Amanda Hargrove | Scholars@Duke

Amanda Hargrove
Associate Professor of Chemistry

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Current Appointments & Affiliations

Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2020
Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

124 Science Drive, Box 90346, 3219 French Sci Center, Durham, NC 27708-0346
3219 French Science Center, Box 90346, Durham, NC 27708
amanda.hargrove@duke.edu (919) 660-1522
Hargrove Research Group

Background
Education, Training, & Certifications
- NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013
- Ph.D., University of Texas, Austin 2010
- B.S., Trinity University 2004
Previous Appointments & Affiliations
- Assistant Professor in Biochemistry, Biochemistry, Basic Science Departments 2015 - 2020
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2020
- Scholar In Residence in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013
Recognition
In the News
- NOV 23, 2021
  
  Taking New Aim at COVID-19
- SEP 21, 2021 Office of Faculty Advancement
  
  Meet the Newly Tenured Faculty of 2021
- FEB 10, 2021
  
  Duke Celebrates Women and Girls in Science Day
- SEP 22, 2020
  
  New Drug Candidate Found for Hand, Foot and Mouth Disease
- APR 17, 2020
  
  Trinity College Honors 11 for Teaching, Leadership, Diversity
- FEB 12, 2020 Trinity College of Arts and Sciences
  
  Amanda Hargrove Has a Target on Hard-to-Fight Diseases
- OCT 13, 2017 Duke Research Blog
  
  Designing Drugs Aimed at a Different Part of Lifes Code
- OCT 22, 2015
  
  Amanda Hargrove Named Young Investigator by Prostate Cancer Foundation
- APR 27, 2015 Duke Research Blog
  
