Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 1995
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  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2015 - 2020
• Research
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  Selected Grants

  • Development of point-of-care testing for Lassa and other hemorrhagic fever arenaviruses awarded by National Institutes of Health 2022 - 2027
  • A Fully Integrated Point-of-Care Test for Ebola awarded by National Institutes of Health 2020 - 2025
  • Humanized Antibody to Treat Pulmonary Fibrosis awarded by North Carolina Biotechnology Center 2022 - 2023
  • Generation of antibodies specific for optimal non-HRP2 malaria diagnostic antigens awarded by National Institutes of Health 2020 - 2023
  • Development of anti-Salmonella Single-chain Abs as serum diagnostics awarded by National Institutes of Health 2012 - 2019
  • SO150005: Smartphone Enabled Point-of-care Diagnostics for Operationally Significant Pathogens awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
  • Generation of Zika virus-specific recombinant antibodies awarded by National Institutes of Health 2016 - 2018
  • Development of anti-Aspergillus single chain Abs as serum and imaging diagnostics awarded by National Institutes of Health 2010 - 2015
  • TIE2-Associated Molecular Targets in Tumor Vasculature awarded by National Institutes of Health 2002 - 2005
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Fontes, Cassio M., Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, et al. “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.” Science Translational Medicine 13, no. 588 (April 2021): eabd9696. https://doi.org/10.1126/scitranslmed.abd9696.
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    • Chen, Yu-Hsun, Barbara D. Lipes, Daniel J. Kenan, Herman F. Staats, and Michael D. Gunn. “Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library.” J Immunol Methods 340, no. 2 (January 30, 2009): 144–53. https://doi.org/10.1016/j.jim.2008.10.013.
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    • Lipes, Barbara D., Yu-Hsun Chen, Hongzheng Ma, Herman F. Staats, Daniel J. Kenan, and Michael Dee Gunn. “An entirely cell-based system to generate single-chain antibodies against cell surface receptors.” J Mol Biol 379, no. 2 (May 30, 2008): 261–72. https://doi.org/10.1016/j.jmb.2008.03.072.
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    • Chi, Sulene L., Miriam L. Wahl, Yvonne M. Mowery, Siqing Shan, Somnath Mukhopadhyay, Susana C. Hilderbrand, Daniel J. Kenan, et al. “Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.” Cancer Res 67, no. 10 (May 15, 2007): 4716–24. https://doi.org/10.1158/0008-5472.CAN-06-1094.
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    • Lipes, Barbara D., and Jack D. Keene. “Autoimmune epitopes in messenger RNA.” Rna 8, no. 6 (June 2002): 762–71. https://doi.org/10.1017/s1355838202021507.
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    • Wang, M., S. Shouse, B. Lipes, U. J. Kim, H. Shizuya, and E. Lai. “Bacterial artificial chromosome cloning and mapping of a 630-kb human extrachromosomal structure.” Genome Res 6, no. 7 (July 1996): 612–19. https://doi.org/10.1101/gr.6.7.612.
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    • Wrestler, J. C., B. D. Lipes, B. W. Birren, and E. Lai. “Pulsed-field gel electrophoresis.” Methods Enzymol 270 (1996): 255–72. https://doi.org/10.1016/s0076-6879(96)70013-7.
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    • Gray, T. K., B. Lipes, T. Linkhart, S. Mohan, and D. Baylink. “Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.” Connect Tissue Res 20, no. 1–4 (1989): 23–32. https://doi.org/10.3109/03008208909023871.
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  • Conference Papers

    • Huang, Min-Nung, Lowell Nicholson, Kristen Batich, David Kopin, Vijay Prabhakar, Barbara Lipes, John Sampson, and Michael Gunn. “Dual antigen transfer pathways mediate highly efficacious anti-tumor immunity induced by intravenously injected antigen loaded monocytes.” In Journal of Immunology, Vol. 198. AMER ASSOC IMMUNOLOGISTS, 2017.
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