Skip to main content

Allan Krekeler Chrisman

Associate Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
832 Pinehurst Drive, Chapel Hill, NC 27517
832 Pinehurst Drive, Chapel Hill, NC 27517

Selected Publications


Debate: #Together despite the distance.

Journal Article Child Adolesc Ment Health · September 2020 The pandemic COVID-19 (SARS-CoV-2) has had a major global impact on the healthcare systems worldwide as they deal with the surge of critically ill persons. Additionally, the preventative measure of stay-at-home orders and closure of nonessential businesses ... Full text Link to item Cite

Child/Adolescent anxiety multimodal study: evaluating safety.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2015 OBJECTIVE: To evaluate the frequency of adverse events (AEs) across 4 treatment conditions in the Child/Adolescent Anxiety Multimodal Study (CAMS), and to compare the frequency of AEs between children and adolescents. METHOD: Participants ages 7 to 17 year ... Full text Link to item Cite

An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults.

Journal Article J Subst Abuse Treat · January 2015 Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subje ... Full text Link to item Cite

Mass trauma: disasters, terrorism, and war.

Journal Article Child Adolesc Psychiatr Clin N Am · April 2014 Disasters, war, and terrorism expose millions of children globally to mass trauma with increasing frequency and severity. The clinical impact of such exposure is influenced by a child's social ecology, which is understood in a risk and resilience framework ... Full text Link to item Cite

A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD.

Journal Article J Atten Disord · February 2014 OBJECTIVE: The goal of this study was to assess the efficacy and tolerability of lis-dexamfetamine dimesylate (LDX) as an adjunct to nicotine replacement therapy in adult smokers with ADHD who were undergoing a quit attempt. METHODS: Thirty-two regular adu ... Full text Link to item Cite

A+KIDS, a web-based antipsychotic registry for North Carolina youths: an alternative to prior authorization.

Journal Article Psychiatr Serv · September 1, 2013 OBJECTIVE: The rise in use of antipsychotics among U.S. children is well documented. Compliance rates with current safety-monitoring guidelines are low. In response, the North Carolina Division of Medical Assistance established the Antipsychotics-Keeping I ... Full text Link to item Cite

Still Struggling: characteristics of youth with OCD who are partial responders to medication treatment.

Journal Article Child Psychiatry Hum Dev · August 2011 The primary aim of this paper is to examine the characteristics of a large sample of youth with OCD who are partial responders (i.e., still have clinically significant symptoms) to serotonin reuptake inhibitor (SRI) medication. The sample will be described ... Full text Link to item Cite

A double-blind, placebo-controlled study of atomoxetine in young children with ADHD.

Journal Article Pediatrics · April 2011 OBJECTIVE: To evaluate the efficacy and tolerability of atomoxetine for the treatment of attention-deficit/hyperactivity disorder (ADHD) in 5- and 6-year-old children. METHODS: This was an 8-week, double-blind, placebo-controlled randomized clinical trial ... Full text Link to item Cite

Practice parameter for the assessment and treatment of children and adolescents with posttraumatic stress disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2010 This Practice Parameter reviews the evidence from research and clinical experience and highlights significant advances in the assessment and treatment of posttraumatic stress disorder since the previous Parameter was published in 1998. It highlights the im ... Link to item Cite

Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).

Journal Article Psychopharmacology (Berl) · May 2009 RATIONALE: There has been controversy over the abuse potential of methylphenidate (MPH) in the context of treatment for attention deficit hyperactivity disorder (ADHD). OBJECTIVE: The objective of this study was to compare the reinforcing and subjective ef ... Full text Link to item Cite

The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned.

