Current Appointments & Affiliations
Associate Professor of Neurosurgery
·
2023 - Present
Neurosurgery,
Neurosurgery
Associate Professor in Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Associate Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.
Journal Article Clin Cancer Res · February 17, 2026 PURPOSE: Exhaustion represents a collection of programmed T-cell differentiation states and an important mode of T-cell dysfunction. T-cell progression from progenitor to terminal exhaustion is associated with upregulation of the transcription factor thymo ... Full text Link to item CiteHCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.
Journal Article Commun Biol · January 20, 2026 The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched Hyper ... Full text Link to item CiteA surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.
Journal Article Sci Rep · October 23, 2025 Many cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma. Evolocumab is a clinically approved PCSK9 in ... Full text Link to item CiteRecent Grants
McCain/Bayh Glioblastoma Consortium
Clinical TrialCo Investigator · Awarded by Department of Defense · 2025 - 2029Integrating genome-wide association study data with single-cell `omics' to reveal the cellular effectors of glioblastoma predisposition
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029Integrative transcriptomic and epigenomic profiling of subependymal giant cell astrocytoma at single-cell resolution
ResearchCo Investigator · Awarded by Department of Defense · 2025 - 2027View All Grants
Education
Harvard Medical School ·
2009
M.D.