Scholars@Duke

• Background
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  Education, Training, & Certifications

  • M.D., Harvard Medical School 2009
• Research
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  Selected Grants

  • Deep interrogation and modeling of intratumoral heterogeneity, plasticity, and tumor evolution in glioblastoma awarded by Burroughs Wellcome Fund 2023 - 2026
  • Translating Single Cell Analysis into Actionable Therapeutic Strategies for Glioblastoma awarded by Kuni Foundation 2023 - 2024
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  External Relationships

  • Sygnomics
• Publications & Artistic Works
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  Selected Publications

  • Books

    • Sekhar, L. N., and A. P. Patel. Foreword, 2019.

  • Academic Articles

    • Mitchell, Kelly, Samuel A. Sprowls, Sonali Arora, Sajina Shakya, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, et al. “WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.” Genes Dev 37, no. 3–4 (February 1, 2023): 86–102. https://doi.org/10.1101/gad.349803.122.
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    • Park, James H., Abdullah H. Feroze, Samuel N. Emerson, Anca B. Mihalas, C Dirk Keene, Patrick J. Cimino, Adrian Lopez Garcia de Lomana, et al. “A single-cell based precision medicine approach using glioblastoma patient-specific models.” Npj Precis Oncol 6, no. 1 (August 8, 2022): 55. https://doi.org/10.1038/s41698-022-00294-4.
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    • Rajesh, A. E., J. T. Rubinstein, M. Ferreira, A. P. Patel, R. A. Bly, and G. D. Kohlberg. “Automated objective surgical planning for lateral skull base tumors.” Int J Comput Assist Radiol Surg 17, no. 3 (March 2022): 427–36. https://doi.org/10.1007/s11548-022-02564-9.
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    • Kalmbach, Brian E., Rebecca D. Hodge, Nikolas L. Jorstad, Scott Owen, Rebecca de Frates, Anna Marie Yanny, Rachel Dalley, et al. “Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons.” Neuron 109, no. 18 (September 15, 2021): 2914-2927.e5. https://doi.org/10.1016/j.neuron.2021.08.030.
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    • Park, J. H., A. L. G. de Lomana, D. M. Marzese, T. Juarez, A. Feroze, P. Hothi, C. Cobbs, et al. “A systems approach to brain tumor treatment.” Cancers 13, no. 13 (July 1, 2021). https://doi.org/10.3390/cancers13133152.
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    • Wu, Steven J., Scott N. Furlan, Anca B. Mihalas, Hatice S. Kaya-Okur, Abdullah H. Feroze, Samuel N. Emerson, Ye Zheng, et al. “Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression.” Nat Biotechnol 39, no. 7 (July 2021): 819–24. https://doi.org/10.1038/s41587-021-00865-z.
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    • O’Connor, Samantha A., Heather M. Feldman, Sonali Arora, Pia Hoellerbauer, Chad M. Toledo, Philip Corrin, Lucas Carter, et al. “Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma.” Mol Syst Biol 17, no. 6 (June 2021): e9522. https://doi.org/10.15252/msb.20209522.
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    • Tawil, Nadim, Rayhaan Bassawon, Brian Meehan, Ali Nehme, Laura Montermini, Tenzin Gayden, Nicolas De Jay, et al. “Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.” Blood Adv 5, no. 6 (March 23, 2021): 1682–94. https://doi.org/10.1182/bloodadvances.2020002998.
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    • Gutschenritter, T., V. A. Venur, S. E. Combs, B. Vellayappan, A. P. Patel, M. Foote, K. J. Redmond, et al. “The judicious use of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy in the management of large brain metastases.” Cancers 13, no. 1 (January 1, 2021): 1–15. https://doi.org/10.3390/cancers13010070.
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    • Sekhar, Laligam N., Gordana Juric-Sekhar, Zeeshan Qazi, Anoop Patel, Lynn B. McGrath, James Pridgeon, Niveditha Kalavakonda, and Blake Hannaford. “The Future of Skull Base Surgery: A View Through Tinted Glasses.” World Neurosurg 142 (October 2020): 29–42. https://doi.org/10.1016/j.wneu.2020.06.172.
