Anthony D Sung | Scholars@Duke

Anthony D Sung
Assistant Professor of Medicine

I am dedicated to the treatment of hematologic malignancies through cellular therapies such as hematopoietic stem cell transplantation (HCT). My research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections. In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016

Contact Information

DUMC Box 3961, Durham, NC 27712
anthony.sung@duke.edu (919) 668-1002

Background
Education, Training, & Certifications
- Fellowship, Hematology Oncology, Duke University School of Medicine 2011 - 2014
- Residency, Osler Medical Housestaff Training Program, Johns Hopkins University School of Medicine 2008 - 2011
- M.D., Harvard University 2008
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Hematological Malignancies, Medicine 2014 - 2017
Recognition
In the News
- NOV 20, 2017
  
  Microbe Scientists Launching Expanded Microbiome Center
Research
Selected Grants
- Protocol Number CA209920 awarded by Merck Sharp & Dohme 2018 - 2023
- Mitigators of Radiation-Induced Endovascular Injury: Targeting Tie2 and Thrombocytopenia awarded by National Institutes of Health 2017 - 2022
- Patient-centered home-based hematopoietic stem cell transplantation awarded by National Institutes of Health 2016 - 2021
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- Personalized Prebiotics to Optimize Microbiota Metabolism and Improve Transplant Outcomes awarded by Damon Runyon Cancer Research Foundation 2018
- Prevention of Gastrointestinal Toxicity from total body irradation or high dose Chemo with SOM230 awarded by Novartis Pharmaceuticals Corporation 2013 - 2018
- Duke CTSA (KL2) awarded by National Institutes of Health 2013 - 2018
- Microbiota-focused strategies to mitigate GVHD awarded by MD Anderson Cancer Center 2015 - 2018
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Anand, S, Thomas, S, Corbet, K, Gasparetto, C, Long, GD, Lopez, R, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, Horwitz, ME, Kanda, J, Rizzieri, DA, Gasparetto, C, Long, GD, Chute, JP, Sullivan, KM, Morris, A, Smith, CA, Hogge, DE, Nitta, J, Song, K, Niedzwiecki, D, Chao, NJ, and Horwitz, ME. "Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine ConditioningAdult Dual Umbilical Cord Blood Transplantation Using Myeloablative Total Body Irradiation (1350cGy) and Fludarabine Conditioning (PublishedPublished)." November 19, 2010. Link to Item
- Journal Articles
  - O'Sullivan, ML, Shelby, RA, Dorfman, CS, Kelleher, SA, Fisher, HM, Rowe Nichols, KA, Keefe, FJ, Sung, AD, and Somers, TJ. "The effect of pre-transplant pain and chronic disease self-efficacy on quality of life domains in the year following hematopoietic stem cell transplantation." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 26, no. 4 (April 2018): 1243-1252. Full Text
  - Guo, M, Chao, NJ, Li, J-Y, Rizzieri, DA, Sun, Q-Y, Mohrbacher, A, Krakow, EF, Sun, W-J, Shen, X-L, Zhan, X-R, Wu, D-P, Liu, L, Wang, J, Zhou, M, Yang, L-H, Bao, Y-Y, Dong, Z, Cai, B, Hu, K-X, Yu, C-L, Qiao, J-H, Zuo, H-L, Huang, Y-J, Sung, AD, Qiao, J-X, Liu, Z-Q, Liu, T-Q, Yao, B, Zhao, H-X, Qian, S-X, Liu, W-W, Forés, R, Duarte, RF, Ai, H-S, and Microtransplantation Interest Group, . "HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia: Results From the Microtransplantation Interest Group." JAMA oncology 4, no. 1 (January 2018): 54-62. Full Text
  - Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation (December 12, 2017). Full Text
  - Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157. Full Text
  - Sivaraj, D, Green, MM, Li, Z, Sung, AD, Sarantopoulos, S, Kang, Y, Long, GD, Horwitz, ME, Lopez, RD, Sullivan, KM, Rizzieri, DA, Chao, NJ, and Gasparetto, C. "Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 262-268. Full Text