  Geeky Goggles Let You Take a Field Trip Without Leaving Class
- JUL 28, 2014
  
  Two Win Powe Award from Oak Ridge
Awards & Honors
- WCC Rising Star Award. American Chemical Society. 2022
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Center for Structural Biology of HIV RNA awarded by Regents of the University of Michigan 2022 - 2027
- MRI: Acquisition of a Microscale Thermophoresis System awarded by National Science Foundation 2022 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer awarded by National Institutes of Health 2023 - 2024
- Deciphering patterns in selective small molecule:RNA interactions awarded by Alfred P. Sloan Foundation 2020 - 2024
- CAREER:Shape-based differentiation of RNA elements using small molecules awarded by National Science Foundation 2018 - 2024
- LUMICKS C-TRAP awarded by National Institutes of Health 2022 - 2023
- Targeting the SARS-CoV-2 Frameshift site pseudoknot awarded by Research Corporation for Science Advancement 2020 - 2023
- Small Molecule Targeting Of RNAs Driving Tumor Aggressiveness awarded by United States Army Medical Research Acquisition Activity 2020 - 2023
- Targeting RNA splicing in race-related aggressive and lethal prostate cancer awarded by Prostate Cancer Foundation 2018 - 2022
- The Center for HIV RNA Studies (CRNA): Synthetic Libraries for Sampling RNA-targeted Chemical Space in HIV RNA Targets awarded by Regents of the University of Michigan 2014 - 2022
- Harnessing Small Molecules to Probe the Structure and Function of Long Noncoding RNAs awarded by National Institutes of Health 2017 - 2022
- Targeting an inactive conformation of HIV-1 TAR awarded by National Institutes of Health 2020 - 2022
- Harnessing Small Molecule Receptors to Identify Patterns in RNA Structure and Implement A Course-based Interdisciplinary Research Experience awarded by Research Corporation for Science Advancement 2017 - 2020
- PC150506: Small molecule targeting of RNA splice variants driving tumor aggressiveness awarded by United States Army Medical Research Acquisition Activity 2016 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Targeting lncRNA SChLAP1 through assembly of multivalent small molecule inhibitors awarded by Prostate Cancer Foundation 2015 - 2019
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Structural Biology and Biophysics Training Program awarded by National Institutes of Health 1994 - 2015
- Harnessing small molecules to characterize the regulatory activity and therapeutic potential of long noncoding RNAs awarded by Oak Ridge Associated Universities 2014 - 2015
- missing activity
- missing activity
External Relationships
- Arrakis Therapuetics, Inc.
- AstraZeneca
- Flagship VL59
- GLG
- Genentech
- Intronx
- Janssen Research & Development, LLC
- Reactive Biosciences
- Remix Therapeutics
- Toray Industries, Inc.
- Vertex Pharmaceuticals Inc.
Publications & Artistic Works
Selected Publications
- Books
  - Hargrove, A. E. Preface. Vol. 623, 2019. https://doi.org/10.1016/S0076-6879(19)30266-6.
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- Academic Articles
  - Bagnolini, Greta, TinTin B. Luu, and Amanda E. Hargrove. “Recognizing the power of machine learning and other computational methods to accelerate progress in small molecule targeting of RNA.” Rna (New York, N.Y.) 29, no. 4 (April 2023): 473–88. https://doi.org/10.1261/rna.079497.122.
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  - Zafferani, Martina, Justin G. Martyr, Dhanasheel Muralidharan, Nadeska I. Montalvan, Zhengguo Cai, and Amanda E. Hargrove. “Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability In Vitro.” Acs Chemical Biology 17, no. 9 (September 2022): 2437–47. https://doi.org/10.1021/acschembio.2c00124.
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  - Zafferani, Martina, Dhanasheel Muralidharan, Nadeska I. Montalvan, and Amanda E. Hargrove. “RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures.” Rsc Chemical Biology 3, no. 7 (July 2022): 905–15. https://doi.org/10.1039/d2cb00015f.
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  - Donlic, Anita, Emily G. Swanson, Liang-Yuan Chiu, Sarah L. Wicks, Aline Umuhire Juru, Zhengguo Cai, Kamillah Kassam, et al. “R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures.” Acs Chemical Biology 17, no. 6 (June 2022): 1556–66. https://doi.org/10.1021/acschembio.2c00224.
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  - Cai, Zhengguo, Martina Zafferani, Olanrewaju M. Akande, and Amanda E. Hargrove. “Quantitative Structure-Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure.” Journal of Medicinal Chemistry 65, no. 10 (May 2022): 7262–77. https://doi.org/10.1021/acs.jmedchem.2c00254.
