Scholars@Duke
Brandon Schickling

Selected Publications

Peripartum sertraline impacts maternal neurobehavioral and neurodegenerative mechanisms in pregnant and postpartum mice.

Journal Article Molecular psychiatry · November 2025 Selective Serotonin Reuptake Inhibitors (SSRIs) are among the most common medications used for depression in postpartum and lactating people, who experience increased depression risk. However, there is a limited understanding of peripartum SSRI impacts on ... Full text Cite

Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia.

Journal Article Neuroscience · July 2025 Preeclampsia (PE) is a hypertensive disorder of pregnancy, among the leading global drivers of maternal morbidity. PE can precipitate neuropsychiatric risk, including for peripartum anxiety, depression, and cognitive problems. To investigate mechanisms und ... Full text Cite

Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder.

Journal Article Journal of neurodevelopmental disorders · March 2025 BackgroundDespite the power and promise of early detection and treatment in autism spectrum disorder (ASD), early-life biomarkers are limited. An early-life risk biosignature would advance the field's understanding of ASD pathogenies and targets f ... Full text Cite

Identification of Ovarian High-Grade Serous Carcinoma with Mitochondrial Gene Variation.

Journal Article International journal of molecular sciences · February 2025 Women diagnosed with advanced-stage ovarian cancer have a much worse survival rate than women diagnosed with early-stage ovarian cancer, but the early detection of this disease remains a clinical challenge. Some recent reports indicate that genetic variati ... Full text Cite

Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.

Journal Article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · April 2024 Psychiatric and obstetric diseases are growing threats to public health and share high rates of co-morbidity. G protein-coupled receptor signaling (e.g., vasopressin, serotonin) may be a convergent psycho-obstetric risk mechanism. Regulator of G Protein Si ... Full text Cite

ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle.

Journal Article Journal of cellular physiology · April 2024 Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein- and lipid-enriched hubs that mediate interorganellar communication by contributing to the dynamic transfer of Ca2+, lipid, and other metabolites between these organel ... Full text Cite

ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic

Journal Article Frontiers in Endocrinology · January 1, 2024 Introduction: Reducing Optic Atrophy 1 (OPA1) expression in skeletal muscle in male mice induces Activation Transcription Factor 4 (ATF4) and the integrated stress response (ISR). Additionally, skeletal muscle secretion of Fibroblast Growth Factor 21 (FGF2 ... Full text Cite

311 Biomarkers of poor volume handling predict preeclampsia in a symptomatic population

Conference American Journal of Obstetrics and Gynecology · January 2024 Full text Cite

Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression.

Journal Article Pregnancy hypertension · March 2023 Arginine vasopressin (AVP) signaling is altered in preeclampsia and physiologic stress. AVP is implicated in fluid homeostasis and cardiovascular (CV) function, which is disrupted in some progeny from preeclamptic pregnancies. However, whether altered feta ... Full text Cite

Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.

Journal Article Scientific reports · January 2023 Placenta accreta spectrum (PAS) is characterized by abnormal attachment of the placenta to the uterus, and attempts at placental delivery can lead to catastrophic maternal hemorrhage and death. Multidisciplinary delivery planning can significantly improve ... Full text Cite

BRCA2 Status Alters the Effect of the P53 Reactivator HO-3867 in Ovarian Cancer Cells

Journal Article Journal of Cancer Science and Clinical Therapeutics · 2023 Full text Cite

Selective serotonin reuptake inhibitors and preeclampsia: A quality assessment and meta-analysis.

Journal Article Pregnancy hypertension · December 2022 Serotonin modulates vascular, immune, and neurophysiology and is dysregulated in preeclampsia. Despite biological plausibility that selective serotonin reuptake inhibitors (SSRIs) prevent preeclampsia pathophysiology, observational studies have indicated i ... Full text Cite

Cord Blood Metabolomics and Autism Spectrum Disorder

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 INTRODUCTION: Autism spectrum disorder (ASD) has increased dramatically in prevalence and incidence in recent years (1:59 in the US, CDC). With prenatal and/or genetic origins, early detection and intervention are critical to improve outcomes. Few studies ... Full text Cite

Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.

Journal Article Cardiovasc Res · February 21, 2022 AIMS: The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation, and pro-inflammatory signalling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis. METHODS AND RESULTS: SM22-Cre+/Dbnflox/flox/ ... Full text Open Access Link to item Cite

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.

