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Ares D. Pasipoularides

Ares D. Pasipoularides

Associate Research Professor Emeritus of Surgery
Surgery, Cardiovascular and Thoracic Surgery
apasipou@duke.edu
Box 3851 Med Ctr, Durham, NC 27710
4554 Hospital South, Durham, NC 27710

Selected Publications

Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins.

Journal Article J Mol Cell Cardiol · August 2019 Bicuspid aortic valve (BAV) arises during valvulogenesis when 2 leaflets/cusps of the aortic valve (AOV) are fused together. Its clinical manifestations pertain to faulty AOV function, the associated aortopathy, and other complications surveyed in Part 1 o ... Full text Link to item Cite

Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.

Journal Article J Mol Cell Cardiol · August 2019 Clinical BAV manifestations pertain to faulty aortic valve (AOV) function, the associated aortopathy, and other complications such as endocarditis, thrombosis and thromboembolism. BAV arises during valvulogenesis when 2 of the 3 leaflets/cusps of the AOV a ... Full text Link to item Cite

Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective.

Journal Article J Mol Cell Cardiol · January 2019 Morphology underlies subdivision of the primary/heritable sarcomeric cardiomyopathies (CMs) into hypertrophic (HCM) and dilated (DCM). Next-generation DNA-sequencing (NGS) has identified important disease-variants, improving CM diagnosis, management, genet ... Full text Link to item Cite

Implementing genome-driven personalized cardiology in clinical practice.

Journal Article J Mol Cell Cardiol · February 2018 Genomics designates the coordinated investigation of a large number of genes in the context of a biological process or disease. It may be long before we attain comprehensive understanding of the genomics of common complex cardiovascular diseases (CVDs) suc ... Full text Link to item Cite

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.

Journal Article Int J Cardiol · March 1, 2017 For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in ge ... Full text Link to item Cite

Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.

Journal Article J Cardiovasc Transl Res · August 2016 In part 1, we considered cytomolecular mechanisms underlying calcific aortic valve disease (CAVD), hemodynamics, and adaptive feedbacks controlling pathological left ventricular hypertrophy provoked by ensuing aortic valvular stenosis (AVS). In part 2, we ... Full text Link to item Cite

Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.

Journal Article J Cardiovasc Transl Res · April 2016 Aortic valvular stenosis (AVS), produced by calcific aortic valve disease (CAVD) causing reduced cusp opening, afflicts mostly older persons eventually requiring valve replacement. CAVD had been considered "degenerative," but newer investigations implicate ... Full text Link to item Cite

William Campbell Little, M.D. In Memoriam.

Journal Article J Cardiovasc Transl Res · December 2015 Full text Link to item Cite

Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions.

Journal Article J Cardiovasc Transl Res · December 2015 A unique myocardial characteristic is its ability to grow/remodel in order to adapt; this is determined partly by genes and partly by the environment and the milieu intérieur. In the "post-genomic" era, a need is emerging to elucidate the physiologic funct ... Full text Link to item Cite

Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.

Journal Article J Cardiovasc Transl Res · July 2015 Epigenetic mechanisms are fundamental in cardiac adaptations, remodeling, reverse remodeling, and disease. A primary goal of translational cardiovascular research is recognizing whether disease-related changes in phenotype can be averted by eliminating or ... Full text Link to item Cite

Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1.

Journal Article J Cardiovasc Transl Res · February 2015 Epigenetic mechanisms are fundamental in cardiac adaptations, remodeling, reverse remodeling, and disease. This two-article series proposes that variable forces associated with diastolic RV/LV rotatory intraventricular flows can exert physiologically and c ... Full text Link to item Cite

Vortex formation time is not an index of ventricular function.

Journal Article J Cardiovasc Transl Res · February 2015 The diastolic intraventricular ring vortex formation and pinch-off process may provide clinically useful insights into diastolic function in health and disease. The vortex ring formation time (FT) concept, based on hydrodynamic experiments dealing with unc ... Full text Link to item Cite

Galen, father of systematic medicine. An essay on the evolution of modern medicine and cardiology.

Journal Article Int J Cardiol · March 1, 2014 Galen (129-217) was the ultimate authority on all medical subjects for 15 centuries. His anatomical/physiological concepts remained unchallenged until well into the 17th century. He wrote over 600 treatises, of which less than one-third exist today. The Ga ... Full text Link to item Cite

Historical continuity in the methodology of modern medical science: Leonardo leads the way.

