Bach Nguyen

Journal Article J Am Chem Soc · February 4, 2026 Darobactins are ribosomally synthesized and post-translationally modified peptides (RiPPs) with potent activity against Gram-negative pathogens. Their antibiotic function depends on a distinctive β-strand architecture stabilized by an ether cross-link betw ... Full text Link to item Cite

Radical-Mediated Nucleophilic Peptide Cross-Linking in Dynobactin Biosynthesis.

Journal Article J Am Chem Soc · November 20, 2024 Dynobactins are recently discovered ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotics that selectively kill Gram-negative pathogens by inhibiting the β-barrel assembly machinery (Bam) located on their outer membranes. Suc ... Full text Link to item Cite

In Silico Pharmacophore Study and Structural Optimization of Nafamostat Yield Potentially Novel Transmembrane Protease Serine 2 (TMPRSS2) Inhibitors Which Block the Entry of SARS-CoV-2 Virus into Human Cells

Preprint · May 21, 2020 Full text Cite