Scholars@Duke
Aparna Sharad Rege

Aparna Sharad Rege

Assistant Professor of Surgery
Surgery, Abdominal Transplant Surgery
aparna.rege@duke.edu
228 Hanes House, Box 3522, Durham, NC 27710

Selected Publications

Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

Journal Article Am J Kidney Dis · May 2023 There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest i ... Full text Link to item Cite

Preemptive VAE-An Important Tool for Managing Blood Loss in MVT Candidates With PMT.

Journal Article Transplant Direct · March 2021 UNLABELLED: Explantation of native viscera in multivisceral transplant candidates, particularly in those with extensive portomesenteric thrombosis (PMT), carries considerable morbidity due to extensive vascularized adhesions. Preemptive visceral angioembol ... Full text Link to item Cite

Global kidney exchange should expand wisely.

Journal Article Transpl Int · September 2020 Full text Link to item Cite

Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.

Journal Article Am J Transplant · March 2020 This study aimed to understand the relationship of preoperative measurements and risk factors on operative time and outcomes of laparoscopic donor nephrectomy. Two hundred forty-two kidney donors between 2010 and 2017 were identified. Patients' demographic ... Full text Open Access Link to item Cite

Elderly Transplant Recipients

Chapter · January 1, 2020 There is a proven benefit of transplantation for the elderly in terms of quality of life and survival advantage over alternative therapies like dialysis. Frailty, comorbidity, access to transplantation, increasing wait time, and delayed allograft function ... Full text Cite

The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization.

Journal Article Ann Surg · June 2018 OBJECTIVE: The aim of this study was to investigate the volume-outcome relationship in kidney transplantation by examining graft and patient outcomes using standardized risk adjustment (observed-to-expected outcomes). A secondary objective was to examine t ... Full text Link to item Cite

Effects of Ideal Versus Total Body Weight Dosage of Rabbit Antithymocyte Globulin on Outcomes of Kidney Transplant Patients With High Immunologic Risk.

Journal Article Exp Clin Transplant · October 2016 OBJECTIVES: The optimal dose of rabbit antithymocyte globulin induction therapy in kidney transplant recipients with high immunologic risk lacks consensus. The purpose of this study was to evaluate the effect of using ideal body weight rather than total bo ... Full text Link to item Cite

Intestinal transplantation.

Journal Article Best Pract Res Clin Gastroenterol · April 2016 Intestinal transplantation has now emerged as a lifesaving therapeutic option and standard of care for patients with irreversible intestinal failure. Improvement in survival over the years has justified expansion of the indications for intestinal transplan ... Full text Link to item Cite

Pediatric small bowel transplantation: An update

Chapter · January 1, 2016 Most pediatric patients with irreversible intestinal failure are dependent on parenteral nutrition (PN) and eventually develop life-threatening complications from long-term PN. Intestinal transplantation is now an accepted treatment for the pediatric popul ... Full text Cite

Update on surgical therapies for intestinal failure.

Journal Article Curr Opin Organ Transplant · June 2014 PURPOSE OF REVIEW: Parenteral nutrition enables long-term survival in patients with intestinal failure; however, it is associated with life-threatening complications necessitating alternative techniques of management to enable weaning parenteral nutrition ... Full text Link to item Cite

Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia.

Journal Article Pediatr Transplant · March 2014 The most common identifiable causes of acute liver failure in pediatric patients are infection, drug toxicity, metabolic disease, and autoimmune processes. In many cases, the etiology of acute liver failure cannot be determined. Acute leukemia is an extrem ... Full text Link to item Cite

The surgical approach to short bowel syndrome-autologous reconstruction versus transplantation

Journal Article Viszeralmedizin: Gastrointestinal Medicine and Surgery · January 1, 2014 Background: Short bowel syndrome (SBS) is a state of malabsorption resulting from massive small bowel resection leading to parenteral nutrition (PN) dependency. Considerable advances have been achieved in the medical and surgical management of SBS over the ... Full text Cite

Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.

Journal Article Am J Transplant · March 2013 Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hy ... Full text Link to item Cite

Autologous gastrointestinal reconstruction: review of the optimal nontransplant surgical options for adults and children with short bowel syndrome.

Journal Article Nutr Clin Pract · February 2013 Short bowel syndrome (SBS) results in loss of absorptive capacity of the development of gut, leading to malabsorption due to protein, energy, fluid, and electrolyte loss and imbalance while on enteral diet alone. Various nonsurgical and surgical therapeuti ... Full text Link to item Cite

Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases.

Journal Article Am J Transplant · August 2012 Restoring abdominal wall cover and contour in children undergoing bowel and multivisceral transplantation is often challenging due to discrepancy in size between donor and recipient, poor musculature related to birth defects and loss of abdominal wall inte ... Full text Link to item Cite

Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules.

Journal Article Ann Thorac Surg · June 2012 Benign metastasizing leiomyoma (BML) is a rare cause of pulmonary nodules that occurs when uterine leiomyomas metastasize to the lung. The management of these lesions varies from resection and hysterectomy to nonsurgical treatments such as hormonal therapy ... Full text Link to item Cite