Scholars@Duke
Andreas Seas

Selected Publications

Lessons from both sides of the bedrail

Journal Article Lancet Haematology · January 1, 2026 Full text Cite

Assessment of neurosurgical workforce, infrastructure, and service delivery capacity in East Africa: A collaborative survey.

Journal Article Neurosurg Rev · November 28, 2025 Workforce development in healthcare is critical, especially in resource-limited regions such as East Africa, where a scarcity of neurosurgeons hinders patient care. This study aims to analyze neurosurgical workforce trends in Kenya, Rwanda, Tanzania, and U ... Full text Link to item Cite

Transfacet transforaminal lumbar interbody fusion (TF-TLIF) results in greater change in spondylolisthesis and posterior disc height compared to percutaneous TLIF (Perc-TLIF) or minimally invasive TLIF (MIS-TLIF): a retrospective study.

Journal Article J Spine Surg · September 30, 2025 BACKGROUND: The evolution of the transforaminal lumbar interbody fusion (TLIF) has resulted in the popularization of three main techniques: the minimally invasive TLIF (MIS-TLIF), the transfacet TLIF (TF-TLIF), and the percutaneous TLIF (Perc-TLIF). While ... Full text Open Access Link to item Cite

Disparities in clinical trial enrollment related to laser interstitial thermal therapy for central nervous system metastases.

Journal Article Neurosurg Rev · July 22, 2025 OBJECTIVE: Laser interstitial thermal therapy (LITT) is a minimally invasive option for the management of a variety of intracranial pathologies, including radiographically progressive tumor following stereotactic radiosurgery. Although LITT has been increa ... Full text Link to item Cite

Magnetic resonance-guided focused ultrasound thalamotomy as a viable option for essential tremor after deep brain stimulation explantation: illustrative case.

Journal Article J Neurosurg Case Lessons · July 7, 2025 BACKGROUND: Essential tremor (ET) has limited pharmacological treatments, and deep brain stimulation (DBS) has emerged as an effective surgical intervention. DBS, although effective and safe, is inherently invasive. Patients at high risk for surgery or who ... Full text Link to item Cite

Study Protocol: Single-Blinded, Controlled, Clinical Trial Evaluating the Feasibility of Spinal Cord Stimulation for Improving Neuropathic Pain and Rehabilitation Outcomes in Patients With Thoracic Spinal Cord Injury.

Journal Article Neurosurg Pract · June 2025 BACKGROUND AND OBJECTIVES: Traumatic thoracic spinal cord injury (SCI) is complicated by chronic neuropathic pain and neurological deficits including bowel and bladder dysfunction. Treatment with spinal cord stimulation (SCS) has demonstrated possible util ... Full text Link to item Cite

Focused ultrasound as an emerging therapy for neuropsychiatric disease: Historical perspectives and a review of current clinical data.

Journal Article Psychiatry Clin Neurosci · May 2025 Psychiatric disorders are a common source of disease morbidity with high rates of refractoriness to first-line treatments. As such, many have investigated the utility of neurosurgical interventions for treatment-resistant forms of these conditions. More re ... Full text Link to item Cite

Perceived Barriers to a Neurosurgical Career for Medical Students and Unspecialized Residents Worldwide: A Systematic Literature Review.

Journal Article World neurosurgery · May 2025 Globally, a large deficit of neurosurgeons exists along with a growing burden of disease requiring neurosurgical care. Also, considerable geographical disparities remain in the neurosurgical workforce distribution. Augmenting and diversifying the neurosurg ... Full text Cite

Revisiting the Endoscopic Third Ventriculostomy Success Score using machine learning: can we do better?

Journal Article J Neurosurg Pediatr · March 1, 2025 OBJECTIVE: The Endoscopic Third Ventriculostomy Success Score (ETVSS) is a useful decision-making heuristic when considering the probability of surgical success, defined traditionally as no repeat cerebrospinal fluid diversion surgery needed within 6 month ... Full text Link to item Cite

Building sustainable neurosurgical capacity: lessons from the Duke Division of Global Neurosurgery and Neurology.

Journal Article Neurosurg Focus · March 1, 2025 Neurosurgery has long faced significant disparities in access to care in low- and middle-income countries (LMICs), where millions lack access to timely, lifesaving neurosurgical interventions. The Duke Division of Global Neurosurgery and Neurology (DGNN) w ... Full text Link to item Cite

Machine learning in the diagnosis, management, and care of patients with low back pain: a scoping review of the literature and future directions.

