Scholars@Duke
Armando Diego Bedoya

Armando Diego Bedoya

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
armando.bedoya@duke.edu
2424 Erwin Road Office 12036, Durham, NC 27705

Selected Publications

The Epidemiology of Combined Pulmonary Fibrosis and Emphysema among Mid-Atlantic Veterans.

Journal Article Ann Am Thorac Soc · October 2025 Rationale: Combined pulmonary fibrosis and emphysema (CPFE) is a unique phenotype with important prognosis and management implications in patients with idiopathic pulmonary fibrosis (CPFE-IPF) and other forms of fibrotic interstitial lung disease (CPFE-fIL ... Full text Link to item Cite

An evaluation framework for ambient digital scribing tools in clinical applications.

Journal Article NPJ Digit Med · June 13, 2025 Ambient digital scribing (ADS) tools alleviate clinician documentation burden, reducing burnout and enhancing efficiency. As AI-driven ADS tools integrate into clinical workflows, robust governance is essential for ethical and secure deployment. This study ... Full text Link to item Cite

Application of unified health large language model evaluation framework to In-Basket message replies: bridging qualitative and quantitative assessments.

Journal Article J Am Med Inform Assoc · April 1, 2025 OBJECTIVES: Large language models (LLMs) are increasingly utilized in healthcare, transforming medical practice through advanced language processing capabilities. However, the evaluation of LLMs predominantly relies on human qualitative assessment, which i ... Full text Link to item Cite

Ethics in Patient Preferences for Artificial Intelligence-Drafted Responses to Electronic Messages.

Journal Article JAMA Netw Open · March 3, 2025 IMPORTANCE: The rise of patient messages sent to clinicians via a patient portal has directly led to physician burnout and dissatisfaction, prompting uptake of artificial intelligence (AI) to alleviate this burden. It is important to understand patient pre ... Full text Link to item Cite

Addressing cost barriers to healthy eating with Eat Well, a prescription produce subsidy, for patients with diabetes and at risk for food insecurity: Study protocol for a type 1 hybrid effectiveness-implementation pragmatic randomized controlled trial.

Journal Article Contemp Clin Trials · October 2024 BACKGROUND: Patients with diabetes at risk of food insecurity face cost barriers to healthy eating and, as a result, poor health outcomes. Population health management strategies are needed to improve food security in real-world health system settings. We ... Full text Link to item Cite

Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing Among Immunocompromised Patients With Pneumonia.

Journal Article Open Forum Infect Dis · August 2024 BACKGROUND: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios where this tool offers the highest ... Full text Link to item Cite

Incorporating informatively collected laboratory data from EHR in clinical prediction models.

Journal Article BMC Med Inform Decis Mak · July 24, 2024 BACKGROUND: Electronic Health Records (EHR) are widely used to develop clinical prediction models (CPMs). However, one of the challenges is that there is often a degree of informative missing data. For example, laboratory measures are typically taken when ... Full text Open Access Link to item Cite

Use of artificial intelligence in critical care: opportunities and obstacles.

Journal Article Crit Care · April 8, 2024 BACKGROUND: Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstacles to achieving those goals more m ... Full text Link to item Cite

Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients With Pneumonia: A Prospective Observational Study.

Journal Article Clin Infect Dis · March 20, 2024 BACKGROUND: Pneumonia is a common cause of morbidity and mortality, yet a causative pathogen is identified in a minority of cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield in immunocompromised patients with pneumonia. METHODS: ... Full text Link to item Cite

Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare.

Journal Article J Am Med Inform Assoc · February 16, 2024 OBJECTIVE: The complexity and rapid pace of development of algorithmic technologies pose challenges for their regulation and oversight in healthcare settings. We sought to improve our institution's approach to evaluation and governance of algorithmic techn ... Full text Link to item Cite

Development of an interactive dashboard for gun violence pattern analysis and intervention design at the local level.

