Anabel De Caceres Bustos
Research Scientist, Senior
Current Appointments & Affiliations
- Research Scientist, Senior, Anesthesiology, Clinical Science Departments
Contact Information
- 3 Genome Ct., MSRB3, Room 6200, Durham, NC 27710
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anabel.caceres@duke.edu
+1 919 684 1319
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Anabel's LinkedIn
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Jordt Lab
- Recognition
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Awards & Honors
- Cold Spring Harbor Laboratory - Scientific Writing Retreat (Award). National Institute of General Medical Sciences (NIGMS) . 2017
- Scholarship - Cold Spring Harbor Laboratory course on Single Cell Analysis. National Institute of General Medical Sciences (NIGMS) . 2015
- Fulbright/MEC Postdoctoral Fellowship. Spanish Ministry of Education and Science. 2007
- Ph.D. Thesis with High Honors (Summa Cum Laude) and Ph.D Excellence Award. University of Valladolid School of Medicine (Spain). 2007
- Predoctoral Fellowship (FPI) . Spanish Ministry of Science and Technology. 2004
- Expertise
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Subject Headings
- Research
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Selected Grants
- Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries awarded by National Institutes of Health 2022 - 2025
- S/R-Nicotine in Commercial Products Containing Synthetic Nicotine: Product Survey by Chemical Analysis and Toxicological Properties awarded by Yale University 2023
- Nicotine Pouches: Chemical Composition, Toxicity and Behavioral Effects of a New Tobacco Product Category awarded by National Institutes of Health 2022 - 2023
- Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury awarded by National Institutes of Health 2019 - 2023
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2013 - 2023
- Inhibition of soluble epoxide hydrolase protects against phosgene-induced lung injuries awarded by National Institutes of Health 2021 - 2023
- Anesthetic and synthetic cooling flavors in E-cigarettes: Chemistry, respiratory effects and behavioral pharmacology awarded by National Institutes of Health 2018 - 2022
- Cellular Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes awarded by Yale University 2019 - 2021
- Biomarkers of lung injury in methyl isocyanate exposed rodents and pigs awarded by University of Colorado - Denver 2016 - 2021
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2014 - 2018
- Mechanisms of Itch in Poison Ivy-Induced Allergic Contact Dermatitis awarded by National Institutes of Health 2016 - 2018
- Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity awarded by National Institutes of Health 2014 - 2018
- Counter-Irritation by Menthol: Molecular Targets and Role in Airway Disease-Supplement awarded by National Institutes of Health 2014 - 2015
- Counter-Irritation by Menthol: Molecular Targets and Role in Airway Disease awarded by National Institutes of Health 2011 - 2015
- Accelerating Inflammation Resolution to Counteract Chemical Injury awarded by National Institutes of Health 2012 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kaelberer, Melanie Maya, Ana Isabel Caceres, and Sven-Eric Jordt. “Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.” Am J Physiol Lung Cell Mol Physiol 318, no. 5 (May 1, 2020): L953–64. https://doi.org/10.1152/ajplung.00403.2019.Full Text Link to Item
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Liu, Boyi, Yan Tai, Boyu Liu, Ana I. Caceres, Chengyu Yin, and Sven-Eric Jordt. “Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.” Jci Insight 5, no. 14 (June 11, 2019). https://doi.org/10.1172/jci.insight.124497.Full Text Link to Item
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Caceres, Ana I., Boyi Liu, Sairam V. Jabba, Satyanarayana Achanta, John B. Morris, and Sven-Eric Jordt. “Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.” Br J Pharmacol 174, no. 9 (May 2017): 867–79. https://doi.org/10.1111/bph.13760.Full Text Link to Item
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Liu, Boyi, Yan Tai, Satyanarayana Achanta, Melanie M. Kaelberer, Ana I. Caceres, Xiaomei Shao, Jianqiao Fang, and Sven-Eric Jordt. “IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.” Proc Natl Acad Sci U S A 113, no. 47 (November 22, 2016): E7572–79. https://doi.org/10.1073/pnas.1606608113.Full Text Link to Item
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Liu, Boyi, Yan Tai, Ana I. Caceres, Satyanarayana Achanta, Shrilatha Balakrishna, Xiaomei Shao, Junfan Fang, and Sven-Eric Jordt. “Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.” Plos One 11, no. 11 (2016): e0165200. https://doi.org/10.1371/journal.pone.0165200.Full Text Link to Item
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Ha, Michael A., Gregory J. Smith, Joseph A. Cichocki, Lu Fan, Yi-Shiuan Liu, Ana I. Caceres, Sven Eric Jordt, and John B. Morris. “Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.” Plos One 10, no. 2 (2015): e0117128. https://doi.org/10.1371/journal.pone.0117128.Full Text Open Access Copy Link to Item