Journal Article Child Adolesc Psychiatry Ment Health · March 25, 2009 BACKGROUND: In 2003, the National Institute of Mental Health funded the Child and Adolescent Psychiatry Trials Network (CAPTN) under the Advanced Center for Services and Intervention Research (ACSIR) mechanism. At the time, CAPTN was believed to be both a ... Full text Link to item Cite

Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2008 OBJECTIVE: In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, ... Full text Link to item Cite

Improving attention-deficit/hyperactivity disorder treatment outcomes through use of a collaborative consultation treatment service by community-based pediatricians: a cluster randomized trial.

Journal Article Arch Pediatr Adolesc Med · September 2007 OBJECTIVE: To test whether adoption of a collaborative consultative service model results in improved patient outcomes. DESIGN: Twelve pediatric practices were randomly assigned to receive access to collaborative consultative services or to a control group ... Full text Link to item Cite

AACAP 2005 Research Forum: speeding the adoption of evidence-based practice in pediatric psychiatry.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2007 OBJECTIVES: At the 2005 Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), the Academy's Workgroup on Research conducted a Research Forum entitled "Increasing Research Literacy Through the Adoption of Evidence-Based Practice ... Full text Link to item Cite

Teaching evidence-based medicine pediatric psychopharmacology: integrating psychopharmacologic treatment into the broad spectrum of care.

Journal Article Child Adolesc Psychiatr Clin N Am · January 2007 Pediatric psychopharmacology is taught at the Duke University Hospital Child and Adolescent Psychiatry Residency Training Program within the context of an evidence-based medicine model. The basic goal of the course is to develop competence in the psychopha ... Full text Link to item Cite

Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial.

Journal Article CNS Spectr · August 2006 INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a serious neurobehavioral disorder of childhood onset that often persists into adolescence and adulthood. Functional impairments, underachievement, and difficult interpersonal relationships i ... Full text Link to item Cite

Assessment of Childhood Depression.

Journal Article Child Adolesc Ment Health · May 2006 Depression as a disorder in childhood began to be increasingly recognised in the 1970s. Epidemiologic community and clinic-based studies have characterised the prevalence, clinical course, and complications of this illness throughout childhood and adolesce ... Full text Link to item Cite

Using and teaching evidence-based medicine: the Duke University child and adolescent psychiatry model.

Journal Article Child Adolesc Psychiatr Clin N Am · April 2005 Evidence-based medicine (EBM) is defined as a set of processes that facilitate the conscientious, explicit, and judicious integration of individual clinical expertise with the best available external clinical evidence from systematic research in making dec ... Full text Link to item Cite

Comparison of increasingly detailed elicitation methods for the assessment of adverse events in pediatric psychopharmacology.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2004 OBJECTIVE: To improve the gathering of adverse events (AEs) in pediatric psychopharmacology by examining the value and acceptability of increasingly detailed elicitation methods. METHOD: Trained clinicians administered the Safety Monitoring Uniform Report ... Full text Link to item Cite

Part 2. Adult ADHD: Clinical Criteria for Diagnosis and Management

Journal Article Primary Psychiatry · March 1, 2004 Historically considered a childhood disorder, the recognition of ADHD in adults is increasing among the public and medical community. Follow-up studies have consistently documented the persistence of ADHD into adulthood, yet disagreement over the degree to ... Cite

Debate: #Together despite the distance.

Journal Article Child Adolesc Ment Health · September 2020 The pandemic COVID-19 (SARS-CoV-2) has had a major global impact on the healthcare systems worldwide as they deal with the surge of critically ill persons. Additionally, the preventative measure of stay-at-home orders and closure of nonessential businesses ... Full text Link to item Cite

Child/Adolescent anxiety multimodal study: evaluating safety.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2015 OBJECTIVE: To evaluate the frequency of adverse events (AEs) across 4 treatment conditions in the Child/Adolescent Anxiety Multimodal Study (CAMS), and to compare the frequency of AEs between children and adolescents. METHOD: Participants ages 7 to 17 year ... Full text Link to item Cite

An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults.

