Scholars@Duke
Barbara D Lipes

Barbara D Lipes

Assistant Professor in Medicine
Medicine, Cardiology
blipes@duke.edu
Box 102143 Med Ctr, Durham, NC 27710
198A CARL Building, Durham, NC 27710

Selected Publications

EXTH-68. Targeting Tumor Heterogeneity And Plasticity in Glioblastoma With Novel CAR T Cells Targeting PTPRZ1

Conference Neuro-Oncology · November 11, 2025 AbstractGlioblastoma (GBM) remains among the most aggressive and intractable human cancers, driven by profound intratumoral heterogeneity, dynamic cellular plasticity, and robust mechanisms of immune esca ... Full text Cite

Abstract 3193: Overcoming glioblastoma heterogeneity and plasticity through the development of novel chimeric antigen receptor (CAR)-T cells targeting PTPRZ1

Conference Cancer Research · April 21, 2025 AbstractGlioblastoma (GBM) is an aggressive and heterogeneous brain tumor characterized by extensive plasticity, which contributes to resistance against conventional therapies. To address this challenge, we ... Full text Cite

Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.

Journal Article Sci Transl Med · April 7, 2021 Ebola virus (EBOV) hemorrhagic fever outbreaks have been challenging to deter due to the lack of health care infrastructure in disease-endemic countries and a corresponding inability to diagnose and contain the disease at an early stage. EBOV vaccines and ... Full text Open Access Link to item Cite

Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library.

Journal Article J Immunol Methods · January 30, 2009 The generation of recombinant single-chain antibodies from either non-immune or immune phage display antibody libraries is an effective means to obtain high affinity antibodies against a specific target. Non-immune libraries contain a wide variety of antib ... Full text Link to item Cite

An entirely cell-based system to generate single-chain antibodies against cell surface receptors.

Journal Article J Mol Biol · May 30, 2008 The generation of recombinant antibodies (Abs) using phage display is a proven method to obtain a large variety of Abs that bind with high affinity to a given antigen. Traditionally, the generation of single-chain Abs depends on the use of recombinant prot ... Full text Link to item Cite

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.

Journal Article Cancer Res · May 15, 2007 The antiangiogenic protein angiostatin inhibits ATP synthase on the endothelial cell surface, blocking cellular proliferation. To examine the specificity of this interaction, we generated monoclonal antibodies (mAb) directed against ATP synthase. mAb direc ... Full text Link to item Cite

Autoimmune epitopes in messenger RNA.

Journal Article RNA · June 2002 Patients with systemic autoimmune disorders produce autoantibodies against sequence-specific conformational RNA epitopes on U1 snRNA, 28S rRNA, and transfer RNAs. The molecular basis for immunological reactivity with these highly abundant and stable RNAs i ... Full text Link to item Cite

Bacterial artificial chromosome cloning and mapping of a 630-kb human extrachromosomal structure.

Journal Article Genome Res · July 1996 We have cloned and mapped a circular 630-kb human extrachromosomal structure (termed amplisome) using the bacterial artificial chromosome (BAC) cloning system. Twenty-one BACs were isolated from an amplisome-enriched library by colony hybridization. The in ... Full text Link to item Cite

Pulsed-field gel electrophoresis.

Journal Article Methods Enzymol · 1996 Full text Link to item Cite

Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.

Journal Article Connect Tissue Res · 1989 A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited gro ... Full text Link to item Cite