Ares D. Pasipoularides | Scholars@Duke

Ares D. Pasipoularides
Associate Research Professor Emeritus of Surgery

Cardiovascular physiology and pathophysiology; cardiovascular disease; coronary arterial disease; ventricular function; systolic performance and loading; diastolic performance and loading; systolic ejection dynamics; diastolic filling dynamics; arterial dynamics; ventriculo-arterial coupling; myocardial mechanics and properties; cardiac fluid dynamics and computational fluid dynamics; supercomputing simulations of normal and abnormal intracardiac flows; functional imaging of ventricular function.

Prof. Ares Pasipoularides, M.D., Ph.D., F.A.C.C. has made important advances in cardiac research, hemodynamics and genomics by applying methods and principles of chemical engineering, applied mechanics and fluid dynamics to the study of cardiovascular function in health and disease. Throughout his career, he has enjoyed teaching medical, graduate, and undergraduate students and cardiology and cardiac surgery trainees. He received both the M.D., and the Ph.D. (Mathematical Hemodynamics and Chemical Engineering) degrees at the University of Minnesota Medical and Graduate Schools in Minneapolis, respectively, and his postgraduate training in Internal Medicine at Brown University and affiliated hospitals. He is fluent in French, German and Greek, and has reading knowledge of Dutch, Italian, Spanish and Latin.

He has served as an editorial leader for numerous national and international journals and has served as NIH scientific consultant and member of the Study Sections of Cardiac Contractility and Heart Failure, and Surgical Sciences, and Biotechnology.

Before coming to Duke, he was professor of Engineering at Brown University (Section of Fluid Mechanics and Heat Transfer), on the Faculty at Harvard Medical School (the Department of Medicine, the Division of Mathematical Biology, and the New England Regional Primate Research Center), and Associate in Medicine at the Peter Bent Brigham Hospital (Department of Medicine) and the Massachusetts General Hospital (Cardiac Unit); Director of Cardiovascular Research at Brooke Army Medical Center (Cardiology Service, Department of Medicine), Fort Sam Houston, San Antonio, Texas, and professor of Medicine (Cardiovascular Division) at the UTHSC at San Antonio.

At Duke, he has been professor of Medicine (Cardiovascular Division) and of Surgery (Division of Cardiac and Thoracic Surgery) in the School of Medicine, and of Biomedical Engineering in the Duke School of Engineering, and the Director of Cardiac Function at the Duke/NSF Engineering Research Center for Emerging Cardiovascular Technologies.

In all these Institutions, he has taught formal courses in cardiovascular fluid mechanics, clinical hemodynamics, cardiovascular physiology and medicine, mathematical modeling of cardiovascular function in health and disease, computational fluid dynamics of intracardiac flows in health and disease, and artificial organs biotechnology to thousands of medical, science and engineering graduate and undergraduate students, academic cardiologists, anesthesiologists, cardiac imaging specialists, and cardiac surgeons.

His students/fellows at Brown, Harvard, University of Texas and Duke have included trainees at every level of postgraduate medical and graduate engineering, science and applied mathematics education.

He has supervised and participated in the Master’s and PhD Thesis Committees (as Chairman, or member) of numerous graduate biomedical engineering, biomedical science and radiology (cardiac imaging) students at Duke University Graduate School.

He has taught formal academic courses in the Division of Engineering at Brown University, and at the School of Engineering at Duke University, and organized and delivered teaching seminars in the Division of Biology and Medicine at Brown, at the New England Primate Research Center of Harvard Medical School, at the Cardiac Unit of the Massachusetts General Hospital, at the Cardiology Service at Brooke Army Medical Center and the UTHSC at San Antonio (Cardiovascular Division), and at the Cardiac Catheterization Laboratory at Duke School of Medicine and Medical Center.

Current Appointments & Affiliations

Associate Research Professor Emeritus of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2003