Journal Article J Subst Abuse Treat · January 2015 Methylphenidate (MPH) is commonly prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and is often used illicitly by young adults. Illicit users often coadminister MPH with marijuana. Little is known about physiologic and subje ... Full text Link to item Cite

Mass trauma: disasters, terrorism, and war.

Journal Article Child Adolesc Psychiatr Clin N Am · April 2014 Disasters, war, and terrorism expose millions of children globally to mass trauma with increasing frequency and severity. The clinical impact of such exposure is influenced by a child's social ecology, which is understood in a risk and resilience framework ... Full text Link to item Cite

A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD.

Journal Article J Atten Disord · February 2014 OBJECTIVE: The goal of this study was to assess the efficacy and tolerability of lis-dexamfetamine dimesylate (LDX) as an adjunct to nicotine replacement therapy in adult smokers with ADHD who were undergoing a quit attempt. METHODS: Thirty-two regular adu ... Full text Link to item Cite

A+KIDS, a web-based antipsychotic registry for North Carolina youths: an alternative to prior authorization.

Journal Article Psychiatr Serv · September 1, 2013 OBJECTIVE: The rise in use of antipsychotics among U.S. children is well documented. Compliance rates with current safety-monitoring guidelines are low. In response, the North Carolina Division of Medical Assistance established the Antipsychotics-Keeping I ... Full text Link to item Cite

Still Struggling: characteristics of youth with OCD who are partial responders to medication treatment.

Journal Article Child Psychiatry Hum Dev · August 2011 The primary aim of this paper is to examine the characteristics of a large sample of youth with OCD who are partial responders (i.e., still have clinically significant symptoms) to serotonin reuptake inhibitor (SRI) medication. The sample will be described ... Full text Link to item Cite

A double-blind, placebo-controlled study of atomoxetine in young children with ADHD.

Journal Article Pediatrics · April 2011 OBJECTIVE: To evaluate the efficacy and tolerability of atomoxetine for the treatment of attention-deficit/hyperactivity disorder (ADHD) in 5- and 6-year-old children. METHODS: This was an 8-week, double-blind, placebo-controlled randomized clinical trial ... Full text Link to item Cite

Practice parameter for the assessment and treatment of children and adolescents with posttraumatic stress disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2010 This Practice Parameter reviews the evidence from research and clinical experience and highlights significant advances in the assessment and treatment of posttraumatic stress disorder since the previous Parameter was published in 1998. It highlights the im ... Link to item Cite

Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).

Journal Article Psychopharmacology (Berl) · May 2009 RATIONALE: There has been controversy over the abuse potential of methylphenidate (MPH) in the context of treatment for attention deficit hyperactivity disorder (ADHD). OBJECTIVE: The objective of this study was to compare the reinforcing and subjective ef ... Full text Link to item Cite

The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned.

Journal Article Child Adolesc Psychiatry Ment Health · March 25, 2009 BACKGROUND: In 2003, the National Institute of Mental Health funded the Child and Adolescent Psychiatry Trials Network (CAPTN) under the Advanced Center for Services and Intervention Research (ACSIR) mechanism. At the time, CAPTN was believed to be both a ... Full text Link to item Cite

Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2008 OBJECTIVE: In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, ... Full text Link to item Cite

Improving attention-deficit/hyperactivity disorder treatment outcomes through use of a collaborative consultation treatment service by community-based pediatricians: a cluster randomized trial.

Journal Article Arch Pediatr Adolesc Med · September 2007 OBJECTIVE: To test whether adoption of a collaborative consultative service model results in improved patient outcomes. DESIGN: Twelve pediatric practices were randomly assigned to receive access to collaborative consultative services or to a control group ... Full text Link to item Cite

AACAP 2005 Research Forum: speeding the adoption of evidence-based practice in pediatric psychiatry.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2007 OBJECTIVES: At the 2005 Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), the Academy's Workgroup on Research conducted a Research Forum entitled "Increasing Research Literacy Through the Adoption of Evidence-Based Practice ... Full text Link to item Cite

Teaching evidence-based medicine pediatric psychopharmacology: integrating psychopharmacologic treatment into the broad spectrum of care.