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  - Cai, Zhengguo, Martina Zafferani, Olanrewaju Akande, and Amanda Hargrove. “Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure,” December 27, 2021. https://doi.org/10.33774/chemrxiv-2021-czl9p-v2.
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  - Cable, Jennifer, Edith Heard, Tetsuro Hirose, Kannanganattu V. Prasanth, Ling-Ling Chen, Jonathan E. Henninger, Sofia A. Quinodoz, et al. “Noncoding RNAs: biology and applications-a Keystone Symposia report.” Annals of the New York Academy of Sciences 1506, no. 1 (December 2021): 118–41. https://doi.org/10.1111/nyas.14713.
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  - Zafferani, Martina, Christina Haddad, Le Luo, Jesse Davila-Calderon, Liang-Yuan Chiu, Christian Shema Mugisha, Adeline G. Monaghan, et al. “Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.” Science Advances 7, no. 48 (November 2021): eabl6096. https://doi.org/10.1126/sciadv.abl6096.
    Full Text Open Access Copy
  - Cai, Zhengguo, Martina Zafferani, and Amanda Hargrove. “Ensemble learning-based quantitative structure-activity relationship platform predicts binding behavior of RNA-targeted small molecules,” July 23, 2021. https://doi.org/10.33774/chemrxiv-2021-czl9p.
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  - Zafferani, Martina, and Amanda E. Hargrove. “Small molecule targeting of biologically relevant RNA tertiary and quaternary structures.” Cell Chemical Biology 28, no. 5 (May 2021): 594–609. https://doi.org/10.1016/j.chembiol.2021.03.003.
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  - Falese, James P., Anita Donlic, and Amanda E. Hargrove. “Targeting RNA with small molecules: from fundamental principles towards the clinic.” Chemical Society Reviews 50, no. 4 (March 2021): 2224–43. https://doi.org/10.1039/d0cs01261k.
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  - McFadden, Emily, James Falese, and Amanda Hargrove. “Conserved Structure Modules within the lncRNA SChLAP1 Mediate Protein Recognition Implicated in Aggressive Prostate Cancer,” 2021. https://doi.org/10.1101/2021.10.21.465303.
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  - Martina, Zafferani, Haddad Christina, Luo Le, Davila-Calderon Jesse, Yuan-Chiu Liang, Shema Mugisha Christian, Adeline G. Monaghan, et al. “Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.” Biorxiv, December 6, 2020. https://doi.org/10.1101/2020.12.05.409821.
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  - Hargrove, Amanda E. “Small molecule-RNA targeting: starting with the fundamentals.” Chemical Communications (Cambridge, England) 56, no. 94 (November 2020): 14744–56. https://doi.org/10.1039/d0cc06796b.
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  - Davila-Calderon, Jesse, Neeraj N. Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa R. Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda E. Hargrove, and Blanton S. Tolbert. “IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.” Nature Communications 11, no. 1 (September 2020): 4775. https://doi.org/10.1038/s41467-020-18594-3.
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  - Donlic, Anita, Martina Zafferani, Giacomo Padroni, Malavika Puri, and Amanda E. Hargrove. “Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.” Nucleic Acids Research 48, no. 14 (August 2020): 7653–64. https://doi.org/10.1093/nar/gkaa585.
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  - Padroni, G., N. N. Patwardhan, M. Schapira, and A. E. Hargrove. “Systematic analysis of the interactions driving small molecule-RNA recognition.” Rsc Medicinal Chemistry 11, no. 7 (July 2020): 802–13. https://doi.org/10.1039/d0md00167h.
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  - Umuhire Juru, Aline, Zhengguo Cai, Adina Jan, and Amanda E. Hargrove. “Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.” Chemical Communications (Cambridge, England) 56, no. 24 (March 2020): 3555–58. https://doi.org/10.1039/d0cc00266f.
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  - Ganser, Laura R., Megan L. Kelly, Neeraj N. Patwardhan, Amanda E. Hargrove, and Hashim M. Al-Hashimi. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.” J Mol Biol 432, no. 4 (February 14, 2020): 1297–1304. https://doi.org/10.1016/j.jmb.2019.12.009.