Journal Article Pharmaceuticals (Basel, Switzerland) · September 2021 Elevated expression of placenta-specific protein 1 (PLAC1) is associated with the increased proliferation and invasiveness of a variety of human cancers, including ovarian cancer. Recent studies have shown that the tumor suppressor p53 directly suppresses ... Full text Open Access Cite

Outside-in Signaling by Adventitial Fibroblasts.

Journal Article Arterioscler Thromb Vasc Biol · February 2021 Full text Link to item Cite

Redox-regulation of NADPH Oxidase 4 in Cardiovascular Disease

Conference Free Radical Biology and Medicine · December 2019 Full text Cite

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.

Journal Article Arterioscler Thromb Vasc Biol · February 2019 Objective- PDI (protein disulfide isomerase A1) was reported to support Nox1 (NADPH oxidase) activation mediated by growth factors in vascular smooth muscle cells. Our aim was to investigate the molecular mechanism by which PDI activates Nox1 and the funct ... Full text Link to item Cite

Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group study.

Journal Article Gynecologic oncology · December 2017 ObjectiveEndometrial cancer can be diagnosed early and cured, yet cases that recur portend a very poor prognosis with over 10,000 women succumbing to the disease every year. In this study we addressed the question of how to recognize cases likely ... Full text Cite

Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.

Journal Article International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · May 2017 ObjectiveExpression of the trophoblast-specific gene placenta-specific protein 1 (PLAC1) has been detected in a wide variety of cancers. However, to date, PLAC1 expression has not been shown in cervical cancer. We have carried out a preliminary st ... Full text Cite

p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.

Journal Article International journal of oncology · May 2017 Placenta-specific protein 1 (PLAC1) expression is co-opted in numerous human cancers. As a consequence of PLAC1 expression, tumor cells exhibit enhanced proliferation and invasiveness. This characteristic is associated with increased aggressiveness and wor ... Full text Cite

Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.

Journal Article Mol Ther · April 2016 Inhibition of vascular smooth muscle cell (VSMC) proliferation by drug eluting stents has markedly reduced intimal hyperplasia and subsequent in-stent restenosis. However, the effects of antiproliferative drugs on endothelial cells (EC) contribute to delay ... Full text Link to item Cite

Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.

Journal Article Oncology reports · April 2016 Altered expression of cullin-5 (CUL5), a member of the cullin-RING E3 ubiquitin ligase family, has been implicated in a number of types of cancers including breast, cervical and hepatocellular cancers. In the present study, we found that CUL5 expression wa ... Full text Cite

Nox1 in cardiovascular diseases: regulation and pathophysiology.

Journal Article Clin Sci (Lond) · February 2016 Since its discovery in 1999, a number of studies have evaluated the role of Nox1 NADPH oxidase in the cardiovascular system. Nox1 is activated in vascular cells in response to several different agonists, with its activity regulated at the transcriptional l ... Full text Link to item Cite

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.

Journal Article Oncology reports · February 2015 In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxi ... Full text Cite

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Journal Article Circ Res · November 7, 2014 RATIONALE: Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an attractive potential therapy, but requires a better understanding of the molecular modifications con ... Full text Link to item Cite

Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma

Journal Article Diseases · July 1, 2014 Hepatocellular carcinoma (HCC) is one of the most lethal malignancies due to underlying co-morbid cirrhosis and chemo-resistance. Vaccination and improved treatment for hepatitis are the most effective means to reduce the burden of liver cancer wor ... Full text Cite

Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning.

Journal Article Cardiovasc Res · April 1, 2014 AIMS: Ischaemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and a ... Full text Link to item Cite

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.

Journal Article Toxicol Appl Pharmacol · November 1, 2013 Most head and neck squamous cell carcinomas (HNSCCs) overexpress epidermal growth factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC. However, many HNSCC tumors do not respond or become refractory to EGFR inhibitors. Au ... Full text Link to item Cite

Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs

Journal Article Free Radical Biology and Medicine · November 2013 Full text Cite

Nox1 Phosphorylation in Cardiovascular Disease

Conference Free Radical Biology and Medicine · November 2012 Full text Cite

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

Journal Article Cancer cell international · August 2011 BackgroundMany potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer cell subpopulation, termed ... Full text Cite

H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium.

Journal Article Proceedings in Obstetrics and Gynecology · June 27, 2011 Full text Cite