  - Krakow, EF, Ai, H-S, Shaffer, B, Delisle, J-S, Hu, K-X, and Sung, AD. "Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers." Current drug targets 18, no. 3 (January 2017): 281-295. (Review) Full Text
  - Sung, A, and Horwitz, M. "Reply to Strahilevitz and Shapira." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (December 12, 2016).
  - Sung, AD, Sung, JAM, Thomas, S, Hyslop, T, Gasparetto, C, Long, G, Rizzieri, D, Sullivan, KM, Corbet, K, Broadwater, G, Chao, NJ, and Horwitz, ME. "Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 63, no. 8 (October 2016): 999-1006. Full Text
  - Green, MMB, Chao, N, Chhabra, S, Corbet, K, Gasparetto, C, Horwitz, A, Li, Z, Venkata, JK, Long, G, Mims, A, Rizzieri, D, Sarantopoulos, S, Stuart, R, Sung, AD, Sullivan, KM, Costa, L, Horwitz, M, and Kang, Y. "Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery." Journal of hematology & oncology 9, no. 1 (August 17, 2016): 71-. Full Text Open Access Copy
  - Wild, D, Sung, AD, Cardona, D, Cirricione, C, Sullivan, K, Detweiler, C, Shealy, M, Balmadrid, B, Rowes, KL, Chao, N, Piryani, S, Karimabad, HM, Martin, P, and Poleski, M. "The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective Review." Digestive diseases and sciences 61, no. 3 (March 2016): 806-813. Full Text
  - Sung, AD, Grima, DT, Bernard, LM, Brown, S, Carrum, G, Holmberg, L, Horwitz, ME, Liesveld, JL, Kanda, J, McClune, B, Shaughnessy, P, Tricot, GJ, and Chao, NJ. "Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone." Bone Marrow Transplantation 48, no. 11 (November 1, 2013): 1444-1449. Full Text
  - Sung, AD, and Chao, NJ. "Acute graft-versus-host disease: are we close to bringing the bench to the bedside?." Best practice & research. Clinical haematology 26, no. 3 (September 2013): 285-292. (Review) Full Text
  - Rein, LA, Sung, AD, and Rizzieri, DA. "New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation." Int J Hematol Oncol 2, no. 1 (February 2013). Full Text Link to Item
  - Sung, AD, Grima, DT, Bernard, LM, Brown, S, Carrum, G, Holmberg, L, Horwitz, ME, Liesveld, JL, Kanda, J, McClune, B, and al, E. "Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone." Bone Marrow Transplantation (2013). Full Text Open Access Copy
  - Sung, AD, and Chao, NJ. "Concise review: Acute graft-versus-host disease: Immunobiology, prevention, and treatment." Stem Cells Translational Medicine 2, no. 1 (2013): 25-32. Full Text
  - Evans, MW, Sung, AD, Gojo, I, Tidwell, M, Greer, J, Levis, M, Karp, J, and Baer, MR. "Risk assessment in human immunodeficiency virus-associated acute myeloid leukemia." Leukemia & lymphoma 53, no. 4 (April 2012): 660-664. Full Text
  - DeZern, AE, Sung, A, Kim, S, Smith, BD, Karp, JE, Gore, SD, Jones, RJ, Fuchs, E, Luznik, L, McDevitt, M, and Levis, M. "Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: outcomes from 133 consecutive newly diagnosed patients from a single institution." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 17, no. 9 (September 2011): 1404-1409. Full Text
  - Sung, AD, Collins, ME, Smith, AK, Sanders, AM, Quinn, MA, Block, SD, and Arnold, RM. "Crying: experiences and attitudes of third-year medical students and interns." Teaching and learning in medicine 21, no. 3 (July 2009): 180-187. Full Text
  - Sung, AD, Anderson, ME, Zurakowski, D, Hornicek, FJ, and Gebhardt, MC. "Unicameral bone cyst: a retrospective study of three surgical treatments." Clinical orthopaedics and related research 466, no. 10 (October 2008): 2519-2526. Full Text
  - Sung, AD, Cheng, S, Moslehi, J, Scully, EP, Prior, JM, and Loscalzo, J. "Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature." The American journal of cardiology 102, no. 5 (September 2008): 643-645. Full Text

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

Selected Publications

Conference Papers

Journal Articles