Journal Article Spine J · January 2025 BACKGROUND CONTEXT: Low back pain (LBP) remains the leading cause of disability globally. In recent years, machine learning (ML) has emerged as a potentially useful tool to aid the diagnosis, management, and prognostication of LBP. PURPOSE: In this review, ... Full text Open Access Link to item Cite

Focused Ultrasound in the Treatment of Epilepsy: Current Applications and Future Directions.

Journal Article Stereotact Funct Neurosurg · 2025 INTRODUCTION: Epilepsy is the fourth most common neurological disorder, affecting nearly 1% of the global population. Despite recent advancements in medical therapies, approximately one-third of patients remain refractory to treatment, necessitating consid ... Full text Link to item Cite

Exploring the Evolution of Research Connectivity and Funding in Global Neurosurgical Publications.

Journal Article World Neurosurg · December 2024 BACKGROUND: There are critical disparities in the neurosurgical care provided around the globe due to challenges in resource allocation, training, and infrastructure. Global neurosurgical collaborations have replaced classical mission trips to address thes ... Full text Link to item Cite

Four-tract tractography: multiparametric direct targeting of the dentatorubrothalamic tract.

Journal Article Neurosurg Focus Video · October 2024 This video article presents a case study of a 70-year-old male with medically refractory essential tremor treated with magnetic resonance-guided focused ultrasound (MRgFUS). Following an initial successful ablation of the right thalamus, the patient underw ... Full text Link to item Cite

Shifting Trends in the Epidemiology of Cervical Spine Injuries: An Analysis of 11,822 Patients from the National Electronic Injury Surveillance System over Two Decades.

Journal Article J Neurotrauma · September 2024 Cervical spine injuries (CSIs) are heterogeneous in nature and often lead to long-term disability and morbidity. However, there are few recent and comprehensive epidemiological studies on CSI. The objective of this study was to characterize recent trends i ... Full text Open Access Link to item Cite

Disparities in the treatment of movement disorders using deep brain stimulation.

Journal Article J Neurosurg · July 1, 2024 OBJECTIVE: Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD) and essential tremor (ET). Although the prevalence of PD and ET can vary by sex and race, little is known about the accessibility of neurosurgical treatmen ... Full text Link to item Cite

Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor in a patient with von Willebrand disease: perioperative optimization for patients with coagulopathies. Illustrative case.

Journal Article J Neurosurg Case Lessons · June 10, 2024 BACKGROUND: Essential tremor (ET) is one of the most common movement disorders worldwide. In medically refractory ET, deep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus is the current standard of care. However, DBS carries an ... Full text Link to item Cite

The Scope, Trends, and Challenges of Neurosurgical Research in Nigeria: A Bibliometric Review.

Journal Article World Neurosurg · May 2024 OBJECTIVE: This study investigates the scope, trends, and challenges of neurosurgical research in Nigeria since inception of the specialty in 1962. METHODS: A bibliometric review of the neurosurgical literature from Nigeria was performed. Variables extract ... Full text Link to item Cite

Profile of Pediatric Neurosurgery in Nigeria from 1962 to 2021: A Systematic Review.

Journal Article World Neurosurg · May 2024 OBJECTIVE: This study aims to provide a comprehensive overview of pediatric neurosurgery in Nigeria, since 1962, by assessing epidemiological data, management strategies, and case outcomes. METHODS: A systematic bibliometric review of Nigerian neurosurgica ... Full text Link to item Cite

The Role of International Collaborations in Sustainable Neurosurgical Development in Nigeria.

Journal Article World Neurosurg · May 2024 OBJECTIVE: Despite 6 decades of existence, neurosurgery is still in the developing stages in Nigeria. In this era of collaborative health system capacity-building in low- and middle-income countries, this article reviews past efforts and future prospects f ... Full text Link to item Cite

Epidemiological Burden of Neurotrauma in Nigeria: A Systematic Review and Pooled Analysis of 45,763 Patients.

Journal Article World Neurosurg · May 2024 OBJECTIVE: Neurotrauma is a significant cause of morbidity and mortality in Nigeria. We conducted this systematic review to generate nationally generalizable reference data for the country. METHODS: Four research databases and gray literature sources were ... Full text Link to item Cite

Epidemiology and Management Trends of Neuro-Oncology in Nigeria: A Systematic Review and Pooled Analysis.

Journal Article World Neurosurg · May 2024 OBJECTIVE: Access to neuro-oncologic care in Nigeria has grown exponentially since the first reported cases in the mid-1960s. In this systematic review and pooled analysis, we characterize the growth of neurosurgical oncology in Nigeria and build a referen ... Full text Link to item Cite

The Epidemiological Burden of Neurovascular Pathology in Nigeria: A Systematic Review and Pooled Patient-Level Analysis.