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  - Hargrove, Amanda E. “The next 20 years of Medicinal Research Reviews.” Medicinal Research Reviews 40, no. 1 (January 2020): 7–8. https://doi.org/10.1002/med.21656.
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  - Davila-Calderon, Jesse, Neeraj Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda Hargrove, and Blanton Tolbert. “Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex,” 2020. https://doi.org/10.1101/2020.03.10.981167.
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  - Morgan, Brittany S., Bilva G. Sanaba, Anita Donlic, Diane B. Karloff, Jordan E. Forte, Yuqi Zhang, and Amanda E. Hargrove. “R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.” Acs Chemical Biology 14, no. 12 (December 2019): 2691–2700. https://doi.org/10.1021/acschembio.9b00631.
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  - Patwardhan, Neeraj N., Zhengguo Cai, Aline Umuhire Juru, and Amanda E. Hargrove. “Driving factors in amiloride recognition of HIV RNA targets.” Organic & Biomolecular Chemistry 17, no. 42 (October 2019): 9313–20. https://doi.org/10.1039/c9ob01702j.
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  - Wicks, Sarah L., and Amanda E. Hargrove. “Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.” Methods (San Diego, Calif.) 167 (September 2019): 3–14. https://doi.org/10.1016/j.ymeth.2019.04.018.
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  - Umuhire Juru, Aline, Neeraj N. Patwardhan, and Amanda E. Hargrove. “Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.” Acs Chemical Biology 14, no. 5 (May 2019): 824–38. https://doi.org/10.1021/acschembio.8b00945.
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  - Donlic, Anita, Brittany S. Morgan, Jason L. Xu, Anqi Liu, Carlos Roble, and Amanda E. Hargrove. “Corrigendum: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.” Angewandte Chemie (International Ed. in English) 58, no. 17 (April 2019): 5482. https://doi.org/10.1002/anie.201900875.
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  - Eubanks, Christopher S., Bo Zhao, Neeraj N. Patwardhan, Rhese D. Thompson, Qi Zhang, and Amanda E. Hargrove. “Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules.” Journal of the American Chemical Society 141, no. 14 (April 2019): 5692–98. https://doi.org/10.1021/jacs.8b09665.
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  - Patwardhan, Neeraj N., Zhengguo Cai, Colby N. Newson, and Amanda E. Hargrove. “Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.” Organic & Biomolecular Chemistry 17, no. 7 (February 2019): 1778–86. https://doi.org/10.1039/c8ob02467g.
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  - Eubanks, Christopher S., and Amanda E. Hargrove. “RNA Structural Differentiation: Opportunities with Pattern Recognition.” Biochemistry 58, no. 4 (January 2019): 199–213. https://doi.org/10.1021/acs.biochem.8b01090.
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  - Donlic, Anita, Brittany S. Morgan, Jason L. Xu, Anqi Liu, Carlos Roble, and Amanda E. Hargrove. “Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.” Angewandte Chemie (International Ed. in English) 57, no. 40 (October 2018): 13242–47. https://doi.org/10.1002/anie.201808823.
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  - Donlic, Anita, Brittany S. Morgan, Jason L. Xu, Anqi Liu, Carlos Roble, and Amanda E. Hargrove. “Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA‐Binding Scaffold.” Angewandte Chemie 130, no. 40 (October 2018): 13426–31. https://doi.org/10.1002/ange.201808823.
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  - Morgan, Brittany S., Jordan E. Forte, and Amanda E. Hargrove. “Insights into the development of chemical probes for RNA.” Nucleic Acids Research 46, no. 16 (September 2018): 8025–37. https://doi.org/10.1093/nar/gky718.
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  - Donlic, Anita, and Amanda E. Hargrove. “Targeting RNA in mammalian systems with small molecules.” Wiley Interdisciplinary Reviews. Rna 9, no. 4 (July 2018): e1477. https://doi.org/10.1002/wrna.1477.
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  - Eubanks, Christopher S., and Amanda E. Hargrove. “Sensing the impact of environment on small molecule differentiation of RNA sequences.” Chemical Communications (Cambridge, England) 53, no. 100 (December 2017): 13363–66. https://doi.org/10.1039/c7cc07157d.
