Scholars@Duke
David S. Caldwell

David S. Caldwell

Associate Professor of Medicine
Medicine, Rheumatology and Immunology
caldw009@mc.duke.edu
Duke Box 2978, Durham, NC 27710
014 Baker House, Durham, NC 27710

Selected Publications

Effects of a Weight and Pain Management Program in Patients With Rheumatoid Arthritis With Obesity: A Randomized Controlled Pilot Investigation.

Journal Article J Clin Rheumatol · January 1, 2022 BACKGROUND: Obesity is associated with poor outcomes for patients with rheumatoid arthritis (RA). Effective weight management is imperative. Although traditional lifestyle behavioral weight loss programs have demonstrated efficacy for reducing weight, thes ... Full text Link to item Cite

Self-Efficacy for Pain Communication Moderates the Relation Between Ambivalence Over Emotional Expression and Pain Catastrophizing Among Patients With Osteoarthritis.

Journal Article J Pain · September 2018 UNLABELLED: Pain catastrophizing (ie, the tendency to focus on and magnify pain sensations and feel helpless in the face of pain) is one of the most important and consistent psychological predictors of the pain experience. The present study examined, in 60 ... Full text Link to item Cite

The development and assessment of the Worry About Pain Questionnaire.

Journal Article Eur J Pain · August 2017 BACKGROUND: Worry can be conceptualized as a cognitive-affective automatic process initiated in order to address uncertainty and potential personal inadequacies that could result in negative outcomes. The purpose of the current study was to develop a measu ... Full text Link to item Cite

Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation.

Journal Article Osteoarthritis Cartilage · September 2016 OBJECTIVE: To investigate the effects of pain coping skills training (PCST) and a lifestyle behavioral weight management (BWM) program on inflammatory markers and biomarker associations with pain and function in the OA LIFE study. METHOD: Serum samples wer ... Full text Link to item Cite

Cognitive behavioral therapy for chronic pain is effective, but for whom?

Journal Article Pain · September 2016 Moderator analyses are reported for posttreatment outcomes in a large, randomized, controlled effectiveness trial for chronic pain for hip and knee osteoarthritis (N = 256). Pain Coping Skills Training, a form of cognitive behavioral therapy, was compared ... Full text Link to item Cite

Automated Internet-based pain coping skills training to manage osteoarthritis pain: a randomized controlled trial.

Journal Article Pain · May 2015 Osteoarthritis (OA) places a significant burden on worldwide public health because of the large and growing number of people affected by OA and its associated pain and disability. Pain coping skills training (PCST) is an evidence-based intervention targeti ... Full text Link to item Cite

North Carolina medical legacy.

Journal Article N C Med J · April 2015 Full text Link to item Cite

Nurse practitioners can effectively deliver pain coping skills training to osteoarthritis patients with chronic pain: A randomized, controlled trial.

Journal Article Pain · September 2014 A multisite, randomized, controlled clinical effectiveness trial was conducted for osteoarthritis patients with chronic pain of the knee or hip. Adult health nurse practitioners provided a 10-session intervention, pain coping skills training (PCST), in pat ... Full text Link to item Cite

Pain, physical functioning, and overeating in obese rheumatoid arthritis patients: do thoughts about pain and eating matter?

Journal Article J Clin Rheumatol · August 2014 BACKGROUND: Obese rheumatoid arthritis (RA) patients have higher levels of pain, disability, and disease activity than do nonobese patients with RA. Patients' health-related thoughts about arthritis and weight may be important to consider in obese patients ... Full text Link to item Cite

Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study.

Journal Article Pain · June 2012 Overweight and obese patients with osteoarthritis (OA) experience more OA pain and disability than patients who are not overweight. This study examined the long-term efficacy of a combined pain coping skills training (PCST) and lifestyle behavioral weight ... Full text Link to item Cite

Disease severity and domain-specific arthritis self-efficacy: relationships to pain and functioning in patients with rheumatoid arthritis.

Journal Article Arthritis Care Res (Hoboken) · June 2010 OBJECTIVE: To examine the degree to which disease severity and domains of self-efficacy (pain, function, and other symptoms) explain pain and functioning in rheumatoid arthritis (RA) patients. METHODS: Patients (n = 263) completed the Arthritis Impact Meas ... Full text Link to item Cite

The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis.