Contact Information

4554 Hospital South, Durham, NC 27710
Box 3851 Med Ctr, Durham, NC 27710
apasipou@duke.edu (919) 681-5789

Background
Education, Training, & Certifications
- Ph.D., University of Minnesota, Twin Cities 1972
- M.D., University of Minnesota, Twin Cities 1971
Previous Appointments & Affiliations
- Consulting Professor in the Department of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2009 - 2010
- Associate Research Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 1997 - 2003
- Assistant Research Professor of Experimental Surgery in the Department of Surgery, Surgery, Section of Surgical Disciplines 1993 - 1997
- Associate Research Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1995 - 1997
- Associate Research Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1993 - 1994
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1988 - 1993
- Assistant Professor of Experimental Surgery in the Department of Surgery, Surgery, Section of Surgical Disciplines 1992 - 1993
- Assistant Clinical Professor in Medicine, Medicine, Clinical Science Departments 1989 - 1992
Research
Selected Grants
- Systolic Mechanics of the Failing Right Ventricle. awarded by National Institutes of Health 1997 - 2001
- Cardiac Energetics And Mechanics In Congestive Failure awarded by National Institutes of Health 1998 - 1999
- New Models of RV Diastolic Function in Heart Failure awarded by National Heart, Lung, and Blood Institute (NHLBI) 1994 - 1998
- New Models of RV Diastolic Function in Heart Failure awarded by National Institutes of Health 1994 - 1997
- New Models of RV Diastolic Function in Heart Failure awarded by National Institutes of Health 1994 - 1997
- Support of Pilot Studies for NIH Grant Entilled: Aortic Stenosis in Old Age: Basic & Clinical Studies awarded by Lord Foundation of North Carolina 1991 - 1992
Publications & Artistic Works
Selected Publications
- Books
  - Pasipoularides, Ares. Heart's Vortex: Intracardiac Blood Flow Phenomena. PMPH-USA, 2009.
- Academic Articles
  - Pasipoularides, A. “COVID-19, Big Data: how it will change the way we practice Medicine.” Qjm 114, no. 5 (August 29, 2021): 293–95. https://doi.org/10.1093/qjmed/hcaa299.
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  - Pasipoularides, Ares. “Emulating Leonardo da Vinci (1452-1519): the convergence of science and art in biomedical research and practice.” Cardiovasc Res 115, no. 14 (December 1, 2019): e181–83. https://doi.org/10.1093/cvr/cvz275.
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  - Pasipoularides, Ares. “Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins.” J Mol Cell Cardiol 133 (August 2019): 233–46. https://doi.org/10.1016/j.yjmcc.2019.05.022.
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  - Pasipoularides, Ares. “Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.” J Mol Cell Cardiol 133 (August 2019): 223–32. https://doi.org/10.1016/j.yjmcc.2019.05.017.
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  - Pasipoularides, Ares. “Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective.” J Mol Cell Cardiol 126 (January 2019): 23–35. https://doi.org/10.1016/j.yjmcc.2018.10.024.
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  - Pasipoularides, Ares. “The new era of whole-exome sequencing in congenital heart disease: brand-new insights into rare pathogenic variants.” J Thorac Dis 10, no. Suppl 17 (June 2018): S1923–29. https://doi.org/10.21037/jtd.2018.05.56.
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  - Pasipoularides, Ares. “Challenges and Controversies in Hypertrophic Cardiomyopathy: Clinical, Genomic and Basic Science Perspectives.” Rev Esp Cardiol (Engl Ed) 71, no. 3 (March 2018): 132–38. https://doi.org/10.1016/j.rec.2017.07.003.
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  - Pasipoularides, Ares. “Implementing genome-driven personalized cardiology in clinical practice.” J Mol Cell Cardiol 115 (February 2018): 142–57. https://doi.org/10.1016/j.yjmcc.2018.01.008.
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  - Pasipoularides, Ares. “Know Me! Unraveling the Riddle of Calcific Aortic Valve Disease by Bioinformatics.” Tohoku J Exp Med 243, no. 4 (December 2017): 255–61. https://doi.org/10.1620/tjem.243.255.
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  - Pasipoularides, Ares. “Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.” Int J Cardiol 230 (March 1, 2017): 384–401. https://doi.org/10.1016/j.ijcard.2016.12.097.
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  - Pasipoularides, Ares. “Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.” J Cardiovasc Transl Res 9, no. 4 (August 2016): 374–99. https://doi.org/10.1007/s12265-016-9695-z.
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  - Pasipoularides, Ares. “Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.” J Cardiovasc Transl Res 9, no. 2 (April 2016): 102–18. https://doi.org/10.1007/s12265-016-9679-z.
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  - Pasipoularides, Ares. “William Campbell Little, M.D. In Memoriam.” J Cardiovasc Transl Res 8, no. 9 (December 2015): 569. https://doi.org/10.1007/s12265-015-9645-1.
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  - Pasipoularides, Ares. “Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions.” J Cardiovasc Transl Res 8, no. 9 (December 2015): 506–27. https://doi.org/10.1007/s12265-015-9658-9.
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  - Pasipoularides, Ares. “Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.” J Cardiovasc Transl Res 8, no. 5 (July 2015): 293–318. https://doi.org/10.1007/s12265-015-9630-8.