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Liu, Boyi, Jasmine Escalera, Shrilatha Balakrishna, Lu Fan, Ana I. Caceres, Eve Robinson, Aiwei Sui, et al. “TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.” Faseb J 27, no. 9 (September 2013): 3549–63. https://doi.org/10.1096/fj.13-229948.Full Text Link to Item
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Rocher, Asuncion, Ana Isabel Caceres, Ana Obeso, and Constancio Gonzalez. “Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body.” Marine Drugs 9, no. 12 (December 15, 2011): 2683–2704. https://doi.org/10.3390/md9122683.Full Text
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Caceres, Ana I., Marian Brackmann, Maxwell D. Elia, Bret F. Bessac, Donato del Camino, Marc D’Amours, JoAnn S. Witek, et al. “A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.” Proc Natl Acad Sci U S A 106, no. 22 (June 2, 2009): 9099–9104. https://doi.org/10.1073/pnas.0900591106.Full Text Link to Item
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Bessac, Bret F., Michael Sivula, Chrisitan A. von Hehn, Ana I. Caceres, Jasmine Escalera, and Sven E. Jordt. “TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases.” Faseb Journal 23 (April 1, 2009).Link to Item
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Bessac, Bret F., Michael Sivula, Christian A. von Hehn, Ana I. Caceres, Jasmine Escalera, and Sven-Eric Jordt. “Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.” Faseb J 23, no. 4 (April 2009): 1102–14. https://doi.org/10.1096/fj.08-117812.Full Text Link to Item
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Caceres, Ana I., Ana Obeso, Constancio Gonzalez, and Asuncion Rocher. “Molecular identification and functional role of voltage-gated sodium channels in rat carotid body chemoreceptor cells. Regulation of expression by chronic hypoxia in vivo.” Journal of Neurochemistry 102, no. 1 (July 2007): 231–45. https://doi.org/10.1111/j.1471-4159.2007.04465.x.Full Text
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Gilles-Gonzalez, Marie-Alda, Ana Isabel Caceres, Eduardo Henrique Silva Sousa, Diana R. Tomchick, Chad Brautigam, Constancio Gonzalez, and Mischa Machius. “A Proximal Arginine R206 Participates in Switching of the Bradyrhizobium japonicum FixL Oxygen Sensor.” Journal of Molecular Biology 360, no. 1 (June 2006): 80–89. https://doi.org/10.1016/j.jmb.2006.04.054.Full Text
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Rocher, Asunción, Emilio Geijo-Barrientos, Ana Isabel Cáceres, Ricardo Rigual, Constancio González, and Laura Almaraz. “Role of voltage-dependent calcium channels in stimulus-secretion coupling in rabbit carotid body chemoreceptor cells.” The Journal of Physiology 562, no. 2 (January 15, 2005): 407–20. https://doi.org/10.1113/jphysiol.2004.075523.Full Text
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Prieto-Lloret, J., A. I. Caceres, A. Obeso, A. Rocher, R. Rigual, M. T. Agapito, R. Bustamante, et al. “Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia.” The Journal of Physiology 554, no. 1 (January 2004): 126–44. https://doi.org/10.1113/jphysiol.2003.049445.Full Text
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Conference Papers
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Caceres, Ana Isabel, Boyi Liu, Sairam V. Jabba, John B. Morris, and Sven-Eric Jordt. “TRPM8 Mediates the Anti-inflammatory Effects of Eucalyptol in a Mouse Model of LPS-Induced Pulmonary Inflammation.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.Link to Item
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Jordt, Sven-Eric, Michael A. Ha, J. Smith, Joseph A. Cichocki, Shrilatha Balakrishna, Lu Fan, Yi-Shiuan Liu, Ana I. Caceres, Marina R. Picciotto, and John B. Morris. “Menthol Attenuates Chemosensory Irritation and Elevates blood Cotinine in Cigarette Smoke Exposed Mice.” In Chemical Senses, 40:596–596. OXFORD UNIV PRESS, 2015.Link to Item
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Jordt, S. E., M. M. Kaelberer, B. Liu, A. I. Caceres, G. J. Smith, J. A. Cichocki, M. A. Ha, and J. B. Morris. “Activation Of Chemosensory Receptors And Respiratory Irritation Responses By Electronic Cigarette Flavorants And Vapors.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.Link to Item
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Liu, Boyi, J. Escalera, S. Balakrishna, Lu Fan, A. I. Caceres, E. Robinson, A. Sui, et al. “TRPA1 CONTROLS INFLAMMATION AND PRURITOGEN RESPONSES IN ALLERGIC CONTACT DERMATITIS.” In Acta Dermato Venereologica, 93:616–616. ACTA DERMATO-VENEREOLOGICA, 2013.Link to Item
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Caceres, Ana Isabel, Marian Brackmann, Bret F. Bessac, Lauren Cohn, and Sven Eric Jordt. “Decreased Ovalbumin-induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1.” In Faseb Journal, Vol. 23. FEDERATION AMER SOC EXP BIOL, 2009.Link to Item
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Caceres, A. I., M. Brackmann, B. F. Bessac, A. Sui, L. Cohn, and S. E. Jordt. “Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1.” In American Journal of Respiratory and Critical Care Medicine, Vol. 179. AMER THORACIC SOC, 2009.Link to Item
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