Journal Article Int J Cardiol · February 1, 2014 Early modern medical science did not arise ex nihilo, but was the culmination of a long history stretching back through the Renaissance, the Middle Ages, Byzantium and Roman times, into Greek Antiquity. The long interval between Aristotle and Galen and Har ... Full text Link to item Cite

Greek underpinnings to his methodology in unraveling De Motu Cordis and what Harvey has to teach us still today.

Journal Article Int J Cardiol · October 9, 2013 William Harvey's writings betray amazing insights born out of countless hours of thoughtful experimentation. Throughout his life, Harvey worked as a tireless and thoughtful researcher and a transmitter and intermediary between the ancient Greek natural phi ... Full text Link to item Cite

Evaluation of right and left ventricular diastolic filling.

Journal Article J Cardiovasc Transl Res · August 2013 A conceptual fluid-dynamics framework for diastolic filling is developed. The convective deceleration load (CDL) is identified as an important determinant of ventricular inflow during the E wave (A wave) upstroke. Convective deceleration occurs as blood mo ... Full text Link to item Cite

Historical Perspective: Harvey's epoch-making discovery of the Circulation, its historical antecedents, and some initial consequences on medical practice.

Journal Article J Appl Physiol (1985) · June 2013 In Harvey's Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus of 1628, we see the mechanisms of the Circulation worked out more or less in full from the results of experimental demonstration, virtually complete but for the direct visual evide ... Full text Link to item Cite

Right and left ventricular diastolic pressure-volume relations: a comprehensive review.

Journal Article J Cardiovasc Transl Res · April 2013 Ventricular compliance alterations can affect cardiac performance and adaptations. Moreover, diastolic mechanics are important in assessing both diastolic and systolic function, since any filling impairment can compromise systolic function. A sigmoidal pas ... Full text Link to item Cite

LV twisting and untwisting in HCM: ejection begets filling. Diastolic functional aspects of HCM.

Journal Article Am Heart J · November 2011 Conventional and emerging concepts on mechanisms by which hypertrophic cardiomyopathy (HCM) engenders diastolic dysfunction are surveyed. A shift from familiar left ventricular (LV) diastolic function approaches to large-scale (twist-untwist) and small-sca ... Full text Link to item Cite

Heart's Vortex: Intracardiac Blood Flow Phenomena

Book · December 31, 2009 This 1000 page book includes over 400 figures, which were prepared by the author and form a vital part of the pedagogy. It is organized in three parts. ... Cite

RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models.

Journal Article Am J Physiol Heart Circ Physiol · November 2003 Intraventricular diastolic right ventricular (RV) flow field dynamics were studied by functional imaging using three-dimensional (3D) real-time echocardiography with sonomicrometry and computational fluid dynamics in seven awake dogs at control with normal ... Full text Link to item Cite

Diastolic right ventricular filling vortex in normal and volume overload states.

Journal Article Am J Physiol Heart Circ Physiol · April 2003 Functional imaging computational fluid dynamics simulations of right ventricular (RV) inflow fields were obtained by comprehensive software using individual animal-specific dynamic imaging data input from three-dimensional (3-D) real-time echocardiography ... Full text Link to item Cite

RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations.

Journal Article Am J Physiol Heart Circ Physiol · January 2003 We describe a novel functional imaging approach for quantitative analysis of right ventricular (RV) blood flow patterns in specific experimental animals (or humans) using real-time, three-dimensional (3-D) echocardiography (RT3D). The method is independent ... Full text Link to item Cite

Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.

Journal Article Am J Physiol Heart Circ Physiol · November 2002 By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was deve ... Full text Link to item Cite

Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia.

Journal Article J Thorac Cardiovasc Surg · November 2002 OBJECTIVE: Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricula ... Full text Link to item Cite

New methods for assessment of RV relaxation and pressure-volume relations

Journal Article Journal of cardiovascular diagnosis and procedures · 1996 Cite

Geometric modeling of the right ventricle and CFD simulation of the early diastolic inflow

Journal Article Journal of cardiovascular diagnosis and procedures · 1996 Cite

Effect of subacute pressure overload and release on RV relaxation and filling patterns

Journal Article Journal of cardiovascular diagnosis and procedures · 1996 Cite

Diastolic ventricular morphometry: Analysis of polymeric and paraffin casting

Journal Article Journal of cardiovascular diagnosis and procedures · 1996 Cite

FINITE-ELEMENT ANALYSIS OF VENTRICULAR EJECTION

Conference CIRCULATION · October 1, 1994 Link to item Cite

Effects of anaesthesia and recent surgery on diastolic function.

