Alireza Nazarian

Journal Article GeroScience · February 2023 The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer's disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patte ... Full text Cite

Genome-wide analysis of genetic predisposition to common polygenic cancers.

Journal Article Journal of applied genetics · May 2022 Lung, breast, prostate, and colorectal cancers are among the most common and fatal malignancies worldwide. They are mainly caused by multifactorial mechanisms and are genetically heterogeneous. We investigated the genetic architecture of these cancers thro ... Full text Cite

The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.

Journal Article Journal of applied genetics · February 2020 The generalized linear mixed models (GLMMs) methodology is the standard framework for genome-wide association studies (GWAS) of complex diseases in family-based cohorts. Fitting GLMMs in very large cohorts, however, can be computationally demanding. Also, ... Full text Cite

View All Publications

Recent Grants

Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context

ResearchResearch Associate · Awarded by National Institutes of Health · 2020 - 2026

Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases

ResearchResearch Associate · Awarded by National Institute on Aging · 2020 - 2026

ApoE2 and protective molecular signatures in Alzheimer's disease and aging

ResearchResearch Associate · Awarded by National Institutes of Health · 2018 - 2025

View All Grants