Journal Article JAMIA Open · December 2023 INTRODUCTION: Gun violence remains a concerning and persistent issue in our country. Novel dashboards may integrate and summarize important clinical and non-clinical data that can inform targeted interventions to address the underlying causes of gun violen ... Full text Link to item Cite

The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.

Journal Article Pulm Ther · September 2022 INTRODUCTION: The disease origins of idiopathic pulmonary fibrosis (IPF), which occurs at higher rates in certain races/ethnicities, are not understood. The highest rates occur in white persons of European descent, particularly those with light skin, who a ... Full text Open Access Link to item Cite

A framework for the oversight and local deployment of safe and high-quality prediction models.

Journal Article J Am Med Inform Assoc · August 16, 2022 Artificial intelligence/machine learning models are being rapidly developed and used in clinical practice. However, many models are deployed without a clear understanding of clinical or operational impact and frequently lack monitoring plans that can detec ... Full text Open Access Link to item Cite

Vitals are Vital: Simpler Clinical Data Model Predicts Decompensation in COVID-19 Patients

Journal Article ACI Open · January 2022 Abstract Objective Several risk scores have been developed and tested on coronavirus disease 2019 (COVID-19) patients to predict clinical decompensation. We aimed to compare an institutional, automated, custom-bui ... Full text Open Access Cite

Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study.

Journal Article PLoS One · 2021 BACKGROUND: The epidemiology of Interstitial Lung Diseases (ILD) in the Veterans Health Administration (VHA) is presently unknown. RESEARCH QUESTION: Describe the incidence/prevalence, clinical characteristics, and outcomes of ILD patients within the Veter ... Full text Open Access Link to item Cite

Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?

Journal Article Front Physiol · 2021 Analysis of pulmonary function tests (PFTs) is an area where machine learning (ML) may benefit clinicians, researchers, and the patients. PFT measures spirometry, lung volumes, and carbon monoxide diffusion capacity of the lung (DLCO). The results are usua ... Full text Open Access Link to item Cite

Integrating a Machine Learning System Into Clinical Workflows: Qualitative Study.

Journal Article J Med Internet Res · November 19, 2020 BACKGROUND: Machine learning models have the potential to improve diagnostic accuracy and management of acute conditions. Despite growing efforts to evaluate and validate such models, little is known about how to best translate and implement these products ... Full text Link to item Cite

Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.

Journal Article Respir Care · September 2020 BACKGROUND: Unanticipated respiratory compromise that lead to unplanned intubations is a known phenomenon in hospitalized patients. Most events occur in patients at high risk in well-monitored units; less is known about the incidence, risk factors, and tra ... Full text Link to item Cite

Evaluation of ML-Based Clinical Decision Support Tool to Replace an Existing Tool in an Academic Health System: Lessons Learned.

Journal Article J Pers Med · August 27, 2020 There is increasing application of machine learning tools to problems in healthcare, with an ultimate goal to improve patient safety and health outcomes. When applied appropriately, machine learning tools can augment clinical care provided to patients. How ... Full text Open Access Link to item Cite

Real-World Integration of a Sepsis Deep Learning Technology Into Routine Clinical Care: Implementation Study.

Journal Article JMIR Med Inform · July 15, 2020 BACKGROUND: Successful integrations of machine learning into routine clinical care are exceedingly rare, and barriers to its adoption are poorly characterized in the literature. OBJECTIVE: This study aims to report a quality improvement effort to integrate ... Full text Link to item Cite

Machine learning for early detection of sepsis: an internal and temporal validation study.

Journal Article JAMIA Open · July 2020 OBJECTIVE: Determine if deep learning detects sepsis earlier and more accurately than other models. To evaluate model performance using implementation-oriented metrics that simulate clinical practice. MATERIALS AND METHODS: We trained internally and tempor ... Full text Open Access Link to item Cite

Overcoming barriers to the adoption and implementation of predictive modeling and machine learning in clinical care: what can we learn from US academic medical centers?

