Scholars@Duke
Annie Liu

Annie Liu

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Surgery
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Selected Publications

Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.

Journal Article NPJ Precis Oncol · May 31, 2024 Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treat ... Full text Link to item Cite

Transforming the Future of Surgeon-Scientists.

Journal Article Annals of surgery · February 2024 ObjectiveTo create a blueprint for surgical department leaders, academic institutions, and funding agencies to optimally support surgeon-scientists.BackgroundScientific contributions by surgeons have been transformative across many medica ... Full text Cite

Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization.

Journal Article bioRxiv · September 21, 2023 Enhancers possess both structural elements mediating promoter looping and functional elements mediating gene expression. Traditional models of enhancer-mediated gene regulation imply genomic overlap or immediate adjacency of these elements. We test this mo ... Full text Link to item Cite

Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.

Journal Article Proc Natl Acad Sci U S A · September 19, 2023 Evidence has long suggested that epidermal growth factor receptor (EGFR) may play a prominent role in triple-negative breast cancer (TNBC) pathogenesis, but clinical trials of EGFR inhibitors have yielded disappointing results. Using a candidate drug scree ... Full text Link to item Cite

Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.

Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item Cite

Neoplasms of the vermiform appendix and peritoneum

Chapter · May 9, 2023 This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org/ The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition ... ... Cite

Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.

Journal Article NPJ Precis Oncol · October 23, 2022 Intrahepatic cholangiocarcinoma (ICC) remains a deadly malignancy lacking systemic therapies for advanced disease. Recent advancements include selective FGFR1-3 inhibitors for the 15% of ICC patients harboring fusions, although survival is limited by poor ... Full text Link to item Cite

Patterns and Impact of Fragmented Care in Stage II and III Gastric Cancer.

Journal Article Ann Surg Oncol · September 2022 BACKGROUND: Optimal management of stage II/III gastric cancer requires multidisciplinary care, often necessitating treatment at more than one facility. We aimed to determine patterns of "fragmented" care and its impact on outcomes, including concordance wi ... Full text Link to item Cite

Perioperative and oncologic outcomes of hepatic artery infusion pump therapy at an expanding HAI program.

Conference Journal of Clinical Oncology · February 1, 2022 120 Background: Hepatic artery infusion (HAI) is a liver directed therapy to treat unresectable or resected colorectal liver metastases (CRLM) and unresectable intrahepatic cholangiocarcinoma (ICC). Historically, HAI has only bee ... Full text Cite

Mouse Navigation Strategies for Odor Source Localization.

Journal Article Frontiers in neuroscience · January 2020 Navigating an odor landscape is a critical behavior for the survival of many species, including mice. An ethologically relevant mouse behavior is locating food using information about odor concentration. To approximate this behavior, we used an open field ... Full text Cite

Pancreatic Cancer Presenting as a Pancreatic Duct Disruption.

Journal Article Case reports in surgery · January 2019 The high mortality rate associated with pancreatic cancer necessitates accurate and early detection methods. Computed tomography currently is the primary diagnostic modality used; however, subtle imaging features in concert with novel clinical presentation ... Full text Cite

Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb.

Journal Article eNeuro · September 2017 Early sensory experience shapes the anatomy and function of sensory circuits. In the mouse olfactory bulb (OB), prenatal and early postnatal odorant exposure through odorized food (food/odorant pairing) not only increases the volume of activated glomeruli ... Full text Cite

Olfactory Bulb Deep Short-Axon Cells Mediate Widespread Inhibition of Tufted Cell Apical Dendrites.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · February 2017 In the main olfactory bulb (MOB), the first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, a lack of known selective markers for MOB interneurons has s ... Full text Cite

Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · November 2016 The highly specific organization of the olfactory bulb (OB) is well known, but the impact of early odorant experience on its circuit structure is unclear. Olfactory sensory neurons (OSNs) project axons from the olfactory epithelium to the OB, where they fo ... Full text Cite

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.

Journal Article Neurobiology of disease · February 2015 Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Parkin, the product of gene PARK2 who ... Full text Cite

Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.

Journal Article Neuron · December 2013 Neuronal computation involves the integration of synaptic inputs that are often distributed over expansive dendritic trees, suggesting the need for compensatory mechanisms that enable spatially disparate synapses to influence neuronal output. In hippocampa ... Full text Cite