients with acute cholecystitis. DESIGN: Prospective open study. SETTING: University hospital. SUBJECTS: 42 patients undergoing cholec ... Link to item Cite

Linear logistic regression analysis. The application of a statistical method to the prediction of operative risk in surgical patients

Journal Article Chirurgia · 1993 The precise prediction of postoperative mortality is obviously of great interest to the clinician. It is important in defining both high-risk patients, as well as situations in which nonoperative therapy may be desirable. The authors suggest the use of ste ... Cite

Wound infection after cholecystectomy. Correlation between bacteria in bile and wound infection after operation on the gallbladder for acute and chronic gallstone disease.

Journal Article Eur J Surg · February 1992 OBJECTIVE: To see if there was a difference in the wound infection rates after operation for acute and chronic cholecystitis, and to see if the presence of bacteria in the bile had any influence on those rates. DESIGN: Prospective open study. SETTING: Univ ... Link to item Cite

Evaluation of postoperative fever after abdominal surgery

Journal Article Chirurgia · January 1, 1991 Evaluation of fever in the early postoperative period often includes a battery of diagnostic tests to determine the source of or to exclude a serious infection. The aim of this retrospective study was to define the feature of postoperative fever. Of the 34 ... Cite

[Computers in surgery].

Journal Article Il Giornale di chirurgia · November 1990 The introduction of computers in medicine, particularly for what surgery is concerned, has many implications related to its optimal utilization. Possible applications as well as advantages and limits of such recording system in a surgical ward are examined ... Cite

Prediction of choledocholithiasis in patients with gallbladder stones using a personal computer

Journal Article Chirurgia · 1989 A statistic method, using a personal computer, has been developed to predict the presence of choledocholithiasis in a prospective series of 123 patients undergoing cholecistectomy. Twenty-two factors were evaluated and the most important four of them were ... Cite

Renal failure after surgical treatment of biliary obstruction

Journal Article Chirurgia · 1989 The risk of renal failure and mortality related to it after biliary surgery for obstructive jaundice have been evaluated. Renal failure has been differentiated in functional and organic forms while predictivity of clinical and biochemical data was analysed ... Cite