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  - Pasipoularides, Ares, Pavlos P. Vlachos, and William C. Little. “Vortex formation time is not an index of ventricular function.” J Cardiovasc Transl Res 8, no. 1 (February 2015): 54–58. https://doi.org/10.1007/s12265-015-9607-7.
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  - Pasipoularides, Ares. “Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1.” J Cardiovasc Transl Res 8, no. 1 (February 2015): 76–87. https://doi.org/10.1007/s12265-015-9611-y.
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  - Pasipoularides, Ares. “Fluid dynamics of ventricular filling in heart failure: overlooked problems of RV/LV chamber dilatation.” Hellenic J Cardiol 56, no. 1 (January 2015): 85–95.
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  - Pasipoularides, Ares. “Galen, father of systematic medicine. An essay on the evolution of modern medicine and cardiology.” Int J Cardiol 172, no. 1 (March 1, 2014): 47–58. https://doi.org/10.1016/j.ijcard.2013.12.166.
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  - Pasipoularides, Ares. “Historical continuity in the methodology of modern medical science: Leonardo leads the way.” Int J Cardiol 171, no. 2 (February 1, 2014): 103–15. https://doi.org/10.1016/j.ijcard.2013.11.133.
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  - Pasipoularides, Ares. “Greek underpinnings to his methodology in unraveling De Motu Cordis and what Harvey has to teach us still today.” Int J Cardiol 168, no. 4 (October 9, 2013): 3173–82. https://doi.org/10.1016/j.ijcard.2013.07.253.
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  - Pasipoularides, Ares. “Evaluation of right and left ventricular diastolic filling.” J Cardiovasc Transl Res 6, no. 4 (August 2013): 623–39. https://doi.org/10.1007/s12265-013-9461-4.
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  - Pasipoularides, Ares. “Historical Perspective: Harvey's epoch-making discovery of the Circulation, its historical antecedents, and some initial consequences on medical practice.” J Appl Physiol (1985) 114, no. 11 (June 2013): 1493–1503. https://doi.org/10.1152/japplphysiol.00216.2013.
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  - Pasipoularides, Ares. “Right and left ventricular diastolic flow field: why are measured intraventricular pressure gradients small?” Rev Esp Cardiol (Engl Ed) 66, no. 5 (May 2013): 337–41. https://doi.org/10.1016/j.rec.2012.07.011.
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  - Pasipoularides, Ares. “Right and left ventricular diastolic pressure-volume relations: a comprehensive review.” J Cardiovasc Transl Res 6, no. 2 (April 2013): 239–52. https://doi.org/10.1007/s12265-012-9424-1.
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  - Pasipoularides, Ares. “Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus.” Hellenic J Cardiol 53, no. 6 (November 2012): 458–69.
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  - Pasipoularides, Ares. “Optimal hematocrit: a Procrustean bed for maximum oxygen transport rate?” J Appl Physiol (1985) 113, no. 3 (August 2012): 353–54. https://doi.org/10.1152/japplphysiol.00654.2012.
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  - Pasipoularides, Ares. “LV twisting and untwisting in HCM: ejection begets filling. Diastolic functional aspects of HCM.” Am Heart J 162, no. 5 (November 2011): 798–810. https://doi.org/10.1016/j.ahj.2011.08.019.
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  - Pasipoularides, Ares. “Fluid dynamic aspects of ejection in hypertrophic cardiomyopathy.” Hellenic J Cardiol 52, no. 5 (September 2011): 416–26.
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  - Pasipoularides, Ares. “To the editor: functional imaging(FI) combines imaging datasets and computational fluid dynamics to simulate cardiac flows.” J Appl Physiol (1985) 105, no. 3 (September 2008): 1015. https://doi.org/10.1152/japplphysiol.zdg-8134-vpcomm.2008.
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  - Pasipoularides, Ares. “Complementarity and competitiveness of the intrinsic and extrinsic components of the total ventricular load: demonstration after valve replacement in aortic stenosis.” Am Heart J 153, no. 1 (January 2007): 4–6. https://doi.org/10.1016/j.ahj.2006.10.035.
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  - Pasipoularides, Ares, Ming Shu, Ashish Shah, Alessandro Tucconi, and Donald D. Glower. “RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models.” Am J Physiol Heart Circ Physiol 285, no. 5 (November 2003): H1956–65. https://doi.org/10.1152/ajpheart.00372.2003.
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  - Pasipoularides, Ares, Ming Shu, Ashish Shah, Michael S. Womack, and Donald D. Glower. “Diastolic right ventricular filling vortex in normal and volume overload states.” Am J Physiol Heart Circ Physiol 284, no. 4 (April 2003): H1064–72. https://doi.org/10.1152/ajpheart.00804.2002.
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  - Pasipoularides, Ares D., Ming Shu, Michael S. Womack, Ashish Shah, Olaf Von Ramm, and Donald D. Glower. “RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations.” Am J Physiol Heart Circ Physiol 284, no. 1 (January 2003): H56–65. https://doi.org/10.1152/ajpheart.00577.2002.
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  - Pasipoularides, Ares D., Ming Shu, Ashish Shah, and Donald D. Glower. “Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia.” J Thorac Cardiovasc Surg 124, no. 5 (November 2002): 964–72. https://doi.org/10.1067/mtc.2002.126677.
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  - Pasipoularides, Ares, Ming Shu, Ashish Shah, Scott Silvestry, and Donald D. Glower. “Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.” Am J Physiol Heart Circ Physiol 283, no. 5 (November 2002): H2140–50. https://doi.org/10.1152/ajpheart.00462.2002.
