Scholars@Duke
Anna Lisa Chamis

Anna Lisa Chamis

Professor of Medicine
Medicine, Cardiology
annalisa.chamis@duke.edu
Duke Box 2805, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Selected Publications

Infective Endocarditis in Patients on Chronic Hemodialysis.

Journal Article J Am Coll Cardiol · April 6, 2021 BACKGROUND: Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD). OBJECTIVES: This study sought to investigate whether there are significant differences in complications, cardiac surgery, relapses ... Full text Link to item Cite

Resolution and Speckle Reduction in Cardiac Imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · April 2021 Cardiac imaging depends on clear visualization of several different structural and functional components to determine left ventricular and overall cardiac health. Ultrasound imaging is confounded by the characteristic speckle texture resulting from subwave ... Full text Link to item Cite

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Journal Article JAMA Netw Open · January 4, 2021 IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ... Full text Link to item Cite

Perceptions on Diversity in Cardiology: A Survey of Cardiology Fellowship Training Program Directors.

Journal Article J Am Heart Assoc · September 2020 Background The lack of diversity in the cardiovascular physician workforce is thought to be an important driver of racial and sex disparities in cardiac care. Cardiology fellowship program directors play a critical role in shaping the cardiology workforce. ... Full text Link to item Cite

Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.

Journal Article Am Heart J · May 2020 BACKGROUND: The evolution and clinical impact of cardiac remodeling after large ST-elevation myocardial infarction (STEMI) is not well delineated in the current therapeutic era. METHODS: The PRESERVATION I trial longitudinally assessed cardiac structure an ... Full text Link to item Cite

K-space Compounding for Improved Endocardial Border Detection

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Visualization of the endocardial border is essential in determining left ventricular and overall cardiac function. Ultrasound imaging systems typically rely on image post-processing for contrast and detail enhancement. Spatial compounding is a physics-base ... Full text Cite

Improved Visualization in Difficult-to-Image Stress Echocardiography Patients Using Real-Time Harmonic Spatial Coherence Imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · March 2019 Stress echocardiography is used to detect myocardial ischemia by evaluating cardiovascular function both at rest and at elevated heart rates. Stress echocardiography requires excellent visualization of the left ventricle (LV) throughout the cardiac cycle. ... Full text Link to item Cite

Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2018 OBJECTIVES: This study introduced and validated a novel flow-independent delayed enhancement technique that shows hyperenhanced myocardium while simultaneously suppressing blood-pool signal. BACKGROUND: The diagnosis and assessment of myocardial infarction ... Full text Open Access Link to item Cite

Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation.

Journal Article Int J Cardiovasc Imaging · November 2018 Quality in stress echocardiography interpretation is often gauged against coronary angiography (CA) data but anatomic obstructive coronary disease on CA is an imperfect gold standard for a stress induced wall motion abnormality. We examined the utility of ... Full text Link to item Cite

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.

Journal Article JAMA · September 25, 2018 IMPORTANCE: The appropriate duration of antibiotics for staphylococcal bacteremia is unknown. OBJECTIVE: To test whether an algorithm that defines treatment duration for staphylococcal bacteremia vs standard of care provides noninferior efficacy without in ... Full text Open Access Link to item Cite

Two-dimensional global longitudinal strain is superior to left ventricular ejection fraction in prediction of outcome in patients with left-sided infective endocarditis.

Journal Article Int J Cardiol · June 1, 2018 BACKGROUND: Impaired cardiac function is the main predictor of poor outcome in infective endocarditis (IE). Global longitudinal strain (GLS) derived from two-dimensional strain echocardiography has proven superior in prediction of long-term outcome as comp ... Full text Link to item Cite

Infective Endocarditis

Chapter · January 1, 2018 Infective endocarditis (IE) is an infection of the endocardial lining of the heart, the heart valves, intracardiac devices or prosthetic valves. The infection is mainly localized on the valvular structures, generally on the flow side of the valves or at lo ... Full text Cite

Notice of Removal: Improved left ventricular wall visualization in stress-echocardiography using real-time GPU-based harmonic spatial coherence imaging

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Stress echocardiography is an ultrasound imaging technique to assess the functionality of wall segments of the left ventricle (LV). However, image quality is inadequate in up to 30% of patients, requiring the administration of contrast agents. Coherence-ba ... Full text Cite

The Role for Cardiovascular Remodeling in Cardiovascular Outcomes.

Journal Article Curr Atheroscler Rep · May 2017 PURPOSE OF REVIEW: Ischemic and non-ischemic injury to the heart causes deleterious changes in ventricular size, shape, and function. This adverse remodeling is mediated by neurohormonal and hemodynamic alterations and is reflected in non-invasive measures ... Full text Link to item Cite

Efficient Strategies for Estimating the Spatial Coherence of Backscatter.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · March 2017 The spatial coherence of ultrasound backscatter has been proposed to reduce clutter in medical imaging, to measure the anisotropy of the scattering source, and to improve the detection of blood flow. These techniques rely on correlation estimates that are ... Full text Link to item Cite

Choice of agreement indices for assessing and improving measurement reproducibility in a core laboratory setting.

