Schickling, Brandon | Scholars@Duke

Brandon Schickling
Affiliate

Current Appointments & Affiliations

Affiliate, Medicine, Cardiology, Medicine

Contact Information

Recognition
Awards & Honors
Expertise
Subject Headings
Research
Fellowships, Supported Research, & Other Grants
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 2018 - 2021
- Mouse mRNA and miRNA profiling in heart disease – Product Development Project awarded by HTG Molecular Diagnostics 2018 - 2019
- MicroRNA Regulation of Smooth Muscle Nox4 in Vascular Disease awarded by American Heart Association 2016 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gumusoglu, Serena, Lauren Davis, Brandon Schickling, Eric Devor, Lydia Von Tersch, Mark Santillan, and Donna Santillan. “Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression.” Pregnancy Hypertens 31 (March 2023): 1–3. https://doi.org/10.1016/j.preghy.2022.11.005.
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  - Yu, Hope Y., Serena B. Gumusoglu, David E. Cantonwine, Daniela A. Carusi, Prem Gurnani, Brandon Schickling, Robert C. Doss, Mark K. Santillan, Kevin P. Rosenblatt, and Thomas F. McElrath. “Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.” Sci Rep 12, no. 1 (January 5, 2023): 21922. https://doi.org/10.1038/s41598-022-24869-0.
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  - Gumusoglu, Serena B., Brandon M. Schickling, Julie A. Vignato, Donna A. Santillan, and Mark K. Santillan. “Selective serotonin reuptake inhibitors and preeclampsia: A quality assessment and meta-analysis.” Pregnancy Hypertens 30 (December 2022): 36–43. https://doi.org/10.1016/j.preghy.2022.08.001.
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  - Schickling, B., S. Gumusoglu, D. A. Santillan, and M. K. Santillan. “Cord Blood Metabolomics and Autism Spectrum Disorder.” Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 36 (May 1, 2022). https://doi.org/10.1096/fasebj.2022.36.S1.R5837.
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  - Wu, Jiao-Hui, Lisheng Zhang, Igor Nepliouev, Leigh Brian, Taiqin Huang, Kamie P. Snow, Brandon M. Schickling, et al. “Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.” Cardiovasc Res 118, no. 3 (February 21, 2022): 772–84. https://doi.org/10.1093/cvr/cvab156.
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  - Devor, Eric J., Brandon M. Schickling, Jace R. Lapierre, David P. Bender, Jesus Gonzalez-Bosquet, and Kimberly K. Leslie. “The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.” Pharmaceuticals (Basel) 14, no. 9 (September 21, 2021). https://doi.org/10.3390/ph14090942.
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  - Schickling, Brandon M., and Francis J. Miller. “Outside-in Signaling by Adventitial Fibroblasts.” Arterioscler Thromb Vasc Biol 41, no. 2 (February 2021): 711–13. https://doi.org/10.1161/ATVBAHA.120.315466.
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  - Gimenez, Marcela, Sidney Veríssimo-Filho, Ilka Wittig, Brandon M. Schickling, Fabian Hahner, Christoph Schürmann, Luis E. S. Netto, et al. “Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.” Arterioscler Thromb Vasc Biol 39, no. 2 (February 2019): 224–36. https://doi.org/10.1161/ATVBAHA.118.311038.
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  - Devor, Eric J., Jeffrey Miecznikowski, Brandon M. Schickling, Jesus Gonzalez-Bosquet, Heather A. Lankes, Premal Thaker, Peter A. Argenta, et al. “Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group study.” Gynecol Oncol 147, no. 3 (December 2017): 648–53. https://doi.org/10.1016/j.ygyno.2017.09.025.
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  - Devor, Eric J., Henry D. Reyes, Jesus Gonzalez-Bosquet, Akshaya Warrier, Susan A. Kenzie, Nonye V. Ibik, Marina D. Miller, et al. “Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.” Int J Gynecol Cancer 27, no. 4 (May 2017): 784–90. https://doi.org/10.1097/IGC.0000000000000957.
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  - Devor, Eric J., Jesus Gonzalez-Bosquet, Akshaya Warrier, Henry D. Reyes, Nonye V. Ibik, Brandon M. Schickling, Andreea Newtson, Michael J. Goodheart, and Kimberly K. Leslie. “p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.” Int J Oncol 50, no. 5 (May 2017): 1721–28. https://doi.org/10.3892/ijo.2017.3931.
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  - Devor, Eric J., Brandon M. Schickling, Henry D. Reyes, Akshaya Warrier, Brittany Lindsay, Michael J. Goodheart, Donna A. Santillan, and Kimberly K. Leslie. “Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.” Oncol Rep 35, no. 4 (April 2016): 2461–65. https://doi.org/10.3892/or.2016.4605.