Journal Article World Neurosurg · May 2024 OBJECTIVE: Vascular neurosurgery has developed significantly in Nigeria, but its burden and challenges remain unclear. This study systematically reviewed vascular neurosurgical literature from Nigeria. METHODS: Four research databases and gray literature s ... Full text Link to item Cite

The Epidemiology of Spinal Neurosurgery in Nigeria: A Systematic Review and Patient-Level Analysis.

Journal Article World Neurosurg · May 2024 OBJECTIVE: Spinal pathologies are prevalent in Nigeria, though epidemiological data remains sparse. This systematic review used pooled patient-level data from across the country to generate a standardized epidemiological reference. METHODS: Four research d ... Full text Link to item Cite

Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2024 Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature cortical evoked p ... Full text Cite

Management and outcomes of pediatric traumatic brain injury in Africa: a systematic review.

Journal Article J Neurosurg Pediatr · February 1, 2024 OBJECTIVE: Traumatic brain injury (TBI) carries a major global burden of disease; however, it is well established that patients in low- and middle-income countries, such as those in Africa, have higher mortality rates. Pediatric TBI, specifically, is a doc ... Full text Link to item Cite

Scoping review on the state of racial disparities literature in the treatment of neurosurgical disease: a call for action.

Journal Article Neurosurg Focus · November 2023 OBJECTIVE: Racial disparities are ubiquitous across medicine in the US. This study aims to assess the evidence of racial disparities within neurosurgery and across its subspecialties, with a specific goal of quantifying the distribution of articles devoted ... Full text Link to item Cite

Promoting diversity in neurosurgery through a virtual symposium.

Journal Article J Neurosurg · October 1, 2023 OBJECTIVE: The rates of women and underrepresented racial and ethnic minority (UREM) students successfully matching into neurosurgical residency are extremely low and do not reflect the makeup of the general population. As of 2019, only 17.5% of neurosurgi ... Full text Link to item Cite

Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.

Journal Article Epilepsy Behav · October 2023 INTRODUCTION: Epilepsy is considered one of the most burdensome neurologic diseases by the World Health Organization due to the high risk of morbidity and mortality. Few studies have investigated the epidemiology of idiopathic epilepsy in Sub-Saharan Afric ... Full text Link to item Cite

Association of moyamoya vasculopathy with autoimmune disease: a systematic review and pooled analysis.

Journal Article Neurosurgical review · September 2023 Despite more than six decades of extensive research, the etiology of moyamoya disease (MMD) remains unknown. Inflammatory or autoimmune (AI) processes have been suggested to instigate or exacerbate the condition, but the data remains mixed. The objective o ... Full text Cite

Fulfilling the specialist neurosurgical workforce needs in Africa: a systematic review and projection toward 2030.

Journal Article J Neurosurg · April 1, 2023 OBJECTIVE: Africa contributes significantly to the global neurosurgical disease burden but has only 1% of the neurosurgery workforce. This study appraises the neurosurgical workforce and training capacity in Africa and projects the workforce capacity by 20 ... Full text Link to item Cite

The Scope, Growth, and Inequities of the Global Neurosurgery Literature: A Bibliometric Analysis.

Journal Article World Neurosurg · November 2022 BACKGROUND: Here, we evaluate the evolution and growth of global neurosurgery publications over time, further focusing on the contributions and impact of authors in low- and middle-income countries (LMICs). METHODS: In this systematic bibliometric analysis ... Full text Link to item Cite

Assessing the Success and Sustainability of Global Neurosurgery Collaborations: Systematic Review and Adaptation of the Framework for Assessment of InteRNational Surgical Success Criteria.

Journal Article World Neurosurg · November 2022 BACKGROUND: The high unmet neurosurgical burden in low- and middle-income countries has necessitated multiple global neurosurgical collaborations. We identified these collaborations and their peer-reviewed journal publications and evaluated them using a mo ... Full text Link to item Cite

Deep Learning to Predict Traumatic Brain Injury Outcomes in the Low-Resource Setting.

Journal Article World Neurosurg · August 2022 OBJECTIVE: Traumatic brain injury (TBI) disproportionately affects low- and middle-income countries (LMICs). In these settings, accurate patient prognostication is both difficult and essential for high-quality patient care. With the ultimate goal of enhanc ... Full text Link to item Cite

Machine Learning to Predict Successful Opioid Dose Reduction or Stabilization After Spinal Cord Stimulation.