Journal Article Arch Phys Med Rehabil · November 2009 OBJECTIVE: To examine the degree to which 2 commonly used measures of pain and disability, the Arthritis Impact Measurement Scales (AIMS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), relate to objective gait measurements. ... Full text Link to item Cite

Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability.

Journal Article J Pain Symptom Manage · May 2009 This study examined the degree to which pain catastrophizing and pain-related fear explain pain, psychological disability, physical disability, and walking speed in patients with osteoarthritis (OA) of the knee. Participants in this study were 106 individu ... Full text Link to item Cite

A randomized, controlled trial of emotional disclosure in rheumatoid arthritis: can clinician assistance enhance the effects?

Journal Article Pain · July 2008 Emotional disclosure by writing or talking about stressful life experiences improves health status in non-clinical populations, but its success in clinical populations, particularly rheumatoid arthritis (RA), has been mixed. In this randomized, controlled ... Full text Link to item Cite

Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain.

Journal Article Pain · June 2008 This study examined arthritis self-efficacy and self-efficacy for resisting eating as predictors of pain, disability, and eating behaviors in overweight or obese patients with osteoarthritis (OA) of the knee. Patients (N=174) with a body mass index between ... Full text Link to item Cite

A comparison of conventional pain coping skills training and pain coping skills training with a maintenance training component: a daily diary analysis of short- and long-term treatment effects.

Journal Article J Pain · September 2006 UNLABELLED: Pain coping skills training (PCST) has been shown to produce immediate improvements in pain and disability in rheumatoid arthritis (RA). However, some patients have difficulty maintaining these gains. This study compared a conventional PCST pro ... Full text Link to item Cite

Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences.

Journal Article J Pain Symptom Manage · March 2006 Studies have documented the efficacy of coping skills training (CST) for managing pain, distress, and disability in persons with arthritis. However, no laboratory studies have examined the effects of CST on descending modulation of nociception. This study ... Full text Link to item Cite

Laboratory pain perception and clinical pain in post-menopausal women and age-matched men with osteoarthritis: relationship to pain coping and hormonal status.

Journal Article Pain · December 2004 The present study examined relationships between pain coping, hormone replacement therapy, and laboratory and clinical pain reports in post-menopausal women and age-matched men with osteoarthritis. Assessment of nociceptive flexion reflex threshold was fol ... Full text Link to item Cite

Gender differences in patient-spouse interactions: a sequential analysis of behavioral interactions in patients having osteoarthritic knee pain.

Journal Article Pain · November 2004 Theory and research suggest that spousal responses to displays of pain behavior can vary markedly. To our knowledge, observational research on spousal responses to pain behavior has been carried out only in chronic low back pain patients, but not in other ... Full text Link to item Cite

Effects of spouse-assisted coping skills training and exercise training in patients with osteoarthritic knee pain: a randomized controlled study.

Journal Article Pain · August 2004 This study tested the separate and combined effects of spouse-assisted pain coping skills training (SA-CST) and exercise training (ET) in a sample of patients having persistent osteoarthritic knee pain. Seventy-two married osteoarthritis (OA) patients with ... Full text Link to item Cite

Gender differences in pain, coping, and mood in individuals having osteoarthritic knee pain: a within-day analysis.

Journal Article Pain · August 2004 This study examined gender differences in prospective within-day assessments of pain, pain coping, and mood in men and women having OA, and analyzed gender differences in dynamic relations between pain, mood, and pain coping. A sample of 64 women and 36 me ... Full text Link to item Cite

Recent advances and future directions in the biopsychosocial assessment and treatment of arthritis.

Journal Article J Consult Clin Psychol · June 2002 This article provides an overview of the emerging literature on biopsychosocial assessment and treatment for two of the most common forms of arthritis: osteoarthritis and rheumatoid arthritis. The article is divided into 3 parts. In the 1st part, the basic ... Full text Link to item Cite

Living with rheumatoid arthritis: the role of daily spirituality and daily religious and spiritual coping.

Journal Article J Pain · April 2001 The objective of this preliminary study was to evaluate more fully the role of daily spiritual experiences and daily religious/spiritual coping in the experience of individuals with pain due to rheumatoid arthritis (RA). Thirty-five individuals with RA wer ... Full text Link to item Cite

The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing.

