Scholars@Duke
David William Butterly

David William Butterly

Professor of Medicine
Medicine, Nephrology
butte001@mc.duke.edu
Duke Box 2747, Durham, NC 27710
2424 Erwin Road - Suite 605, Durham, NC 27705

Selected Publications

Genetic services survey—experience of people with rare diseases and their families accessing genetic services in the Irish Republic

Journal Article Journal of Community Genetics · December 1, 2023 Irish Health Service objectives state that patients with rare diseases should have timely access to genomic diagnostics with appropriate pre and post-test counselling. However, waiting times for clinical genetics outpatient appointments, during the study p ... Full text Cite

Multi-center experience of 164 consecutive Hemodialysis Reliable Outflow [HeRO] graft implants for hemodialysis treatment.

Journal Article Eur J Vasc Endovasc Surg · July 2012 OBJECTIVE: To report a multi-center experience with the novel Hemodialysis Reliable Outflow (HeRO) vascular access graft. MATERIALS AND METHODS: Four centers conducted a retrospective review of end stage renal disease patients who received the HeRO device ... Full text Link to item Cite

Familial hypocalciuric hypercalcemia in the donor and recipient of a living related donor kidney transplant.

Journal Article Am J Transplant · March 2007 Familial hypocalciuric hypercalcemia (FHH) is caused by heterozygous inactivation of the calcium-sensing receptor, which is notably expressed in parathyroid and kidney. FHH is characterized by asymptomatic hypercalcemia and hypophosphatemia and confers min ... Full text Link to item Cite

Postinfectious glomerulonephritis in renal allograft recipients.

Journal Article Transplantation · November 15, 2006 Postinfectious glomerulonephritis (PIGN) is a rare etiology of de novo glomerulonephritis following kidney transplantation. To date, there have only been eight cases reported in the literature. We report an additional three patients transplanted at our ins ... Full text Link to item Cite

The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease.

Journal Article Am J Kidney Dis · October 2006 Glomerular lesions that complicate patients with human immunodeficiency virus (HIV) infection include HIV-associated nephropathy, membranous glomerulopathy, and immune-complex glomerulonephritides. This case series presents 3 patients with clinically signi ... Full text Link to item Cite

Obesity predicts increased overall complications following pancreas transplantation.

Journal Article Transplant Proc · October 2005 PURPOSE: We sought to evaluate the role of recipient body mass index (BMI) on postoperative complications in patients receiving pancreas transplants. METHODS: A single-institution retrospective study of 145 consecutive patients undergoing either simultaneo ... Full text Link to item Cite

The spectrum of infection-related morbidity in hospitalized haemodialysis patients.

Journal Article Nephrol Dial Transplant · June 2005 BACKGROUND: Infection is a common cause of mortality and morbidity in haemodialysis patients. Few prospective studies have examined the clinical consequences of infection-related hospitalizations in haemodialysis patients or the risk factors predictive of ... Full text Link to item Cite

Intravenous immunoglobulin and plasmapheresis in acute humoral rejection: experience in renal allograft transplantation.

Journal Article Hum Immunol · April 2005 Acute humoral rejection (AHR) in kidney transplantation is associated with higher rates of allograft loss when compared with acute cellular rejection (ACR). Treatment with intravenous immunoglobulin (IVIG) combined with plasmapheresis (PP) has been used re ... Full text Link to item Cite

Acute kidney transplant failure following transurethral bladder polyp fulguration.

Journal Article J Natl Med Assoc · March 2005 Ureteral obstruction and anastomotic leak represent the most common urologic complications of kidney transplantation. Delay in diagnosis or treatment can lead to allograft loss. Obstruction of the ureter occurs in 2% of kidney transplant recipients. Althou ... Link to item Cite

Post transplant erythrocytosis in hypercalcemic renal transplant recipients.

