Scholars@Duke
Archan Chakraborty

Archan Chakraborty

Research Associate, Senior
Pharmacology & Cancer Biology

Selected Publications

Synaptic vesicle glycoprotein 2 enables viable aneuploidy following centrosome amplification.

Journal Article Genetics · October 8, 2025 Amplified centrosome number causes genomic instability, most severely through division into >2 aneuploid daughter cells (multipolar mitosis). Several mechanisms that suppress multipolar division have been uncovered, yet mechanisms that favor viable multipo ... Full text Link to item Cite

High-speed 4D fluorescence light field tomography of whole freely moving organisms.

Journal Article Optica · May 20, 2025 Volumetric fluorescence imaging techniques, such as confocal, multiphoton, light sheet, and light field microscopy, have become indispensable tools across a wide range of cellular, developmental, and neurobiological applications. However, it is difficult t ... Full text Link to item Cite

Conserved chamber-specific polyploidy maintains heart function in Drosophila.

Journal Article Development · August 15, 2023 Developmentally programmed polyploidy (whole-genome duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct polyploidy level ... Full text Link to item Cite

Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila.

Journal Article bioRxiv · February 11, 2023 Developmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We highlight a conse ... Full text Link to item Cite

Drosophila CTP synthase regulates collective cell migration by controlling the polarized endocytic cycle.

Journal Article Development (Cambridge, England) · August 2022 Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 in collective cell migration remain elusive. This study highlights the regulatory role of cytidine triphosphate synthase (CTPsyn) in ... Full text Cite

SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.

Journal Article Journal of cell science · May 2020 Under metabolic stress, cellular components can assemble into distinct membraneless organelles for adaptation. One such example is cytidine 5'-triphosphate synthase (CTPS, for which there are CTPS1 and CTPS2 forms in mammals), which forms filamentous struc ... Full text Cite

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.

Journal Article Cell reports · September 2018 CTP synthase (CTPS) forms compartmentalized filaments in response to substrate availability and environmental nutrient status. However, the physiological role of filaments and mechanisms for filament assembly are not well understood. Here, we provide evide ... Full text Cite

Ubiquitination and filamentous structure of cytidine triphosphate synthase.

Journal Article Fly · July 2016 Living organisms respond to nutrient availability by regulating the activity of metabolic enzymes. Therefore, the reversible post-translational modification of an enzyme is a common regulatory mechanism for energy conservation. Recently, cytidine-5'-tripho ... Full text Cite

Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila.

Journal Article Genetics · December 2015 CTP synthase (CTPsyn) plays an essential role in DNA, RNA, and lipid synthesis. Recent studies in bacteria, yeast, and Drosophila all reveal a polymeric CTPsyn structure, which dynamically regulates its enzymatic activity. However, the molecular mechanism ... Full text Cite