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  - Shu, Ming, Badri Ramaswami, Shuchi Shah, Craig E. Fleishman, Takahiro Ota, Jefferey E. Bischoff, George Stetten, Olaf T. Von Ramm, and Ares D. Pasipoularides. “Tricuspid velocity profiles reflect right ventricular diastolic wall motion abnormalities: Real-time 3D echocardiography and computational fluid dynamics.” Circulation 96, no. 8 SUPPL (1997): i534–i534.
  - Bischoff, J. E., M. Shu, B. Ramaswami, J. R. Costello, P. T. Pennington, E. Lilly, and A. D. Pasipoularides. “Effect of subacute pressure overload and release on RV relaxation and filling patterns.” Journal of Cardiovascular Diagnosis and Procedures 13 (1996): 295–295.
  - Pennington, P. T., J. E. Bischoff, A. Kypson, M. Shu, B. Ramaswami, and A. D. Pasipoularides. “Diastolic ventricular morphometry: Analysis of polymeric and paraffin casting.” Journal of Cardiovascular Diagnosis and Procedures 13 (1996): 285–285.
  - Ramaswami, B., M. Shu, P. T. Pennington, J. E. Bischoff, D. D. Glower, and A. D. Pasipoularides. “Geometric modeling of the right ventricle and CFD simulation of the early diastolic inflow.” Journal of Cardiovascular Diagnosis and Procedures 13 (1996): 296–296.
  - Shu, M., J. E. Bischoff, B. Ramaswami, P. T. Pennington, J. R. Costello, D. D. Glower, and A. D. Pasipoularides. “New methods for assessment of RV relaxation and pressure-volume relations.” Journal of Cardiovascular Diagnosis and Procedures 13 (1996): 294–294.
  - Shu, Ming, George D. Stetten, Chikai J. Ohazama, Jeffrey E. Bischoff, Badri Ramaswami, Olaf T. Von Ramm, and Ares D. Pasipoularides. “Digital geometric models using biventricular real-time 3D echocardiography.” Circulation 94, no. 8SUPPL (1996): I211–I211.
  - Pasipoularides, A., R. Uppal, C. Straley, T. Hampton, M. Shu, D. Glower, and P. K. Smith. “Right and left ventricular diastolic pressure-volume relations.” Circulation 92, no. 1 (1995): 72–72.
  - Ihara, T., R. P. Shannon, K. Komamura, A. Pasipoularides, T. Patrick, Y. T. Shen, and S. F. Vatner. “Effects of anaesthesia and recent surgery on diastolic function.” Cardiovasc Res 28, no. 3 (March 1994): 325–36. https://doi.org/10.1093/cvr/28.3.325.
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  - Hampton, T., Y. T. Shim, R. Raziano, R. Uppal, D. Craig, D. Glower, P. K. Smith, and A. Pasipoularides. “Finite-element analysis of ventricular ejection.” Circulation 90, no. 4 (1994): 12–12.
  - Shim, Y., A. Pasipoularides, C. A. Straley, T. G. Hampton, P. F. Soto, C. H. Owen, J. W. Davis, and D. D. Glower. “Arterial windkessel parameter estimation: a new time-domain method.” Ann Biomed Eng 22, no. 1 (January 1994): 66–77. https://doi.org/10.1007/BF02368223.
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  - Pasipoularides, Ares, R. Uppal, C. Straley, D. Craig, T. Hampton, Y. Shim, D. Glower, and P. K. Smith. “Left-ventricular filling dynamics - sigmoidal pressure-volume relations.” Circulation 88, no. 4 (1993): 57–57.
  - Pasipoularides, Ares, Rakesh Uppal, Craig Straley, Damian Craig, Thomas Hampton, Youngtack Shim, Donald Glower, and Peter K. Smith. “Left ventricular filling dynamics: sigmoidal pressure-volume relations.” Circulation 88, no. 4 PART 2 (1993): I57–I57.
  - Shim, Youngtack, Ares Pasipoularides, Craig Straley, Thomas Hampton, Owen Clarence, James Davis, and Donald Glower. “New method for evaluation of arterial properties by three-element windkessel.” Journal of the American College of Cardiology 21, no. 2 Suppl A (1993): 61A-61A.
  - Shim, Youngtack, Ares Pasipoularides, Craig Straley, Thomas Hampton, Owen Clarence, James Davis, and Donald Glower. “New method for evaluation of arterial properties by three-element windkessel.” Journal of the American College of Cardiology 21, no. 2 Suppl A (1993): 61A-61A.
  - Uppal, Rakesh, Damian Craig, Donald Glower, Hide Utsunomiya, Ares Pasipoularides, David C. Sabiston, Jr., and Peter K. Smith. “Right ventricular systolic performance in a porcine model.” Journal of the American College of Cardiology 21, no. 2 Suppl A (1993): 421A-421A.
  - Hampton, T., Y. Shim, C. Straley, and A. Pasipoularides. “Finite element analysis of cardiac ejection dynamics: Ultrasonic implications.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 22 (December 1, 1992): 371–74.
  - Shim, Y., T. G. Hampton, C. A. Straley, J. K. Harrison, L. A. Spero, T. M. Bashore, and A. D. Pasipoularides. “Ejection load changes in aortic stenosis. Observations made after balloon aortic valvuloplasty.” Circ Res 71, no. 5 (November 1992): 1174–84. https://doi.org/10.1161/01.res.71.5.1174.
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  - Komamura, K., R. P. Shannon, A. Pasipoularides, T. Ihara, A. S. Lader, T. A. Patrick, S. P. Bishop, and S. F. Vatner. “Alterations in left ventricular diastolic function in conscious dogs with pacing-induced heart failure.” J Clin Invest 89, no. 6 (June 1992): 1825–38. https://doi.org/10.1172/JCI115787.
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  - Craig, D., R. Uppal, D. Glower, C. Straley, T. Hampton, A. Pasipoularides, and P. K. Smith. “Simultaneous computation of right and left-ventricular systolic function.” Computers in Cardiology Proceedings (1992): 511–14.
  - Georgiadis, J. G., M. Wang, and A. Pasipoularides. “Computational fluid dynamics of left ventricular ejection.” Ann Biomed Eng 20, no. 1 (1992): 81–97. https://doi.org/10.1007/BF02368507.
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  - Hampton, T., R. Uppal, Y. Shim, C. Straley, D. Craig, P. K. Smith, and A. Pasipoularides. “Heart-rate Effects on right and left-ventricular relaxation dynamics.” Circulation 86, no. 4 (1992): 529–529.
