Alireza Nazarian

Journal Article GeroScience · June 2025 Genetics is the second strongest risk factor for Alzheimer's disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. ... Full text Cite

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.

Journal Article GeroScience · February 2023 The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer's disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patte ... Full text Cite

Genome-wide analysis of genetic predisposition to common polygenic cancers.

Journal Article Journal of applied genetics · May 2022 Lung, breast, prostate, and colorectal cancers are among the most common and fatal malignancies worldwide. They are mainly caused by multifactorial mechanisms and are genetically heterogeneous. We investigated the genetic architecture of these cancers thro ... Full text Cite

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Recent Grants

Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context

ResearchResearch Associate · Awarded by National Institutes of Health · 2020 - 2026

Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases

ResearchResearch Associate · Awarded by National Institute on Aging · 2020 - 2026

ApoE2 and protective molecular signatures in Alzheimer's disease and aging

ResearchResearch Associate · Awarded by National Institutes of Health · 2018 - 2025

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