Journal Article Pain · September 2000 One hundred and sixty-eight patients with osteoarthritis (OA) of the knees participated in this study. Of the participants, 72 were men and 96 were women. All participants completed the Arthritis Impact Measurement Scales (AIMS), underwent a 10 min standar ... Full text Link to item Cite

Understanding the adoption of arthritis self-management: stages of change profiles among arthritis patients.

Journal Article Pain · September 2000 Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of chan ... Full text Link to item Cite

Everyday life with osteoarthritis or rheumatoid arthritis: independent effects of disease and gender on daily pain, mood, and coping.

Journal Article Pain · December 1999 The effects of disease (form of arthritis) and gender on pain, mood, and pain coping strategies were examined in a prospective 30-day diary study of 71 patients with osteoarthritis (OA) and 76 with rheumatoid arthritis (RA). Diary instruments included join ... Full text Link to item Cite

Spouse-assisted coping skills training in the management of knee pain in osteoarthritis: long-term followup results.

Journal Article Arthritis Care Res · April 1999 OBJECTIVE: To evaluate the long-term effects of a spouse-assisted coping skills intervention in patients with osteoarthritis (OA) of the knees, and to evaluate how pre- to posttreatment changes in marital adjustment and self-efficacy relate to long-term im ... Full text Link to item Cite

The relationship of arthritis self-efficacy to daily pain, daily mood, and daily pain coping in rheumatoid arthritis patients.

Journal Article Pain · March 1999 There is an increasing awareness in the medical community that psychosocial variables such as beliefs in self-efficacy are important determinants of treatment outcome. However, before measures of self-efficacy are widely incorporated into clinical practice ... Full text Link to item Cite

Pain coping strategies that predict patients' and spouses' ratings of patients' self-efficacy.

Journal Article Pain · November 1997 This study examined the relationship of pain coping strategies to osteoarthritis patients' ratings of self-efficacy and to spouses' ratings of the patients' self-efficacy. Subjects, 130 individuals having osteoarthritis of the knees and persistent knee pai ... Full text Link to item Cite

Self-efficacy for arthritis pain: relationship to perception of thermal laboratory pain stimuli.

Journal Article Arthritis Care Res · June 1997 OBJECTIVE: To examine how self-efficacy for arthritis pain relates to the perception of controlled laboratory pain stimuli. METHODS: Forty patients with osteoarthritis completed self-report measures of self-efficacy for arthritis pain. They then participat ... Full text Link to item Cite

Cognitive behavioral control of arthritis pain.

Journal Article Med Clin North Am · January 1997 Cognitive-behavioral approaches appear to offer a viable alternative for the management of arthritis pain. Controlled studies have documented the efficacy of CBT protocols for managing pain in individuals having OA and RA. Preliminary studies examining the ... Full text Link to item Cite

A computer-assisted observational method for assessing spouses' ratings of osteoarthritis patients' pain

Journal Article Psychology, Health and Medicine · January 1, 1997 This article presents preliminary data on a new method for analysing spouses' ratings of their marital partner's pain. Subjects were 19 individuals with persistent osteoarthritic knee pain and their spouses. Spouses viewed a videotape of the patient engagi ... Full text Cite

Pain coping strategies and coping efficacy in rheumatoid arthritis: a daily process analysis.

Journal Article Pain · January 1997 Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and pos ... Full text Link to item Cite

Spouse-assisted coping skills training in the management of osteoarthritic knee pain.

Journal Article Arthritis Care Res · August 1996 OBJECTIVE: To evaluate the effects of a spouse-assisted pain-coping skills training intervention on pain, psychological disability, physical disability, pain-coping, and pain behavior in patients with osteoarthritis (OA) of the knees. METHODS: Eighty-eight ... Full text Link to item Cite

Cyclosporin A therapy for Wegener's granulomatosis.

Journal Article Adv Exp Med Biol · 1993 Five patients with active Wegener's granulomatosis were treated with the immunosuppressive agent Cyclosporin A, along with low dose prednisone. All five patients had previously taken cyclophosphamide, but further treatment with this agent was not desired, ... Full text Link to item Cite

Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.

Journal Article J Rheumatol · September 1992 We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX fo ... Link to item Cite

Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.

Journal Article J Clin Immunol · September 1992 Rheumatoid arthritis is a complex inflammatory disease of unknown cause. Although various laboratory and clinical measurements are useful in managing these patients, there is a need for better tests to quantitatively assess disease activity. The purpose of ... Full text Link to item Cite

Analyzing pain in rheumatoid arthritis patients. Pain coping strategies in patients who have had knee replacement surgery.