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    • Ene, Chibawanye I., Shannon A. Kreuser, Miyeon Jung, Huajia Zhang, Sonali Arora, Kara White Moyes, Frank Szulzewsky, et al. “Anti-PD-L1 antibody direct activation of macrophages contributes to a radiation-induced abscopal response in glioblastoma.” Neuro Oncol 22, no. 5 (May 15, 2020): 639–51. https://doi.org/10.1093/neuonc/noz226.
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    • Neftel, Cyril, Julie Laffy, Mariella G. Filbin, Toshiro Hara, Marni E. Shore, Gilbert J. Rahme, Alyssa R. Richman, et al. “An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.” Cell 178, no. 4 (August 8, 2019): 835-849.e21. https://doi.org/10.1016/j.cell.2019.06.024.
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    • Chiarelli, Peter A., Anoop P. Patel, Amy Lee, Srinivasa R. Chandra, and Laligam N. Sekhar. “Sternocleidomastoid Encephalomyosynangiosis for Treatment-Resistant Moyamoya Disease.” Oper Neurosurg (Hagerstown) 17, no. 1 (July 1, 2019): E23–28. https://doi.org/10.1093/ons/opy234.
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    • GBD 2016 Neurology Collaborators, Lee W. “Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.” Lancet Neurol 18, no. 5 (May 2019): 459–80. https://doi.org/10.1016/S1474-4422(18)30499-X.
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    • Zeeshan, Qazi, Anoop Patel, Chun-Yu Cheng, Ning-Hui Zhao, Jason Barber, Basavaraj V. Ghodke, and Laligam N. Sekhar. “Resection of Meningiomas Involving Major Dural Venous Sinuses: Classification, Technique, and Long-Term Results.” World Neurosurg 125 (May 2019): e521–36. https://doi.org/10.1016/j.wneu.2019.01.128.
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    • GBD 2016 Brain and Other CNS Cancer Collaborators, Bridget. “Global, regional, and national burden of brain and other CNS cancer, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.” Lancet Neurol 18, no. 4 (April 2019): 376–93. https://doi.org/10.1016/S1474-4422(18)30468-X.
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    • Karaayvaz, Mihriban, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, and Leif W. Ellisen. “Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.” Nat Commun 9, no. 1 (September 4, 2018): 3588. https://doi.org/10.1038/s41467-018-06052-0.
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    • Stapleton, Christopher J., Anoop P. Patel, Brian P. Walcott, Collin M. Torok, Matthew J. Koch, Thabele M. Leslie-Mazwi, James D. Rabinov, William E. Butler, and Aman B. Patel. “Surgical management of superior petrosal sinus dural arteriovenous fistulae with dominant internal carotid artery supply.” Interv Neuroradiol 24, no. 3 (June 2018): 331–38. https://doi.org/10.1177/1591019917754038.
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    • Young, Christopher C., Brian W. Hanak, Anoop P. Patel, and Laligam N. Sekhar. “Rapid Intraoperative in Situ Synthetic Cranioplasty.” World Neurosurg 112 (April 2018): 161–65. https://doi.org/10.1016/j.wneu.2018.01.126.
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    • Puram, Sidharth V., Itay Tirosh, Anuraag S. Parikh, Anoop P. Patel, Keren Yizhak, Shawn Gillespie, Christopher Rodman, et al. “Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.” Cell 171, no. 7 (December 14, 2017): 1611-1624.e24. https://doi.org/10.1016/j.cell.2017.10.044.
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    • Venteicher, Andrew S., Itay Tirosh, Christine Hebert, Keren Yizhak, Cyril Neftel, Mariella G. Filbin, Volker Hovestadt, et al. “Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.” Science 355, no. 6332 (March 31, 2017). https://doi.org/10.1126/science.aai8478.
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    • Liau, Brian B., Cem Sievers, Laura K. Donohue, Shawn M. Gillespie, William A. Flavahan, Tyler E. Miller, Andrew S. Venteicher, et al. “Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.” Cell Stem Cell 20, no. 2 (February 2, 2017): 233-246.e7. https://doi.org/10.1016/j.stem.2016.11.003.
