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Bruce Alan Sullenger

Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
Surgery, Surgical Sciences
Box 103035, Durham, NC 27710
DUMC 103035, Durham, NC 27710

Selected Grants


Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Advanced Immunobiology Traning Program for Surgeons

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Directed Evolution of gRNA Variants to Improve CRISPR Gene Editing Efficiency for Gene Therapy Applications

FellowshipPrincipal Investigator · Awarded by National Human Genome Research Institute · 2024 - 2027

Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Advanced Immunobiology Traning Program for Surgeons

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Directed Evolution of gRNA Variants to Improve CRISPR Gene Editing Efficiency for Gene Therapy Applications

FellowshipPrincipal Investigator · Awarded by National Human Genome Research Institute · 2024 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Hematology & Transfusion Medicine (T32)

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1975 - 2026

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

NINDS Research Education Programs for Residents and Fellows in Neurosurgery

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2009 - 2025

Aptamer-small molecule conjugate as potent and reversible surgical anticoagulants

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2023 - 2024

Cas9 RNP delivery to immune cells in vivo via molecular targeting

ResearchPrincipal Investigator · Awarded by University of California - Berkeley · 2019 - 2024

Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer

ResearchInvestigator · Awarded by Department of Defense · 2016 - 2024

Viral Oncology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2024

Reducing prostate cancer aggressiveness via aptamer-mediated nuclear delivery of splice-switching oligonucleotides

ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2023 - 2024

Engineering Polymers to Scavenge DAMPs in Arthritis and Lupus

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2023

Duke Resident Physician-Scientist Program - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2023

Direct Detection and Characterization of Blood Clots In Vivo

ResearchPrincipal Investigator · Awarded by University of California - Davis · 2019 - 2023

Project 3: RNA Aptamers as Probes and Regulators of Coagulation

ResearchPrincipal Investigator · Awarded by Children's Hospital of Philadelphia · 2018 - 2023

Reducing prostate cancer aggressiveness via aptamer-mediated nuclear delivery of splice-switching oligonucleotides

ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2023

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Utilizing Nucleic Acid Binding Polymers to Ameliorate Inflammation-driven Metastatic Progression in Breast Cancer

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021

Targeting DAMP-induced inflammation to prevent metastasis

ResearchPrincipal Investigator · Awarded by Department of Defense · 2016 - 2020

Targeting DAMP-induced inflammation to prevent metastasis

ResearchPartnering PI · Awarded by Department of Defense · 2016 - 2020

POEGMA Conjugation of Aptamers

ResearchPrincipal Investigator · Awarded by Gateway Bio, Inc. · 2018 - 2020

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Antithrombotic Aptamers and Antidotes

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2020

Aptamer-based Detection and Binding of Peptide-MHC

ResearchPrincipal Investigator · Awarded by MD Anderson Cancer Center · 2018 - 2019

APTAMER BEACONS FOR EPIGENETIC HIGH-THROUGHOUT ASSAY DEVELOPMENT

ResearchPrincipal Investigator · Awarded by EpiCypher, Inc. · 2018 - 2019

Duke-UNC Clinical Hematology and Transfusion Research Career Development Program

ResearchMentor · Awarded by National Institutes of Health · 2006 - 2019

DTMI-Center for Thrombotic and Hemostatic Disorders

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2019

Neutralizing Antibody & AAV VIX Gene Therapy

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2017 - 2019

Next-Generation Detection Reagents for Chromatin Immunoprecipitation

ResearchPrincipal Investigator · Awarded by EpiCypher, Inc. · 2017 - 2018

Studying Anticoagulant Synergy of Factor Xa Aptamer and Catalytic Site Inhibitors

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018

TRC-THD Administrative Coordinating Center (ACC)

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2012 - 2017

Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer

FellowshipMentor · Awarded by Department of Defense · 2014 - 2016

Targeting DNA Neutrophil Extracellular Traps in Sickle Cell Disease

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2013 - 2016

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

RNA Therapeutics for Pancreatic Cancer

ResearchMentor · Awarded by National Institutes of Health · 2011 - 2015

Anticoagulant Synergy of Factor Xa Aptamer and Catalytic Site Inhibitors: Mechanistic and Translational Studies

FellowshipPrincipal Investigator · Awarded by PhRMA Foundation · 2015 - 2015

In Vivo Selection of Tumor-Specific RNA Binding Motifs

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2015

Regulation of inflammatory responses by nucleic-acid binding polymers

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2014

RNA aptamers as cell surface receptor agonists and siRNA delivery agents

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2014

Nucleic Acid Binding Polymers as Anti-Inflammatory Agents

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013

CTSA UL

ResearchDirector · Awarded by National Institutes of Health · 2006 - 2012

In Vivo Selection of Aptamers Targeting Pancreatic Cancer

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2012

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Development and Analysis of Aptamer-Antidote Pairs

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2010

Enhancement of Thrombolysis through Inhibition of PAI-1 and Antiplasmin

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2008

E2F-Mediated Control of Vascular Growth and Remodeling

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2008

The Angiopoietins in Vascular Maintenance and Remodeling

ResearchConsultant · Awarded by National Institutes of Health · 2002 - 2007

Analysis of Group I and II Introns in Mammalian Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2007

Development of Oligonucleotide-based CTLA-4 Inhibitors.

ResearchCo Investigator · Awarded by National Institutes of Health · 2004 - 2006

Disrupting Viral Gene with Group II Introns

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2006

Rna Ligands: E2f Function and Cell Proliferation

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1999 - 2003

Developing RNA-Mimotopes Of Hiv Antigens

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Ribozyme Mediated Repair of Sickle B-Globin Transcripts

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 2001

Trans-splicing by a Group I Ribozyme in Mammalial Cells.

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Probing expressed genome organization with ribozymes

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2000

Ribozyme-Mediated Repair Of Sickle B-Globin Transcripts

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Trans Splicing By A Group I Ribozyme In Mammalian Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Trans-Splicing By A Group I Ribozyme In Mammalian Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

External Relationships


  • A M Pappas Ventures
  • AZURNA
  • Basking Biosciences
  • Dragon Therapeutics
  • Eli Lilly & Co.
  • A M Pappas Ventures
  • AZURNA
  • Basking Biosciences
  • Dragon Therapeutics
  • Eli Lilly & Co.
  • Rznomics Inc
  • Somalogic
  • Upstream Therapeutics

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.