Barry W. Allen | Scholars@Duke

Barry W. Allen
Adjunct Assistant Professor in the Department of Anesthesiology

Employing the techniques of analytical electrochemistry, in vitro and in vivo , to elucidate the physiological roles of diffusible signaling molecules in brain, in other excitable tissues, and in blood. Such molecules include Ca++, NO·, and CO.

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2017

Contact Information

0570 Clin Res II, Durham, NC 27710
Box 3823 Med Ctr, Durham, NC 27710
(919) 668-0031

Background
Education, Training, & Certifications
- Ph.D., Duke University 1984
Duke Appointment History
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2006 - 2016
- Assistant Research Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 2006
Research
Selected Grants
- Critical Molecular Targets for the Toxic Effects of Hyperbaric Oxygen and a Novel Pharmacological Approach for Preventing Acute Toxicity awarded by Office of Naval Research 2011 - 2018
- Neurogenic Mechanisms in CNS and Pulmonary Oxygen Toxicity awarded by Office of Naval Research 2003 - 2010
- Nitric Oxide and CNS-Pulmonary Interactions in 02 Toxicity awarded by Office of Naval Research 2003 - 2007
- Toxic And Therapeutic Effects Of Oxygen awarded by National Institutes of Health 1990 - 1999
- Toxic And Therapeutic Effects Of Oxygen awarded by National Institutes of Health 1990 - 1999
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Allen, BW, Debevec, T, Madsen, PL, and Millet, GP. "Commentaries on Viewpoint: Anemia contributes to cardiovascular disease through reductions in nitric oxideCOMMENTARY ON VIEWPOINT: ANEMIA CONTRIBUTES TO CARDIOVASCULAR DISEASE THROUGH REDUCTIONS IN NITRIC OXIDECAN EXERCISE IN HYPOXIA ALLEVIATE NO-DEPENDENT DETRIMENTAL EFFECTS OF ANEMIA?COMMENTARY ON VIEWPOINT: ANEMIA CONTRIBUTES TO CARDIOVASCULAR DISEASE THROUGH REDUCTIONS IN NITRIC OXIDE." Journal of Applied Physiology 122, no. 2 (February 1, 2017): 418-419. Full Text
  - Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity." Brain research 1657 (February 2017): 347-354. Full Text
  - Gasier, HG, Demchenko, IT, Allen, BW, and Piantadosi, CA. "Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia." Journal of applied physiology (Bethesda, Md. : 1985) 119, no. 11 (December 2015): 1282-1288. Full Text
  - Demchenko, IT, Gasier, HG, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Baroreceptor afferents modulate brain excitation and influence susceptibility to toxic effects of hyperbaric oxygen." Journal of applied physiology (Bethesda, Md. : 1985) 117, no. 5 (September 2014): 525-534. Full Text
  - Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Baroreflex-mediated cardiovascular responses to hyperbaric oxygen." J Appl Physiol (1985) 115, no. 6 (September 2013): 819-828. Full Text Link to Item
  - Demchenko, IT, Mahon, RT, Allen, BW, and Piantadosi, CA. "Brain oxygenation and CNS oxygen toxicity after infusion of perfluorocarbon emulsion." J Appl Physiol (1985) 113, no. 2 (July 2012): 224-231. Full Text Link to Item
  - Demchenko, IT, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity." J Appl Physiol (1985) 112, no. 11 (June 2012): 1814-1823. Full Text Link to Item
  - Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Piantadosi, CA, and Allen, BW. "Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury." Am J Physiol Lung Cell Mol Physiol 300, no. 1 (January 2011): L102-L111. Full Text Link to Item
  - Allen, BW, Stamler, JS, and Piantadosi, CA. "Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation." Trends Mol Med 15, no. 10 (October 2009): 452-460. (Review) Full Text Link to Item
  - Demchenko, IT, Ruehle, A, Allen, BW, Vann, RD, and Piantadosi, CA. "Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen." J Appl Physiol (1985) 106, no. 4 (April 2009): 1234-1242. Full Text Link to Item
  - Allen, BW, Demchenko, IT, and Piantadosi, CA. "Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity." J Appl Physiol (1985) 106, no. 2 (February 2009): 662-667. (Review) Full Text Link to Item
  - Demchenko, IT, Atochin, DN, Gutsaeva, DR, Godfrey, RR, Huang, PL, Piantadosi, CA, and Allen, BW. "Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects." Am J Physiol Lung Cell Mol Physiol 294, no. 5 (May 2008): L984-L990. Full Text Link to Item
  - Demchenko, IT, Welty-Wolf, KE, Allen, BW, and Piantadosi, CA. "Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide." Am J Physiol Lung Cell Mol Physiol 293, no. 1 (July 2007): L229-L238. Full Text Link to Item
  - Allen, BW, and Piantadosi, CA. "How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm." Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1507-H1512. (Review) Full Text Link to Item
  - Demchenko, IT, Luchakov, YI, Moskvin, AN, Gutsaeva, DR, Allen, BW, Thalmann, ED, and Piantadosi, CA. "Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure." J Cereb Blood Flow Metab 25, no. 10 (October 2005): 1288-1300. Full Text Link to Item
  - Allen, BW, Liu, J, and Piantadosi, CA. "Electrochemical detection of nitric oxide in biological fluids." Methods Enzymol 396 (2005): 68-77. Full Text Link to Item
  - Wang, CY, Liu, J, Piantadosi, CA, and Allen, BW. "A novel electrochemical sensor for nitric oxide using aligned RuO ₂ nanowires on a Pt filament." 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings (2005): 434-437.
  - Allen, BW, and Piantadosi, CA. "How do red blood cells dilate blood vessels?." Circ Res 94, no. 12 (June 25, 2004): e105-. (Letter) Link to Item
  - Allen, BW, and Piantadosi, CA. "Electrochemical activation of electrodes for amperometric detection of nitric oxide." Nitric Oxide 8, no. 4 (June 2003): 243-252. Link to Item
  - Allen, BW, Coury, LA, and Piantadosi, CA. "Electrochemical detection of physiological nitric oxide: materials and methods." Methods Enzymol 359 (2002): 125-134. Link to Item
  - Allen, BW, and Piantadosi, CA. "Activation of NO electrodes." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S76-S76. Link to Item
  - Allen, BW, Piantadosi, CA, and Coury, LA. "Electrode materials for nitric oxide detection." Nitric Oxide 4, no. 1 (February 2000): 75-84. Full Text Link to Item
  - Moore, TJ, Joseph, MJ, Allen, BW, and Coury, LA. "Enzymatically amplified voltammetric sensor for microliter sample volumes of salicylate." Anal Chem 67, no. 11 (June 1, 1995): 1896-1902. Link to Item
  - Somjen, GG, Allen, BW, Balestrino, M, and Aitken, PG. "Pathophysiology of pH and Ca2+ in bloodstream and brain." Can J Physiol Pharmacol 65, no. 5 (May 1987): 1078-1085. Link to Item
  - ALLEN, BW, and SOMJEN, GG. "THE INFLUENCE OF PH ON [CA-2+] IN CIRCULATING BLOOD." FEDERATION PROCEEDINGS 42, no. 3 (1983): 296-296. Link to Item
  - ALLEN, BW, POSILLICO, JT, and SOMJEN, GG. "LOWERED BLOOD CALCIUM ACTIVITY, NEUROMUSCULAR FUNCTION, AND RESPIRATION." FEDERATION PROCEEDINGS 41, no. 5 (1982): 1734-1734. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Journal Articles