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  - Thiel, William H., Carla L. Esposito, David D. Dickey, Justin P. Dassie, Matthew E. Long, Joshua Adam, Jennifer Streeter, et al. “Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.” Mol Ther 24, no. 4 (April 2016): 779–87. https://doi.org/10.1038/mt.2015.235.
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  - Gimenez, Marcela, Brandon M. Schickling, Lucia R. Lopes, and Francis J. Miller. “Nox1 in cardiovascular diseases: regulation and pathophysiology.” Clin Sci (Lond) 130, no. 3 (February 2016): 151–65. https://doi.org/10.1042/CS20150404.
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  - Gimenez, Marcela, Brandon Schickling, Ilka Wittig, Francis Miller, and Lucia Rossetti Lopes. “Redox-Dependent Interaction Between Protein Disulfide Isomerase and P47phox activates Nox1 NADPH Oxidase in Vascular Disease.” Free Radical Biology and Medicine 87 (October 2015): S54–S54. https://doi.org/10.1016/j.freeradbiomed.2015.10.141.
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  - Schickling, Brandon M., and Francis J. Miller. “Coordinated MicroRNA Silencing of Nox4 NADPH Oxidase and Myocardin Regulates Smooth Muscle Cell Dedifferentiation in Vascular Disease.” Free Radical Biology and Medicine 87 (October 2015): S58–S58. https://doi.org/10.1016/j.freeradbiomed.2015.10.152.
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  - Schickling, Brandon M., Sarah K. England, Nukhet Aykin-Burns, Lyse A. Norian, Kimberly K. Leslie, and Victoria P. Frieden-Korovkina. “BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.” Oncol Rep 33, no. 2 (February 2015): 533–38. https://doi.org/10.3892/or.2014.3617.
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  - Streeter, Jennifer, Brandon M. Schickling, Shuxia Jiang, Bojana Stanic, William H. Thiel, Lokesh Gakhar, Jon C. D. Houtman, and Francis J. Miller. “Phosphorylation of Nox1 regulates association with NoxA1 activation domain.” Circ Res 115, no. 11 (November 7, 2014): 911–18. https://doi.org/10.1161/CIRCRESAHA.115.304267.
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  - Meng, Xiangbing, Eric Devor, Shujie Yang, Brandon Schickling, and Kimberly Leslie. “Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma.” Diseases 2, no. 3 (July 1, 2014): 209–25. https://doi.org/10.3390/diseases2030209.
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  - DEVOR, ERIC J., BRANDON M. SCHICKLING, and KIMBERLY K. LESLIE. “microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families.” Biomedical Reports 2, no. 3 (May 2014): 384–87. https://doi.org/10.3892/br.2014.239.
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  - Jiang, Shuxia, Jennifer Streeter, Brandon M. Schickling, Kathy Zimmerman, Robert M. Weiss, and Francis J. Miller. “Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning.” Cardiovasc Res 102, no. 1 (April 1, 2014): 79–87. https://doi.org/10.1093/cvr/cvu027.
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  - Sobhakumari, Arya, Brandon M. Schickling, Laurie Love-Homan, Ayanna Raeburn, Elise V. M. Fletcher, Adam J. Case, Frederick E. Domann, Francis J. Miller, and Andrean L. Simons. “NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.” Toxicol Appl Pharmacol 272, no. 3 (November 1, 2013): 736–45. https://doi.org/10.1016/j.taap.2013.07.013.
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  - Streeter, Jennifer, Brandon Schickling, and Francis J. Miller. “Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs.” Free Radical Biology and Medicine 65 (November 2013): S83–S83. https://doi.org/10.1016/j.freeradbiomed.2013.10.594.
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  - Devor, Eric J. “Conserved Sequences and Secondary RNA Structures Confirm That H19 Functions as a Pri-miRNA and as an RNA-binding Protein Platform.” The Open Genomics Journal 6, no. 1 (July 26, 2013): 1–7. https://doi.org/10.2174/1875693x20130703001.
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  - Schickling, Brandon M., Nukhet Aykin-Burns, Kimberly K. Leslie, Douglas R. Spitz, and Victoria P. Korovkina. “An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.” Cancer Cell Int 11, no. 1 (August 2, 2011): 25. https://doi.org/10.1186/1475-2867-11-25.
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  - Devor, Eric J., Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie. “H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.” Gynecologic Oncology 2, no. 1 (June 27, 2011): 1–1. https://doi.org/10.17077/2154-4751.1101.
