Scholars@Duke
Anabel De Caceres Bustos

Anabel De Caceres Bustos

Research Scientist, Senior
Anesthesiology
anabel.caceres@duke.edu
PO Box: 3094, MS 27, 3 Genome Ct. MSRB3, Room 6200, Durham, NC 27710
3 Genome Ct., MSRB3, Room 6200, Durham, NC 27710
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Selected Publications

Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.

Conference Pain · February 27, 2024 Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the ... Full text Link to item Cite

Neutrophilia with damage to the blood-brain barrier and neurovascular unit following acute lung injury.

Journal Article Res Sq · October 23, 2023 BACKGROUND: Links between acute lung injury (ALI), infectious disease, and neurological outcomes have been frequently discussed over the past few years, especially due to the COVID-19 pandemic. Yet, much of the cross-communication between organs, particula ... Full text Link to item Cite

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Journal Article Br J Pharmacol · October 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions wit ... Full text Link to item Cite

Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.

Journal Article Br J Anaesth · February 2023 BACKGROUND: Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies. Her ... Full text Link to item Cite

Conserved YKL-40 changes in mice and humans after postoperative delirium.

Journal Article Brain Behav Immun Health · December 2022 Delirium is a common postoperative neurologic complication among older adults. Despite its prevalence (14%-50%) and likely association with inflammation, the exact mechanisms that underpin postoperative delirium are unclear. This project aimed to character ... Full text Link to item Cite

Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 1, 2020 The lungs and the immune and nervous systems functionally interact to respond to respiratory environmental exposures and infections. The lungs are innervated by vagal sensory neurons of the jugular and nodose ganglia, fused together in smaller mammals as t ... Full text Link to item Cite

Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.

Journal Article JCI Insight · June 11, 2019 In the United States, poison ivy exposure is the most common naturally occurring allergen to cause allergic contact dermatitis (ACD). The immune and pruritic mechanisms associated with poison ivy ACD remain largely unexplored. Here, we compared skin whole ... Full text Link to item Cite

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Journal Article Br J Pharmacol · May 2017 BACKGROUND AND PURPOSE: Eucalyptol (1,8-cineol), the major ingredient in the essential oil of eucalyptus leaves and other medicinal plants, has long been known for its anti-inflammatory properties. Eucalyptol interacts with the TRP cation channels among ot ... Full text Link to item Cite

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Journal Article Proc Natl Acad Sci U S A · November 22, 2016 Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing cont ... Full text Link to item Cite

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.

Journal Article PLoS One · 2016 Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as septic ... Full text Link to item Cite

Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Journal Article PLoS One · 2015 Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit ... Full text Open Access Link to item Cite

Activation Of Chemosensory Receptors And Respiratory Irritation Responses By Electronic Cigarette Flavorants And Vapors

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.

Journal Article FASEB J · September 2013 Allergic contact dermatitis is a common skin disease associated with inflammation and persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory neurons mediate acute inflammatory and pruritic responses following exoge ... Full text Link to item Cite

Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.

Conference Pain · February 27, 2024 Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the ... Full text Link to item Cite

Neutrophilia with damage to the blood-brain barrier and neurovascular unit following acute lung injury.

Journal Article Res Sq · October 23, 2023 BACKGROUND: Links between acute lung injury (ALI), infectious disease, and neurological outcomes have been frequently discussed over the past few years, especially due to the COVID-19 pandemic. Yet, much of the cross-communication between organs, particula ... Full text Link to item Cite

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Journal Article Br J Pharmacol · October 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions wit ... Full text Link to item Cite

Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.

Journal Article Br J Anaesth · February 2023 BACKGROUND: Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies. Her ... Full text Link to item Cite

Conserved YKL-40 changes in mice and humans after postoperative delirium.

Journal Article Brain Behav Immun Health · December 2022 Delirium is a common postoperative neurologic complication among older adults. Despite its prevalence (14%-50%) and likely association with inflammation, the exact mechanisms that underpin postoperative delirium are unclear. This project aimed to character ... Full text Link to item Cite

Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 1, 2020 The lungs and the immune and nervous systems functionally interact to respond to respiratory environmental exposures and infections. The lungs are innervated by vagal sensory neurons of the jugular and nodose ganglia, fused together in smaller mammals as t ... Full text Link to item Cite

Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.

Journal Article JCI Insight · June 11, 2019 In the United States, poison ivy exposure is the most common naturally occurring allergen to cause allergic contact dermatitis (ACD). The immune and pruritic mechanisms associated with poison ivy ACD remain largely unexplored. Here, we compared skin whole ... Full text Link to item Cite

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Journal Article Br J Pharmacol · May 2017 BACKGROUND AND PURPOSE: Eucalyptol (1,8-cineol), the major ingredient in the essential oil of eucalyptus leaves and other medicinal plants, has long been known for its anti-inflammatory properties. Eucalyptol interacts with the TRP cation channels among ot ... Full text Link to item Cite

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Journal Article Proc Natl Acad Sci U S A · November 22, 2016 Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing cont ... Full text Link to item Cite

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.

Journal Article PLoS One · 2016 Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as septic ... Full text Link to item Cite

Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Journal Article PLoS One · 2015 Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit ... Full text Open Access Link to item Cite

Activation Of Chemosensory Receptors And Respiratory Irritation Responses By Electronic Cigarette Flavorants And Vapors

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.

Journal Article FASEB J · September 2013 Allergic contact dermatitis is a common skin disease associated with inflammation and persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory neurons mediate acute inflammatory and pruritic responses following exoge ... Full text Link to item Cite

Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body

Journal Article Marine Drugs · December 15, 2011 Carotid bodies (CBs) are secondary sensory receptors in which the sensing elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic hypoxia). Upon activation, chemoreceptor cells (also known as Type I and glomus cells) incr ... Full text Cite

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.

Journal Article Proc Natl Acad Sci U S A · June 2, 2009 Asthma is an inflammatory disorder caused by airway exposures to allergens and chemical irritants. Studies focusing on immune, smooth muscle, and airway epithelial function revealed many aspects of the disease mechanism of asthma. However, the limited effi ... Full text Link to item Cite

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.

Journal Article FASEB J · April 2009 The release of methyl isocyanate in Bhopal, India, caused the worst industrial accident in history. Exposures to industrial isocyanates induce lacrimation, pain, airway irritation, and edema. Similar responses are elicited by chemicals used as tear gases. ... Full text Link to item Cite

Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Molecular identification and functional role of voltage‐gated sodium channels in rat carotid body chemoreceptor cells. Regulation of expression by chronic hypoxia in vivo

Journal Article Journal of Neurochemistry · July 2007 AbstractWe have assessed the expression, molecular identification and functional role of Na+ channels (Nav) in carotid bodies (CB) obtained from normoxic and chronically hypoxic adu ... Full text Cite

Role of voltage‐dependent calcium channels in stimulus–secretion coupling in rabbit carotid body chemoreceptor cells

Journal Article The Journal of Physiology · January 15, 2005 We have defined Ca2+ channel subtypes expressed in rabbit carotid body (CB) chemoreceptor cells and their participation in the stimulus‐evoked catecholamine (CA) release. Ca2+ currents (I Full text Cite

Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia

Journal Article The Journal of Physiology · January 2004 Hypoxia increases the release of neurotransmitters from chemoreceptor cells of the carotid body (CB) and the activity in the carotid sinus nerve (CSN) sensory fibers, elevating ventilatory drive. According to previous reports, perinatal hyperoxia c ... Full text Cite