Journal Article JAMIA Open · July 2020 There is little known about how academic medical centers (AMCs) in the US develop, implement, and maintain predictive modeling and machine learning (PM and ML) models. We conducted semi-structured interviews with leaders from AMCs to assess their use of PM ... Full text Open Access Link to item Cite

“The human body is a black box”: Supporting clinical decision-making with deep learning

Conference Fat 2020 Proceedings of the 2020 Conference on Fairness Accountability and Transparency · January 27, 2020 Machine learning technologies are increasingly developed for use in healthcare. While research communities have focused on creating state-of-the-art models, there has been less focus on real world implementation and the associated challenges to fairness, t ... Full text Cite

Development, Implementation, and Evaluation of an In-Hospital Optimized Early Warning Score for Patient Deterioration.

Journal Article MDM Policy Pract · 2020 Background. Identification of patients at risk of deteriorating during their hospitalization is an important concern. However, many off-shelf scores have poor in-center performance. In this article, we report our experience developing, implementing, and ev ... Full text Open Access Link to item Cite

Minimal Impact of Implemented Early Warning Score and Best Practice Alert for Patient Deterioration.

Journal Article Crit Care Med · January 2019 OBJECTIVES: Previous studies have looked at National Early Warning Score performance in predicting in-hospital deterioration and death, but data are lacking with respect to patient outcomes following implementation of National Early Warning Score. We sough ... Full text Link to item Cite

Respiratory Failure and Unplanned Intubations in General Floor Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

What Is Sepsis: Investigating the Heterogeneity of Patient Populations Captured by Different Sepsis Definitions

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

An Improved Multi-Output Gaussian Process RNN with Real-Time Validation for Early Sepsis Detection

Journal Article · August 19, 2017 Sepsis is a poorly understood and potentially life-threatening complication that can occur as a result of infection. Early detection and treatment improves patient outcomes, and as such it poses an important challenge in medicine. In this work, we develop ... Open Access Link to item Cite

Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases.

Journal Article Am J Case Rep · July 31, 2017 BACKGROUND Recurrent respiratory papillomatosis (RRP), caused by human papillomavirus (HPV), is the most common benign neoplasm of the larynx and central airways. RRP has a significant impact on quality life and high annual costs to healthcare. Currently, ... Full text Open Access Link to item Cite

Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Antibody desensitization therapy in highly sensitized lung transplant candidates.

Journal Article Am J Transplant · April 2014 As HLAs antibody detection technology has evolved, there is now detailed HLA antibody information available on prospective transplant recipients. Determining single antigen antibody specificity allows for a calculated panel reactive antibodies (cPRA) value ... Full text Link to item Cite

Evaluation of longitudinal clinical outcomes and adherence to care among HIV-infected refugees.

Journal Article J Int Assoc Provid AIDS Care · 2013 BACKGROUND: HIV-infected refugees resettled in the United States face many challenges. Longitudinal data regarding HIV-specific outcomes in this population are limited. METHODS: We reviewed charts of 51 HIV-infected sub-Saharan African refugees matched to ... Full text Link to item Cite

Lung Transplantation For Pulmonary Complications After Bone Marrow Transplantation

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth.

Journal Article Pathol Res Pract · September 15, 2011 Aspartyl-asparaginyl-β-hydroxylase (AAH) regulates cell motility and invasiveness by enhancing Notch signaling. Invasive trophoblastic cells, which mediate placentation, normally express high levels of AAH. Previously, we showed that ethanol-impaired place ... Full text Link to item Cite

Fever and an expanding pancreatic fluid collection.

Journal Article Med Health R I · March 2011 Link to item Cite

Prosthetic valve endocarditis: a complication of spinal epidural abscess.

Journal Article Case Rep Med · 2010 Epidural injections for chronic low back pain are controversial, and their effectiveness is debated. Although epidural injections are considered a minor procedure with low morbidity, catastrophic complications may occur. We describe a case of prosthetic va ... Full text Link to item Cite