Journal Article Am J Transplant · July 2003 In vitro data suggest that calcium plays an important role in normal and disordered erythropoiesis. The purpose of this study is to determine whether there is an association between serum calcium, various hormone levels, and the development of post transpl ... Full text Link to item Cite

Impact of dialysis dose and membrane on infection-related hospitalization and death: results of the HEMO Study.

Journal Article J Am Soc Nephrol · July 2003 Infection is the second most common cause of death among hemodialysis patients. A predefined secondary aim of the HEMO study was to determine if dialysis dose or flux reduced infection-related deaths or hospitalizations. The effects of dialysis dose, dialy ... Full text Link to item Cite

Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection.

Journal Article Transplantation · May 15, 2003 BACKGROUND: Acute humoral rejection (AHR) has been associated with enhanced graft loss. Our study compared the renal allograft survival of patients with AHR treated with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) with allograft survival in p ... Full text Link to item Cite

Coronary steal from a left internal mammary artery coronary bypass graft by a left upper extremity arteriovenous hemodialysis fistula.

Journal Article Am J Kidney Dis · October 2002 In patients with end-stage renal disease undergoing hemodialysis, the upper extremity arteriovenous (AV) fistula is the dialysis access recommended by the DOQI guidelines for patients with appropriate vasculature. Upper extremity AV fistulae have long peri ... Full text Link to item Cite

The case against chronic venous hemodialysis access.

Journal Article J Am Soc Nephrol · August 2002 Full text Link to item Cite

Declining influence of race on the outcome of living-donor renal transplantation.

Journal Article Am J Transplant · March 2002 A racial disparity in graft survival for renal transplant recipients has been documented for both cadaveric and living-donor transplants. In the present single-center study we analyzed graft survival by race for recipients of living-donor kidney transplant ... Full text Link to item Cite

Diagnosis of polyomavirus nephritis:: A correlative approach

Journal Article Pathology Case Reviews · January 1, 2002 Full text Cite

Comparison of transposed brachiobasilic fistulas to upper arm grafts and brachiocephalic fistulas.

Journal Article Kidney Int · October 2001 BACKGROUND: Renewed interest in transposed brachiobasilic fistulas has occurred since the release of the National Kidney Foundation-Dialysis Outcomes Quality Initiative (NKF-DOQI) guidelines because it is an alternative method to achieve an upper arm fistu ... Full text Link to item Cite

Viral infections after renal transplantation.

Journal Article Am J Kidney Dis · April 2001 Viral infections are a leading cause of posttransplantation morbidity and mortality. A number of recent developments have altered our understanding and management of these disorders. The pathogenetic roles of several viruses, including human herpesviruses ... Full text Link to item Cite

Catheter access for hemodialysis: an overview.

Journal Article Semin Dial · 2001 The provision of hemodialysis requires repeated, reliable access to the central circulatory system. Long-term hemodialysis has best been provided by arteriovenous fistulae and arteriovenous grafts. In recent years, more and more patients have been chronica ... Full text Link to item Cite

Renal Revascularization: Who Benefits?

Journal Article Journal of Vascular and Interventional Radiology · January 1, 2001 Full text Cite

Dialysis access infections.

Journal Article Curr Opin Nephrol Hypertens · November 2000 Infections and specifically infectious complications of vascular access remain a major cause of morbidity and mortality in the hemodialysis population. Primary arteriovenous fistulas have the lowest rates of infections and are the access of choice whenever ... Full text Link to item Cite

A role for leukotrienes in cyclosporine nephrotoxicity.

Journal Article Kidney Int · June 2000 BACKGROUND: Nephrotoxicity associated with cyclosporine A (CsA) administration is characterized by marked renal vasoconstriction, interstitial fibrosis, and arteriolar hypertrophy. While the molecular mechanisms of CsA toxicity are not well characterized, ... Full text Link to item Cite

Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients.