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    • Tirosh, Itay, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Anoop P. Patel, Keren Yizhak, Jonathan M. Fisher, et al. “Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma.” Nature 539, no. 7628 (November 10, 2016): 309–13. https://doi.org/10.1038/nature20123.
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    • Nigim, Fares, Jill Cavanaugh, Anoop P. Patel, William T. Curry, Shin-ichi Esaki, Ekkehard M. Kasper, Andrew S. Chi, et al. “Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment.” J Neuropathol Exp Neurol 74, no. 7 (July 2015): 710–22. https://doi.org/10.1097/NEN.0000000000000210.
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    • Walcott, Brian P., Anoop P. Patel, Christopher J. Stapleton, Rikin A. Trivedi, Adam M. H. Young, and Christopher S. Ogilvy. “Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: characterization of differential expression patterns in cerebral vasospasm.” J Clin Neurosci 21, no. 12 (December 2014): 2135–39. https://doi.org/10.1016/j.jocn.2014.06.004.
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    • Riggi, Nicolò, Birgit Knoechel, Shawn M. Gillespie, Esther Rheinbay, Gaylor Boulay, Mario L. Suvà, Nikki E. Rossetti, et al. “EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.” Cancer Cell 26, no. 5 (November 10, 2014): 668–81. https://doi.org/10.1016/j.ccell.2014.10.004.
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    • Patel, Anoop P., Itay Tirosh, John J. Trombetta, Alex K. Shalek, Shawn M. Gillespie, Hiroaki Wakimoto, Daniel P. Cahill, et al. “Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.” Science 344, no. 6190 (June 20, 2014): 1396–1401. https://doi.org/10.1126/science.1254257.
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    • Suvà, Mario L., Esther Rheinbay, Shawn M. Gillespie, Anoop P. Patel, Hiroaki Wakimoto, Samuel D. Rabkin, Nicolo Riggi, et al. “Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.” Cell 157, no. 3 (April 24, 2014): 580–94. https://doi.org/10.1016/j.cell.2014.02.030.
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    • Venteicher, Andrew S., Brian P. Walcott, Sameer A. Sheth, Matija Snuderl, Anoop P. Patel, William T. Curry, and Brian V. Nahed. “Clinical features of brain metastasis from salivary gland tumors.” J Clin Neurosci 20, no. 11 (November 2013): 1533–37. https://doi.org/10.1016/j.jocn.2012.11.024.
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    • Rheinbay, Esther, Mario L. Suvà, Shawn M. Gillespie, Hiroaki Wakimoto, Anoop P. Patel, Mohammad Shahid, Ozgur Oksuz, et al. “An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.” Cell Rep 3, no. 5 (May 30, 2013): 1567–79. https://doi.org/10.1016/j.celrep.2013.04.021.
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    • Barnard, Zachary, Hiroaki Wakimoto, Cecile Zaupa, Anoop P. Patel, Jacquelyn Klehm, Robert L. Martuza, Samuel D. Rabkin, and William T. Curry. “Expression of FMS-like tyrosine kinase 3 ligand by oncolytic herpes simplex virus type I prolongs survival in mice bearing established syngeneic intracranial malignant glioma.” Neurosurgery 71, no. 3 (September 2012): 741–48. https://doi.org/10.1227/NEU.0b013e318260fd73.
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    • Wakimoto, Hiroaki, Gayatry Mohapatra, Ryuichi Kanai, William T. Curry, Stephen Yip, Mai Nitta, Anoop P. Patel, et al. “Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.” Neuro Oncol 14, no. 2 (February 2012): 132–44. https://doi.org/10.1093/neuonc/nor195.
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  • Book Sections

    • Patel, A. P. “High-Grade Gliomas.” In Principles of Neurological Surgery, 580-585.e2, 2018. https://doi.org/10.1016/B978-0-323-43140-8.00039-1.
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    • Patel, A. P., S. Amin-Hanjani, and C. S. Ogilvy. “Surgical Management of Cavernous Malformations of the Nervous System.” In Schmidek and Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results: Sixth Edition, 1:977–93, 2012. https://doi.org/10.1016/B978-1-4160-6839-6.10081-4.
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