Current Appointments & Affiliations
Associate Professor of Neurosurgery
·
2023 - Present
Neurosurgery,
Neurosurgery
Associate Professor in Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Analysis of DNA Methylation in Gliomas: Assessment of Preanalytical Variables.
Journal Article Lab Invest · December 2024 Precision oncology is driven by biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation is an important prognostic and treatment clinical bi ... Full text Link to item CiteA brave new framework for glioma drug development.
Journal Article Lancet Oncol · October 2024 Patients with brain tumours are motivated to participate in clinical trials involving repeat tissue sampling. Normalising the use of neoadjuvant and staged surgical trials necessitates collaboration among patients, regulatory agencies, and researchers. Ini ... Full text Link to item CiteGene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.
Journal Article Sci Adv · June 7, 2024 Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell sub ... Full text Link to item CiteRecent Grants
Licensing Immunotherapeutic Responses in GBM: Developing A Novel GPCR-Targeted Approach
ResearchSignificant Contributor · Awarded by Charlie Teo Foundation · 2024 - 2026Deep interrogation and modeling of intratumoral heterogeneity, plasticity, and tumor evolution in glioblastoma
ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2023 - 2026Translating Single Cell Analysis into Actionable Therapeutic Strategies for Glioblastoma
ResearchPrincipal Investigator · Awarded by Kuni Foundation · 2023 - 2024View All Grants
Education, Training & Certifications
Harvard Medical School ·
2009
M.D.