  - Hampton, T., Y. Shim, C. Straley, and A. Pasipoularides. “Finite element analysis of cardiac ejection dynamics: ultrasonic implications.” Advances in Bioengineering, Bed 22 (1992): 371–74.
  - Pasipoularides, A. “Cardiac mechanics: basic and clinical contemporary research.” Ann Biomed Eng 20, no. 1 (1992): 3–17. https://doi.org/10.1007/BF02368503.
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  - Shim, Y., R. Uppal, D. Craig, T. Hampton, C. Straley, D. C. Sabiston, P. K. Smith, and A. Pasipoularides. “Ejection dynamics and systolic load during arterial vasodilation.” Circulation 86, no. 4 (1992): 461–461.
  - Shim, Yountack, Rakesh Uppal, Damian Craig, Thomas Hampton, Craig Straley, David C. Sabiston, Jr, Peter K. Smith, and Ares Pasipoularides. “Ejection dynamics and systolic load during arterial vasodilation.” Circulation 86, no. 4 SUPPL 1 (1992): I461–I461.
  - Straley, C., R. Uppal, T. Hampton, Y. Shim, D. Craig, P. K. Smith, and A. Pasipoularides. “Comparison of left and right ventricular compliances.” Circulation 86, no. 4 (1992): 726–726.
  - Straley, Craig, Rakesh Uppal, Thomas Hampton, Youngtack Shim, Damian Craig, Peter K. Smith, and Ares Pasipoularides. “Comparison of left and right ventricular compliances.” Circulation 86, no. 4 SUPPL 1 (1992): I726–I726.
  - Hintze, T. H., J. M. Stewart, A. V. Loud, M. Gewitz, M. Schustek, Y. Shim, and A. Pasipoularides. “Correlation between atrial appendage wall stress and tissue ANF content.” The Faseb Journal 6, no. 4 (1992): A1234–A1234.
  - Ihara, T., K. Komamura, R. P. Shannon, Y. T. Shen, A. Pasipoularides, T. A. Patrick, and S. F. Vatner. “Anesthesia impairs diastolic function independently of loading conditions and depressed contractility.” The Faseb Journal 6, no. 4 (1992): A1232–A1232.
  - Gelpi, R. J., A. Pasipoularides, A. S. Lader, T. A. Patrick, N. Chase, L. Hittinger, R. P. Shannon, S. P. Bishop, and S. F. Vatner. “Changes in diastolic cardiac function in developing and stable perinephritic hypertension in conscious dogs.” Circ Res 68, no. 2 (February 1991): 555–67. https://doi.org/10.1161/01.res.68.2.555.
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  - Pasipoularides, Ares, William G. Kussmaul, Barry S. Myers, Brian J. Doherty, Thomas L. Stoughton, and Warren K. Laskey. “Phasik characteristics of transaortic pressure gradients in valvular aortic stenosis.” Journal of the American College of Cardiology 17, no. 2 (February 1991): A254–A254. https://doi.org/10.1016/0735-1097(91)91983-l.
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  - Isaaz, K., and A. Pasipoularides. “Noninvasive assessment of intrinsic ventricular load dynamics in dilated cardiomyopathy.” J Am Coll Cardiol 17, no. 1 (January 1991): 112–21. https://doi.org/10.1016/0735-1097(91)90712-i.
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  - Pasipoularides, Ares, W. G. Kussmaul, B. S. Myers, B. J. Doherty, and T. L. Stoughton. “Phasic characteristics of transaortic pressure gradients in valvular aortic stenosis.” Journal of the American College of Cardiology 17, no. 2 Suppl A (1991): 254A-254A.
  - Komamura, K., R. P. Shannon, A. Pasipoularides, and S. F. Vatner. “Diastolic Dysfunction in pacing-induced heart-failure is due to loading conditions.” Clinical Research 39, no. 2 (1991): A261–A261.
  - Pasipoularides, A. “Clinical assessment of ventricular ejection dynamics with and without outflow obstruction.” J Am Coll Cardiol 15, no. 4 (March 15, 1990): 859–82. https://doi.org/10.1016/0735-1097(90)90287-y.
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  - Gelpi, R. J., A. Pasipoularides, A. S. Lader, T. A. Patrick, N. Chase, L. Hittinger, R. P. Shannon, S. P. Bishop, and S. F. Vatner. “Changes in diastolic function in conscious dogs with developing and stable hypertension.” Circulation 82, no. 4 SUPPL 3 (1990): III206–III206.
  - Isaaz, K., and A. Pasipoularides. “Left ventricular outflow acceleration in dilated cardiomyopathy its relationship with intrinsic ventricular load dynamics.” European Heart Journal 11 (1990): 427–427.
  - Komamura, K., R. P. Shannon, A. S. Lader, S. P. Bishop, A. Pasipoularides, and S. F. Vatner. “Diastolic dysfunction in conscious dogs with pacing-induced cardiomyopathy.” Circulation 82, no. 4 SUPPL 3 (1990): III112–III112.
  - Mirsky, I., and A. Pasipoularides. “Clinical assessment of diastolic function.” Prog Cardiovasc Dis 32, no. 4 (January 1990): 291–318. https://doi.org/10.1016/0033-0620(90)90018-w.
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  - Pasipoularides, Ares, D. C. Thomas, C. L. Dandrea, J. K. Harrison, L. A. Spero, M. B. Harding, and T. M. Bashore. “Ventricular ejection load changes after balloon aortic valvuloplasty.” Circulation 82, no. 4 SUPPL 3 (1990): III724–III724.
  - Gelpi, R. J., A. Pasipoularides, A. S. Lader, T. A. Patrick, N. Chase, L. Hittinger, R. P. Shannon, S. P. Bishop, and S. F. Vatner. “Changes in diastolic function in conscious dogs with developing and stable hypertension.” Circulation 82, no. 4 (1990): 206–206.
  - Komamura, K., R. P. Shannon, A. S. Lader, S. P. Bishop, A. Pasipoularides, and S. F. Vatner. “Diastolic dysfunction in conscious dogs with pacing-induced cardiomyopathy.” Circulation 82, no. 4 (1990): 112–112.
  - Pasipoularides, Ares, D. C. Thomas, C. L. Dandrea, J. K. Harrison, L. A. Spero, M. B. Harding, and T. M. Bashore. “Ventricular ejection load changes after baloon aortic valvuloplasty.” Circulation 82, no. 4 (1990): 724–724.
  - Morera, J., S. D. Hoadley, J. M. Roland, A. Pasipoularides, R. Darragh, G. Gaitan, and D. R. Pieroni. “Estimation of the ratio of pulmonary to systemic pressures by pulsed-wave Doppler echocardiography for assessment of pulmonary arterial pressures.” Am J Cardiol 63, no. 12 (April 1, 1989): 862–66. https://doi.org/10.1016/0002-9149(89)90058-1.