Journal Article Pain · August 1991 This study used the Coping Strategies Questionnaire (CSQ) to investigate pain coping strategies in 52 rheumatoid arthritis patients who reported having knee pain 1 year or more following knee replacement surgery. Data analysis revealed that, as a group, th ... Full text Link to item Cite

Psoriatic arthritis of the foot and ankle: analysis of joint involvement and diagnostic errors.

Journal Article Foot Ankle · August 1991 Forty-two patients with psoriatic arthritis arthritis who were referred to a tertiary medical center from 1983 to 1987 were reviewed. The foot and/or ankle was the most common site of joint or bone involvement, (N = 36, 86%). Twenty-six of these patients d ... Full text Link to item Cite

Biofeedback as a means to alter electromyographic activity in a total knee replacement patient.

Journal Article Biofeedback Self Regul · March 1991 This paper presents a single case controlled study of a 75-year-old male having bilateral total knee replacement. Baseline EMG recordings demonstrated differential levels of vastus medialis and vastus lateralis muscle activity in both knees during exercise ... Full text Link to item Cite

Pain coping strategies in rheumatoid arthritis: Relationships to pain, disability, depression and daily hassles

Journal Article Behavior Therapy · January 1, 1991 The present study investigated the relation of pain coping strategies to physical disability, pain, psychological disability, depression and daily hassles in rheumatoid arthritis (RA) patients. Subjects were 65 RA patients recruited from an outpatient rheu ... Full text Cite

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.

Journal Article Clin Immunol Immunopathol · February 1990 To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in ... Full text Link to item Cite

Pain coping skills training in the management of osteoarthritic knee pain: A comparative study

Journal Article Behavior Therapy · January 1, 1990 The purpose of this study was to determine whether a cognitive-behavioral intervention designed to improve pain coping skills could reduce pain, physical disability, psychological disability, and pain behavior in osteoarthritic knee pain patients. Patients ... Full text Cite

Pain coping skills training in the management of osteoarthritic knee pain-II: Follow-up results

Journal Article Behavior Therapy · January 1, 1990 This study examines six months follow-up data obtained from osteoarthritic knee pain patients participating in a study comparing pain coping skills training, arthritis education, and a standard care control condition. At the time of follow-up, patients rec ... Full text Cite

Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy.

Journal Article Pain · April 1989 The present study examined catastrophizing in rheumatoid arthritis (RA) patients. Subjects were 223 RA patients who were participants in a longitudinal study. Each patient completed the Catastrophizing scale of the Coping Strategies Questionnaire (CSQ) on ... Full text Link to item Cite

Dysphagia due to diffuse idiopathic skeletal hyperostosis.

Journal Article Am Fam Physician · April 1989 Although diffuse idiopathic skeletal hyperostosis generally affects the lumbar spine, any segment of the spine may be involved. When the cervical spine is affected, dysphagia may occur. Diabetes mellitus is commonly present. A history of previous cervical ... Link to item Cite

Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis.

Journal Article Am J Med · December 1988 PURPOSE: Beginning in the 1980s, methotrexate has been used successfully to treat rheumatoid arthritis. The magnitude and severity of short- and long-term methotrexate toxicity, however, have not been adequately investigated. Our study was performed to det ... Full text Link to item Cite

Early detection of carpal erosions in patients with rheumatoid arthritis: a pilot study of magnetic resonance imaging.

Journal Article J Rheumatol · September 1988 A pilot study comparing standard radiography to magnetic resonance imaging (MRI) was performed on the wrists of 10 patients with early (anatomic Stage I or II) rheumatoid arthritis (RA). MRI was found to be superior to standard radiographs in 2 respects: ( ... Link to item Cite

Polymyositis after propylthiouracil treatment for hyperthyroidism.

Journal Article Ann Rheum Dis · April 1988 An additional disorder in the spectrum of thyroid related muscle disease is presented. Hypothyroid and hyperthyroid disease are both associated with a variety of muscle abnormalities, from myalgias to myopathy. Polymyositis, however, has never been reporte ... Full text Link to item Cite

Survival in systemic lupus erythematosus. A multivariate analysis of demographic factors.