Journal Article Transplantation · November 15, 1999 BACKGROUND: Interstitial nephritis caused by BK polyomavirus is a recognized complication of renal transplantation. A study of renal transplant recipients at Duke University Medical Center was undertaken to evaluate diagnostic modalities and assess clinica ... Full text Link to item Cite

Reducing the risk of hemodialysis access.

Journal Article Am J Kidney Dis · August 1999 Full text Link to item Cite

Focal segmental glomerulosclerosis: a need for caution in live-related renal transplantation.

Journal Article Am J Kidney Dis · May 1999 Focal segmental glomerulosclerosis (FSGS) has increasingly been recognized to occur in a familial pattern. We have observed the development of biopsy-confirmed FSGS and subsequent end-stage renal disease (ESRD) in one live related kidney donor and ESRD wit ... Full text Link to item Cite

Losartan in post-transplant erythrocytosis.

Journal Article Nephrol Dial Transplant · December 1996 Full text Link to item Cite

Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys.

Journal Article Acad Radiol · December 1996 RATIONALE AND OBJECTIVES: To evaluate whether decoupling improves signal-to-noise ratio and frequency resolution of in vivo kidney spectra, and to compare native and well-functioning transplant kidneys. METHODS: Proton decoupling in conjunction with three- ... Full text Link to item Cite

A clustering of epidural abscesses in chronic hemodialysis patients: risks of salvaging access catheters in cases of infection.

Journal Article J Am Soc Nephrol · October 1996 The objective of this study was to investigate factors that might increase the risk of epidural abscesses in hemodialysis patients. The charts of all hemodialysis patients presenting with an epidural abscess over a period of 5 yr at Duke University Hospita ... Full text Link to item Cite

Osseous complications of renal transplantation

Journal Article Seminars in Dialysis · January 1, 1996 Osseous complications are an important cause of long-term morbidity in renal transplant recipients. The etiology of these complications is multifactorial and relates to abnormalities of calcium homeostasis that persist after engraftment along with toxic ef ... Full text Cite

Hemodialysis vascular access: effect on urea kinetics and the dialysis prescription.

Journal Article Am J Nephrol · 1996 The effective delivery of dialysis requires repeated reliable access to the central circulation capable of providing rapid blood flow. This access to the circulation continues to be the 'weak link' in the provision of long-term renal replacement therapy. D ... Full text Link to item Cite

Late withdrawal of cyclosporine in stable renal transplant recipients.

Journal Article Am J Kidney Dis · September 1995 The use of cyclosporine (CsA) in renal transplantation has been associated with an improvement in 1-year graft survival, but has not changed the rate of late graft loss. We sought to determine whether the intent to withdraw CsA late after renal transplanta ... Full text Link to item Cite

Role of platelet activating factor in kidney transplant rejection in the rat.

Journal Article Kidney Int · August 1995 Platelet activating factor (PAF) is a potent lipid mediator with a broad range of biologic activities. Experimental evidence suggests that PAF plays a role in the pathogenesis of a variety of inflammatory processes including allograft rejection. In this st ... Full text Link to item Cite

Clinical and pathologic features of familial focal segmental glomerulosclerosis.

Journal Article Am J Kidney Dis · July 1995 The occurrence of focal segmental glomerulosclerosis (FSGS) in a familial pattern has been rarely reported previously. Over the last 10 years we have treated 31 patients among eight families with familial FSGS. The diagnosis was confirmed by renal biopsy i ... Full text Link to item Cite

A quality improvement program for hemodialysis vascular access.

Journal Article Adv Ren Replace Ther · July 1994 The effective delivery of dialysis requires repeated reliable access to the central circulation capable of providing rapid extracorporeal blood flow. Unfortunately, this access to the circulation continues to be the "weak link" in the effective delivery of ... Full text Link to item Cite

Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.

Journal Article J Immunol · January 15, 1994 To investigate the role of leukotrienes in renal allograft rejection, we studied the effects of specific leukotriene inhibitors in a rat kidney transplant model. The enhanced renal production of leukotrienes observed in allograft recipients was reduced in ... Link to item Cite