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Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.

Publication ,  Journal Article
Pasipoularides, A
Published in: J Cardiovasc Transl Res
April 2016

Aortic valvular stenosis (AVS), produced by calcific aortic valve disease (CAVD) causing reduced cusp opening, afflicts mostly older persons eventually requiring valve replacement. CAVD had been considered "degenerative," but newer investigations implicate active mechanisms similar to atherogenesis--genetic predisposition and signaling pathways, lipoprotein deposits, chronic inflammation, and calcification/osteogenesis. Consequently, CAVD may eventually be controlled/reversed by lifestyle and pharmacogenomics remedies. Its management should be comprehensive, embracing not only the valve but also the left ventricle and the arterial system with their interdependent morphomechanics/hemodynamics, which underlie the ensuing diastolic and systolic LV dysfunction. Compared to even a couple of decades ago, we now have an increased appreciation of genomic and cytomolecular pathogenetic mechanisms underlying CAVD. Future pluridisciplinary studies will characterize better and more completely its pathobiology, evolution, and overall dynamics, encompassing intricate feedback processes involving specific signaling molecules and gene network cascades. They will herald more effective, personalized medicine treatments of CAVD/AVS.

Duke Scholars

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2016

Volume

9

Issue

2

Start / End Page

102 / 118

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Risk Factors
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Mechanotransduction, Cellular
  • Humans
  • Hemodynamics
  • Genetic Predisposition to Disease
  • Feedback, Physiological
 

Citation

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Pasipoularides, A. (2016). Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks. J Cardiovasc Transl Res, 9(2), 102–118. https://doi.org/10.1007/s12265-016-9679-z
Pasipoularides, Ares. “Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.J Cardiovasc Transl Res 9, no. 2 (April 2016): 102–18. https://doi.org/10.1007/s12265-016-9679-z.
Pasipoularides, Ares. “Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.J Cardiovasc Transl Res, vol. 9, no. 2, Apr. 2016, pp. 102–18. Pubmed, doi:10.1007/s12265-016-9679-z.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2016

Volume

9

Issue

2

Start / End Page

102 / 118

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Risk Factors
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Mechanotransduction, Cellular
  • Humans
  • Hemodynamics
  • Genetic Predisposition to Disease
  • Feedback, Physiological