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  - Morgan, Brittany S., Jordan E. Forte, Rebecca N. Culver, Yuqi Zhang, and Amanda E. Hargrove. “Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.” Angewandte Chemie 129, no. 43 (October 16, 2017): 13683–87. https://doi.org/10.1002/ange.201707641.
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  - Morgan, Brittany S., Jordan E. Forte, Rebecca N. Culver, Yuqi Zhang, and Amanda E. Hargrove. “Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.” Angewandte Chemie (International Ed. in English) 56, no. 43 (October 2017): 13498–502. https://doi.org/10.1002/anie.201707641.
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  - Patwardhan, Neeraj N., Laura R. Ganser, Gary J. Kapral, Christopher S. Eubanks, Janghyun Lee, Bharathwaj Sathyamoorthy, Hashim M. Al-Hashimi, and Amanda E. Hargrove. “Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.” Medchemcomm 8, no. 5 (May 1, 2017): 1022–36. https://doi.org/10.1039/C6MD00729E.
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  - Eubanks, Christopher S., Jordan E. Forte, Gary J. Kapral, and Amanda E. Hargrove. “Small Molecule-Based Pattern Recognition To Classify RNA Structure.” Journal of the American Chemical Society 139, no. 1 (January 2017): 409–16. https://doi.org/10.1021/jacs.6b11087.
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  - McFadden, Emily J., and Amanda E. Hargrove. “Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.” Biochemistry 55, no. 11 (March 2016): 1615–30. https://doi.org/10.1021/acs.biochem.5b01141.
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  - Burg, Jonathan M., Jennifer E. Link, Brittany S. Morgan, Frederick J. Heller, Amanda E. Hargrove, and Dewey G. McCafferty. “KDM1 class flavin-dependent protein lysine demethylases.” Biopolymers 104, no. 4 (July 2015): 213–46. https://doi.org/10.1002/bip.22643.
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  - Hargrove, Amanda E., Thomas F. Martinez, Alissa A. Hare, Alexis A. Kurmis, John W. Phillips, Sudha Sud, Kenneth J. Pienta, and Peter B. Dervan. “Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.” Plos One 10, no. 11 (January 2015): e0143161. https://doi.org/10.1371/journal.pone.0143161.
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  - Morgan, B. S., and A. E. Hargrove. “Synthetic receptors for oligonucleotides and nucleic acids.” Monographs in Supramolecular Chemistry 2015-January, no. 14 (January 1, 2015): 253–325.
  - Nickols, Nicholas G., Jerzy O. Szablowski, Amanda E. Hargrove, Benjamin C. Li, Jevgenij A. Raskatov, and Peter B. Dervan. “Activity of a Py-Im polyamide targeted to the estrogen response element.” Molecular Cancer Therapeutics 12, no. 5 (May 2013): 675–84. https://doi.org/10.1158/1535-7163.mct-12-1040.
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  - Raskatov, Jevgenij A., Nicholas G. Nickols, Amanda E. Hargrove, Georgi K. Marinov, Barbara Wold, and Peter B. Dervan. “Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.” Proceedings of the National Academy of Sciences of the United States of America 109, no. 40 (October 2012): 16041–45. https://doi.org/10.1073/pnas.1214267109.
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  - Hargrove, Amanda E., Jevgenij A. Raskatov, Jordan L. Meier, David C. Montgomery, and Peter B. Dervan. “Characterization and solubilization of pyrrole-imidazole polyamide aggregates.” Journal of Medicinal Chemistry 55, no. 11 (June 2012): 5425–32. https://doi.org/10.1021/jm300380a.
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  - Raskatov, Jevgenij A., Amanda E. Hargrove, Alex Y. So, and Peter B. Dervan. “Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.” Journal of the American Chemical Society 134, no. 18 (May 2012): 7995–99. https://doi.org/10.1021/ja302588v.
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  - Hargrove, Amanda E., Sonia Nieto, Tianzhi Zhang, Jonathan L. Sessler, and Eric V. Anslyn. “Artificial receptors for the recognition of phosphorylated molecules.” Chemical Reviews 111, no. 11 (November 2011): 6603–6782. https://doi.org/10.1021/cr100242s.
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  - Hargrove, Amanda E., Andrew D. Ellington, Eric V. Anslyn, and Jonathan L. Sessler. “Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.” Bioconjugate Chemistry 22, no. 3 (March 2011): 388–96. https://doi.org/10.1021/bc100376x.
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  - Hargrove, Amanda E., Ryan N. Reyes, Ian Riddington, Eric V. Anslyn, and Jonathan L. Sessler. “Boronic acid porphyrin receptor for ginsenoside sensing.” Organic Letters 12, no. 21 (November 2010): 4804–7. https://doi.org/10.1021/ol1019647.
