Skip to main content
construction release_alert
The Scholars Team is working with OIT to resolve some issues with the Scholars search index
cancel

Amanda Hargrove

Research Professor of Chemistry
Chemistry
124 Science Drive, Box 90346, 3219 French Sci Center, Durham, NC 27708-0346
3219 French Science Center, Box 90346, Durham, NC 27708

Overview


The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Current Appointments & Affiliations


Research Professor of Chemistry · 2024 - Present Chemistry, Trinity College of Arts & Sciences
Adjunct Associate Professor of Biochemistry · 2024 - Present Biochemistry, Basic Science Departments
Member of the Duke Cancer Institute · 2013 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published September 15, 2023
Duke Companies and Faculty Share Ideas with Investors at Triangle Venture Day
Published November 23, 2021
Taking New Aim at COVID-19
Published September 21, 2021
Meet the Newly Tenured Faculty of 2021

View All News

Recent Publications


Chemical matter that binds RNA

Chapter · July 5, 2024 The recent "RNA revolution" has spurred the growth of studies focused on targeting disease-relevant RNAs with various chemical probes, from sequence-based antisense oligonucleotides to structure-based small molecules. Among these, small molecules attracted ... Full text Cite

Stability-Based Proteomics for Investigation of Structured RNA-Protein Interactions.

Journal Article Analytical chemistry · February 2024 RNA-protein interactions are essential to RNA function throughout biology. Identifying the protein interactions associated with a specific RNA, however, is currently hindered by the need for RNA labeling or costly tiling-based approaches. Conventional stra ... Full text Cite
View All Publications

Recent Grants


Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2025

View All Grants

Education, Training & Certifications


University of Texas, Austin · 2010 Ph.D.
Trinity University · 2004 B.S.