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  - Moody, Jr, J. M., A. Pasipoularides, and J. P. Johns. “Left ventricular isovolumic contraction period vanishes during intense exercise.” Journal of the American College of Cardiology 13, no. 2 Suppl A (1989): 102A-102A.
  - Morera, J., A. Pasipoularides, and S. D. Hoadley. “Assessment of right ventricular to aortic systolic pressure ratio by pulsed Doppler echocardiography: A noninvasive method for calculation of right ventricular or pulmonary arterial systolic pressures.” American Journal of Cardiology 63 (1989): 862–66.
  - Pasipoularides, A. “On mechanisms of improved ejection fraction by early reperfusion in acute myocardial infarction: myocardial salvage or infarct stiffening?” J Am Coll Cardiol 12, no. 4 (October 1988): 1037–38. https://doi.org/10.1016/0735-1097(88)90473-1.
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  - Pasipoularides, A., and I. Mirsky. “Models and concepts of diastolic mechanics: Pitfalls in their misapplication.” Mathematical and Computer Modelling 11, no. C (January 1, 1988): 232–34. https://doi.org/10.1016/0895-7177(88)90488-8.
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  - Condos, W. R., R. D. Latham, S. D. Hoadley, and A. Pasipoularides. “Hemodynamics of the Mueller maneuver in man: right and left heart micromanometry and Doppler echocardiography.” Circulation 76, no. 5 (November 1987): 1020–28. https://doi.org/10.1161/01.cir.76.5.1020.
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  - Pasipoularides, A., J. P. Murgo, J. W. Miller, and W. E. Craig. “Nonobstructive left ventricular ejection pressure gradients in man.” Circ Res 61, no. 2 (August 1987): 220–27. https://doi.org/10.1161/01.res.61.2.220.
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  - Hoadley, S. D., and A. Pasipoularides. “Are ejection phase doppler-echo indices sensitive markers of contractile dysfunction in cardiomyopathy? Role of afterload mismatch.” Circulation 76, no. 4 Part 2 (1987): IV-404-IV–404.
  - Hoadley, S. D., and A. Pasipoularides. “Are ejection phase doppler echo indexes sensitive markers of contractile dysfunction in cardiomyopathy - role of afterload mismatch.” Circulation 76, no. 4 (1987): 404–404.
  - Krouse, J. R., W. E. Craig, A. Pasipoularides, J. P. Murlow, and J. P. Murgo. “Right ventricular hemodynamic abnormalities in hypertrophic cardiomyopathy.” Journal of the American College of Cardiology 9, no. 2 (1987): A231–A231.
  - Pasipoularides, A., I. Mirsky, O. M. Hess, J. Grimm, and H. P. Krayenbuehl. “Myocardial relaxation and passive diastolic properties in man.” Circulation 74, no. 5 (November 1986): 991–1001. https://doi.org/10.1161/01.cir.74.5.991.
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  - Pasipoularides, Ares, R. Latham, and R. Schatz. “The genesis of aortic root pressure waveform patterns in man.” American Heart Association Monograph 124 (1986): II-166-II–166.
  - Pasipoularides, Ares, R. Latham, and R. Schatz. “The genesis of aortic root pressure wave-form patterns in man.” Circulation 74, no. 4 (1986): 166–166.
  - Pasipoularides, Ares, and R. Latham. “External left-ventricular load during Mueller and valsalva maneuvers in man.” Circulation 74, no. 4 (1986): 441–441.
  - Paulus, W. J., W. Grossman, T. Serizawa, P. D. Bourdillon, A. Pasipoularides, and I. Mirsky. “Different effects of two types of ischemia on myocardial systolic and diastolic function.” Am J Physiol 248, no. 5 Pt 2 (May 1985): H719–28. https://doi.org/10.1152/ajpheart.1985.248.5.H719.
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  - Morera, J., A. Pasipoularides, S. D. Hoadley, and J. P. Murgo. “Quantitative calculation of systolic right ventricular pulmonary-artery pressure by doppler echocardiography.” Circulation 72, no. 4 (1985): 351–351.
  - Pasipoularides, A., I. Palacios, W. Frist, S. Rosenthal, J. B. Newell, and W. J. Powell. “Contribution of activation-inactivation dynamics to the impairment of relaxation in hypoxic cat papillary muscle.” Am J Physiol 248, no. 1 Pt 2 (January 1985): R54–62. https://doi.org/10.1152/ajpregu.1985.248.1.R54.
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  - Morera, J., A. Pasipoularides, S. D. Hoadley, and J. P. Murgo. “Quantitative calculation of systolic right ventricular-pulmonary artery pressure by doppler echocardiography.” American Heart Association Monograph, no. 114 (1985): III-351-III–351.
  - Pasipoularides, A., J. P. Murgo, J. J. Bird, and W. E. Craig. “Fluid dynamics of aortic stenosis: mechanisms for the presence of subvalvular pressure gradients.” Am J Physiol 246, no. 4 Pt 2 (April 1984): H542–50. https://doi.org/10.1152/ajpheart.1984.246.4.H542.
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  - Pasipoularides, Ares, J. Miller, B. J. Rubal, and J. P. Murgo. “Left-ventricular (LV) ejection pressure-gradients in normal man are determined by geometry, wall kinematics and velocity patterns.” Circulation 70, no. 4 (1984): 354–354.
  - Vatner, S. F., A. Pasipoularides, and I. Mirsky. “Measurement of arterial pressure-dimension relationships in conscious animals.” Ann Biomed Eng 12, no. 5 (1984): 521–34. https://doi.org/10.1007/BF02363921.
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  - Pasipoularides, Ares, J. Miller, B. J. Rubal, and J. P. Murgo. “Left ventricular ejection pressure gradients in normal man are determined by geometry wall kinematics and velocity patterns.” American Heart Association Monograph, no. 107 (1984): II-354-II–354.
  - Pasipoularides, A., J. P. Murgo, J. J. Bird, and W. E. Graig. “Fluid dynamics of aortic stenosis: Mechanisms of subvalvular gradient generation.” Journal of Biomechanics 16, no. 4 (January 1983): 280–280. https://doi.org/10.1016/0021-9290(83)90138-0.
