Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1984
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2006 - 2016
  • Assistant Research Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 2006
• Research
• 

  Selected Grants

  • Critical Molecular Targets for the Toxic Effects of Hyperbaric Oxygen and a Novel Pharmacological Approach for Preventing Acute Toxicity awarded by Office of Naval Research 2011 - 2019
  • Neurogenic Mechanisms in CNS and Pulmonary Oxygen Toxicity awarded by Office of Naval Research 2003 - 2010
  • Nitric Oxide and CNS-Pulmonary Interactions in 02 Toxicity awarded by Office of Naval Research 2003 - 2007
  • Toxic And Therapeutic Effects Of Oxygen awarded by National Institutes of Health 1990 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Cole, Ashley E., Fatmah M. Hani, Brian W. Allen, Paul C. Kline, and Elliot Altman. “Nonfunctional Missense Mutants in Two Well Characterized Cytosolic Enzymes Reveal Important Information About Protein Structure and Function.” Protein J 37, no. 5 (October 2018): 407–27. https://doi.org/10.1007/s10930-018-9786-6.
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    • Jackman, Christopher P., Asvin M. Ganapathi, Huda Asfour, Ying Qian, Brian W. Allen, Yanzhen Li, and Nenad Bursac. “Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.” Biomaterials 159 (March 2018): 48–58. https://doi.org/10.1016/j.biomaterials.2018.01.002.
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    • Shadrin, Ilya Y., Brian W. Allen, Ying Qian, Christopher P. Jackman, Aaron L. Carlson, Mark E. Juhas, and Nenad Bursac. “Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.” Nat Commun 8, no. 1 (November 28, 2017): 1825. https://doi.org/10.1038/s41467-017-01946-x.
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    • Allen, Barry W., Tadej Debevec, Grégoire P. Millet, and Per Lav Madsen. “Commentaries on Viewpoint: Anemia contributes to cardiovascular disease through reductions in nitric oxide.” J Appl Physiol (1985) 122, no. 2 (February 1, 2017): 418–19. https://doi.org/10.1152/japplphysiol.01047.2016.
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    • Demchenko, Ivan T., Sergei Yu Zhilyaev, Alexander N. Moskvin, Alexander I. Krivchenko, Claude A. Piantadosi, and Barry W. Allen. “Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity.” Brain Research 1657 (February 2017): 347–54. https://doi.org/10.1016/j.brainres.2016.12.032.
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    • Gasier, Heath G., Ivan T. Demchenko, Barry W. Allen, and Claude A. Piantadosi. “Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia.” J Appl Physiol (1985) 119, no. 11 (December 1, 2015): 1282–88. https://doi.org/10.1152/japplphysiol.00432.2015.
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    • Demchenko, Ivan T., Heath G. Gasier, Sergei Yu Zhilyaev, Alexander N. Moskvin, Alexander I. Krivchenko, Claude A. Piantadosi, and Barry W. Allen. “Baroreceptor afferents modulate brain excitation and influence susceptibility to toxic effects of hyperbaric oxygen.” J Appl Physiol (1985) 117, no. 5 (September 1, 2014): 525–34. https://doi.org/10.1152/japplphysiol.00435.2014.
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    • Demchenko, Ivan T., Sergei Y. Zhilyaev, Alexander N. Moskvin, Alexander I. Krivchenko, Claude A. Piantadosi, and Barry W. Allen. “Baroreflex-mediated cardiovascular responses to hyperbaric oxygen.” J Appl Physiol (1985) 115, no. 6 (September 2013): 819–28. https://doi.org/10.1152/japplphysiol.00625.2013.
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    • Demchenko, Ivan T., Richard T. Mahon, Barry W. Allen, and Claude A. Piantadosi. “Brain oxygenation and CNS oxygen toxicity after infusion of perfluorocarbon emulsion.” J Appl Physiol (1985) 113, no. 2 (July 2012): 224–31. https://doi.org/10.1152/japplphysiol.00308.2012.
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    • Demchenko, Ivan T., Alexander N. Moskvin, Alexander I. Krivchenko, Claude A. Piantadosi, and Barry W. Allen. “Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity.” J Appl Physiol (1985) 112, no. 11 (June 2012): 1814–23. https://doi.org/10.1152/japplphysiol.00902.2011.
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    • Demchenko, Ivan T., S Yu Zhilyaev, A. N. Moskvin, Claude A. Piantadosi, and Barry W. Allen. “Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury.” Am J Physiol Lung Cell Mol Physiol 300, no. 1 (January 2011): L102–11. https://doi.org/10.1152/ajplung.00178.2010.
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    • Allen, Barry W., Jonathan S. Stamler, and Claude A. Piantadosi. “Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.” Trends Mol Med 15, no. 10 (October 2009): 452–60. https://doi.org/10.1016/j.molmed.2009.08.002.
