Selected Grants
Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Drug Development for Dystonia
ResearchCo Investigator · Awarded by Department of Defense · 2023 - 2027Duke ACS Institutional Research Grant
ResearchSignificant Contributor · Awarded by American Cancer Society, Inc. · 2024 - 2026The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026Deciphering Immunological Biomarkers in Myasthenia Gravis by Using Multi-omics
ResearchSignificant Contributor · Awarded by Myasthenia Gravis Foundation · 2024 - 2026Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Drug Development for Dystonia
ResearchCo Investigator · Awarded by Department of Defense · 2023 - 2027Duke ACS Institutional Research Grant
ResearchSignificant Contributor · Awarded by American Cancer Society, Inc. · 2024 - 2026The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026Deciphering Immunological Biomarkers in Myasthenia Gravis by Using Multi-omics
ResearchSignificant Contributor · Awarded by Myasthenia Gravis Foundation · 2024 - 2026Integrated analysis of a NLRP3-dependent adaptive resistance mechanism to pembrolizumab immunotherapy in advanced gastroesophageal cancer
ResearchCollaborator · Awarded by Merck Sharp & Dohme · 2022 - 2026IL-6 in PDIGREE (AO31704)
ResearchPrincipal Investigator · Awarded by Alliance for Clinical Trials in Oncology Foundation · 2020 - 2025Circulating Protein Biomarker Analysis for women with HR-positive advanced breast cancer
ResearchPrincipal Investigator · Awarded by Alliance Foundation Trials, LLC · 2023 - 2025A Randomized Phase 2 Trial to Evaluate Prebiotic Intervention in Allogeneic Hematopoietic Stem Cell Transplantation
ResearchInvestigator · Awarded by National Institutes of Health · 2020 - 2025Brain Vasular Malformation Consortium: Predictors of clinical course
ResearchCo Investigator · Awarded by The Regents of the University of California · 2014 - 2025Anti-PD1 in combination with an inhibitor of PCSK9 to increase MHC class I molecule expression on tumor cells as immunotherapy for NSCLC
Clinical TrialCo Investigator · Awarded by Department of Defense · 2021 - 2025Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2025Clinical Biomarker Study of the Tumor NLRP3 Inflammasome and its Role in Anti-PD-1 Immunotherapy Resistance
ResearchCollaborator · Awarded by Conquer Cancer Foundation · 2021 - 2024Identification and validation of plasma-based protein biomarkers for cediranib and olaparib in GY005, phase III
ResearchPrincipal Investigator · Awarded by NRG Oncology · 2020 - 2024A Phase IB/II Multi-Cohort Study of Targeted Agents with Atezolizumab for Patients with Recurrent or Persistent Endometrial Cancer
ResearchPrincipal Investigator · Awarded by Alliance Foundation Trials, LLC · 2021 - 2024Mountaineer Biomarker Study: A Phase II, Open Label Study of Tucatinib Combined with Trastuzumab in Patients with HET2+ Metastatic Colorectal Cancer.
ResearchPrincipal Investigator · Awarded by Seattle Genetics, Inc · 2020 - 2024Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2023Duke-UNC-Wash U Partnership for Early Phase Clinical Trials in Cancer
Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2014 - 2023Immune signatures in metastatic colorectal cancer
ResearchPrincipal Investigator · Awarded by Genentech, Inc. · 2017 - 2023Single-cell cytokine profiling in metastatic colorectal cancer patients receiving immunotherapy
ResearchPrincipal Investigator · Awarded by Mario Family Foundation · 2022 - 2022Home Transplant to Preserve the Microbiota and Decrease GVHD
ResearchCollaborator · Awarded by American Society of Hematology · 2019 - 2022Plasma Angiome and Serum Androgens as Predictors of Overall Survival in Metastatic Prostate Cancer
ResearchPrincipal Investigator · Awarded by Department of Defense · 2018 - 2022Plasma Angiome and Serum Androgens as Predictors of Overall Survival in Metastatic Prostate Cancer
ResearchPartnering PI · Awarded by Department of Defense · 2018 - 2022MSI in mCRC
ResearchPrincipal Investigator · Awarded by Promega · 2020 - 2022Cell-Free DNA for Diagnosis of Malignancy, Genetic Mutations and Prognosis in Lung Cancer Related Pleural Effusions
ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2022The role of Claudin-2 in metastatic colorectal cancer
ResearchPrincipal Investigator · Awarded by Seattle Genetics, Inc · 2016 - 2022Blood-based Biomarker Profiling for TEW-7197
Clinical TrialPrincipal Investigator · Awarded by MedPacto, Inc · 2017 - 2021Profiling the Adenosine Axis in Metastatic Colorectal Cancer
ResearchPrincipal Investigator · Awarded by MedImmune, Inc. · 2018 - 2021AFT-42 Immune Cells
ResearchPrincipal Investigator · Awarded by Alliance Foundation Trials, LLC · 2019 - 2021New strategies to improve drug development for carcinoid tumors
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2019 - 2021Pilot Study for Feasibility of Next Generation Sequencing for Detection of Lung Cancer ALK and ROS1 Mutation.
