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David William Butterly

Professor of Medicine
Medicine, Nephrology
Duke Box 2747, Durham, NC 27710
2424 Erwin Road - Suite 605, Durham, NC 27705


As a Clinician and Clinical Researcher in the Division of Nephrology my practice is mainly focused on patients with end stage renal disease. I am co-Director of a maintenance hemodialysis unit which cares for approximately 110 patients on maintenance hemodialysis. In addition, I see patients three days weekly through the Private Diagnostic Clinic. We see a variety of consultative nephrology problems, but our major focus remains and stage renal disease and renal transplantation@. In the Renal Transplant Clinic, we see patients both pre- and post-transplant. Over the last two years we have transplanted 90-100 patients annually and care for several hundred other patients who are on the active transplant list.

My research interests thus relate primarily to end stage renal disease. In the dialysis unit we are currently involved in a multi-center NIH-sponsored trial called the AHEMO Trial@, which is looking at causes of long-term morbidity and mortality in the dialysis population and the effect on the dialysis prescription. In addition, our group has been active in maintenance of long-term hemodialysis access in the prospective of monitoring of vascular access to extend long-term graft survival. In the transplantation arena, we will soon be stating another multi-center trial to evaluate a new anti-lymphocyte antibody for the treatment of acute cellular rejection. This will be a multi-center randomized trial evaluating this new antibody versus OKT-3, which is currently standard of care. We are also interested in bone disease after transplantation and the prevention of acute rejection with other pharmacologic mechanisms and are establishing trials and interventions to evaluate these.

End stage renal disease, vascular access, renal transplantation, post-transplantation osseous disorders, consultative Nephrology.

Current Appointments & Affiliations

Professor of Medicine · 2021 - Present Medicine, Nephrology, Medicine

Education, Training & Certifications

Duke University · 1987 M.D.