Skip to main content

Amanda Hargrove

Professor of Chemistry
Chemistry
124 Science Drive, Box 90346, 3219 French Sci Center, Durham, NC 27708-0346
3219 French Science Center, Box 90346, Durham, NC 27708

Selected Grants


Harnessing Small Molecules to Probe the Structure and Function of Regulatory RNAs

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Center for Structural Biology of HIV RNA

ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2022 - 2027

MRI: Acquisition of a Microscale Thermophoresis System

EquipmentPrincipal Investigator · Awarded by National Science Foundation · 2022 - 2025

Harnessing Small Molecules to Probe the Structure and Function of Regulatory RNAs

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Center for Structural Biology of HIV RNA

ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2022 - 2027

MRI: Acquisition of a Microscale Thermophoresis System

EquipmentPrincipal Investigator · Awarded by National Science Foundation · 2022 - 2025

Characterization and targeting of the 3' splice site of cryptic exon 3 in the androgen receptor pre-mRNA

FellowshipPrincipal Investigator · Awarded by PhRMA Foundation · 2024 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2024

Deciphering patterns in selective small molecule:RNA interactions

FellowshipPrincipal Investigator · Awarded by Alfred P. Sloan Foundation · 2020 - 2024

CAREER:Shape-based differentiation of RNA elements using small molecules

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2018 - 2024

Small Molecule Targeting Of RNAs Driving Tumor Aggressiveness

ResearchPrincipal Investigator · Awarded by United States Army Medical Research Acquisition Activity · 2020 - 2024

Targeting RNA splicing in race-related aggressive and lethal prostate cancer

Clinical TrialCo Investigator · Awarded by Prostate Cancer Foundation · 2018 - 2023

LUMICKS C-TRAP

EquipmentMajor User · Awarded by National Institutes of Health · 2022 - 2023

Targeting the SARS-CoV-2 Frameshift site pseudoknot

ResearchPrincipal Investigator · Awarded by Research Corporation for Science Advancement · 2020 - 2023

The Center for HIV RNA Studies (CRNA): Synthetic Libraries for Sampling RNA-targeted Chemical Space in HIV RNA Targets

ResearchPrincipal Investigator · Awarded by Regents of the University of Michigan · 2014 - 2022

Targeting an inactive conformation of HIV-1 TAR

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2022

Harnessing Small Molecule Receptors to Identify Patterns in RNA Structure and Implement A Course-based Interdisciplinary Research Experience

ResearchPrincipal Investigator · Awarded by Research Corporation for Science Advancement · 2017 - 2020

PC150506: Small molecule targeting of RNA splice variants driving tumor aggressiveness

ResearchPrincipal Investigator · Awarded by United States Army Medical Research Acquisition Activity · 2016 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020

Targeting lncRNA SChLAP1 through assembly of multivalent small molecule inhibitors

ResearchPrincipal Investigator · Awarded by Prostate Cancer Foundation · 2015 - 2019

GAANN - Department of Chemistry

Inst. Training Prgm or CMEMentor · Awarded by Department of Education · 2015 - 2019

MRI: Acquisition of a Triple Quadrupole LC/MS System

EquipmentMajor User · Awarded by National Science Foundation · 2015 - 2018

Structural Biology and Biophysics Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015

Harnessing small molecules to characterize the regulatory activity and therapeutic potential of long noncoding RNAs

ResearchPrincipal Investigator · Awarded by Oak Ridge Associated Universities · 2014 - 2015

External Relationships


  • Arrakis Therapuetics, Inc.
  • AstraZeneca
  • GLG
  • Genentech
  • Intronx
  • Arrakis Therapuetics, Inc.
  • AstraZeneca
  • GLG
  • Genentech
  • Intronx
  • Toray Industries, Inc.
  • Vertex Pharmaceuticals Inc.

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.