Journal Article Stat Methods Med Res · December 2016 Clinical core laboratories, such as Echocardiography core laboratories, are increasingly used in clinical studies with imaging outcomes as primary, secondary, or surrogate endpoints. While many factors contribute to the quality of measurements of imaging v ... Full text Link to item Cite

Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.

Journal Article J Am Soc Echocardiogr · December 2016 BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twe ... Full text Open Access Link to item Cite

Echocardiographic agreement in the diagnostic evaluation for infective endocarditis.

Journal Article Int J Cardiovasc Imaging · July 2016 Echocardiography is essential for the diagnosis and management of infective endocarditis (IE). However, the reproducibility for the echocardiographic assessment of variables relevant to IE is unknown. Objectives of this study were: (1) To define the reprod ... Full text Link to item Cite

An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis.

Journal Article J Am Soc Echocardiogr · April 2016 BACKGROUND: In patients with suspected native valve infective endocarditis, current guidelines recommend initial transthoracic echocardiography (TTE) followed by transesophageal echocardiography (TEE) if clinical suspicion remains. The guidelines do not ac ... Full text Link to item Cite

Quality Improvement Implementation: Improving Reproducibility in the Echocardiography Laboratory.

Journal Article J Am Soc Echocardiogr · August 2015 BACKGROUND: Interpretative variability can adversely affect echocardiographic reliability, but there is no widely accepted method to minimize variability and improve reproducibility. METHODS: A continuous quality improvement process was devised that involv ... Full text Link to item Cite

Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.

Journal Article Circ Res · July 17, 2015 RATIONALE: After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the ev ... Full text Open Access Link to item Cite

Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study.

Journal Article Circ Cardiovasc Imaging · July 2015 BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVI ... Full text Link to item Cite

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Journal Article Antimicrob Agents Chemother · April 2015 Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ... Full text Link to item Cite

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

Journal Article Clin Infect Dis · March 1, 2015 BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ... Full text Link to item Cite

One-year outcome following biological or mechanical valve replacement for infective endocarditis.

Journal Article Int J Cardiol · January 15, 2015 BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ... Full text Link to item Cite

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.

Journal Article Circulation · January 13, 2015 BACKGROUND: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) ... Full text Link to item Cite

Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.

Journal Article Clin Infect Dis · January 2013 BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ... Full text Link to item Cite

Relationships between cardiac magnetic resonance imaging abnormalities in the inter-ventricular septum and Selvester QRS scoring criteria for anterior-septal myocardial infarction in patients with right ventricular volume overload.

Journal Article J Electrocardiol · 2013 BACKGROUND: Patients with ostium secundum atrial septal defects (ASDs) were studied to determine the prevalence of Selvester anteroseptal myocardial infarction QRS points, and to test the hypothesis that there is a relationship between these criteria and t ... Full text Link to item Cite

HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.

Journal Article PLoS One · 2013 The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ... Full text Link to item Cite

Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices.

Journal Article JAMA · April 25, 2012 CONTEXT: Infection of implantable cardiac devices is an emerging disease with significant morbidity, mortality, and health care costs. OBJECTIVES: To describe the clinical characteristics and outcome of cardiac device infective endocarditis (CDIE) with att ... Full text Link to item Cite

Coronary arteriovenous fistulae: the complexity of coronary artery-to-coronary sinus connections.

Journal Article Tex Heart Inst J · 2012 Coronary artery fistulae are a rare cardiovascular anomaly. Even less common are multiple fistulae involving more than 1 coronary artery. Herein we report the case of a 47-year-old woman who had fistulae from both the right coronary and left circumflex cor ... Link to item Cite

Clinical application of cine-MRI in the visual assessment of mitral regurgitation compared to echocardiography and cardiac catheterization.

Journal Article PLoS One · 2012 BACKGROUND: Detecting and quantifying the severity of mitral regurgitation is essential for risk stratification and clinical decision-making regarding timing of surgery. Our objective was to assess specific visual parameters by cine-magnetic resonance imag ... Full text Link to item Cite

Direct in vivo myocardial infarct visualization using 3D ultrasound and passive strain contrast

Conference IEEE International Ultrasonics Symposium, IUS · December 1, 2011 An approach for myocardial elastography is presented for infarct visualization. Infarcts are visualized using passive strain in the ventricles induced by atrial contraction. Results are compared against ARFI and delay-enhanced contrast MR. © 2011 IEEE. ... Full text Cite

LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement CMR.

Journal Article JACC Cardiovasc Imaging · July 2011 OBJECTIVES: This study sought to evaluate performance characteristics of routine echo for left ventricular thrombus (LVT). BACKGROUND: Although the utility of dedicated echocardiography (echo) for LVT is established, echo is widely used as a general test f ... Full text Link to item Cite

Cardiovascular complications of breast cancer therapy in older adults.