Journal Article Child Adolesc Psychiatr Clin N Am · January 2007 Pediatric psychopharmacology is taught at the Duke University Hospital Child and Adolescent Psychiatry Residency Training Program within the context of an evidence-based medicine model. The basic goal of the course is to develop competence in the psychopha ... Full text Link to item Cite

Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial.

Journal Article CNS Spectr · August 2006 INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a serious neurobehavioral disorder of childhood onset that often persists into adolescence and adulthood. Functional impairments, underachievement, and difficult interpersonal relationships i ... Full text Link to item Cite

Assessment of Childhood Depression.

Journal Article Child Adolesc Ment Health · May 2006 Depression as a disorder in childhood began to be increasingly recognised in the 1970s. Epidemiologic community and clinic-based studies have characterised the prevalence, clinical course, and complications of this illness throughout childhood and adolesce ... Full text Link to item Cite

Using and teaching evidence-based medicine: the Duke University child and adolescent psychiatry model.

Journal Article Child Adolesc Psychiatr Clin N Am · April 2005 Evidence-based medicine (EBM) is defined as a set of processes that facilitate the conscientious, explicit, and judicious integration of individual clinical expertise with the best available external clinical evidence from systematic research in making dec ... Full text Link to item Cite

Comparison of increasingly detailed elicitation methods for the assessment of adverse events in pediatric psychopharmacology.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2004 OBJECTIVE: To improve the gathering of adverse events (AEs) in pediatric psychopharmacology by examining the value and acceptability of increasingly detailed elicitation methods. METHOD: Trained clinicians administered the Safety Monitoring Uniform Report ... Full text Link to item Cite

Part 2. Adult ADHD: Clinical Criteria for Diagnosis and Management

Journal Article Primary Psychiatry · March 1, 2004 Historically considered a childhood disorder, the recognition of ADHD in adults is increasing among the public and medical community. Follow-up studies have consistently documented the persistence of ADHD into adulthood, yet disagreement over the degree to ... Cite

Adult ADHD: Spelling Out the Clinical Strategies!

Journal Article Medical Crossfire · November 1, 2003 Once thought to be a disease afflicting only children and adolescents, attention-deficit/hyperactivity disorder (ADHD) is now recognized to persist into adulthood in an estimated 10% to 60% of cases. Displaying the hallmark symptoms of inattention, disorga ... Cite

An evidence-based medicine approach to combined treatment for ADHD in children and adolescents.

Journal Article Psychopharmacol Bull · 2003 Psychiatrists need to update their skills to incorporate advances in psychiatric practice and to do so "at the bedside."To this end, evidence-based medicine (EBM), which is widely used as an educational heuristic in other areas medicine and has begun to ma ... Link to item Cite

Sertraline in children and adolescents with social anxiety disorder: an open trial.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2001 OBJECTIVE: The aim of this open-label study was to assess the therapeutic benefits, response pattern, and safety of sertraline in children with social anxiety disorder. METHOD: Fourteen outpatient subjects with a primary Axis I diagnosis of social anxiety ... Full text Link to item Cite

The clinician as the agent of change or terminator under managed care: Hasta la vista baby, au revoir, or good-bye?

Journal Article Journal of Practical Psychiatry and Behavioral Health · November 1, 1996 Cite

How kids are different: Child and adolescent services under managed care

Journal Article Journal of Practical Psychiatry and Behavioral Health · July 1, 1996 Cite

Towards a standard documentation for behavioral health

Journal Article Journal of Practical Psychiatry and Behavioral Health · March 1, 1996 The authors present a suggested standardized documentation record that they hope will eventually achieve wider usage, especially in private practice settings. They first discuss current problems caused by a lack of standard documentation and the influence ... Cite