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  - Pasipoularides, Ares, J. P. Murgo, and B. J. Rubal. “Left ventricular systolic dynamics and intrinsic hydrodynamic loading.” Federation Proceedings 42, no. 4 (1983): 2758–2758.
  - Pasipoularides, Ares, S. Damore, J. Miller, B. J. Rubal, and J. P. Murgo. “Left-ventricular (LV) systolic dynamics in normal man.” Circulation 68, no. 4 (1983): 305–305.
  - Pagani, M., P. Pizzinelli, M. Gussoni, W. E. Craig, A. Pasipoularides, and J. P. Murgo. “Diastolic abnormalities of hypertrophic cardiomyopathy reproduced by asynchrony of the left-ventricle in conscious dogs.” Journal of the American College of Cardiology 1, no. 2 (1983): 641–641.
  - Pasipoularides, Ares, J. P. Murgo, and B. J. Rubal. “Left-ventricular systolic dynamics and intrinsic hydrodynamic loading.” Federation Proceedings 42, no. 4 (1983): 763–763.
  - Pasipoularides, Ares, S. Damore, J. Miller, B. J. Rubal, and J. P. Murgo. “Left ventricular systolic dynamics in normal man.” American Heart Association Monograph, no. 101 (1983): III-305-III–305.
  - Pasipoularides, A., and J. P. Murgo. “Cardiopulmonary interactions.” Circulation 66, no. 6 (December 1982): 1347–48. https://doi.org/10.1161/01.cir.66.6.1347.
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  - Bird, J. J., J. P. Murgo, and A. Pasipoularides. “Fluid dynamics of aortic stenosis: subvalvular gradients without subvalvular obstruction.” Circulation 66, no. 4 (October 1982): 835–40. https://doi.org/10.1161/01.cir.66.4.835.
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  - Pasipoularides, Ares, I. Palacios, W. Frist, S. Rosenthal, J. B. Newell, and W. J. Powell. “Activation-inactivation dynamics and impaired relaxation in hypoxia.” Circulation 66, no. 4 (1982): 305–305.
  - Pasipoularides, Ares, I. Palacios, W. Frist, S. Rosenthal, J. B. Newell, and W. J. Powell, Jr. “Activation inactivation dynamics and impaired relaxation in hypoxia.” American Heart Asociation Monograph, no. 91 (1982): II-305-II–305.
  - Pasipoularides, Ares, J. P. Murgo, J. J. Bird, and W. E. Craig. “Fluid dynamic mechanisms of sub-valvular gradient generation in aortic-stenosis.” Circulation 66, no. 4 (1982): 253–253.
  - Bird, J. J., J. P. Murgo, A. Pasipoularides, D. Phillip, and B. J. Rubal. “Left-ventricular external work loss in valvular aortic-stenosis - correlation with severity.” Circulation 64, no. 4 (1981): 247–247.
  - Pasipoularides, Ares, I. Palacios, W. Frist, S. Rosenthal, J. B. Newell, and W. J. Powell, Jr. “Activation inactivation dynamics in hypoxic cat papillary muscle.” Clinical Research 29, no. 2 (1981): 497A-497A.
  - Paulus, W. J., B. H. Lorell, W. E. Craig, J. Wynne, A. Pasipoularides, J. P. Murgo, and W. Grossman. “Improved left ventricular diastolic properties in hypertrophic cardio myopathy treated with nifedipine altered loading or improved muscle inactivation?” American Heart Association Monograph, no. 82 (1981): IV-249-IV–249.
  - Schatz, R. A., A. Pasipoularides, and J. P. Murgo. “The effect of arterial-pressure reflections on myocardial supply-demand dynamics.” Circulation 64, no. 4 (1981): 324–324.
  - Bird, J. J., J. P. Murgo, A. Pasipoularides, D. Phillip, and B. J. Rubal. “Left ventricular external work loss in valvular aortic stenosis correlation with severity.” American Heart Association Monograph, no. 82 (1981): IV-247-IV–247.
  - Paulus, W. J., P. D. Bourdillon, T. Serizawa, W. Grossman, A. Pasipoularides, and I. Mirsky. “Altered passive mechanical-properties of ischemic left-ventricular myocardium after pacing tachycardia in dogs with coronary stenoses.” Circulation 64, no. 4 (1981): 211–211.
  - Schatz, R. A., A. Pasipoularides, and J. P. Murgo. “The effect of arterial pressure reflections on myo cardial supply demand dynamics.” American Heart Association Monograph, no. 82 (1981): IV-324-IV–324.
  - Mirsky, I., and A. Pasipoularides. “Elastic properties of normal and hypertrophied cardiac muscle.” Fed Proc 39, no. 2 (February 1980): 156–61.
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  - Pasipoularides, Ares, I. Mirsky, O. M. Hess, and H. P. Krayenbuehl. “Incomplete relaxation and passive diastolic muscle properties in man.” Circulation Supplement 62, no. 3 (1980): III-205-III–205.
  - Vatner, S. F., M. Pagani, W. T. Manders, and A. D. Pasipoularides. “Alpha adrenergic vasoconstriction and nitroglycerin vasodilation of large coronary arteries in the conscious dog.” J Clin Invest 65, no. 1 (January 1980): 5–14. https://doi.org/10.1172/JCI109659.
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  - Pasipoularides, Ares, I. Mirsky, O. M. Hess, and H. P. Krayenbuehl. “Incomplete relaxation and passive diastolic muscle properties in man.” Circulation 62, no. 4 (1980): 205–205.
  - Mirsky, I., A. Pasipoularides, M. M. Laks, and G. E. Adomian. “Time course of changes in the mechanical properties in hypertrophy.” Circulation Supplement 60, no. 2 (1979): II-92-II–92.
  - Pagani, M., H. Baig, A. Pasipoularides, and S. Vatner. “Coronary arterial elasticity in conscious dogs.” Circulation Supplement 60, no. 2 (1979): II-100-II–100.
  - Mirsky, I., A. Pasipoularides, M. M. Laks, and G. E. Adomian. “Time course of changes in the mechanical-properties in hypertrophy.” Circulation 60, no. 4 (1979): 92–92.
  - Pagani, M., H. Baig, A. Pasipoularides, and S. Vatner. “Coronary arterial elasticity in conscious dogs.” Circulation 60, no. 4 (1979): 100–100.
- Book Sections
  - Pasipoularides, A., and J. H. McElhaney. “Introduction,” 20:1–2, 1992. https://doi.org/10.1007/BF02368502.
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  - Craig, W. E., J. P. Murgo, and A. Pasipoularides. “Calculation of the time constant of relaxation.” In Diastolic Relaxation of the Heart, edited by W. Grossman and B. Lorell, 125–32. The Hague: Martinus Nijhoff, 1987.