Journal Article Arthritis Rheum · December 1987 We analyzed survival rate and important clinical outcomes in 411 patients with systemic lupus erythematosus who were seen at our center between 1969 and 1984. All eligible subjects met 4 of the revised American Rheumatism Association criteria for systemic ... Full text Link to item Cite

Pain coping strategies in osteoarthritis patients.

Journal Article J Consult Clin Psychol · April 1987 Full text Link to item Cite

Osteoarthritic knee pain: a behavioral analysis.

Journal Article Pain · March 1987 This study used behavioral assessment techniques to analyze pain in osteoarthritis (OA) patients. Eighty-seven OA patients having chronic knee pain served as subjects. Pain behavior was evaluated using a standard observation method and functional impairmen ... Full text Link to item Cite

Pectoralis pyomyositis: an unusual cause of chest wall pain in a patient with diabetes mellitus and rheumatoid arthritis.

Journal Article J Rheumatol · April 1986 We describe a case of isolated pectoralis swelling and tenderness, without systemic signs of infection, in a North American adult with diabetes mellitus and rheumatoid arthritis. The etiology was discovered to be pyomyositis, usually thought to be a diseas ... Link to item Cite

Peripheral nerve entrapment due to steroid-induced lipomatosis of the popliteal fossa. Case report.

Journal Article J Neurosurg · April 1986 A case of peroneal nerve entrapment is reported in a patient with scleroderma. Compression was due to a lipoma in the popliteal fossa and resulted in increasingly severe foot-drop. Complete recovery occurred after the lipoma was resected. A brief review of ... Full text Link to item Cite

Rheumatologic manifestations of cancer.

Journal Article Med Clin North Am · March 1986 A variety of musculoskeletal syndromes have been described in association with malignancy. The majority of such descriptions have dealt with the connective tissue disorder as a paraneoplastic syndrome, frequently the presenting feature of an otherwise occu ... Full text Link to item Cite

Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector cells and ocular epithelial antigens using monoclonal antibodies.

Journal Article Arthritis Rheum · June 1984 Tissue immune effector cells and epithelial surface antigens present in eye tissue of rheumatoid arthritis (RA) patients with sterile corneal ulceration were studied using a large panel of monoclonal antibodies. During periods of active corneal ulceration, ... Full text Link to item Cite

LATE ONSET SYSTEMIC LUPUS-ERYTHEMATOSUS CHANGING CONCEPTS

Journal Article CLINICAL RESEARCH · January 1, 1984 Link to item Cite

LATE ONSET SYSTEMIC LUPUS-ERYTHEMATOSUS - RACE AND SEX FACTORS

Journal Article CLINICAL RESEARCH · January 1, 1984 Link to item Cite

Occult fractures of the knee: tomographic evaluation.

Journal Article Radiology · August 1983 Seven adults with painful effusions of the knee were examined for occult fractures using pluridirectional tomography in the coronal and lateral planes. Six patients (ages 50-82 years) were osteopenic and gave histories ranging from none to mild trauma; one ... Full text Link to item Cite

Aspiration of the asymptomatic metatarsophalangeal joint in gout patients and hyperuricemic controls.

Journal Article Arthritis Rheum · February 1982 Asymptomatic metatarsophalangeal joints were aspirated in a group of patients with gout, in 2 control groups with hyperuricemia, and in 1 normouricemic control group. Extracellular urate crystals were present in 70% of gout patients, in 1 of 19 patients wi ... Full text Link to item Cite

Carcinoma polyarthritis manifestations and differential diagnosis

Journal Article Medical Grand Rounds · January 1, 1982 It has become clear over the past few years that the recent onset of arthritis can be an early manifestation of an occult malignancy. Indeed, the development of arthritis in the older patient will sometimes present a difficult differential for the concerne ... Cite

Musculoskeletal syndromes associated with malignancy.

Journal Article Semin Arthritis Rheum · February 1981 Evidence has been presented supporting a causal relationship between malignancies and musculoskeletal syndromes. This discussion has dealt primarily with lesser known relationships, more common associations such as hypertrophic osteoarthropathy and dermato ... Full text Link to item Cite

Renal agenesis after first trimester exposure to chlorambucil.

Journal Article South Med J · October 1980 One of a set of twins aborted at 20 weeks' gestation had unilateral renal agenesis after exposure to chlorambucil and prednisone since conception. There are no firm clinical data suggesting that second or third trimester exposure to any of the immunosuppre ... Full text Link to item Cite