Current Duke Appointments & Affiliations
Associate Professor of Neurosurgery
·
2023 - Present
Neurosurgery,
Neurosurgery
Associate Professor in Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Associate Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Evolution of randomized controlled trials in adult neurosurgical critical care from 1990 to 2024 in the United States.
Journal article Neurosurg Rev · July 14, 2026 Randomized controlled trials (RCTs) are the gold standard for clinical care. Acute conditions such as traumatic brain injury, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and spinal cord injury are associated with high morbidity and mortal ... Full text Link to item CiteIL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma.
Journal article J Immunother Cancer · March 24, 2026 BACKGROUND: Glioblastoma (GBM) remains uniformly lethal due to pronounced intratumoral heterogeneity and a highly immunosuppressive microenvironment that limits the efficacy of targeted therapies. METHODS: We engineered chimeric antigen receptor (CAR) T ce ... Full text Link to item CiteUpregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.
Journal article Clin Cancer Res · February 17, 2026 PURPOSE: Exhaustion represents a collection of programmed T-cell differentiation states and an important mode of T-cell dysfunction. T-cell progression from progenitor to terminal exhaustion is associated with upregulation of the transcription factor thymo ... Full text Link to item CiteRecent Grants
Epigenetic mechanisms of adaptive plasticity in glioblastoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031Genetics and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031McCain/Bayh Glioblastoma Consortium
Clinical TrialCo Investigator · Awarded by Department of Defense · 2025 - 2029View All Grants
Education
Harvard Medical School ·
2009
M.D.