Journal Article Oncologist · 2011 Older adults frequently have pre-existing and cancer-related risk factors for cardiovascular toxicity from cancer treatment. In this review, we discuss the risk factors and strategies for prevention and management of cardiovascular complications in older w ... Full text Link to item Cite

The aorta wall of patients presenting to the emergency department with acute myocardial infarction by cardiac magnetic resonance.

Journal Article Atherosclerosis · September 2010 BACKGROUND: Inflammation has been shown to be a major component in the pathophysiology of acute coronary syndrome (ACS). In patients presenting with acute myocardial infarction (AMI), a critical component of the ACS spectrum, multiple coronary arteries are ... Full text Link to item Cite

Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation.

Journal Article J Cardiovasc Electrophysiol · August 1, 2010 INTRODUCTION: Catheter-directed atrial fibrillation (AF) ablation is contraindicated among patients with left atrial appendage (LAA) thrombus. The prevalence of LAA thrombus among fully anticoagulated patients undergoing AF ablation is unknown. METHODS AND ... Full text Link to item Cite

The utility of modified Butler-Leggett criteria for right ventricular hypertrophy in detection of clinically significant shunt ratio in ostium secundum-type atrial septal defect in adults.

Journal Article J Electrocardiol · 2010 BACKGROUND: This study was performed to test the hypothesis that there exists a correlation between the Butler-Leggett (BL) criterion for right ventricular hypertrophy on the electrocardiogram and the Qp/Qs shunt ratio in adults with ostium secundum atrial ... Full text Link to item Cite

Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease.

Journal Article PLoS Med · April 21, 2009 BACKGROUND: Unrecognized myocardial infarction (UMI) is known to constitute a substantial portion of potentially lethal coronary heart disease. However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. T ... Full text Link to item Cite

Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction.

Journal Article J Am Coll Cardiol · July 8, 2008 OBJECTIVES: This study sought to assess the prevalence and markers of left ventricular (LV) thrombus among patients with systolic dysfunction. BACKGROUND: Prior studies have yielded discordant findings regarding prevalence and markers of LV thrombus. Delay ... Full text Link to item Cite

Direct en face imaging of secundum atrial septal defects by velocity-encoded cardiovascular magnetic resonance in patients evaluated for possible transcatheter closure.

Journal Article Circ Cardiovasc Imaging · July 2008 BACKGROUND: Atrial septal defect (ASD) flow can be measured indirectly by velocity-encoded cardiovascular magnetic resonance (veCMR) of the pulmonary artery and aorta. Imaging the secundum ASD en face could potentially enable direct flow measurement and pr ... Full text Link to item Cite

Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia.

Journal Article Crit Care Med · February 2008 OBJECTIVE: Infection and thrombosis are important complications of intravascular catheters. The purpose of this study was to determine the incidence of thrombosis in patients with central venous catheter-associated Staphylococcus aureus bacteremia and the ... Full text Link to item Cite

Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.

Journal Article Am Heart J · November 2007 BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ... Full text Link to item Cite

A clinical cardiovascular magnetic resonance service: operational considerations and the basic examination.

Journal Article Magn Reson Imaging Clin N Am · November 2007 Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ... Full text Link to item Cite

A clinical cardiovascular magnetic resonance service: operational considerations and the basic examination.

Journal Article Cardiol Clin · February 2007 Cardiovascular magnetic resonance (CMR) is now considered the "gold standard" for the assessment of regional and global systolic function, myocardial infarction and viability, and congenital heart disease. At specialized centers, CMR has become a clinical ... Full text Link to item Cite

Transesophageal assessment of left atrial thrombus using a 3.3-mm monoplane probe.

Journal Article J Am Soc Echocardiogr · December 2005 OBJECTIVES: Our study was designed to demonstrate that transesophageal echocardiography using a 3.3-mm monoplane probe can accurately evaluate the left atrium for patients with arrhythmias before cardioversion. BACKGROUND: Standard probes cause discomfort ... Full text Link to item Cite

Clinical use of cardiac magnetic resonance imaging

Journal Article Advanced Studies in Medicine · July 1, 2005 PURPOSE: To review the uses of cardiac magnetic resonance (CMR) imaging in the management of patients with heart disease. EPIDEMIOLOGY: CMR has applications in the evaluation of congenital heart defects, which are present in more than 1 million adults in t ... Cite

Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators.

Journal Article Circulation · August 28, 2001 BACKGROUND: Although cardiac device infections (CDIs) are a devastating complication of permanent pacemakers or implantable cardioverter-defibrillators, the incidence of CDI in patients with bacteremia is not well defined. The objective of this study was t ... Full text Link to item Cite

The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints.

Journal Article Med Microbiol Immunol · April 2001 Although polysaccharide intercellular adhesin (PIA) is thought to be crucial in the pathogenesis of prosthetic device infections caused by Staphylococcus epidermidis, its role in prosthetic device infections caused by Staphylococcus aureus is unknown. To a ... Full text Link to item Cite