  - Pagani, M., A. Pasipoularides, and S. F. Vatner. “Elastic properties of coronary arteries in conscious dogs.” In Cardiovascular Physiology: Heart, Peripheral Circulation and Methodology, 8:263–70. Oxford, England: Pergamon Press, 1981.
- Other Articles
  - Pasipoularides, A., M. Shu, A. Shah, A. Tucconi, and D. D. Glower. “Erratum: RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models (American Journal of Physiology - Heart and Circulatory Physiology (2003) 285:54 (H1956-H1965) DOI: 10.1152/ajpheart.00372.2003).” American Journal of Physiology Heart and Circulatory Physiology, November 1, 2004. https://doi.org/10.1152/ajpheart.00865.2004.
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- Conference Papers
  - Pasipoularides, A. D., M. Shu, A. S. Shah, M. Womack, Z. Atkins, G. D. Stetten, S. P. Rednam, O. T. von Ramm, P. K. Smith, and D. D. Glower. “Diastolic right ventricular vortical flow: Increased symmetry in volume overload with paradoxic septal motion.” In Circulation, 98:844–844. LIPPINCOTT WILLIAMS & WILKINS, 1998.
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  - Shu, M., B. Ramaswami, S. Shah, C. E. Fleishman, T. Ota, P. T. Pennington, J. E. Bischoff, G. Stetten, O. T. vonRamm, and A. D. Pasipoularides. “Tricuspid velocity profiles reflect right ventricular diastolic wall motion abnormalities: Real-time 3D echocardiography and computational fluid dynamics.” In Circulation, 96:2990–2990. AMER HEART ASSOC, 1997.
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  - Shu, M., G. D. Stetten, C. J. Ohazama, J. E. Bischoff, B. Ramaswami, O. T. vonRamm, and A. D. Pasipoularides. “Digital geometric models using biventricular real-time 3D echocardiography.” In Circulation, 94:1230–1230. AMER HEART ASSOC, 1996.
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  - HAMPTON, T., Y. T. SHIM, R. RAZIANO, R. UPPAL, D. CRAIG, D. GLOWER, P. K. SMITH, and A. PASIPOULARIDES. “FINITE-ELEMENT ANALYSIS OF VENTRICULAR EJECTION.” In Circulation, 90:12–12. AMER HEART ASSOC, 1994.
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  - Hampton, Thomas, Youngtack Shim, Craig Straley, Rakesh Uppal, Peter K. Smith, Donald Glower, and Ares Pasipoularides. “Computational fluid dynamics of ventricular ejection on the CRAY Y-MP.” In Computers in Cardiology 1992, Proceedings Of, 295–98. IEEE, 1992.
  - Craig, W. E., and A. Pasipoularides. “Ventricular diastolic dynamics: Effects of wall asynchrony on global relaxation indices.” In Proceedings of the 21st Annual Meeting of the Association for the Advancement of Medical Instrumentation. Chicago, 1986.
  - Cox, W. R., A. Pasipoularides, B. J. Rubal, H. H. Peel, and J. P. Murgo. “Amplification of the arterial pulse between aortic root and bronchial artery.” In Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation. Boston, 1985.
  - Glover, D. K., T. A. Patrick, D. A. Kirby, W. T. Manders, A. Pasipoularides, and S. F. Vatner. “Measurement of phasic velocities and blood flow distribution in conscious animals.” In Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation. Boston, 1985.
  - PASIPOULARIDES, A. D. “MATHEMATICAL-MODEL OF PULSE-WAVE REFLECTION.” In Ieee Transactions on Biomedical Engineering, 32:883–883. IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 1985.
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  - Pasipoularides, A., and J. P. Murgo. “Ejection dynamics in man with and without outflow obstruction.” In Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation. Boston, 1985.
  - Pasipoularides, A., J. P. Murgo, and N. Westerhof. “AORTIC INPUT IMPEDANCE AND PRESSURE WAVEFORMS IN MAN.” In Proceedings of the 19th Annual Meeting of the Association for the Advancement of Medical Instrumentation, 64–64. Washington, DC, 1984.
  - Pasipoularides, A., J. Miller, B. J. Rubal, and J. P. Murgo. “Left ventricular ejection dynamics in normal man.” In Proceedings of the Vith International Conference and Workshop of the Cardiovascular System Dynamics Society, 45–48. Philadelphia, 1984.
  - Murgo, J. P., W. E. Craig, and A. Pasipoularides. “The relationship between diastolic function and ejection in hypertrophic cardiomyopathy.” In Proceedings of Symposium on Diastolic Function of the Heart. Hamburg, Germany, 1982.
  - Pasipoularides, A., J. P. Murgo, J. J. Bird, and W. E. Craig. “Fluid dynamics of aortic stenosis: Mechanisms of subvalvular gradient generation.” In Proceedings of the Sixth Annual Conference of the American Society of Biomechanics. Seattle, 1982.
  - Paulus, W. J., P. D. Bourdillon, T. Serizawa, W. Grossman, A. Pasipoularides, and I. Mirsky. “Regional left ventricular diastolic properties during pacing induced ischemia in dogs with coronary stenoses.” In Proceeding of Second Joint Meeting of the Working Groups of the European Society of Cardiology, 2: Suppl A:80–80. Oxford University Press (OUP), 1981.
  - Vatner, S. F., M. Pagani, W. T. Manders, and A. D. Pasipoularides. “Alpha adrenergic control of large coronary arterial resistance and elastic stiffness in the conscious dog.” In Proceedings of the Symposium International Les Alpha Bloquants. Pharmacologie Experimentale Et Clinique, 167–78. Paris, France, 1981.
  - Pagani, M., A. Pasipoularides, and S. F. Vatner. “Mechanical properties of coronary arteries in conscious dogs. Special Symposium on Vascular Mechanics.” In Proceedings of the 28th International Congress of Physiological Sciences. Budapest, Hungary, 1980.
  - Zimpfer, M., A. Pasipoularides, and S. F. Vatner. “Control of cardiac performance by Frank-Starling and Bowditch mechanisms in primates.” In Proceedings of the 7th World Congress of Anesthesiologists. Hamburg, Germany, 1980.

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