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    • Demchenko, Ivan T., Alex Ruehle, Barry W. Allen, Richard D. Vann, and Claude A. Piantadosi. “Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen.” J Appl Physiol (1985) 106, no. 4 (April 2009): 1234–42. https://doi.org/10.1152/japplphysiol.91407.2008.
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    • Allen, Barry W., Ivan T. Demchenko, and Claude A. Piantadosi. “Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity.” J Appl Physiol (1985) 106, no. 2 (February 2009): 662–67. https://doi.org/10.1152/japplphysiol.91109.2008.
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    • Demchenko, Ivan T., Dmitriy N. Atochin, Diana R. Gutsaeva, Ryan R. Godfrey, Paul L. Huang, Claude A. Piantadosi, and Barry W. Allen. “Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects.” Am J Physiol Lung Cell Mol Physiol 294, no. 5 (May 2008): L984–90. https://doi.org/10.1152/ajplung.00420.2007.
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    • Demchenko, Ivan T., Karen E. Welty-Wolf, Barry W. Allen, and Claude A. Piantadosi. “Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide.” Am J Physiol Lung Cell Mol Physiol 293, no. 1 (July 2007): L229–38. https://doi.org/10.1152/ajplung.00450.2006.
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    • Allen, Barry W., and Claude A. Piantadosi. “How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm.” Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1507–12. https://doi.org/10.1152/ajpheart.00310.2006.
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    • Wang, C. Y., J. Liu, C. A. Piantadosi, and B. W. Allen. “A novel electrochemical sensor for nitric oxide using aligned RuO 2 nanowires on a Pt filament.” 2005 Nsti Nanotechnology Conference and Trade Show  Nsti Nanotech 2005 Technical Proceedings, December 1, 2005, 434–37.
    • Demchenko, Ivan T., Yuriy I. Luchakov, Alexander N. Moskvin, Diana R. Gutsaeva, Barry W. Allen, Edward D. Thalmann, and Claude A. Piantadosi. “Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure.” J Cereb Blood Flow Metab 25, no. 10 (October 2005): 1288–1300. https://doi.org/10.1038/sj.jcbfm.9600110.
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    • Allen, Barry W., Jie Liu, and Claude A. Piantadosi. “Electrochemical detection of nitric oxide in biological fluids.” Methods Enzymol 396 (2005): 68–77. https://doi.org/10.1016/S0076-6879(05)96007-2.
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    • Allen, Barry W., and Claude A. Piantadosi. “How do red blood cells dilate blood vessels?” Circ Res 94, no. 12 (June 25, 2004): e105.
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    • Allen, Barry W., and Claude A. Piantadosi. “Electrochemical activation of electrodes for amperometric detection of nitric oxide.” Nitric Oxide 8, no. 4 (June 2003): 243–52. https://doi.org/10.1016/s1089-8603(03)00029-6.
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    • Allen, Barry W., Louis A. Coury, and Claude A. Piantadosi. “Electrochemical detection of physiological nitric oxide: materials and methods.” Methods Enzymol 359 (2002): 125–34. https://doi.org/10.1016/s0076-6879(02)59177-1.
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    • Allen, B. W., and C. A. Piantadosi. “Activation of NO electrodes.” Free Radical Biology and Medicine 31 (January 1, 2001): S76–S76.
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    • Allen, B. W., C. A. Piantadosi, and L. A. Coury. “Electrode materials for nitric oxide detection.” Nitric Oxide 4, no. 1 (February 2000): 75–84. https://doi.org/10.1006/niox.2000.0273.
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    • Moore, T. J., M. J. Joseph, B. W. Allen, and L. A. Coury. “Enzymatically amplified voltammetric sensor for microliter sample volumes of salicylate.” Analytical Chemistry 67, no. 11 (June 1995): 1896–1902. https://doi.org/10.1021/ac00107a022.
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    • Somjen, G. G., B. W. Allen, M. Balestrino, and P. G. Aitken. “Pathophysiology of pH and Ca2+ in bloodstream and brain.” Can J Physiol Pharmacol 65, no. 5 (May 1987): 1078–85. https://doi.org/10.1139/y87-169.
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    • ALLEN, B. W., and G. G. SOMJEN. “THE INFLUENCE OF PH ON [CA-2+] IN CIRCULATING BLOOD.” Federation Proceedings 42, no. 3 (January 1, 1983): 296–296.
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    • ALLEN, B. W., J. T. POSILLICO, and G. G. SOMJEN. “LOWERED BLOOD CALCIUM ACTIVITY, NEUROMUSCULAR FUNCTION, AND RESPIRATION.” Federation Proceedings 41, no. 5 (January 1, 1982): 1734–1734.
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  • Conference Papers

    • Demchenko, Ivan, Heath Gasier, Barry Allen, and Claude Piantadosi. “HBO2-triggered baroreflex: Mechanisms, pathways, benefits and limitations.” Undersea and Hyperbaric Medical Society, n.d.

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