Brian Chan

Journal Article Macromolecules · August 12, 2025 Pressure differentials across polymer solutions cause fluid flow. We develop a theory for the spatial variation of polymer concentration in solutions under steady flow between two interfaces permeable to the solvent but not to the polymer. The balance betw ... Full text Cite

Activity-driven chromatin organization during interphase: Compaction, segregation, and entanglement suppression.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · May 2024 In mammalian cells, the cohesin protein complex is believed to translocate along chromatin during interphase to form dynamic loops through a process called active loop extrusion. Chromosome conformation capture and imaging experiments have suggested that c ... Full text Cite

Theory of chromatin organization maintained by active loop extrusion.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · June 2023 The active loop extrusion hypothesis proposes that chromatin threads through the cohesin protein complex into progressively larger loops until reaching specific boundary elements. We build upon this hypothesis and develop an analytical theory for active lo ... Full text Cite