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- Conference Papers
  - “Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease.” In Free Radical Biology and Medicine, 145:S109–S109. Elsevier BV, 2019. https://doi.org/10.1016/j.freeradbiomed.2019.10.291.
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  - Schickling, Brandon M., Jennifer Streeter, and Francis J. Miller. “Nadph Oxidase Nox1-dependent Endocytosis and Activation is Regulated by a Conserved Trafficking Motif in Vascular Smooth Muscle Cells.” In Circulation Research, Vol. 125. LIPPINCOTT WILLIAMS & WILKINS, 2019.
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  - Conti, Amanda L., Brandon M. Schickling, and Francis Miller. “Smooth Muscle Cell MicroRNA-9 is Transcriptionally Regulated by MicroRNA-25 in Vascular Disease.” In Faseb Journal, Vol. 33, 2019.
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  - Sartoretto, Simone M., Brandon M. Schickling, Laurynn Garcia, Jennifer L. Lucitti, and Francis J. Miller. “Transcriptional Activation of Nox1 NADPH Oxidase by Protein Disulfide Isomerase in Chronic Inflammation.” In Arteriosclerosis Thrombosis and Vascular Biology, Vol. 39, 2019.
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  - Scott, Danielle A., Brandon M. Schickling, and Francis J. Miller. “Expression of Nox4 NADPH Oxidase Splice Variants Generate Hydrogen Peroxide and Modify the Cell Cycle.” In Faseb Journal, Vol. 33, 2019.
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  - Schickling, Brandon, and Francis Miller. “Alternative splicing of Nox4 regulates subcellular redox-dependent pathways in vascular smooth muscle cells.” In Free Radical Biology and Medicine, 128:S39–S39. Elsevier BV, 2018. https://doi.org/10.1016/j.freeradbiomed.2018.10.056.
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  - Schickling, Brandon M., Maysam Takapoo, Eric J. Devor, and Francis J. Miller. “Abstract 172: Vascular Smooth Muscle Cell Activation is Regulated by miR25 Induced miR-9 Suppression of Nox4 and Myocardin.” In Circulation Research, Vol. 121. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Miller, M. D., E. Devor, A. Warrier, H. D. Reyes, B. M. Schickling, M. J. Goodheart, K. K. Leslie, and J. Gonzalez Bosquet. “Placenta-specific protein 1 (PLAC1) expression in serous ovarian cancer is significantly determined by p53 mutation status.” In Gynecologic Oncology, 145:104–104. Elsevier BV, 2017. https://doi.org/10.1016/j.ygyno.2017.03.245.
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  - Schickling, Brandon M., Maysam Takapoo, Rohan Khera, and Francis J. Miller. “Circulating EGF-Like Ligands in Obesity Increase Neointimal Formation through Upregulation of NADPH Oxidase 1.” In Free Radical Biology and Medicine, 100:S151–S151. Elsevier BV, 2016. https://doi.org/10.1016/j.freeradbiomed.2016.10.397.
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  - Thiel, William H., Carla L. Esposito, David D. Dickey, Justin P. Dassie, Matthew E. Long, Joshua Adam, Jennifer Streeter, et al. “61. Vascular Smooth Muscle Cell RNA Aptamers for the Treatment of Cardiovascular Disease.” In Molecular Therapy, 23:S27–S27. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33666-8.
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  - Thiel, William H., David D. Dickey, Jennifer Streeter, Schickling Brandon, Justin P. Dassie, Maysam Takapoo, Xiuying Liu, Francis J. Miller, and Paloma H. Giangrande. “Cell-Targeted RNA-Based Therapies for Cardiovascular Disease.” In Molecular Therapy, 22:S230–S230. NATURE PUBLISHING GROUP, 2014.
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  - Makki, Nader M., Eric G. Heller, Wassef Y. Karrowni, Shuxia Jiang, Maysam Takapoo, Brandon M. Schickling, Bojana Stanic, Frances Johnson, and Francis J. Miller. “EGF-Like Ligands Contribute to Neointimal Formation via Nox1-Mediated SMC Growth.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Streeter, Jennifer, Brandon Schickling, William Thiel, and Francis Miller. “Nox1 Phosphorylation in Cardiovascular Disease.” In Free Radical Biology and Medicine, 53:S175–S175. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.483.
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Scholarly, Clinical, & Service Activities
Service to the Profession

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Awards & Honors

Subject Headings

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Conference Papers

Service to the Profession