Scholars@Duke

• Background
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  Education, Training, & Certifications

  • M.D., University of Massachusetts Medical School 2014
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  Previous Appointments & Affiliations

  • Medical Instructor in the Department of Radiology, Radiology, Cardiothoracic Imaging, Radiology 2020 - 2021
  • Clinical Associate in the Department of Radiology, Radiology, Cardiothoracic Imaging, Radiology 2019 - 2020
• Research
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  Selected Grants

  • Accuracy and Precision in CT Quantification of COPD Through Virtual Imaging Trials awarded by National Institutes of Health 2021 - 2026
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • O’Sullivan-Murphy, B., Driehuys, B., & Mammarappallil, J. (2022). MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We? Radiol Clin North Am, 60(6), 1021–1032. https://doi.org/10.1016/j.rcl.2022.06.007
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    • Washington, L., O’Sullivan-Murphy, B., Christensen, J. D., & McAdams, H. P. (2022). Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review. Radiol Clin North Am, 60(3), 371–381. https://doi.org/10.1016/j.rcl.2022.01.011
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    • Murugan, V. A., Murphy, B. O., Dupuis, C., Goldstein, A., & Kim, Y. H. (2020). Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting. Ultrasonography, 39(2), 178–189. https://doi.org/10.14366/usg.19043
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    • Gagne, S., O Sullivan-Murphy, B., Lo, H. S., & McIntosh, L. J. (2018). Pancreaticobiliary Trauma: A Multimodality Imaging Update. Semin Ultrasound Ct Mr, 39(4), 355–362. https://doi.org/10.1053/j.sult.2018.03.004
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    • Yang, C., Diiorio, P., Jurczyk, A., O’Sullivan-Murphy, B., Urano, F., & Bortell, R. (2013). Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia, 56(12), 2638–2646. https://doi.org/10.1007/s00125-013-3044-4
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    • Jung, D. Y., Chalasani, U., Pan, N., Friedline, R. H., Prosdocimo, D. A., Nam, M., … Gray, S. (2013). KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. Plos One, 8(10), e77851. https://doi.org/10.1371/journal.pone.0077851
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    • Oslowski, C. M., Hara, T., O’Sullivan-Murphy, B., Kanekura, K., Lu, S., Hara, M., … Urano, F. (2012). Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab, 16(2), 265–273. https://doi.org/10.1016/j.cmet.2012.07.005
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    • O’Sullivan-Murphy, B., & Urano, F. (2012). ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. Diabetes, 61(4), 780–781. https://doi.org/10.2337/db12-0091
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    • Alexandrov, I. M., Ivshina, M., Jung, D. Y., Friedline, R., Ko, H. J., Xu, M., … Richter, J. D. (2012). Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. Plos Genet, 8(1), e1002457. https://doi.org/10.1371/journal.pgen.1002457
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    • Jurczyk, A., Pino, S. C., O’Sullivan-Murphy, B., Addorio, M., Lidstone, E. A., Diiorio, P., … Bortell, R. (2010). A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. Plos One, 5(7), e11812. https://doi.org/10.1371/journal.pone.0011812
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    • Pino, S. C., O’Sullivan-Murphy, B., Lidstone, E. A., Yang, C., Lipson, K. L., Jurczyk, A., … Bortell, R. (2009). CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. Plos One, 4(5), e5468. https://doi.org/10.1371/journal.pone.0005468
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    • Pino, S. C., O’Sullivan-Murphy, B., Lidstone, E. A., Thornley, T. B., Jurczyk, A., Urano, F., … Bortell, R. (2008). Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones, 13(4), 421–434. https://doi.org/10.1007/s12192-008-0038-0
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    • Dragnev, K. H., Pitha-Rowe, I., Ma, Y., Petty, W. J., Sekula, D., Murphy, B., … Dmitrovsky, E. (2004). Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clin Cancer Res, 10(7), 2570–2577. https://doi.org/10.1158/1078-0432.ccr-03-0271
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  • Book Sections

    • Urano, F., & O’Sullivan-Murphy, B. (2014). Pathological ER stress in β cells. In Endoplasmic Reticulum Stress in Health and Disease (pp. 215–230). https://doi.org/10.1007/978-94-007-4351-9_9
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