Journal Article Neurosurgery · August 1, 2022 BACKGROUND: Spinal cord stimulation (SCS) effectively reduces opioid usage in some patients, but preoperatively, there is no objective measure to predict who will most benefit. OBJECTIVE: To predict successful reduction or stabilization of opioid usage aft ... Full text Link to item Cite

Machine Learning for Predicting Discharge Disposition After Traumatic Brain Injury.

Journal Article Neurosurgery · June 1, 2022 BACKGROUND: Current traumatic brain injury (TBI) prognostic calculators are commonly used to predict the mortality and Glasgow Outcome Scale, but these outcomes are most relevant for severe TBI. Because mild and moderate TBI rarely reaches severe outcomes, ... Full text Link to item Cite

Evolution of Intracranial-Intracranial Bypass Surgery: A Bibliometric Analysis.

Journal Article World neurosurgery · June 2022 ObjectiveModern cerebrovascular bypass surgery uses either extracranial-intracranial (EC-IC) or intracranial-intracranial (IC-IC) approaches. Compared with EC-IC bypasses, IC-IC bypasses allow neurosurgeons to safely address tumors, aneurysms, and ... Full text Cite

Machine Learning for Predicting In-Hospital Mortality After Traumatic Brain Injury in Both High-Income and Low- and Middle-Income Countries.

Journal Article Neurosurgery · May 1, 2022 BACKGROUND: Machine learning (ML) holds promise as a tool to guide clinical decision making by predicting in-hospital mortality for patients with traumatic brain injury (TBI). Previous models such as the international mission for prognosis and clinical tri ... Full text Link to item Cite

Upfront Magnetic Resonance Imaging-Guided Stereotactic Laser-Ablation in Newly Diagnosed Glioblastoma: A Multicenter Review of Survival Outcomes Compared to a Matched Cohort of Biopsy-Only Patients.

Journal Article Neurosurgery · December 2019 BackgroundLaser ablation (LA) is used as an upfront treatment in patients with deep seated newly diagnosed Glioblastoma (nGBM).ObjectiveTo evaluate the outcomes of LA in patients with nGBM and compare them with a matched biopsy-only cohor ... Full text Cite

Stent Design Affects Femoropopliteal Artery Deformation.

Journal Article Annals of surgery · July 2019 BackgroundPoor durability of femoropopliteal artery (FPA) stenting is multifactorial, and severe FPA deformations occurring with limb flexion are likely involved. Different stent designs result in dissimilar stent-artery interactions, but the degr ... Full text Cite

Limb flexion-induced axial compression and bending in human femoropopliteal artery segments.

Journal Article Journal of vascular surgery · February 2018 BackgroundHigh failure rates of femoropopliteal artery (FPA) interventions are often attributed in part to severe mechanical deformations that occur with limb movement. Axial compression and bending of the FPA likely play significant roles in FPA ... Full text Cite

A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis.

Journal Article Cell & bioscience · January 2018 BackgroundAlthough the study of calcium (Ca2+) is classically associated with excitable cells such as myocytes or neurons, the ubiquity of this essential element in all cellular processes has led to interest in other cell types. The imp ... Full text Cite

Constitutive description of human femoropopliteal artery aging.

Journal Article Biomechanics and modeling in mechanobiology · April 2017 Femoropopliteal artery (FPA) mechanics play a paramount role in pathophysiology and the artery's response to therapeutic interventions, but data on FPA mechanical properties are scarce. Our goal was to characterize human FPAs over a wide population to deri ... Full text Cite

Limb flexion-induced twist and associated intramural stresses in the human femoropopliteal artery.

Journal Article Journal of the Royal Society, Interface · March 2017 High failure rates of femoropopliteal artery (FPA) interventions are often attributed to severe mechanical deformations that occur with limb movement. Torsion of the FPA likely plays a significant role, but is poorly characterized and the associated intram ... Full text Cite

Morphometric roadmaps to improve accurate device delivery for fluoroscopy-free resuscitative endovascular balloon occlusion of the aorta.

Journal Article The journal of trauma and acute care surgery · June 2016 BackgroundUncontrolled hemorrhage from vessel injuries within the torso remains a significant source of prehospital trauma mortality. Resuscitative endovascular balloon occlusion of the aorta can effectively control noncompressible hemorrhage, but ... Full text Cite

In situ longitudinal pre-stretch in the human femoropopliteal artery.

Journal Article Acta biomaterialia · March 2016 In situ longitudinal (axial) pre-stretch (LPS) plays a fundamental role in the mechanics of the femoropopliteal artery (FPA). It conserves energy during pulsation and prevents buckling of the artery during limb movement. We investigated how LPS is affected ... Full text Cite