Journal Article Cardiovasc Res · March 1994 OBJECTIVE: The aims were to determine the effects and the extent to which halothane anaesthesia affects diastolic function both immediately after and remote from surgery and to investigate whether the effect is due to alterations in loading conditions. MET ... Full text Link to item Cite

Finite-element analysis of ventricular ejection

Journal Article Circulation · 1994 Cite

Arterial windkessel parameter estimation: a new time-domain method.

Journal Article Ann Biomed Eng · 1994 We developed and validated a new, more accurate, and easily applied method for calculating the parameters of the three-element Windkessel to quantitate arterial properties and to investigate ventriculoarterial coupling. This method is based on integrating ... Full text Link to item Cite

New method for evaluation of arterial properties by three-element windkessel

Journal Article Journal of the American College of Cardiology · 1993 Cite

Right ventricular systolic performance in a porcine model

Journal Article Journal of the American College of Cardiology · 1993 Cite

Finite element analysis of cardiac ejection dynamics: Ultrasonic implications

Journal Article American Society of Mechanical Engineers Bioengineering Division Publication BED · December 1, 1992 Noninvasive echocardiographic and Doppler investigations have been used to improve understanding of ejection in the normal or abnormal left ventricle and aortic root. Computational fluid dynamics may serve to elucidate ultrasonic findings and extend fluid ... Cite

Ejection load changes in aortic stenosis. Observations made after balloon aortic valvuloplasty.

Journal Article Circ Res · November 1992 To investigate complementarity and competitiveness between the intrinsic and extrinsic components of the total left ventricular systolic load, hemodynamic data from 18 elderly subjects with severe aortic stenosis were analyzed before and after balloon dila ... Full text Link to item Cite

Alterations in left ventricular diastolic function in conscious dogs with pacing-induced heart failure.

Journal Article J Clin Invest · June 1992 We investigated in conscious dogs (a) the effects of heart failure induced by chronic rapid ventricular pacing on the sequence of development of left ventricular (LV) diastolic versus systolic dysfunction and (b) whether the changes were load dependent or ... Full text Link to item Cite

Computational fluid dynamics of ventricular ejection on the CRAY Y-MP

Conference Computers in Cardiology 1992, Proceedings of · 1992 Cite

Computational fluid dynamics of left ventricular ejection.

Journal Article Ann Biomed Eng · 1992 The present investigation addresses the effects of simple geometric variations on intraventricular ejection dynamics, by methods from computational fluid dynamics. It is an early step in incorporating more and more relevant characteristics of the ejection ... Full text Link to item Cite

Simultaneous computation of right and left ventricular systolic function

Conference Proceedings Computers in Cardiology Cic 1992 · January 1, 1992 Computer software for the IBM PC was developed to assess the contractile properties of the right and left ventricles simultaneously. Four indices of systolic function were computed from pressure and volume data. These four indices consist of the slopes and ... Full text Cite

Cardiac mechanics: basic and clinical contemporary research.

Journal Article Ann Biomed Eng · 1992 This survey of cardiac hemodynamics updates evolving concepts of myocardial and ventricular systolic and diastolic loading and function. The pumping action of the heart and its interactions with arterial and venous systems in health and disease provide an ... Full text Link to item Cite

Comparison of left and right ventricular compliances

Journal Article Circulation · 1992 Cite

Comparison of left and right ventricular compliances

Journal Article Circulation · 1992 Cite

Finite element analysis of cardiac ejection dynamics: ultrasonic implications

Journal Article Advances in Bioengineering, BED · 1992 Cite

HEMODYNAMICS - INTRODUCTION

Journal Article ANNALS OF BIOMEDICAL ENGINEERING · 1992 Full text Cite

Introduction

Chapter · January 1, 1992 Full text Cite

Changes in diastolic cardiac function in developing and stable perinephritic hypertension in conscious dogs.

Journal Article Circ Res · February 1991 The effects of developing perinephritic hypertension (2-3 weeks) and a more stable period of perinephritic hypertension (approximately 14 weeks) were examined on indexes of left ventricular (LV) diastolic function in conscious, chronically instrumented dog ... Full text Link to item Cite

Phasik characteristics of transaortic pressure gradients in valvular aortic stenosis

Journal Article Journal of the American College of Cardiology · February 1991 Full text Cite

Noninvasive assessment of intrinsic ventricular load dynamics in dilated cardiomyopathy.

