Scholars@Duke
Brandon Schickling

Selected Publications

Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.

Journal Article Neuropsychopharmacology · April 2024 Psychiatric and obstetric diseases are growing threats to public health and share high rates of co-morbidity. G protein-coupled receptor signaling (e.g., vasopressin, serotonin) may be a convergent psycho-obstetric risk mechanism. Regulator of G Protein Si ... Full text Link to item Cite

ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle.

Journal Article J Cell Physiol · April 2024 Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein- and lipid-enriched hubs that mediate interorganellar communication by contributing to the dynamic transfer of Ca2+, lipid, and other metabolites between these organelles. Defect ... Full text Link to item Cite

Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression.

Journal Article Pregnancy Hypertens · March 2023 Arginine vasopressin (AVP) signaling is altered in preeclampsia and physiologic stress. AVP is implicated in fluid homeostasis and cardiovascular (CV) function, which is disrupted in some progeny from preeclamptic pregnancies. However, whether altered feta ... Full text Link to item Cite

Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.

Journal Article Sci Rep · January 5, 2023 Placenta accreta spectrum (PAS) is characterized by abnormal attachment of the placenta to the uterus, and attempts at placental delivery can lead to catastrophic maternal hemorrhage and death. Multidisciplinary delivery planning can significantly improve ... Full text Link to item Cite

BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells

Journal Article Journal of Cancer Science and Clinical Therapeutics · 2023 Full text Cite

Selective serotonin reuptake inhibitors and preeclampsia: A quality assessment and meta-analysis.

Journal Article Pregnancy Hypertens · December 2022 Serotonin modulates vascular, immune, and neurophysiology and is dysregulated in preeclampsia. Despite biological plausibility that selective serotonin reuptake inhibitors (SSRIs) prevent preeclampsia pathophysiology, observational studies have indicated i ... Full text Link to item Cite

Cord Blood Metabolomics and Autism Spectrum Disorder

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 INTRODUCTION: Autism spectrum disorder (ASD) has increased dramatically in prevalence and incidence in recent years (1:59 in the US, CDC). With prenatal and/or genetic origins, early detection and intervention are critical to improve outcomes. Few studies ... Full text Cite

Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.

Journal Article Cardiovasc Res · February 21, 2022 AIMS: The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation, and pro-inflammatory signalling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis. METHODS AND RESULTS: SM22-Cre+/Dbnflox/flox/ ... Full text Open Access Link to item Cite

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.

Journal Article Pharmaceuticals (Basel) · September 21, 2021 Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer. Recent studies have shown that the tumor suppressor p53 directly suppresses ... Full text Open Access Link to item Cite

Outside-in Signaling by Adventitial Fibroblasts.

Journal Article Arterioscler Thromb Vasc Biol · February 2021 Full text Link to item Cite

Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease

Conference Free Radical Biology and Medicine · December 2019 Full text Cite

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.

Journal Article Arterioscler Thromb Vasc Biol · February 2019 Objective- PDI (protein disulfide isomerase A1) was reported to support Nox1 (NADPH oxidase) activation mediated by growth factors in vascular smooth muscle cells. Our aim was to investigate the molecular mechanism by which PDI activates Nox1 and the funct ... Full text Link to item Cite

Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group study.

Journal Article Gynecol Oncol · December 2017 OBJECTIVE: Endometrial cancer can be diagnosed early and cured, yet cases that recur portend a very poor prognosis with over 10,000 women succumbing to the disease every year. In this study we addressed the question of how to recognize cases likely to recu ... Full text Link to item Cite

Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.

Journal Article Int J Gynecol Cancer · May 2017 OBJECTIVE: Expression of the trophoblast-specific gene placenta-specific protein 1 (PLAC1) has been detected in a wide variety of cancers. However, to date, PLAC1 expression has not been shown in cervical cancer. We have carried out a preliminary study tha ... Full text Link to item Cite

p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.

Journal Article Int J Oncol · May 2017 Placenta-specific protein 1 (PLAC1) expression is co-opted in numerous human cancers. As a consequence of PLAC1 expression, tumor cells exhibit enhanced proliferation and invasiveness. This characteristic is associated with increased aggressiveness and wor ... Full text Link to item Cite

Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.

Journal Article Mol Ther · April 2016 Inhibition of vascular smooth muscle cell (VSMC) proliferation by drug eluting stents has markedly reduced intimal hyperplasia and subsequent in-stent restenosis. However, the effects of antiproliferative drugs on endothelial cells (EC) contribute to delay ... Full text Link to item Cite

Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.

Journal Article Oncol Rep · April 2016 Altered expression of cullin-5 (CUL5), a member of the cullin-RING E3 ubiquitin ligase family, has been implicated in a number of types of cancers including breast, cervical and hepatocellular cancers. In the present study, we found that CUL5 expression wa ... Full text Link to item Cite

Nox1 in cardiovascular diseases: regulation and pathophysiology.

Journal Article Clin Sci (Lond) · February 2016 Since its discovery in 1999, a number of studies have evaluated the role of Nox1 NADPH oxidase in the cardiovascular system. Nox1 is activated in vascular cells in response to several different agonists, with its activity regulated at the transcriptional l ... Full text Link to item Cite

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.

Journal Article Oncol Rep · February 2015 In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxi ... Full text Link to item Cite

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Journal Article Circ Res · November 7, 2014 RATIONALE: Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications con ... Full text Link to item Cite

Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma

Journal Article Diseases · July 1, 2014 Hepatocellular carcinoma (HCC) is one of the most lethal malignancies due to underlying co-morbid cirrhosis and chemo-resistance. Vaccination and improved treatment for hepatitis are the most effective means to reduce the burden of liver cancer wor ... Full text Cite

Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning.

Journal Article Cardiovasc Res · April 1, 2014 AIMS: Ischaemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and a ... Full text Link to item Cite

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.

Journal Article Toxicol Appl Pharmacol · November 1, 2013 Most head and neck squamous cell carcinomas (HNSCCs) overexpress epidermal growth factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC. However, many HNSCC tumors do not respond or become refractory to EGFR inhibitors. Au ... Full text Link to item Cite

Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs

Journal Article Free Radical Biology and Medicine · November 2013 Full text Cite

Nox1 Phosphorylation in Cardiovascular Disease

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

Journal Article Cancer Cell Int · August 2, 2011 BACKGROUND: Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer cell subpopulation, termed tumor ... Full text Link to item Cite

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

Journal Article Proceedings in Obstetrics and Gynecology · June 27, 2011 Full text Cite