Auri Garcia Gonzalez

Journal Article Seminars in Colon and Rectal Surgery · September 1, 2022 Rectal neuroendocrine tumors (NETs) have increased in prevalence due to increased detection via endoscopic screening for colorectal neoplasia, advances and availability of imaging tools along with the indolent nature of the tumor. Imaging techniques to ide ... Full text Cite

Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism.

Journal Article Nature communications · September 2022 Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis elegans, ... Full text Cite

WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization.

Journal Article Genetics · August 2021 In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology, and the response to therapeutic drugs. Visualization of the metabolic pathways that comprise the metabolic network ... Full text Cite

Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host.

Journal Article eLife · November 2020 Metabolism of host-targeted drugs by the microbiome can substantially impact host treatment success. However, since many host-targeted drugs inadvertently hamper microbiome growth, repeated drug administration can lead to microbiome evolutionary adaptation ... Full text Cite

C. elegans and its bacterial diet: An interspecies model to explore the effects of microbiota on drug response

Journal Article Drug Discovery Today: Disease Models · June 1, 2018 Our body is inhabited by a large community of microorganisms referred to as our microbiota that influences almost all aspects of human physiology, including the response to thereapeutic drugs. Drugs can affect microbiota composition and the microbiota can ... Full text Cite

The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders.

Journal Article Scientific reports · January 2018 Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-nicotin ... Full text Cite

Worms, bugs and drugs: Caenorhabditis elegans as a model for host-microbe-drug interactions

Journal Article Current Opinion in Systems Biology · December 1, 2017 The microbiota plays a critical role in human health and disease. For instance, the gut microbiota aides in the digestion of foods, thereby contributing to our ability to metabolize compounds from our diet. Recently, it has become clear that the microbiota ... Full text Cite

Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics.

Journal Article Cell · April 2017 The human microbiota greatly affects physiology and disease; however, the contribution of bacteria to the response to chemotherapeutic drugs remains poorly understood. Caenorhabditis elegans and its bacterial diet provide a powerful system to study host-ba ... Full text Cite

A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.

Journal Article Journal of neuromuscular diseases · January 2017 Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running wh ... Full text Cite

DNA Repair Is Associated with Information Content in Bacteria, Archaea, and DNA Viruses.

Journal Article The Journal of heredity · September 2015 The concept of a "proteomic constraint" proposes that DNA repair capacity is positively correlated with the information content of a genome, which can be approximated to the size of the proteome (P). This in turn implies that DNA repair genes are more like ... Full text Cite

Human gene-centered transcription factor networks for enhancers and disease variants.

Journal Article Cell · April 2015 Gene regulatory networks (GRNs) comprising interactions between transcription factors (TFs) and regulatory loci control development and physiology. Numerous disease-associated mutations have been identified, the vast majority residing in non-coding regions ... Full text Cite

The distribution of recombination repair genes is linked to information content in bacteria.

Journal Article Gene · October 2013 The concept of a 'proteomic constraint' proposes that the information content of the proteome exerts a selective pressure to reduce mutation rates, implying that larger proteomes produce a greater selective pressure to evolve or maintain DNA repair, result ... Full text Cite

The presence of the DNA repair genes mutM, mutY, mutL, and mutS is related to proteome size in bacterial genomes

Journal Article Frontiers in Genetics · December 1, 2012 DNA repair is expected to be a modulator of underlying mutation rates, however the major factors affecting the distribution of DNA repair pathways have not been determined. The Proteomic Constraint theory proposes that mutation rates are inversely proporti ... Full text Cite