Journal Article J Am Coll Cardiol · January 1991 On the basis of hemodynamic theory, a new noninvasive method is developed to provide improved insights into the significance of depressed Doppler left ventricular ejection variables in patients with dilated cardiomyopathy. The net force (F) associated with ... Full text Link to item Cite

Phasic characteristics of transaortic pressure gradients in valvular aortic stenosis

Journal Article Journal of the American College of Cardiology · 1991 Cite

Clinical assessment of ventricular ejection dynamics with and without outflow obstruction.

Journal Article J Am Coll Cardiol · March 15, 1990 With the advent of multisensor micromanometric/velocimetric catheterization, digital angiography and Doppler and color echocardiography, extensive fluid dynamic quantitation is now possible in cardiology. Such high fidelity instantaneous measurements offer ... Full text Link to item Cite

Clinical assessment of diastolic function.

Journal Article Prog Cardiovasc Dis · 1990 Full text Link to item Cite

Estimation of the ratio of pulmonary to systemic pressures by pulsed-wave Doppler echocardiography for assessment of pulmonary arterial pressures.

Journal Article Am J Cardiol · April 1, 1989 This study describes a method for estimation of the ratio of pulmonary to systemic pressures by pulsed-wave Doppler echocardiography. Sixty-eight patients ages 1 day to 68 years who underwent cardiac catheterization had Doppler studies of the right and lef ... Full text Link to item Cite

Left ventricular isovolumic contraction period vanishes during intense exercise

Journal Article Journal of the American College of Cardiology · 1989 Cite

Models and concepts of diastolic mechanics: Pitfalls in their misapplication

Journal Article Mathematical and Computer Modelling · January 1, 1988 Mathematical models have been remarkably effective in the study of diastolic ventricular mechanics. However, significant pitfalls are found in the misapplication of models and concepts, especially when proper attention is not paid to all the variables that ... Full text Cite

Hemodynamics of the Mueller maneuver in man: right and left heart micromanometry and Doppler echocardiography.

Journal Article Circulation · November 1987 Ten subjects with normal hemodynamics were studied during elective cardiac catheterization with right and left heart multisensor micromanometry to assess hemodynamic responses to the Mueller maneuver. Simultaneous right and left circulatory hemodynamics an ... Full text Link to item Cite

Nonobstructive left ventricular ejection pressure gradients in man.

Journal Article Circ Res · August 1987 Simultaneous intraventricular pressure gradients and ejection flow patterns were measured by a multisensor catheter in 6 patients with normal left ventricular function and no valve abnormalities, at rest and in exercise. Peak measured intraventricular pres ... Full text Link to item Cite

Right ventricular hemodynamic abnormalities in hypertrophic cardiomyopathy

Journal Article Journal of the American College of Cardiology · 1987 Cite

Myocardial relaxation and passive diastolic properties in man.

Journal Article Circulation · November 1986 We have developed a model for assessing the influence of the decaying contractile systolic tension on diastolic wall dynamics and the passive properties of left ventricular muscle. Total measured left ventricular diastolic pressure and stress (sigma T) are ... Full text Link to item Cite

The genesis of aortic root pressure waveform patterns in man

Journal Article American Heart Association Monograph · 1986 Cite

Ventricular diastolic dynamics: Effects of wall asynchrony on global relaxation indices

Conference Proceedings of the 21st Annual Meeting of the Association for the Advancement of Medical Instrumentation · 1986 Cite

Different effects of two types of ischemia on myocardial systolic and diastolic function.

Journal Article Am J Physiol · May 1985 Acute increases in left ventricular (LV) diastolic pressure relative to volume occur during angina in humans and after pacing tachycardia in dogs with coronary stenoses. In this study we assessed myocardial function following pacing tachycardia in dogs wit ... Full text Link to item Cite

MATHEMATICAL-MODEL OF PULSE-WAVE REFLECTION

Conference IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING · January 1, 1985 Link to item Cite

Contribution of activation-inactivation dynamics to the impairment of relaxation in hypoxic cat papillary muscle.

Journal Article Am J Physiol · January 1985 Previous investigation of conventional isometric twitches of normothermic cat papillary muscle has shown that hypoxia prolongs relaxation, and this prolongation is actually accentuated during early reoxygenation. Our aim was to identify how hypoxia and reo ... Full text Link to item Cite

Measurement of phasic velocities and blood flow distribution in conscious animals

Conference Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation · 1985 Cite

Amplification of the arterial pulse between aortic root and bronchial artery

Conference Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation · 1985 Cite

Ejection dynamics in man with and without outflow obstruction

Conference Proceedings of the 20th Annual Meeting of the Association for the Advancement of Medical Instrumentation · 1985 Cite

AORTIC INPUT IMPEDANCE AND PRESSURE WAVEFORMS IN MAN.