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  - Hargrove, A. E., Z. Zhong, J. L. Sessler, and E. V. Anslyn. “Algorithms for the determination of binding constants and enantiomeric excess in complex host: Guest equilibria using optical measurements.” New Journal of Chemistry 34, no. 2 (January 1, 2010): 348–54. https://doi.org/10.1039/b9nj00498j.
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  - Collins, B. E., S. Sorey, A. E. Hargrove, S. H. Shabbir, V. M. Lynch, and E. V. Anslyn. “Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids.” Journal of Organic Chemistry 74, no. 11 (June 5, 2009): 4055–60. https://doi.org/10.1021/jo900187a.
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  - Pikulski, Michael, Amanda Hargrove, Shagufta H. Shabbir, Eric V. Anslyn, and Jennifer S. Brodbelt. “Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.” Journal of the American Society for Mass Spectrometry 18, no. 12 (December 2007): 2094–2106. https://doi.org/10.1016/j.jasms.2007.09.005.
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  - Spence, J. D., A. E. Hargrove, H. L. Crampton, and D. W. Thomas. “Porphyrenediynes: synthesis and cyclization of meso-enediynylporphyrins.” Tetrahedron Letters 48, no. 4 (January 22, 2007): 725–28. https://doi.org/10.1016/j.tetlet.2006.10.164.
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  - Sessler, J. L., J. T. Lee, Z. Ou, T. Köhler, A. E. Hargrove, W. S. Cho, V. Lynch, and K. M. Kadish. “Chemical and electrochemical oxidation of N-alkyl cyclo[n]-pyrroles.” Journal of Porphyrins and Phthalocyanines 10, no. 12 (January 1, 2006): 1329–36. https://doi.org/10.1142/S1088424606000703.
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- Book Sections
  - Hargrove, Amanda E. “Preface.,” 623:xv–xvii, 2019. https://doi.org/10.1016/S0076-6879(19)30266-6.
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  - Hargrove, Amanda E. “RNA Recognition.” In RNA RECOGNITION, edited by A. E. Hargrove, 623:XV–XVII. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019.
    Link to Item
  - Padroni, Giacomo, Christopher S. Eubanks, and Amanda E. Hargrove. “Differentiation and classification of RNA motifs using small molecule-based pattern recognition.,” 623:101–30, 2019. https://doi.org/10.1016/bs.mie.2019.05.022.
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- Conference Papers
  - Haddad, C., B. S. Tolbert, A. E. Hargrove, G. Brewer, and M. L. Li. “The Discovery of Antivirals and Targets for SARS-CoV-2 and EV-A71.” In Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, Vol. 36, 2022. https://doi.org/10.1096/fasebj.2022.36.S1.R4062.
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  - Umuhire Juru, Aline, and Amanda E. Hargrove. “Frameworks for targeting RNA with small molecules.” In The Journal of Biological Chemistry, 296:100191, 2021. https://doi.org/10.1074/jbc.rev120.015203.
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- Preprints
  - Davila-Calderon, Jesse, Mei-Ling Li, Srinivasa R. Penumutchu, Christina Haddad, Linzy Malcolm, Amanda E. Hargrove, Gary Brewer, and Blanton S. Tolbert. “Enterovirus Evolution Reveals the Mechanism of an RNA-Targeted Antiviral and Determinants of Viral Replication.” Cold Spring Harbor Laboratory, February 20, 2023. https://doi.org/10.1101/2023.02.20.529064.
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  - Zafferani, Martina, Dhanasheel Muralidharan, and Amanda Hargrove. “RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures.” BioRxiv, 2022. https://doi.org/10.1101/2022.01.16.476525.
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  - Cai, Zhengguo, Martina Zafferani, Olanrewaju Akande, and Amanda Hargrove. “Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure.” American Chemical Society (ACS), December 27, 2021. https://doi.org/10.26434/chemrxiv-2021-czl9p-v2.
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  - Cai, Zhengguo, Martina Zafferani, and Amanda Hargrove. “Ensemble learning-based quantitative structure-activity relationship platform predicts binding behavior of RNA-targeted small molecules.” American Chemical Society (ACS), July 23, 2021. https://doi.org/10.26434/chemrxiv-2021-czl9p.
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In the News

Awards & Honors

Subject Headings

Selected Grants

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Selected Publications

Books

Academic Articles

Book Sections

Conference Papers

Preprints

Recent Courses

Service to the Profession