https://orcid.org/0000-0002-1292-2606
Overview
Computational biology, machine learning, Bayesian statistics, transcriptional regulation, genomics and epigenomics, graphical models, Bayesian networks, hidden Markov models, systems biology, computational neurobiology, classification, feature selection
Current Duke Appointments & Affiliations
Professor of Computer Science
·
2013 - Present
Computer Science,
Trinity College of Arts & Sciences
Interim Chair in the Department of Computer Science
·
2026 - Present
Computer Science,
Trinity College of Arts & Sciences
Professor of Biology
·
2013 - Present
Biology,
Trinity College of Arts & Sciences
Bass Fellow
·
2014 - Present
Computer Science,
Trinity College of Arts & Sciences
Recent Scholarly Works
Deconvolving the spatiotemporal chromatin landscape through the cell cycle.
Preprint · July 10, 2026 Profiling genomic processes during the cell cycle is challenging because synchronized populations gradually lose synchrony as individual cells progress through the cycle at different rates and divide asymmetrically. Researchers have addressed this challeng ... Full text Link to item CiteComprehensive profiling of chromatin occupancy dynamics through the cell cycle.
Journal article Nucleic Acids Res · January 14, 2026 The occupancy of DNA-binding factors is critical for establishing the chromatin context of DNA-templated processes like transcription and replication. Many studies have investigated relationships between chromatin and transcription in response to genetic a ... Full text Link to item CiteGenome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation.
Journal article Genome Res · January 5, 2026 Epigenetic mechanisms contribute to gene regulation by altering chromatin accessibility through changes in transcription factor (TF) and nucleosome occupancy across the genome. Despite numerous studies focusing on changes in gene expression, the intricate ... Full text Link to item CiteRecent Grants
Computational Biology and Bioinformatics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Methods to Elucidate the Dynamic Interplay of Transcriptional Regulation and Chromatin Occupancy
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2021 - 2027Faith and AI planning grant
Institutional SupportCo-Principal Investigator · Awarded by Lilly Endowment, Inc. · 2026 - 2027View All Grants
Education
Massachusetts Institute of Technology ·
2001
Ph.D.
University of Oxford (United Kingdom) ·
1996
M.Phil.
Duke University ·
1994
B.S.