Conference Proceedings of the 19th Annual Meeting of the Association for the Advancement of Medical Instrumentation · December 1, 1984 High-fidelity pressure measurements in man have revealed major differences in the configuration of central pressures, even in absence of cardiovascular disease. To discriminate between cardiac and arterial factors that could underlie these differences, eva ... Cite

Measurement of arterial pressure-dimension relationships in conscious animals.

Journal Article Ann Biomed Eng · 1984 Currently, considerable clinical interest exists in the vasoactivity of large coronary arteries due to the prevalence of coronary vasospasm in mediating angina pectoris and even myocardial infarction. Although arterial elastic properties have been studied ... Full text Link to item Cite

Left ventricular ejection dynamics in normal man

Conference Proceedings of the VIth International Conference and Workshop of the Cardiovascular System Dynamics Society · 1984 Cite

Left ventricular systolic dynamics in normal man

Journal Article American Heart Association Monograph · 1983 Cite

Cardiopulmonary interactions.

Journal Article Circulation · December 1982 Full text Link to item Cite

Fluid dynamics of aortic stenosis: subvalvular gradients without subvalvular obstruction.

Journal Article Circulation · October 1982 Analysis of a tapering, pulsatile flow field predicts that substantial subvalvular pressure gradients exist in patients with valvular aortic stenosis (AS) without invoking a second anatomic site of obstruction. Using a catheter with two laterally mounted m ... Full text Link to item Cite

Activation inactivation dynamics and impaired relaxation in hypoxia

Journal Article American Heart Asociation Monograph · 1982 Cite

Fluid dynamics of aortic stenosis: Mechanisms of subvalvular gradient generation

Conference Proceedings of the Sixth Annual Conference of the American Society of Biomechanics · 1982 Cite

The relationship between diastolic function and ejection in hypertrophic cardiomyopathy

Conference Proceedings of Symposium on Diastolic Function of the Heart · 1982 Cite

Left ventricular external work loss in valvular aortic stenosis correlation with severity

Journal Article American Heart Association Monograph · 1981 Cite

The effect of arterial pressure reflections on myo cardial supply demand dynamics

Journal Article American Heart Association Monograph · 1981 Cite

Alpha adrenergic control of large coronary arterial resistance and elastic stiffness in the conscious dog

Conference Proceedings of the Symposium international Les Alpha Bloquants. Pharmacologie Experimentale et Clinique · 1981 Cite

Regional left ventricular diastolic properties during pacing induced ischemia in dogs with coronary stenoses

Conference Proceeding of Second Joint Meeting of the Working Groups of the European Society of Cardiology · 1981 Cite

Elastic properties of normal and hypertrophied cardiac muscle.

Journal Article Fed Proc · February 1980 This brief review addresses itself to the following questions on normal and hypertrophied muscle. 1) What changes, if any, take place in the mechanical properties of cardiac muscle during pressure and volume overload hypertrophy? 2) What parameters may sig ... Link to item Cite

Alpha adrenergic vasoconstriction and nitroglycerin vasodilation of large coronary arteries in the conscious dog.

Journal Article J Clin Invest · January 1980 The effects of methoxamine and nitroglycerin on measurements of large vessel (left circumflex) coronary dimensions were examined in eight conscious dogs using an ultrasonic dimension gauge, and total coronary resistance was calculated from measurements of ... Full text Link to item Cite

Incomplete relaxation and passive diastolic muscle properties in man

Journal Article Circulation Supplement · 1980 Cite

Mechanical properties of coronary arteries in conscious dogs. Special Symposium on Vascular Mechanics

Conference Proceedings of the 28th International Congress of Physiological Sciences · 1980 Cite

Control of cardiac performance by Frank-Starling and Bowditch mechanisms in primates

Conference Proceedings of the 7th World Congress of Anesthesiologists · 1980 Cite

Coronary arterial elasticity in conscious dogs

Journal Article Circulation · 1979 Cite

Time course of changes in the mechanical properties in hypertrophy

Journal Article Circulation Supplement · 1979 Cite

Coronary arterial elasticity in conscious dogs

Journal Article Circulation Supplement · 1979 Cite