ResearchPrincipal Investigator · Awarded by HTG Molecular Diagnostics, Inc · 2019 - 2021Angiome Profiling of GY012
ResearchPrincipal Investigator · Awarded by NRG Oncology · 2020 - 2021Identification and validation of plasma-based protein biomarkers for cediranib and olaparib
ResearchPrincipal Investigator · Awarded by Leidos Biomedical Research, Inc. · 2019 - 2020Analysis of baseline blood samples from a clinical study evaluating TRC105 in metastatic renal cell carcinoma cancer patients
ResearchPrincipal Investigator · Awarded by Tracon Pharmaceuticals, Inc. · 2017 - 2019Identification and validation of plasma-based protein biomarkers for cediranib and olaparib
ResearchPrincipal Investigator · Awarded by Leidos Biomedical Research, Inc. · 2019 - 2019Blood-based Biomarker Profiling for Regorafenib in Metastatic Colorectal Cancer
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2017 - 20193D Biology Signatures defined by Nanostring Max System
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2018 - 2019Dovitinib in Treating Patients with Recurrent or Progressive Glioblastoma
ResearchPrincipal Investigator · Awarded by Cleveland Clinic Foundation · 2015 - 2018Anti-Tumor Effects of locally and Systemically Administered EZN-2279 monotherapy in a murine model of Colorectal Carcinoma
ResearchPrincipal Investigator · Awarded by Leadiant Biosciences, Inc. · 2017 - 2018RAP-041 mediated modulation of intratumoral immune cell subpopulations in vivo and effect of combination treatment with anti-PD1 monoclonal antibody
ResearchPrincipal Investigator · Awarded by Acceleron Pharma · 2016 - 2018Predictive value of the IL6 pathway to direct anti-angiogenic therapy in advanced ovarian cancer
ResearchCo Investigator · Awarded by American Association of Obstetricians and Gynecologists Foundation · 2017 - 2018Blood-based Biomarker Profiling for TEW-7197
ResearchCo Investigator · Awarded by MedPacto, Inc · 2016 - 2018Preclinical and Human Correlative Studies of a Novel Bruton Tyronsine Kinase Inhibitor in Pancreatic Cancer
ResearchCo Investigator · Awarded by Department of Defense · 2016 - 2017Anti-endoglin mediated modulation of intratumoral Immune Cell Subpopulationg in vivo and effect of combination treatment with anti-PD1 monoclonal antibodies
ResearchPrincipal Investigator · Awarded by Tracon Pharmaceuticals, Inc. · 2015 - 2017CTOT - Cell Free DNA
ResearchPrincipal Investigator · Awarded by Mount Sinai School of Medicine · 2016 - 2017Biomarker Discovery to Direct Bevacizumab Therapy in Ovarian Cancer - Blood-based Angiome Profiling
ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2017The prevalence of MET gene amplification in metastatic colorectal cancer
ResearchPrincipal Investigator · Awarded by Amgen, Inc. · 2014 - 2016Serum Biomarkers in Lymphoma
ResearchPrincipal Investigator · Awarded by Brigham and Women's Hospital · 2014 - 2015(PQA5) 'Dose and Mechanisms of Exercise in Breast Cancer Prevention'
ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 2014Anti-VEGF in Tumors & Wounds: Efficacy vs Toxicity
ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2012New Clinical Biomarker for Cancer--Wound Angiogenesis
ResearchAssistant Research Professor · Awarded by National Institutes of Health · 2000 - 2006Regulation Of Cyclic Gmp Phosphodiesterase By Gz
ResearchPI-Fellow · Awarded by National Institutes of Health · 1997 - 2001External Relationships
- Alliance for Clinical Trials in Oncology
- Leap Therapeutics
- NRG Oncology
- National Cancer Intitute
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.